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Research Article Free access | 10.1172/JCI106234
Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554
Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554
Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029
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Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554
Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554
Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029
Find articles by Cinque, T. in: JCI | PubMed | Google Scholar
Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554
Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554
Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029
Find articles by Grishman, E. in: JCI | PubMed | Google Scholar
Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554
Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554
Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029
Find articles by Churg, J. in: JCI | PubMed | Google Scholar
Published February 1, 1970 - More info
We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was generally absent in lipoid nephrosis in remission and in benign recurrent hematuria. It is suggested that what seems to be a lower incidence in females is more apparent than real and that fibrin or related material may be present in a less easily identifiable form. Steroid therapy apparently had no effect on the presence or absence of fibrin. Most instances were associated with elevated serum cholesterol and α2-globulin. It is suggested that elevated serum lipids as well as the disease process in the kidney play a role in this phenomenon. It is further suggested that intraglomerular fibrin formation could lead to irreversible renal damage in lipoid nephrosis.
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