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Research and education in health care reform
Ralph I. Horwitz
Ralph I. Horwitz
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI41032.
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Research and education in health care reform

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Abstract

Authors

Ralph I. Horwitz

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Health care reform: without a correct diagnosis, there is no cure
Jeffrey S. Flier
Jeffrey S. Flier
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI41033.
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Health care reform: without a correct diagnosis, there is no cure

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Abstract

Authors

Jeffrey S. Flier

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Health care reform — need for less emotion and more science
C. Ronald Kahn
C. Ronald Kahn
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI41036.
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Health care reform — need for less emotion and more science

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Abstract

Authors

C. Ronald Kahn

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Healing health care
Elizabeth M. McNally
Elizabeth M. McNally
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI41037.
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Healing health care

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Abstract

Authors

Elizabeth M. McNally

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Build it and hope that enough of them will come
Nancy C. Andrews
Nancy C. Andrews
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI41105.
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Build it and hope that enough of them will come

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Abstract

Authors

Nancy C. Andrews

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The debate over health care reform: Houston, we have a problem
Eric G. Neilson
Eric G. Neilson
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI40995.
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The debate over health care reform: Houston, we have a problem

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Abstract

Authors

Eric G. Neilson

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Linking biomedical research to health care
Elizabeth G. Nabel
Elizabeth G. Nabel
Published September 10, 2009
Citation Information: J Clin Invest. 2009. https://doi.org/10.1172/JCI41035.
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Linking biomedical research to health care

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Abstract

Authors

Elizabeth G. Nabel

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How can we improve the translational landscape for a faster cure of type 1 diabetes?
Matthias von Herrath, Andrew Chan
Matthias von Herrath, Andrew Chan
Published May 1, 2009
Citation Information: J Clin Invest. 2009;119(5):1061-1065. https://doi.org/10.1172/JCI37593.
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How can we improve the translational landscape for a faster cure of type 1 diabetes?

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Abstract

Translation of novel therapies for type 1 diabetes and other autoimmune diseases to the clinic has been slow despite significant new initiatives from funding agencies. One reason for this is that different incentives drive industry, academia, and funding bodies. These communities therefore lack common goals and often communicate poorly, resulting in unintended obstacles that hamper progress in efficiently translating basic scientific discoveries into medical practice. Here, based on our own personal experiences, we discuss some of the drivers within each community that cause these problems, existing mechanisms to facilitate the translation of science into medical practice, and remaining issues that need to be solved.

Authors

Matthias von Herrath, Andrew Chan

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How to write an effective referee report
Ushma S. Neill
Ushma S. Neill
Published May 1, 2009
Citation Information: J Clin Invest. 2009;119(5):1058-1060. https://doi.org/10.1172/JCI39424.
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How to write an effective referee report

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Abstract

Most scientists learn how to review papers by being thrown into the deep end of the pool: here’s a paper, write a review. Perhaps this is not the best way to keep an enterprise afloat. But what should be included in a review? What should the tone of a review be? Here I want to outline the specifics of what we at the JCI are looking for in a referee report.

Authors

Ushma S. Neill

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Insulin sensitivity: modulation by nutrients and inflammation
Simon Schenk, … , Maziyar Saberi, Jerrold M. Olefsky
Simon Schenk, … , Maziyar Saberi, Jerrold M. Olefsky
Published September 2, 2008
Citation Information: J Clin Invest. 2008;118(9):2992-3002. https://doi.org/10.1172/JCI34260.
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Insulin sensitivity: modulation by nutrients and inflammation

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Abstract

Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms by which brief nutrient excess and obesity lead to insulin resistance and propose that these mechanisms of action are different but interrelated. We discuss how pathways that “sense” nutrients within skeletal muscle are readily able to regulate insulin action. We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. Overall, we provide our integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity.

Authors

Simon Schenk, Maziyar Saberi, Jerrold M. Olefsky

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