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Citation Information: J Clin Invest. 1973;52(11):2848-2852. https://doi.org/10.1172/JCI107480.
Abstract
X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.
Authors
Jean E. Russell, John D. Termine, Louis V. Avioli
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