Evidence That an Acute Increase in Glomerular Filtration Has Little Effect on Sodium Excretion in the Dog unless Extracellular Volume is Expanded

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Abstract

The concept that acute increases in glomerular filtration rate (GFR) will cause large concomitant increases in sodium excretion has been re-examined. In previous work, GFR was elevated by volume expansion, usually with saline infusions. Recent evidence shows that tubular reabsorption is depressed during saline loading; hence, the independent effect of increased GFR on sodium excretion cannot be assessed.

Authors

Marshall D. Lindheimer, Richard C. Lalone, Norman G. Levinsky