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Research Article Free access | 10.1172/JCI106432

The role of phosphate in the secretion of parathyroid hormone in man

Eric Reiss, Janet M. Canterbury, Margaret A. Bercovitz, and Edwin L. Kaplan

Department of Medicine, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Department of Surgery, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

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Department of Medicine, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Department of Surgery, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Find articles by Canterbury, J. in: PubMed | Google Scholar

Department of Medicine, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Department of Surgery, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Find articles by Bercovitz, M. in: PubMed | Google Scholar

Department of Medicine, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Department of Surgery, Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Find articles by Kaplan, E. in: PubMed | Google Scholar

Published November 1, 1970 - More info

Published in Volume 49, Issue 11 on November 1, 1970
J Clin Invest. 1970;49(11):2146–2149. https://doi.org/10.1172/JCI106432.
© 1970 The American Society for Clinical Investigation
Published November 1, 1970 - Version history
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Abstract

In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.

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