Top-read JCI Insight articles of 2016

10. Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. Jennifer J. DuPont,
 Amy McCurley, Ana P. Davel, Joseph McCarthy, Shawn B. Bender, Kwangseok Hong, Yan Yang, Jeung-Ki Yoo, Mark Aronovitz, Wendy E. Baur, Demetra D. Christou, Michael A. Hill, and Iris Z. Jaffe.

9. Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. Elizabeth R. Davies, Joanne F.C. Kelly, Peter H. Howarth,
David I. Wilson, Stephen T. Holgate, Donna E. Davies, Jeffrey A. Whitsett, and Hans Michael Haitchi.

8. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. Yuki Sato, Akiko Mii, Yoko Hamazaki, Harumi Fujita,  Hirosuke Nakata,
 Kyoko Masuda, Shingo Nishiyama, Shinsuke Shibuya, Hironori Haga, Osamu Ogawa, Akira Shimizu, Shuh Narumiya, Tsuneyasu Kaisho, Makoto Arita, Masashi Yanagisawa,
 Masayuki Miyasaka, Kumar Sharma, Nagahiro Minato, Hiroshi Kawamoto, and Motoko Yanagita.

7. Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata. Julian Mackay-Wiggan, Ali Jabbari, Nhan Nguyen, 
Jane E. Cerise, Charlotte Clark, Grace Ulerio, Megan Furniss, Roger Vaughan, Angela M. Christiano, and Raphael Clynes. 

6. PD-1 blockade enhances the vaccination-induced immune response in glioma. Joseph P. Antonios, Horacio Soto, Richard G. Everson, Joey Orpilla, 
Diana Moughon, Namjo Shin, Shaina Sedighim, William H. Yong, Gang Li, Timothy F. Cloughesy, Linda M. Liau, and Robert M. Prins. 

5. The MEK inhibitor trametinib separates murine graft-versus-host disease from graft-versus-tumor effects. Hidekazu Itamura, Takero Shindo, Isao Tawara, 
Yasushi Kubota, Ryusho Kariya, Seiji Okada, Krishna V. Komanduri, and Shinya Kimura.

4. Elimination of p19^ARF-expressing cells enhances pulmonary function in mice. Michihiro Hashimoto, Azusa Asai, Hiroyuki Kawagishi, Ryuta Mikawa,
 Yuji Iwashita, Kazuki Kanayama, Kazushi Sugimoto, Tadashi Sato, Mitsuo Maruyama, and Masataka Sugimoto. 

3. Zika virus productively infects primary human placenta-specific macrophages. Kellie Ann Jurado, Michael K. Simoni, Zhonghua Tang, Ryuta Uraki, Jesse Hwang,
 Sarah Householder, Mingjie Wu, Brett D. Lindenbach, Vikki M. Abrahams, Seth Guller, and Erol Fikrig. 

2. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. Milène Kennedy Crispin, Justin M. Ko, Brittany G. Craiglow,
 Shufeng Li, Gautam Shankar, Jennifer R. Urban, James C. Chen, Jane E. Cerise, Ali Jabbari, Mårten C.G. Winge, M. Peter Marinkovich, Angela M. Christiano, Anthony E. Oro,
 and Brett A. King.

1. A wearable artificial kidney for patients with end-stage renal disease. Victor Gura, Matthew B. Rivara, Scott Bieber, Raj Munshi, Nancy Colobong Smith,
 Lori Linke, John Kundzins, Masoud Beizai, Carlos Ezon, Larry Kessler, and Jonathan Himmelfarb.