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Research Article Free access | 10.1172/JCI107480

Abnormal Bone Mineral Maturation in the Chronic Uremic State

Jean E. Russell, John D. Termine, and Louis V. Avioli

Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110

Molecular Structure Section, Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Russell, J. in: JCI | PubMed | Google Scholar

Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110

Molecular Structure Section, Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Termine, J. in: JCI | PubMed | Google Scholar

Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110

Molecular Structure Section, Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

Find articles by Avioli, L. in: JCI | PubMed | Google Scholar

Published November 1, 1973 - More info

Published in Volume 52, Issue 11 on November 1, 1973
J Clin Invest. 1973;52(11):2848–2852. https://doi.org/10.1172/JCI107480.
© 1973 The American Society for Clinical Investigation
Published November 1, 1973 - Version history
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Abstract

X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.

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