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CCL17-producing cDC2s in end-stage lupus nephritis and parasitic infections
In this episode, Laura Amo and Silvia Bolland explain that the infiltration into kidneys of iDC2s, with potential to prime local adaptive responses, is an essential regulated event...
Published June 1, 2021
Video Abstracts
Frataxin deficiency and pulmonary hypertension
In this episode, Stephen Chan explains that genetic and acquired frataxin deficiency disrupts genomic integrity to induce endothelial senescence and represents a common mechanism for multiple pulmonary hypertension subtypes...
Published June 1, 2021
Video Abstracts
Regulation of proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy
In this episode, Farah Sheikh presents the identification of a desmosomal COP9 signalosome regulatory complex that restricts desmosomal proteome degradation and genetic cardiac desmosomal disease, arrhythmogenic right ventricular cardiomyopathy...
Published June 1, 2021
Video Abstracts
Thymosin β4 protects against aortic aneurysm
In this episode, Nicola Smart, Sonali Munshaw, and Susann Bruche present their findings that Thymosin β4 is a regulator of LRP1, which protects against aortic aneurysm by regulating PDGFRβ endocytosis and smooth muscle phenotype...
Published May 17, 2021
Video Abstracts
Impairing melanoma phenotype switching and potentiating antitumor immune responses
In this episode, Sonia del Rincón and Fan Huang explain that inhibiting the MNK1/2-eIF4E axis dampens melanoma plasticity and enhances response to anti-PD-1 immunotherapy...
Published April 22, 2021
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Lipid-induced cell adhesion promotes nonalcoholic steatohepatitis pathogenesis
In this episode, Samar Ibrahim explains that lipotoxic stress enhances the expression of LSEC-VCAM-1, in part, through MLK3 signaling...
Published March 15, 2021
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Inflammation of the heart after reperfused myocardial infarction
In this issue, Edward Thorp explains that AXL uniquely promotes a switch to glycolytic metabolism and inflammatory cytokine production by macrophages to worsen ventricular remodeling and lead to heart failure after myocardial infarction...
Published March 15, 2021
Video Abstracts
N-cadherin upregulation in glioblastoma
In this episode, Erwin Van Meir and Satoru Osuka eplain that glioma stem cells adapt to the toxicity of repeated irradiation by upregulating N-cadherin, and this resistance pathway can be antagonized by blocking the IGF1 receptor...
Published March 15, 2021
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Protecting kidney from fibrosis by enhancing fatty acid oxidation
In this episode, Santiago Lamas and Verónica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD...
Published March 1, 2021
Video Abstracts
Targeting a Braf/Mapk pathway in CoQ-deficiency kidney disease
In this episode, Ana Greka and Eriene-Heidi Sidhom explain that an investigation of cell-specific disease mechanisms in rare genetic disorder revealed Braf/Mapk as a candidate pathway for the treatment of kidney diseases...
Published March 1, 2021
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