Chronic Hemolytic Anemia due to Cold Agglutinins: the Mechanism of Resistance of Red Cells to C′ Hemolysis by Cold Agglutinins

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Abstract

The red cells of patients with chronic hemolytic anemia due to cold agglutinins are agglutinated by antiglobulin serum in a nongamma reaction due to the coating of β-globulins, C′4 and C′3. The red cells of such patients are abnormally resistant to C′ hemolysis by cold agglutinin.

Authors

Robert S. Evans, Elizabeth Turner, Margaret Bingham