Advertisement
Research Article Free access | 10.1172/JCI107480
Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110
Molecular Structure Section, Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Find articles by Russell, J. in: JCI | PubMed | Google Scholar
Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110
Molecular Structure Section, Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Find articles by Termine, J. in: JCI | PubMed | Google Scholar
Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110
Molecular Structure Section, Laboratory of Biological Structure, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Find articles by Avioli, L. in: JCI | PubMed | Google Scholar
Published November 1, 1973 - More info
X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.