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Hematopoietic stem cell transplantation for HIV cure
Daniel R. Kuritzkes
Daniel R. Kuritzkes
Published January 5, 2016
Citation Information: J Clin Invest. 2016;126(2):432-437. https://doi.org/10.1172/JCI80563.
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Review Series

Hematopoietic stem cell transplantation for HIV cure

Abstract

The apparent cure of an HIV-infected person following hematopoietic stem cell transplantation (HSCT) from an allogeneic donor homozygous for the ccr5Δ32 mutation has stimulated the search for strategies to eradicate HIV or to induce long-term remission without requiring ongoing antiretroviral therapy. A variety of approaches, including allogeneic HSCT from CCR5-deficient donors and autologous transplantation of genetically modified hematopoietic stem cells, are currently under investigation. This Review covers the experience with HSCT in HIV infection to date and provides a survey of ongoing work in the field. The challenges of developing HSCT for HIV cure in the context of safe, effective, and convenient once-daily antiretroviral therapy are also discussed.

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Daniel R. Kuritzkes

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