A procedure for bioassaying parathyroid hormone-like activity in human urine has been developed. 24-hr urine samples were concentrated with dry Sephadex G-25 and bioassayed in the young thyroparathyrocauterized mouse by the measurement of whole blood calcium. Recovery of biological activity and radioiodinated beef parathyroid hormone was over 80%. Normal subjects usually excreted less than 30 U (USP) of activity per day while 18 patients with proven primary hyperparathyroidism excreted a mean of 182 U/day (USP). The activity was not found in 7 patients with hypoparathyroidism or in 5 patients with carcinoma of the breast, but was present in 9 patients with uremia and in 5 with carcinoma of the lung and hypercalcemia.
John E. Bethune, Randolph A. Turpin
Title and authors | Publication | Year |
---|---|---|
Principles of Bone Biology
CJ Rosen, T Niu |
Principles of Bone Biology | 2008 |
Initial Evaluation of the Patient With Lung Cancer: Symptoms, Signs, Laboratory Tests, and Paraneoplastic Syndromes
SG Spiro, MK Gould, GL Colice |
Chest | 2007 |
Endocrine paraneoplastic syndromes in lung cancer
PJ Mazzone, AC Arroliga |
Current Opinion in Pulmonary Medicine | 2003 |
The Parathyroids
SJ Marx |
The Parathyroids | 2001 |
Disorders of Mineral Metabolism
RK Rude, FR Singer |
Disorders of Mineral Metabolism | 1982 |
Klinische Osteologie · A
BA Ashton, HF DeLuca, HJ Dulce, IM Evans, PP Fietzek, HM Frost, LS Galante, JG Ghazarian, HG Haas, JF Habener, F Heuck, CJ Hillyard, H Höhling, KH Knese, J Knop, T Lauffenburger, C Lentner, I MacIntyre, R Montz, BE Nordin, AJ Olah, JA Parsons, G Pfleiderer, JT Potts, WG Robertson, RK Schenk, K Vanselow, K zum Winkel, JM Zanelli, F Kuhlencordt, H Bartelheimer |
1980 | |
Parathyroid Hormone-, 25-Oh-Vitamin D-, and Digoxin Levels in Patients Treated by Chronic Hemofiltration
K Schaefer, G Offermann, D Herratht, G Asmust, M Hüflert |
Renal Failure | 1977 |
Improved method for determining parathyroid hormone in biological material
AD Kenny, DJ Ahearn, JF Maher |
Biochemical Medicine | 1976 |
ENDOCRINOLOGICALLY ACTIVE MESENCHYMAL TUMORS
JX Laurent, RE Jeanpierre |
Annals of the New York Academy of Sciences | 1974 |
Ca-Stoffwechselst�rungen bei chronischer Niereninsuffizienz
E Ritz, HG Sieberth, B Krempien |
Klinische Wochenschrift | 1971 |
Ergebnisse der Inneren Medizin und Kinderheilkunde
L Heilmeyer, R Schoen, B Rudder |
1960 | |
Hyperparathyroidism
HL Jaffe |
Bulletin of the New York Academy of Medicine | 1940 |