Vitamin D in all body tissues was radio-labeled by supplementing completely vitamin D-deficient weanling rats with oral vitamin D3-4-14C for 2 wk. All vitamin D was then withheld, and radioactivity and vitamin D content in a variety of organs and tissues were measured. Adipose tissue was found to contain by far the greatest quantity of radioactivity throughout the 3 month experimental period. Immediately after supplementation, half of the total radioactivity in adipose tissue corresponded to unaltered vitamin D3, and the other half to polar metabolites and esters of vitamin D3 and unidentified peak II. 1 month later there was approximately the same proportion but a decrease in the total quantity of each form. We conclude that adipose tissue is the major storage site for vitamin D3 in its several forms. Unaltered vitamin D3 was the principal storage form observed and presumably a source available for conversion to other metabolites during deprivation.
Saul J. Rosenstreich, Clayton Rich, Wade Volwiler
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Title and authors | Publication | Year |
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The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans
LB Yanoff, SJ Parikh, A Spitalnik, B Denkinger, NG Sebring, P Slaughter, T McHugh, AT Remaley, JA Yanovski |
Clinical Endocrinology | 2006 |
UVB-induced production of 1,25-dihydroxyvitamin D3 and vitamin D activity in human keratinocytes pretreated with a sterol Δ7-reductase inhibitor
K Vantieghem, AM Kissmeyer, PD Haes, R Bouillon, S Segaert |
Journal of Cellular Biochemistry | 2006 |
Vitamin D Status and the Metabolic Syndrome
LA Martini, RJ Wood |
Nutrition Reviews | 2006 |
Vitamin D and its binding protein Gc: Long‐term variability in peri‐ and postmenopausal women with and without hormone replacement therapy
L Rejnmark, AL Lauridsen, C Brot, P Vestergaard, L Heickendorff, E Nexo, L Mosekilde |
Scandinavian Journal of Clinical & Laboratory Investigation | 2006 |