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Citations to this article

Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis
John L. Duffy, … , Edith Grishman, Jacob Churg
John L. Duffy, … , Edith Grishman, Jacob Churg
Published February 1, 1970
Citation Information: J Clin Invest. 1970;49(2):251-258. https://doi.org/10.1172/JCI106234.
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Research Article

Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis

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Abstract

We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was generally absent in lipoid nephrosis in remission and in benign recurrent hematuria. It is suggested that what seems to be a lower incidence in females is more apparent than real and that fibrin or related material may be present in a less easily identifiable form. Steroid therapy apparently had no effect on the presence or absence of fibrin. Most instances were associated with elevated serum cholesterol and α2-globulin. It is suggested that elevated serum lipids as well as the disease process in the kidney play a role in this phenomenon. It is further suggested that intraglomerular fibrin formation could lead to irreversible renal damage in lipoid nephrosis.

Authors

John L. Duffy, Thomas Cinque, Edith Grishman, Jacob Churg

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Total citations by year

Year: 2023 2022 2009 2003 1997 1995 1992 1991 1990 1989 1988 1987 1985 1984 1982 1981 1980 1979 1976 1975 1974 1973 1972 1971 1970 Total
Citations: 1 1 1 1 1 1 1 1 1 1 3 1 1 2 2 1 2 1 2 1 4 3 7 3 2 45
Citation information
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Citations to this article (45)

Title and authors Publication Year
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International journal of molecular sciences 2023
Histopathological and Clinical Findings of Biopsy-Proven Focal and Segmental Glomerulosclerosis: A Retrospective Study.
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Cureus 2022
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Management of Nephrotic Syndrome in Children
RF Robinson, MC Nahata, JD Mahan, DL Batisky
Pharmacotherapy 2003
Three-year randomized controlled trial of dipyridamole and low-dose warfarin in patients with IgA nephropathy and renal impairment
G Lee, H Choong, G Chiang, K Woo
Nephrology 1997
Role of platelets in progressive glomerular diseases
C Zoja, G Remuzzi
Pediatric Nephrology 1995
Inhibition of active oxygen generation by dipyridamole in human polymorphonuclear leukocytes
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European Journal of Pharmacology: Molecular Pharmacology 1992
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VE Andreucci, LG Fine
1991
Contribution of mononuclear leucocytes to the progression of experimental focal glomerular sclerosis
T Saito, RC Atkins
Kidney International 1990
Analysis of Urinary and Circulating EDP Subfragments and Subunits: Application of the Western-Blot Technique
S Takahashi, Y Noguchi, T Kitagawa
Pediatrics International 1989
Ultrastructural Changes Suggestive of Focal Segmental Glomerulosclerosis in Atypical Minimal Change Nephrotic Syndrome
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RA Clark, PM Henson
1988
Platelet-Vessel Wall Interactions
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British Journal of Experimental Pathology 1984
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P Kincaid-Smith
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Acta Academiae Medicinae Wuhan 1982
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Human Pathology 1982
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Thrombosis Research 1981
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Kidney International 1980
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Thrombosis Research 1980
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Thrombosis Research 1979
THE ROLE OF COAGULATION AND FIBRINOLYSIS IN THE DEVELOPMENT OF RABBIT MASUGI NEPHRITIS
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Pathology International 1976
Are agents affecting platelet functions clinically useful?
M Verstraete
The American Journal of Medicine 1976
Identification of a new platelet aggregating factor released by sensitized leukocytes
KJ Lavelle, BA Ransdell, CW Trygstad
Clinical Immunology and Immunopathology 1975
Urinary fibrin split products in lupus nephritis. Correlation with other parameters of renal disease
SL Marchesi, RG Aptekar, AD Steinberg, HR Gralnick, JL Decker
Arthritis & Rheumatism 1974
Focal and segmental sclerosing glomerulopathy (-nephritis)
HJ Rumpelt, W Thoenes
Virchows Archiv A Pathological Anatomy and Histology 1974
Fibrin/fibrinogen degradation products in children with renal disease
WS Uttley, H Maxwell, JD Cash
Archives of disease in childhood 1974
Focal and segmental sclerosing glomerulopathy (-nephritis): A pathomorphological study
HJ Rumpelt, W Thoenes
Virchows Archiv A Pathological Anatomy and Histopathology 1974
Focal glomerular sclerosis
R Habib
Kidney International 1973
Urinary FDP in children with renal disease
W Uttley
Archives of disease in childhood 1973
Renal vein thrombosis and the nephrotic syndrome
JL Duffy, J Letteri, T Cinque, PP Hsu, L Molho, J Churg
The American Journal of Medicine 1973
PLASMA PROTEIN REQUIREMENTS FOR HUMAN PLATELET AGGREGATION
NU Bang, RO Heidenreich, CW Trygstad
Annals of the New York Academy of Sciences 1972
Platelets and thrombogenesis—Current concepts
GW Schnetzer
American Heart Journal 1972
Nephrosis with cardiac and pulmonary complications
RE Cooke, GS Spear, JP Dorst
The Journal of Pediatrics 1972
Glomerulonephritis in childhood
CW Trygstad, SK Anand
Current Problems in Pediatrics 1972
A comparison of tinctorial and immunohistological methods for the detection of fibrinoid change and fibrin deposition in the kidney
AG MacIver
The Histochemical Journal 1972
The role of platelets in glomerulonephritis and transplantation
E N Wardle
Journal of the Royal College of Physicians of London 1972
Fokal-sklerosierende Glomerulopathie (Glomerulonephritis) ? ein diffuser Proze�
HJ Rumpelt, W Thoenes
Klinische Wochenschrift 1972
IgE IN GLOMERULI OF PATIENTS WITH NEPHROTIC SYNDROME
MA Gerber, F Paronetto
The Lancet 1971
Chronic glomerulonephritis and the nephrotic syndrome induced in rats with N,N′-diacetylbenzidine
JW Harman
The Journal of Pathology 1971
Contributions of renal biopsy studies to the understanding of disease
AE Seymour, BH Spargo, R Penksa
The American Journal of Pathology 1971
Glomerulonephritis
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British medical journal 1970
Renal Allograft Rejection
JR Lawrence
1970

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