Sites of action of sodium depletion on aldosterone biosynthesis in the dog

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Abstract

Secretion of cortisol, corticosterone, and aldosterone was measured in vivo in normal and sodium-depleted hypophysectomized dogs. Biogenesis of steroids was then measured in vitro with outer slices of the adrenals of the same dogs. In some studies, metyrapone or puromycin was added.

Authors

Warren W. Davis, Lawrence R. Burwell, Alfred G. T. Casper, Frederic C. Bartter