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Research Article Free access | 10.1172/JCI107050
Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
Find articles by Shelton, J. in: JCI | PubMed | Google Scholar
Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Section of Hematology, Second Internal Clinic of the Istanbul Medical School, Capa, Istanbul, Turkey
Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia 30902
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91109
First Medical Clinic, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
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Published September 1, 1972 - More info
A presumably spontaneous mutation has resulted in the formation of Hemoglobin (Hb) Istanbul in which glutamine is substituted for histidine in the proximal position of the β-chain (F8(92)). The anemia and other physiological effects that occur in the presence of Hb Istanbul were much ameliorated by splenectomy. Hb Istanbul is a relatively unstable molecule which produces a rather moderate case of “unstable hemoglobin hemolytic anemia.”
In the determination of structure, a method of preferential cleavage of an aspartyl-proline bond at residues 99-100 of the β-chain was used.
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