Rocío López-Posadas and colleagues reveal that loss of Rho-A activation and signaling promotes loss of intestinal barrier function in inflammatory bowel disease…
Published January 11, 2016

José Naranjo and colleagues reveal that downregulation of DREAM mediates derepression of ATF6, and this elevation of ATF6 plays an early neuroprotective role in Huntington’s disease…
Published January 11, 2016

Kai Hu and Bjorn Olsen reveal that osteoblast-derived VEGF serves as a proinflammatory, angiogenic, and osteogenic factor during bone healing…
Published January 5, 2016

Charlotte Egan and colleagues reveal that intestinal TLR4-mediated lymphocyte infiltration and polarization toward a Th17 population promotes neonatal necrotizing enterocolitis…
Published December 21, 2015

Roland Schindler, Chiara Scotton, Jianguo Zhang, and colleagues identify and characterize a mutation in POPDC1 that underlies a familial muscular dystrophy with cardiac arrhythmia…
Published December 7, 2015

Jessica Bowser and colleagues identify a mechanism by which loss of CD73 promotes endometrial cancer progression…
Published December 7, 2015

Leticia Monin and colleagues provide insight how helminth co-infection drives increased susceptibility to severe tuberculosis...
Published November 16, 2015

Junsong Zhou, Yi Wu, and colleagues reveal that the C-terminal redox-active site of protein disulfide isomerase is essential for coagulation…
Published November 3, 2015

Mireille Ouimet, Hasini Ediriweera, and colleagues show that miR-33 controls the macrophage inflammatory program and promotes atherosclerotic plaque development…
Published October 26, 2015

Caroline Bruinsma and colleagues evaluated cerebellar involvement in Angelman’s Syndrome motor deficits…
Published October 20, 2015