Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis

John L. Duffy; Thomas Cinque; Edith Grishman; Jacob Churg

doi:10.1172/JCI106234

^{Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554}

^{Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554}

^{Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029}

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^{Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554}

^{Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554}

^{Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029}

Find articles by Cinque, T. in: PubMed | Google Scholar

^{Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554}

^{Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554}

^{Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029}

Find articles by Grishman, E. in: PubMed | Google Scholar

^{Department of Pathology and Laboratories, Meadowbrook Hospital, East Meadow, New York 11554}

^{Renal Division, Department of Medicine, Meadowbrook Hospital, East Meadow, New York 11554}

^{Division of Renal Pathology, Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York 10029}

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Published in Volume 49, Issue 2 on February 1, 1970
J Clin Invest. 1970;49(2):251–258. https://doi.org/10.1172/JCI106234.
© 1970 The American Society for Clinical Investigation

Published February 1, 1970 - Version history

We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was generally absent in lipoid nephrosis in remission and in benign recurrent hematuria. It is suggested that what seems to be a lower incidence in females is more apparent than real and that fibrin or related material may be present in a less easily identifiable form. Steroid therapy apparently had no effect on the presence or absence of fibrin. Most instances were associated with elevated serum cholesterol and α₂-globulin. It is suggested that elevated serum lipids as well as the disease process in the kidney play a role in this phenomenon. It is further suggested that intraglomerular fibrin formation could lead to irreversible renal damage in lipoid nephrosis.

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