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Citation Information: J Clin Invest. 1972;51(9):2380-2387. https://doi.org/10.1172/JCI107050.
Abstract
A presumably spontaneous mutation has resulted in the formation of Hemoglobin (Hb) Istanbul in which glutamine is substituted for histidine in the proximal position of the β-chain (F8(92)). The anemia and other physiological effects that occur in the presence of Hb Istanbul were much ameliorated by splenectomy. Hb Istanbul is a relatively unstable molecule which produces a rather moderate case of “unstable hemoglobin hemolytic anemia.”
Authors
M. Aksoy, S. Erdem, G. D. Efremov, J. B. Wilson, T. H. J. Huisman, W. A. Schroeder, J. R. Shelton, J. B. Shelton, O. N. Ulitin, A. Müftüoğlu
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