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Citation Information: J Clin Invest. 1970;49(11):2146-2149. https://doi.org/10.1172/JCI106432.
Abstract
In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.
Authors
Eric Reiss, Janet M. Canterbury, Margaret A. Bercovitz, Edwin L. Kaplan
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