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Stem cells

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Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration
Susan M. Majka, … , Margaret A. Goodell, Karen K. Hirschi
Susan M. Majka, … , Margaret A. Goodell, Karen K. Hirschi
Published January 1, 2003
Citation Information: J Clin Invest. 2003;111(1):71-79. https://doi.org/10.1172/JCI16157.
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Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration

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Abstract

Vascular progenitors were previously isolated from blood and bone marrow; herein, we define the presence, phenotype, potential, and origin of vascular progenitors resident within adult skeletal muscle. Two distinct populations of cells were simultaneously isolated from hindlimb muscle: the side population (SP) of highly purified hematopoietic stem cells and non-SP cells, which do not reconstitute blood. Muscle SP cells were found to be derived from, and replenished by, bone marrow SP cells; however, within the muscle environment, they were phenotypically distinct from marrow SP cells. Non-SP cells were also derived from marrow stem cells and contained progenitors with a mesenchymal phenotype. Muscle SP and non-SP cells were isolated from Rosa26 mice and directly injected into injured muscle of genetically matched recipients. SP cells engrafted into endothelium during vascular regeneration, and non-SP cells engrafted into smooth muscle. Thus, distinct populations of vascular progenitors are resident within skeletal muscle, are derived from bone marrow, and exhibit different cell fates during injury-induced vascular regeneration.

Authors

Susan M. Majka, Kathyjo A. Jackson, Kirsten A. Kienstra, Mark W. Majesky, Margaret A. Goodell, Karen K. Hirschi

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Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells
Kohshi Ohishi, … , Barbara Varnum-Finney, Irwin D. Bernstein
Kohshi Ohishi, … , Barbara Varnum-Finney, Irwin D. Bernstein
Published October 15, 2002
Citation Information: J Clin Invest. 2002;110(8):1165-1174. https://doi.org/10.1172/JCI16167.
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Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells

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Abstract

Research Article

Authors

Kohshi Ohishi, Barbara Varnum-Finney, Irwin D. Bernstein

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Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation
Emanuela Gussoni, … , Louis M. Kunkel, Kenneth Weinberg
Emanuela Gussoni, … , Louis M. Kunkel, Kenneth Weinberg
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):807-814. https://doi.org/10.1172/JCI16098.
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Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation

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Abstract

Research Article

Authors

Emanuela Gussoni, Richard R. Bennett, Kristina R. Muskiewicz, Todd Meyerrose, Jan A. Nolta, Irene Gilgoff, James Stein, Yiu-mo Chan, Hart G. Lidov, Carsten G. Bönnemann, Arpad von Moers, Glenn E. Morris, Johan T. den Dunnen, Jeffrey S. Chamberlain, Louis M. Kunkel, Kenneth Weinberg

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Transcriptional dysfunction in Beckwith-Wiedemann syndrome
Jian Chen and colleagues present evidence that dysfunctional TGF-β/β2SP/CTFC signaling underlies spontaneous tumor development in Beckwith-Wiedemann syndrome…
Published January 19, 2016
Scientific Show StopperStem cells

Repairing injured tendons with endogenous stem cells
Chang Lee and colleagues harness endogenous stem/progenitor cells to enhance tendon repair in rats…
Published June 8, 2015
Scientific Show StopperStem cells

Deriving hypothalamic-like neurons
Liheng Wang and colleagues reveal that hypothalamic-like neurons can be derived from human pluripotent stem cells….
Published January 2, 2015
Scientific Show StopperStem cells
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