A Microperfusion Study of Bicarbonate Accumulation in the Proximal Tubule of the Rat Kidney

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Abstract

In order to determine whether HCO3- gains access to the proximal tubular lumen from a source other than the glomerular filtrate, we carried out microperfusion experiments on isolated segments of rat proximal tubules in vivo. The perfusion fluid was essentially free of HCO3- and of a composition that prevented net absorption of sodium and water.

Authors

Norman Bank, Hagop S. Aynedjian