Citations to this article

The Anticoagulant Activity of Lysosomal Cationic Proteins from Polymorphonuclear Leukocytes
Hussain I. Saba, … , Harold R. Roberts, John C. Herion
Hussain I. Saba, … , Harold R. Roberts, John C. Herion
Published April 1, 1967
Citation Information: J Clin Invest. 1967;46(4):580-589. https://doi.org/10.1172/JCI105559.
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Research Article

The Anticoagulant Activity of Lysosomal Cationic Proteins from Polymorphonuclear Leukocytes

Abstract

A cationic protein fraction from rabbit polymorphonuclear leukocyte lysosomes has been shown to exert a potent anticoagulant effect on human blood in vitro. The anticoagulant activity is detectable in the whole blood clotting time, the recalcification time of platelet-rich plasma, the prothrombin time, the partial thromboplastin time, and the thromboplastin generation test. The lysosomal cationic proteins do not inhibit any of the known specific procoagulants. They appear to inhibit clotting by blocking the formation of intrinsic thromboplastin possibly by interfering with the role of phospholipids in the reaction involving Factors V and X and calcium.

Authors

Hussain I. Saba, Harold R. Roberts, John C. Herion

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Year: 2001 1991 1989 1986 1984 1981 1980 1979 1978 1977 1975 1974 1973 1972 1971 1970 1969 1968 Total
Citations: 1 1 1 1 1 1 1 2 3 1 1 3 1 2 1 2 1 3 27
Citation information

Citations to this article (27)

Title and authors Publication Year
Inflammation
JA Hunt 		Encyclopedia of Materials Science and Technology 2001
Interleukin 1 production by monocytic leukemia cells and its possible role in coagulation abnormalities
Y Furukawa, M Ohta, Y Miura, M Saito 		Leukemia Research 1991
Pharmacology of the Skin II
MW Greaves, S Shuster 		1989
Antiheparin activity in human endothelial cells
HI Saba, SR Saba, GA Morelli 		Thrombosis Research 1986
Modulation of phagocytosis and intracellular bactericidal activity of polymorphonuclear and mononuclear cells by cationic proteins from human granulocytes: Alternative pathway of phagocytic enhancement
W Pruzanski, NS Ranadive, S Saito 		Inflammation 1984
Pulmonary embolism in patients with acute leukemia and severe thrombocytopenia
SW Needleman, MN Stein, JC Hoak 		The Western journal of medicine 1981
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Isolation and characterization of granulocyte lysosomal proteins and study of their effects on the clotting system
JC Herion, JR Bucher, R Penniall, RI Walker, M Baker, HR Roberts 		American Journal of Hematology 1979
The platelet as an inflammatory cell
RL Nachman, M Polley 		Transactions of the American Clinical and Climatological Association 1979
The influence of natural and synthetic cationic substances on phagocytic activity of human polymorphonuclear cells
W Pruzanski, S Saito 		Experimental Cell Research 1978
Normal and abnormal hemostasis--an integrated view. A review
RG Mason, HI Saba 		The American Journal of Pathology 1978
Effects of polymorphonuclear leukocytes on endothelial cell growth
HI Saba, RC Hartmann, SR Saba 		Thrombosis Research 1978
PROCOAGULANT ACTIVITY OF LEUKOCYTES
J Niemetz, T Muhlfelder, ME Chierego, B Troy 		Annals of the New York Academy of Sciences 1977
Effect of lysosomal cationic proteins from polymorphonuclear leukocytes upon the fibrinogen and fibrinolysis system
HI Saba, JC Herion, RI Walker, HR Roberts 		Thrombosis Research 1975
Physiochemical and biological properties of the major basic protein from guinea pig eosinophil granules
GJ Gleich, DA Loegering, F Kueppers, SP Bajaj, KG Mann 		Journal of Experimental Medicine 1974
Role of leukocyte nuclei in blood coagulation
DJ Giannitsis, S Pekker 		Die Naturwissenschaften 1974
Mediators of Inflammation
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Hühnergranulozyten: Ein Modell für die antimikrobielle Funktion peroxidasefreier menschlicher Granulozyten
K Brune 		Blut Zeitschrift für die Gesamte Blutforschung 1973
Coagulant Activity of Leukocytes. TISSUE FACTOR ACTIVITY
J Niemetz 		Journal of Clinical Investigation 1972
THE PLATELET AS AN INFLAMMATORY CELL
RL Nachman, B Weksler 		Annals of the New York Academy of Sciences 1972
Role of Leukocytes in Blood Coagulation and the Generalized Shwartzman Reaction
J Niemetz, K Fani 		Nature: New biology 1971
Increased Vascular permeability produced by human platelet granule cationic extract
RL Nachman, B Weksler, B Ferris 		Journal of Clinical Investigation 1970
Leukocyte anticoagulant with myelogenous leukemia
JW Hampton 		The American Journal of Medicine 1970
Cationic Protein-Bearing Granules of Polymorphonuclear Leukocytes: Separation from Enzyme-Rich Granules
HI Zeya, JK Spitznagel 		Science 1969
Arginine-rich proteins of polymorphonuclear leukocyte lysosomes. Antimicrobial specificity and biochemical heterogeneity
HI Zeya, JK Spitznagel 		Journal of Experimental Medicine 1968
Ultrastructural and cytochemical characteristics of leukocytes in various stages of development
SS Spicer, RG Horn, BK Wetzel 		Biochemical Pharmacology 1968
Role of Lysosomes in the Pathogenesis of Rheumatoid Arthritis
RH Persellin 		The Medical clinics of North America 1968

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