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On the Mechanism of Inhibition in Fluid Reabsorption by the Renal Proximal Tubule of the Volume-Expanded Rat
Barry M. Brenner, … , D. P. Nicholas, C. F. Wong
Barry M. Brenner, … , D. P. Nicholas, C. F. Wong
Published August 1, 1971
Citation Information: J Clin Invest. 1971;50(8):1596-1602. https://doi.org/10.1172/JCI106647.
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Research Article

On the Mechanism of Inhibition in Fluid Reabsorption by the Renal Proximal Tubule of the Volume-Expanded Rat

Abstract

We undertook to determine the extent to which the inhibition in absolute proximal fluid reabsorption in response to expansion of extracellular volume with noncolloid-containing solutions is the result of concomitant reductions in postglomerular (efferent arteriolar) protein concentration. Selective elevation of efferent arteriolar oncotic pressure in volume-expanded rats (Ringer's 10% body weight) to levels slightly in excess of normal by microperfusion with 9-10% albumin-Ringer's solution nearly completely reversed the inhibition in absolute and fractional reabsorption in adjacent proximal tubules. In contrast, during similar microperfusion with a 6-7% albumin solution, no increase in proximal reabsorption was measured. We interpret these findings to indicate that the bulk of the inhibition in absolute proximal reabsorption in response to volume expansion with colloid-free solutions is causally mediated by the accompanying parallel decline in postglomerular vascular protein concentration.

Authors

Barry M. Brenner, Julia L. Troy, Terrance M. Daugharty, I. F. Ueki, D. P. Nicholas, C. F. Wong

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