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Citations to this article

Effects of Adrenergic Receptor Activation and Blockade on the Systolic Preejection Period, Heart Rate, and Arterial Pressure in Man
Willard S. Harris, … , Clyde D. Schoenfeld, Arnold M. Weissler
Willard S. Harris, … , Clyde D. Schoenfeld, Arnold M. Weissler
Published November 1, 1967
Citation Information: J Clin Invest. 1967;46(11):1704-1714. https://doi.org/10.1172/JCI105661.
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Research Article Article has an altmetric score of 3

Effects of Adrenergic Receptor Activation and Blockade on the Systolic Preejection Period, Heart Rate, and Arterial Pressure in Man

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Abstract

We have investigated the possibility that alterations in the duration of the systolic preejection period can be used to estimate adrenergic influences on the human left ventricle. The preejection period was determined from high speed, simultaneous recordings of the phonocardiogram, carotid pulse tracing, and electrocardiogram. The preejection period was shortened by isoproterenol, epinephrine, and moderate doses of norepinephrine—all of which activate beta adrenergic receptors—and by cedilanid-D. It was unaltered by changes in heart rate induced by atropine and right atrial electrical pacing. Beta adrenergic receptor blockade by propranolol abolished the shortening effects of the three catecholamines but did not inhibit that due to cedilanid-D. Vasoconstriction, both alpha adrenergic (epinephrine and norepinephrine after propranolol) and nonadrenergic (angiotensin), prolonged the preejection period. Most of the shortening of the preejection period by beta adrenergic receptor activating agents and cedilanid-D and all of the prolongation accompanying pharmacologic vasoconstriction occurred after the onset of the first heart sound, thereby excluding changes in electrical-mechanical delay as a major factor in the observed preejection period responses. Shortening of the preejection period by beta adrenergic activity induced with isoproterenol was dose-related. Increasing doses of propranolol produced parallel shifts to the right in the isoproterenol dose-response curve.

Authors

Willard S. Harris, Clyde D. Schoenfeld, Arnold M. Weissler

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Citations to this article in year 2012 (3)

Title and authors Publication Year
Regulation of adipose tissue energy availability through blood flow control in the metabolic syndrome
M Alemany
Free radical biology & medicine 2012
Effects of Antidepressants, but not Psychopathology, on Cardiac Sympathetic Control: A Longitudinal Study
CM Licht, BW Penninx, EJ de Geus
Neuropsychopharmacology 2012
Estimated preejection period (PEP) based on the detection of the R-wave and dZ/dt-min peaks does not adequately reflect the actual PEP across a wide range of laboratory and ambulatory conditions
R Lien, NM Schutte, JH Meijer, EJ de Geus
International Journal of Psychophysiology 2012

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