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Citations to this article

Dihydrotestosterone in prostatic hypertrophy: I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
Pentti K. Siiteri, Jean D. Wilson
Pentti K. Siiteri, Jean D. Wilson
Published September 1, 1970
Citation Information: J Clin Invest. 1970;49(9):1737-1745. https://doi.org/10.1172/JCI106391.
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Dihydrotestosterone in prostatic hypertrophy: I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man

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Abstract

To explore the relation between androgens and prostatic hypertrophy in man, the concentrations of testosterone, dihydrotestosterone, and androstenedione and the rate of conversion of testosterone to dihydrotestosterone have been measured in normal and hypertrophic prostate tissue. First, a double isotope derivative technique was adapted for the measurement of tissue androgen content in 15 normal and 10 hypertrophic prostates. Although there was no significant difference in the content of androstenedione and testosterone between the two types of tissue, the content of dihydrotestosterone was significantly greater in the hypertrophic tissue (0.60 ±0.10 μg/100 g) than in the normal glands (0.13 ±0.05 μg/100 g). Second, a regional study was performed in three normal prostates and four glands with early hypertrophy, and it was demonstrated that the dihydrotestosterone content was two and three fold greater in the periurethral area where prostatic hypertrophy usually commences than in the outer regions of the gland. Finally, the rate of conversion of testosterone to dihydrotestosterone has been measured under standardized conditions in tissue slices from 4 normal and 20 hypertrophic prostates. There was no significant difference in the rate of dihydrotestosterone formation between the two types of gland (6.0 ±0.8 and 7.8 ±0.5 μμmoles/15 mg of tissue per hr). While the mechanism by which dihydrotestosterone accumulation occurs remains unexplained, it is possible that the local accumulation of dihydrotestosterone may be involved in the pathogenesis of prostatic hypertrophy in man.

Authors

Pentti K. Siiteri, Jean D. Wilson

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M Pollard, DL Snyder, PH Luckert
The Prostate 1987
Induction of estrogen-related hyperplastic changes in the prostate of the cynomolgus monkey (Macaca fascicularis) by androstenedione and its antagonization by the aromatase inhibitor 1-methyl-androsta-1,4-diene-3,17-dione
UF Habenicht, K Schwarz, F Neumann, MF el Etreby
The Prostate 1987
Estrogens and benign prostatic hyperplasia: The basis for aromatase inhibitor therapy
D Henderson, UF Habenicht, Y Nishino, MF Etreby
Steroids 1987
Comparison of nuclear 5α-reductase activities in the stromal and epithelial fractions of human prostatic tissue
RW Hudson
Journal of Steroid Biochemistry 1987
The possibility of aromatization of androgen in human prostate
Y Kaburagi, MB Marino, RY Kirdani, JP Greco, JP Karr, AA Sandberg
Journal of Steroid Biochemistry 1987
Correlation of Biochemical (Receptors, Endogenous Tissue Hormones) and Quantitative Morphologic (Stereologic) Findings in Normal and hyperplastic Human Prostates
G Bartsch, F Keen, G Daxenbichler, C Marth, R Margreiter, A Brüngger, T Sutter, HP Rohr
The Journal of Urology 1987
Characterization of androgen receptors in normal and malignant human prostatic tissues
F Radwan, F Léger, JG Lehoux, M Carmel, M Elhilali
The Prostate 1986
Concentrations of androgens in human benign prostatic hypertrophic tissues incubated for up to three days
NJ Bolton, R Vihko, O Lukkarinen
The Prostate 1986
Regional variation of cytosol androgen receptors throughout the diseased human prostate gland
SP Bowman, DM Barnes, NJ Blacklock, PJ Sullivan
The Prostate 1986
Association states of androgen receptors in nuclei of human benign hypertrophic prostate
N Kyprianou, P Davies
The Prostate 1986
Development of a model for the induction of estrogen-related prostatic hyperplasia in the dog and its response to the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione: Preliminary results
UF Habenicht, K Schwarz, HU Schweikert, F Neumann, ME Etreby
The Prostate 1986
Concentrations of 3β-hydroxy androgens in epithelium and stroma of benign hyperplastic and normal human prostate
W Bartsch, I Kozák, P Gorenflos, H Becker, KD Voigt
The Prostate 1986
Androgen-Binding Proteins from Human Hyperplastic Prostate as Evaluated by Electrophoresis
E Barahona, H Licea, F Torres, J Sierra, S Ortiz, JA Bermudez
Systems Biology in Reproductive Medicine 1986
Prostatic effects induced in dogs by chronic or acute oral administration of 5α-reductase inhibitors
JR Brooks, C Berman, D Garnes, D Giltinan, PF Malatesta, RL Primka, GF Reynolds, GH Rasmusson, LR Gordon
The Prostate 1986
Dihydrotestosterone and 3α-androstanediol dynamics in the normal, involuted, and hyperplastic canine prostate
G McKercher, S Chevalier, KD Roberts, G Bleau, A Chapdelaine
Steroids 1986
3 Changing concepts of active androgens in blood
PK Siiteri, NH Simberg
Clinics in Endocrinology and Metabolism 1986
In vitro metabolism of testosterone in the rat prostate: Influence of aging
M Motta, S Zoppi, L Martini
Journal of Steroid Biochemistry 1986
Intratissular androgens in benign prostatic hyperplasia and prostatic cancer
KD Voigt, W Bartsch
Journal of Steroid Biochemistry 1986
Preponderance of serum and intra-hepatic 5α-dihydrotestosterone in males with hepatocellular carcinoma despite low circulating androgen levels
MJ Iqbal, ML Wilkinson, A Forbes, TP Corbishley, R Williams
Journal of Hepatology 1986
5α-Reductase inhibitory and anti-androgenic activities of some 4-azasteroids in the rat
JR Brooks, C Berman, RL Primka, GF Reynolds, GH Rasmusson
Steroids 1986
The effects of diethyl-4-methyl-3-oxo-4-aza-5α-androstane-17β-carboxamide (4-ma) and (4r)-5,10-SECO-19-norpregna-4,5-diene-3,10,20-trione (SECO) on androgen biosynthesis in the rat testis and epididymis
GM Cooke, B Robaire
Journal of Steroid Biochemistry 1986
L'Estratto Di Serenoa Repens Nell'Iperplasia Prostatica
D Minocci, G Monesi, G Pretti
1986
5α-REDUCTASE ACTIVITY IN HUMAN PROSTATE CANCER IS RELATED TO THE HISTOLOGICAL DIFFERENTIATION OF THE TUMOUR
FK Habib, A Busuttil, RA Robinson, GD Chisholm
Clinical Endocrinology 1985
Tissue interactions and prostatic growth: II. Morphological and biochemical characterization of adult mouse prostatic hyperplasia induced by fetal urogenital sinus implants
GJ Miller, MN Runner, LW Chung
The Prostate 1985
Sex steroid receptors in normal and hyperplastic human prostate
P Robel, B Eychenne, JP Blondeau, EE Baulieu, O Hechter
The Prostate 1985
The effect of 5α-androstane-3α, 17β-diol and 17β-estradiol on the adult and immature chacma baboon prostate
DP de Klerk, HJ Human, JN de Klerk
The Prostate 1985
Hormonal aspects of prostatic cancer: a review
J Waxman
Journal of the Royal Society of Medicine 1985
Quantification of cytosolic steroid receptors in secretory and non-secretory epithelial cells of the canine prostate
D Lamarre, S Chevalier, G McKercher, G Bleau, KD Roberts, A Chapdelaine
Journal of Steroid Biochemistry 1985
The prostasome: its secretion and function in man
G Ronquist, I Brody
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1985
Hydroxylation of [3h]5α-androstane-3β,17β-diol by whole tissue, epithelial cells and fibroblasts from the same hyperplastic human prostate
P Ofner, WH Douglas, SD Spilman, RL Vena, P Krinsky-Feibush, PW LeQuesne
Journal of Steroid Biochemistry 1985
Biochemical Actions of Hormones
D Marver
Biochemical Actions of Hormones 1985
A new dihydrotestosterone-forming index (DHTi)
PI Lundmo, A Sunde, KJ Tveter
Journal of Steroid Biochemistry 1985
Correlated Biochemical and Stereological Studies on Testosterone Metabolism in the Stromal and Epithelial Compartment of Human Benign Prostatic Hyperplasia
HU Schweikert, P Totzauer, HP Rohr, G Bartsch
The Journal of Urology 1985
The Effect of Testicular Irradiation on Established BPH in the Dog: Evidence of a Non-Steroidal Testicular Factor for BPH Maintenance
JT Grayhack, C Lee, W Brand
The Journal of Urology 1985
Discrimination between Normal, Hyperplastic and Malignant Human Prostatic Tissues by Enzymatic Profiles
CB Brendler, AL Follansbee, JT Isaacs
The Journal of Urology 1985
Mitogenic Factors in Prostatic Tissue and Expressed Prostatic Secretion
RE Tackett, WD Heston, RF Parrish, LS Pletscher, WR Fair
The Journal of Urology 1985
Studies on the role of sex-hormone-binding globulin (SHBG) in benign prostatic hypertrophy in men
A Pachman
International Urology and Nephrology 1984
Physicochemical characterization of the androgen receptor from hyperplastic human prostate
LR Murthy, CH Chang, DR Rowley, PT Scardino, DJ Tindall
The Prostate 1984
The articulations of Adam's rib with the lower urinary tract
DD Federman
Kidney International 1984
Nonsteroidal serum factors involved in the regulation of the proliferation of canine prostatic epithelial cells in culture
S Chevalier, G Bleau, KD Roberts, A Chapdelaine
The Prostate 1984
A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasia
G Champault, JC Patel, AM Bonnard
British Journal of Clinical Pharmacology 1984
Induction of benign prostatichypertrophy in baboons
JP Karr, U Kim, JA Resko, S Schneider, LS Chai, GP Murphy, AA Sandberg
Urology 1984
[1-14C]acetate incorporation into free and esterified cholesterol during the development of the rat ventral prostate
MJ Carmena, MA Perez-Albarsanz, MN Recio
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 1984
5α-reductase and 3α-hydroxysteroid dehydrogenase activities in isolated canine prostatic epithelial cells
G McKercher, S Chevalier, KD Roberts, G Bleau, A Chapdelaine
Journal of Steroid Biochemistry 1984
Binding of permixon, a new treatment for prostatic benign hyperplasia, to the cytosolic androgen receptor in the rat prostate
E Carilla, M Briley, F Fauran, C Sultan, C Duvilliers
Journal of Steroid Biochemistry 1984
Novel Approaches to Cancer Chemotherapy
V Petrow, GM Padilla
Novel Approaches to Cancer Chemotherapy 1984
Androgenic control of acetate incorporation into phospholipids and triacylglycerols in rat ventral prostate
N Hoyo, LA Torre, MA Pérez-Albarsanz
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 1984
Benign Prostatic Hyperplasia: A Disorder of Androgen Metabolism in the Male
R Horton
Journal of the American Geriatrics Society 1984
Geriatrics 3
D Platt
1984
4-Azasteroidal 5 alpha-reductase inhibitors without affinity for the androgen receptor
T Liang, CE Heiss, AH Cheung, GF Reynolds, GH Rasmusson
The Journal of biological chemistry 1984
Studies on the role of sex-hormone-binding globulin (SHBG) in benign prostatic hypertrophy in men: I. Clinical research
A Pachman
International Urology and Nephrology 1984
Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate
CB Brendler, SJ Berry, LL Ewing, AR McCullough, RC Cochran, JD Strandberg, BR Zirkin, DS Coffey, LG Wheaton, ML Hiler, MJ Bordy, GD Niswender, WW Scott, PC Walsh
Journal of Clinical Investigation 1983
Tissue content of dihydrotestosterone in human prostatic hyperplasis is not supranormal
PC Walsh, GM Hutchins, LL Ewing
Journal of Clinical Investigation 1983
Nuclear androgen receptors in the epithelium and stroma of human benign prostatic hypertrophic glands
R Lahtonen, NJ Bolton, R Vihko, M Kontturi
The Prostate 1983
Changes in dihydrotestosterone metabolism and the development of benign prostatic hyperplasia in the aging beagle
JT Isaacs
Journal of Steroid Biochemistry 1983
Biochemical and biological studies with 4-aza-steroidal 5α-reductase inhibitors
T Liang, GH Rasmusson, JR Brooks
Journal of Steroid Biochemistry 1983
Kinetic analysis of 5α-reductase isoenzymes in benign prostatic hyperplasia (BPH)
PS Rennie, N Bruchovsky, MG McLoughlin, FH Batzold, EE Dunstan-Adams
Journal of Steroid Biochemistry 1983
Androgens and estrogens: Their interaction with stroma and epithelium of human benign prostatic hyperplasia and normal prostate
M Krieg, W Bartsch, M Thomsen, KD Voigt
Journal of Steroid Biochemistry 1983
Epidermal Growth Factor is not the Major Growth-Promoting Agent in Extracts of Prostatic Tissue
MT Story, SC Jacobs, RK Lawson
The Journal of Urology 1983
Benign Prostatic Hypertrophy
F Hinman, S Boyarsky
1983
The clinical significance of steroid hormone measurements in the management of patients with prostatic cancer
R Ghanadian, CM Puah
World Journal of Urology 1983
Cancer of the Prostate and Kidney
M Pavone-Macaluso, PH Smith
1983
Gene Regulation by Steroid Hormones II
AK Roy, JH Clark
1983
Effect of a new 5α-reductase inhibitor on size, histologic characteristics, and androgen concentrations of the canine prostate
JR Brooks, D Berman, MS Glitzer, LR Gordon, RL Primka, GF Reynolds, GH Rasmusson
The Prostate 1982
Testosterone metabolism by homogenates of human prostates with benign hyperplasia: Effect of tissular concentrations of zinc, magnesium and copper
G Sinquin, R Morfin, JF Charles, HH Floch
Journal of Steroid Biochemistry 1982
Effect of hormone injections on levels of cytosolic receptors for estrogen, androgen and progesterone in dog prostate
G Frenette, JY Dube, RR Tremblay
Journal of Steroid Biochemistry 1982
Effects of the administration of androgenic and estrogenic steroids on 3α-hydroxysteroid dehydrogenase levels of the intact and castrated dog prostate
P Talalay, M Shikita, M Renaud
Journal of Steroid Biochemistry 1982
Studies of the cytosol 3α-hydroxysteroid dehydrogenase of human prostatic tissue: Comparison of enzyme activities in hyperplastic, malignant and normal tissues
RW Hudson
Journal of Steroid Biochemistry 1982
Uptake and retention of androgens by the rat ventral prostate and consideration of their use as site directing agents
EK Symes
Biochemical Pharmacology 1982
Plasma steroids in benign prostatic hypertrophy and carcinoma of the prostate
D Drafta, E Proca, V Zamfir, AE Schindler, E Neacsu, E Stroe
Journal of Steroid Biochemistry 1982
Preparation of Epithelial and Stromal Cell Fractions from Immature Rat Prostatic Tissue Using Percoll Gradients
J Orlowski, CE Bird, AF Clark
Journal of andrology 1982
Testosterone Metabolism of Fibroblasts Grown From Prostatic Carcinoma, Benign Prostatic Hyperplasia and Skin Fibroblasts
HU Schweikert, HJ Hein, JC Romijn, FH Schröder
The Journal of Urology 1982
The Endocrinology of Prostate Tumours
R Ghanadian
1982
Enzymatic estimation of steroids in subpicomole quantities by hydroxysteroid dehydrogenases and nicotinamide nucleotide cycling
DW Payne, M Shikita, P Talalay
The Journal of biological chemistry 1982
Suppressive Effects of Surgical Stress on Circulating Androgens During and After Prostatectomy
R Ghanadian, CM Puah, G Williams, PJ Shah, N McWHlNNEY
British Journal of Urology 1981
Inhibition of Testosterone Metabolism by Medrogestone in Rat Ventral Prostate in Vivo and in Vitro
N Jagarinec, ML Givner
Systems Biology in Reproductive Medicine 1981
Responses of serum levels of testicular steroid hormones to hCG stimulation in patients with prostatic cancer and benign prostatic hypertrophy
K Isurugi, M Kanazawa, T Yanaihara, A Kambegawa
The Prostate 1981
Elevated intranuclear dihydrotestosterone in prostatic hyperplasia of aging dogs
AW Meikle, ES Collier, JD Stringham, SM Fang, GN Taylor
Journal of Steroid Biochemistry 1981
Studies of the nuclear 5α-reductase of human hyperplastic prostatic tissue
RW Hudson
Journal of Steroid Biochemistry 1981
Inhibition of 5 alpha-reductase, receptor binding, and nuclear uptake of androgens in the prostate by a 4-methyl-4-aza-steroid
T Liang, CE Heiss
The Journal of biological chemistry 1981
Stereological analysis of the dog prostate (analytical model)
HP Rohr, I Krisl, O Holliger, M Oberholzer, G Bartsch
Urological Research 1981
Androgen- and Estrogen-Receptor Content in Spontaneous and Experimentally Induced Canine Prostatic Hyperplasia
J Trachtenberg, LL Hicks, PC Walsh
Journal of Clinical Investigation 1980
Alteration in the metabolism of dihydrotestosterone in elderly men with prostate hyperplasia
I Morimoto, A Edmiston, R Horton
Journal of Clinical Investigation 1980
Dihydrotestosterone Receptors in the Human Prostate. I. Nuclear Concentration in Normal, Benign, and Malignant Tissues
JG Lehoux, B Benard, M Elhilali
Systems Biology in Reproductive Medicine 1980
Endocrine control and physiology of the prostate
AA Sandberg
The Prostate 1980
The effect of therapy on the concentration and occupancy of androgen receptors in human prostatic cytosol
BG Mobbs, IE Johnson, JG Connolly
The Prostate 1980
Peripheral and Prostatic Vein Steroid Concentrations in Benign Prostatic Hypertrophy Patients Before and After Removal of the Adenoma
O Lukkarinen, GL Hammond, M Kontturi, R Vihko
Scandinavian Journal of Urology and Nephrology 1980
Characterization of canine prostatic cells from normal and hyperplastic glands
S Chevalier, G Bleau, KD Roberts, A Chapdelaine
Molecular and Cellular Endocrinology 1980
Correlation between clinical response to antiandrogenic therapy and occurrence of receptors in human prostatic cancer
A Martelli, S Grilli, M Soli, CD Giovanni, E Bercovich, MC Galli, G Prodi
Urology 1980
The pathogenesis of benign prostatic hyperplasia
JD Wilson
The American Journal of Medicine 1980
Prostatic tissue distribution of 17β-hydroxy-5α-androstan-3-one and of androgen receptors in benign hyperplasia
DA Sirett, SK Cowan, AE Janeczko, JK Grant, ES Glen
Journal of Steroid Biochemistry 1980
Subcellular distribution of androgens in hyperplastic human prostate
L Verdonck, JP Slypere, MA Sayed, MV Sande, KV Camp, A Vermeulen
Journal of Steroid Biochemistry 1980
Prostatic Carcinoma
ES Hafez, E Spring-Mills
1980
Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol
RJ Moore, JM Gazak, JD Wilson
Journal of Clinical Investigation 1979
Comparison of spontaneous and experimentally induced canine prostatic hyperplasia
DP DeKlerk, DS Coffey, LL Ewing, IR McDermott, WG Reiner, CH Robinson, WW Scott, JD Strandberg, P Talalay, PC Walsh, LG Wheaton, BR Zirkin
Journal of Clinical Investigation 1979
Concentration of Dihydrotestosterone and 3α-Androstanediol in Naturally Occurring and Androgen- Induced Prostatic Hyperplasia in the Dog
RJ Moore, JM Gazak, JF Quebbeman, JD Wilson
Journal of Clinical Investigation 1979
THE HORMONAL STATUS OF PATIENTS WITH BENIGN PROSTATIC HYPERTROPHY: FSH, LH, TSH AND PROLACTIN RESPONSES TO RELEASING HORMONES
GL Hammond, O Lukkarinen, P Vihko, M Kontturi, R Vihko
Clinical Endocrinology 1979
A Morphological Study on the Effect of Cyproterone Acetate on Human Prostatic Carcinoma
KJ Tveter, A Attramada, R Hannestad, B Otnes
Scandinavian Journal of Urology and Nephrology 1979
Serum testosterone and dihydrotestosterone in carcinoma of the prostate
R Ghanadian, CM Puah, EP O'Donoghue
British Journal of Cancer 1979
Benign prostatic hyperplasia in an XX man
MJ Marinello, W Montes, WE Farnsworth, D Hare, B Fisher, RM Bannerman
Urology 1979
Content of 5α-reduced androgens in subcellular compartments of dog prostate
AW Meikle, GV Burton, JD Stringham, F Sen-Maw
Journal of Steroid Biochemistry 1979
A comparative study of binding, metabolism and endogenous levels of androgens in normal, hyperplastic and carcinomatous human prostate
M Krieg, W Bartsch, W Janssen, KD Voigt
Journal of Steroid Biochemistry 1979
Binding of androgens in dog prostate cytosol and in plasma
JY Dubé, RR Tremblay, FT Dionne, P Chapdelaine
Journal of Steroid Biochemistry 1979
9 Ageing and endocrine function
PJ Davis
Clinics in Endocrinology and Metabolism 1979
Hormonal Steroids
W Nowaczynski, P Landais, T Murakami, M Nowaczynski, D Mavoungou, B Vitullo
Hormonal Steroids 1979
A microassay for the measurement of androgen receptors in human prostatic tissue
LL Hicks, PC Walsh
Steroids 1979
Testosterone 5α-reductase and the accumulation of dihydrotestosterone in benign prostatic hyperplasia
RA Cowan, BC Sheila, K Cowan, JK Grant, DA Sirett, AM wallace
Journal of Steroid Biochemistry 1979
C19O2-steroid transformations in the human normal, hyperplastic and cancerous prostate
RF Morfin, JF Charles, HH Floch
Journal of Steroid Biochemistry 1979
Metabolism of C19-radiosteroids by explants of canine prostate and epididymis with disposition as hydroxylated products: A possible mechanism for androgen inactivation
P Ofner, RL Vena, I Leav, DW Hamilton
Journal of Steroid Biochemistry 1979
3-Alpha-Androstanediol and Prostatic Growth: Comparison of 3-Alpha-Androstanediol Formation in Prostates from 8 Species Including Man and Dog
GH Jacobi, JD Wilson
The Journal of Urology 1979
Characterization of the Binding of a Potent Synthetic Androgen, Methyltrienolone, to Human Tissues
M Menon, CE Tananis, LL Hicks, EF Hawkins, MG McLoughlin, PC Walsh
Journal of Clinical Investigation 1978
Androgen Receptor Content of the Normal and Hyperplastic Canine Prostate
SA Shain, RW Boesel
Journal of Clinical Investigation 1978
Sex Steroid Production and Secretion in the Male*,**
R Horton
Andrologia 1978
SERUM STEROIDS IN NORMAL MALES AND PATIENTS WITH PROSTATIC DISEASES
GL Hammond, M Kontturi, P Vihko, R Vihko
Clinical Endocrinology 1978
The influence of aging on androgen dynamics in the male rat
CL Robinette, MG Mawhinney
Archives of Biochemistry and Biophysics 1978
Estrophilic molecules in the male guinea pig
CD Blume, MG Mawhinney
Journal of Steroid Biochemistry 1978
Comparison of testosterone, 5α-dihydrotestosterone and 5α-androstane-3β,17β-diol metabolisms in human normal and hyperplastic prostates
RF Morfin, SD Stefano, JP Bercovici, HH Floch
Journal of Steroid Biochemistry 1978
The use of methyltrienolone in the measurement of the free and bound cytoplasmic receptors for dihydrotestosterone in benign hypertrophied human prostate
R Ghanadian, G Auf, PJ Chaloner, GD Chisholm
Journal of Steroid Biochemistry 1978
Altered Androgen Metabolism in Metastatic Prostate Cancer
B Kliman, GR Prout, RA Maclaughlin, JJ Daly, PP Griffin
The Journal of Urology 1978
The Nuclear Uptake of Androgen by Human Benign Prostate in Vitro: Action of Antiandrogens
EK Symes, EJ Milroy, WI Mainwaring
The Journal of Urology 1978
Pharmacological Intervention in the Aging Process
J Roberts, RC Adelman, VJ Cristofalo
1978
SERUM FSH, LH AND PROLACTIN IN NORMAL MALES AND PATIENTS WITH PROSTATIC DISEASES
GL Hammond, M Kontturi, P Määttälä, M Puukka, R Vihko
Clinical Endocrinology 1977
β-retinoic acid inhibits and reverses testosterone-induced hyperplasia in mouse prostate organ cultures
DP Chopra, LJ Wilkoff
Nature 1977
Steroid receptors in the human prostate. Detection of tissue-specific androgen binding in prostate cancer
EF Hawkins, M Nijs, C Brassinne
Clinica Chimica Acta 1977
Serum Dihydrotestosterone in Patients with Benign Prostatic Hypertrophy
R Ghanadian, JG Lewis, GD Chisholm, EP O'donoghue
British Journal of Urology 1977
Metabolism of Testosterone in the Human Prostate and Seminal Vesicles
O Djøseland, KJ Tveter, A Attramadal, V Hansson, HN Haugen, W Mathisen
Scandinavian Journal of Urology and Nephrology 1977
Biosynthesis of [1,2-3H]5α-androstane-3β,7α,17β-triol
RF Morfin, S Stefano, LG Bardou, HH Floch
Biochimie 1977
Treatment of benign prostatic hyperplasia with hydroxyprogesterone-caproate placebo-controlled study
D Meiraz, Y Margolin, A Lev-Ran, J Lazebnik
Urology 1977
Ultrastructural and Enzyme-histochemical Studies of the Prostate of the Dog under the Effect of Estradiol
C Hohbach
Beiträge zur Pathologie 1977
Metabolism of 5α-dihydrotestosterone in human benign hyperplastic prostate
K Malathi, E Gurpide
Journal of Steroid Biochemistry 1977
Quantification of endogenous testosterone and dihydrotestosterone and their possible intracellular determinants in various tissues of the male guinea pig
FL Schwartz, MG Mawhinney
Journal of Steroid Biochemistry 1977
The Measurement of Androgen Receptors in Human Prostatic Tissue Utilizing Sucrose Density Centrifugation and a Protamine Precipitation Assay
M Menon, CE Tananis, MG Mcloughlin, ME Lippman, PC Walsh
The Journal of Urology 1977
The induction of prostatic hypertrophy in the dog with androstanediol
PC Walsh, JD Wilson
Journal of Clinical Investigation 1976
Influence of steroid-receptor complexes on transcription by human hypertrophied prostatic RNA polymerases
P Davies, K Griffiths
Molecular and Cellular Endocrinology 1976
Testosterone Metabolism in Benign Prostatic Hypertrophy:in vivoStudies of Gestonorone Caproate and Cyproterone Acetate
F Orestano, JE Altwein
British Journal of Urology 1976
A method for tissue extraction and determination of prostate concentrations of endogenous androgens by radioimmunoassay
J Albert, J Geller, S Geller, D Lopez
Journal of Immunological Methods 1976
Male pseudohermaphroditism: The complexities of male phenotypic development
J Imperato-McGinley, RE Peterson
The American Journal of Medicine 1976
Proceedings of the Fourth International Congress on Hormonal Steroids
RK Kalkhoff
Proceedings of the Fourth International Congress on Hormonal Steroids 1976
Mechanism of Action of the Sex Steroid Hormones
L Chan, BW O'Malley
New England Journal of Medicine 1976
Prostate concentrations of endogenous androgens by radioimmunoassay
J Albert, J Geller, S Geller, D Lopez
Journal of Steroid Biochemistry 1976
Urinary hormone excretion in benign prostatic hyperplasia
H Sko¨ldefs, K Carlstro¨m, M Furuhjelm
Journal of Steroid Biochemistry 1976
Intracellular localisation of 5α-dihydrotestosterone in human benign prostatic hypertrophy
R Ghanadian, GD Chisholm, K Fotherby
Clinica Chimica Acta 1976
Enzyme Induction
TD Gelehrter
New England Journal of Medicine 1976
Androgen of the Human Prostate
WE Farnsworth, JR Brown
Endocrine Research 1976
In Vitro Uptake of 3 H Testosterone and its Conversion to Dihydrotestosterone by Prostatic Carcinoma and Other Tissues
GR Prout, B Kliman, JJ Daly, RA Maclaughlin, PP Griffin
The Journal of Urology 1976
Steroid Hormone Action and Cancer
KM Menon, JR Reel
1976
Studies on the regulation of the concentration of androgens and androgen receptors in nuclei of prostatic cells
N Bruchovsky, PS Rennie, A Vanson
Biochimica et Biophysica Acta (BBA) - Biomembranes 1975
Thin-layer chromatography and high resolution selected ion monitoring for the analysis of C19 steroids in human hyperplastic prostate tissue
DS Millington, ME Buoy, G Brooks, ME Harper, K Griffiths
Biological Mass Spectrometry 1975
Similarities between 5α-dihydrotestosterone-receptor complexes from human and rat prostatic tissue: Effects on RNA polymerase activity
P Davies, K Griffiths
Molecular and Cellular Endocrinology 1975
The effect of steroid hormones on the growth pattern and RNA synthesis in human benign prostatic hyperplasia in organ culture
I Lasnitzki, RH Whitaker, JF Withycombe
British Journal of Cancer 1975
Androgen receptor in human skin fibroblasts characterization of a specific 17β-hydroxy-5α-androstan-3-one-protein complex in cell sonicates and nuclei
BS Keenan, WJ Meyer, AJ Hadjian, CJ Migeon
Steroids 1975
The effect of a synthetic progestine on the fine structure of rat prostate (ultrastructural-morphometric analysis)
G Bartsch, C Hindermann, HP Rohr
Experimental and Molecular Pathology 1975
Androgen metabolism in the hypertrophic prostate
JD Wilson, RE Gloyna, PK Siiteri
Journal of Steroid Biochemistry 1975
Mechanism of androgen action at the cellular level
M Sluyser, AA Kassenaar
Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology 1975
Mode of action of progesterone, gestonorone capronate (depostat) and cyproterone acetate (androcur) on the metabolism of testosterone in human prostatic adenoma: in vitro and in vivo investigations
F Orestano, JE Altwein, P Knapsten, K Bandhauer
Journal of Steroid Biochemistry 1975
Testosterene and perogsterone metabolism and their interaction in the human hyperplastic prostate
RF Morfin, JP Bercovici, JF Charles, HH Floch
Journal of Steroid Biochemistry 1975
The influence of androgen receptors on the concentration of androgens in nuclei of hormone-responsive cells
N Bruchovsky, PS Rennie, B Lesser, DJ Sutherland
Journal of Steroid Biochemistry 1975
Properties and subcellular distribution of Δ4 -steroid (progesterone) 5α-reductase in rat anterior pituitary
C Yi-Juang, HJ Karavolas
Steroids 1975
Recent Advances in Steroid Biochemistry
O Domínguez, C Loza, L Morán, A Valencia
1975
Physiologic Basis for Hormonal Therapy in Carcinoma of the Prostate
PC Walsh
The Urologic clinics of North America 1975
Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus
YJ Cheng, HJ Karavolas
The Journal of biological chemistry 1975
A systematic study of testosterone metabolism in benign prostatic hypertrophy (BPH): In vitro results
JE Altwein, F Orestano
Urological Research 1975
In vitro studies of the regulation of androgen-tissue relationship in normal canine and hyperplastic human prostate
EP Giorgi, TF Moses, JK Grant, R Scott, J Sinclair
Molecular and Cellular Endocrinology 1974
The effects of 5alpha-dihydrotestosterone on the kinetics of cell proliferation in rat prostate
B Lesser, N Bruchovsky
Biochemical Journal 1974
Investigations of androgen-prostatic tissue relationships in superfusion experiments using steroid concentrations approaching those found in vivo
JK Grant, EP Giorgi
Journal of Steroid Biochemistry 1974
Studies on the in vivo hormonal control of rat prostatic testosterone 4-ene-5α-reductase activity
DK Lee, CE Bird, AF Clark
Journal of Steroid Biochemistry 1974
Current Topics in Experimental Endocrinology
M Jutisz, C Tertrin-Clary
Current Topics in Experimental Endocrinology 1974
Steroid–Cell Interactions
R King, W Mainwaring
Steroid–Cell Interactions 1974
Male Accessory Sex Organs
D Kirchheim, D Brandes, R Bacon
Male Accessory Sex Organs 1974
Extraction of the reduced nicotinamide adenine dinucleotide phosphate. Δ 4 -3-Ketosteroid-5α-oxidoreductase of rat prostate with digitonin and potassium chloride
RJ Moore, JD Wilson
Biochemistry 1974
In vitro effects of estrogens on rat prostatic 5α-reduction of testosterone
DK Lee, CE Bird, AF Clark
Steroids 1973
Temporal Aspects of Therapeutics
J Urquhart, FE Yates
1973
24. Tagung vom 13. bis 16. September 1972 in Hannover
HK Büscher, R Nagel
1973
Receptors for Reproductive Hormones
BW OMalley, AR Means
1973
HISTOLOGY OF THE PROSTATE IN ELDERLY MEN
TB Harbitz, OA Haugen
Acta Pathologica Microbiologica Scandinavica Section A Pathology 1972
The metabolism of testosterone and dihydrotestosterone in an androgen-dependent tumour. A possible correlation between dihydrotestosterone and tumour growth in vivo
N Bruchovsky
Biochemical Journal 1972
Androgen dynamics in vitro in the human prostate gland. Effect of oestradiol-17
EP Giorgi, JC Stewart, JK Grant, IM Shirley
Biochemical Journal 1972
Hormonal effects in vitro on prostatic ribonucleic acid polymerase
P Davies, AR Fahmy, CG Pierrepoint, K Griffiths
Biochemical Journal 1972
Androgen and estrogen uptake in the canine prostate and their excretion in prostatic fluid
MJ Varkarakis, RY Kirdani, GP Murphy, AA Sandberg
Journal of Surgical Research 1972
Quantification of free dihydrotestosterone in blood plasma and tissue
GC Haltmeyer, KB Eik-Nes
Analytical Biochemistry 1972
Receptors and binding of androgens in the prostate
A Aakvaag, KJ Tveter, O Unhjem, A Attramadal
Journal of Steroid Biochemistry 1972
Physicochemical properties of the 5α-dihydrotestosterone binding protein in human male serum
V Hansson, J Larsen, E Reusch
Steroids 1972
Plasma 5α-dihydrotestosterone (17β-hydroxy-5α-androstan-3-one) in adolescent males at different stages of sexual maturation
D Gupta, E McCafferty, K Rager
Steroids 1972
Recent Studies on the Mechanism of Action of Testosterone
D Deykin, C Balko, JD Wilson
New England Journal of Medicine 1972
Studies on the interaction between androgen and macromolecules in male accessory sex organs of rat and man
V Hansson, KJ Tveter, O Unhjem, O Djöseland
Journal of Steroid Biochemistry 1972
Urological Research
GP Murphy
Urological Research 1972
Pills for the Benign Prostate: Steroids and the Prostate
WB Peeling, K Griffiths
Proceedings of the Royal Society of Medicine 1972
In Vitro and in Vivo Studies on the Functional Significance of Androgen Receptors in Rat Prostate
P Rennie, N Bruchovsky
The Journal of biological chemistry 1972
Hormone metabolism and action: Testosterone and metabolites in prostate organ culture
P Robel, I Lasnitzki, EE Bauliec
Biochimie 1971
The effect of oestrogen on the prostatic metabolism of testosterone in tissue culture
M Groom, ME Harper, AR Fahmy, CG Pierrepoint, K Griffiths
Biochemical Journal 1971
A possible role of zinc in the metabolism of testosterone by the prostate gland
JK Grant, J Minguell, P Taylor, M Weiss
Biochemical Journal 1971
Proceedings of the 1970 Laurentian Hormone Conference
AR Midgley, GD Niswender, VL Gay, LE Reichert
Proceedings of the 1970 Laurentian Hormone Conference 1971
Haut als endokrines Erfolgsorgan Gestagene Geriatrische Endokrinologie des Mannes
J Kracht
1971
Partial Characterization of the Nuclear Reduced Nicotinamide Adenine Dinucleotide Phosphate: Δ4-3-Ketosteroid 5α-Oxidoreductase of Rat Prostate
DW Frederiksen, JD Wilson
The Journal of biological chemistry 1971
Dihydrotestosterone in prostatic hypertrophy I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man
PK Siiteri, JD Wilson
Journal of Clinical Investigation 1970
Testosterone
DW Killinger
Canadian Medical Association journal 1970

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