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Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer
Jerry M. Adams
Jerry M. Adams
Published May 24, 2012
Citation Information: J Clin Invest. 2012;122(6):1965-1967. https://doi.org/10.1172/JCI64120.
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Commentary

Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer

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Abstract

A promising approach to cancer therapy is to elicit apoptosis with “BH3 mimetic” drugs, which target proteins of the BCL-2 family. As of yet, however, such drugs can target only certain BCL-2 family proteins. Hence, in this issue of the JCI, LaBelle et al. assess instead the therapeutic potential of a “stapled” BH3 peptide from the BIM protein, which inactivates all its prosurvival relatives. The peptide killed cultured hematologic tumor cells and abated growth of a leukemia xenograft, without perturbing the hematopoietic compartment. Hence, such peptides might eventually provide a new way to treat refractory leukemias.

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Jerry M. Adams

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