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Research Article Free access | 10.1172/JCI106647
Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, University of California, San Francisco, California 94122
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Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, University of California, San Francisco, California 94122
Find articles by Troy, J. in: JCI | PubMed | Google Scholar
Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, University of California, San Francisco, California 94122
Find articles by Daugharty, T. in: JCI | PubMed | Google Scholar
Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, University of California, San Francisco, California 94122
Find articles by Ueki, I. in: JCI | PubMed | Google Scholar
Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, University of California, San Francisco, California 94122
Find articles by Nicholas, D. in: JCI | PubMed | Google Scholar
Department of Medicine, Veterans Administration Hospital, San Francisco, California 94121
Department of Medicine, University of California, San Francisco, California 94122
Find articles by Wong, C. in: JCI | PubMed | Google Scholar
Published August 1, 1971 - More info
We undertook to determine the extent to which the inhibition in absolute proximal fluid reabsorption in response to expansion of extracellular volume with noncolloid-containing solutions is the result of concomitant reductions in postglomerular (efferent arteriolar) protein concentration. Selective elevation of efferent arteriolar oncotic pressure in volume-expanded rats (Ringer's 10% body weight) to levels slightly in excess of normal by microperfusion with 9-10% albumin-Ringer's solution nearly completely reversed the inhibition in absolute and fractional reabsorption in adjacent proximal tubules. In contrast, during similar microperfusion with a 6-7% albumin solution, no increase in proximal reabsorption was measured. We interpret these findings to indicate that the bulk of the inhibition in absolute proximal reabsorption in response to volume expansion with colloid-free solutions is causally mediated by the accompanying parallel decline in postglomerular vascular protein concentration.