Light and Heavy Chain Components of Gamma Globulins in Urines of Normal Persons and Patients with Agammaglobulinemia

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Abstract

A heavy chain component of γG-globulins in normal urines has the characteristics of the proteolytic digestion product, Fc-fragment. This fragment is estimated to compose up to 15% of the gamma globulins present in urines. In contrast to urinary light chains, the urinary Fc-like fragment probably represents a catabolic component in normal γG-globulin metabolism.

Authors

John H. Vaughan, Ralph F. Jacox, Barry A. Gray