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In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and Gdmediterranean deficiency
Sergio Piomelli, … , Janet Miraglia, Edward L. Amorosi
Sergio Piomelli, … , Janet Miraglia, Edward L. Amorosi
Published April 1, 1968
Citation Information: J Clin Invest. 1968;47(4):940-948. https://doi.org/10.1172/JCI105786.
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Research Article

In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and Gdmediterranean deficiency

Abstract

A decreased level of glucose-6-phosphate dehydrogenase might result from decreased rate of synthesis, synthesis of an enzyme of lower catalytic efficiency, increased lability, or a combined mechanism. To test the hypothesis of increased lability, the rate of decline of the enzyme in vivo was measured in three groups of individuals, controls, Gd(—),A-males, and Gd(—), Mediterranean males, by the slope of decline of activity in fractions containing erythrocytes of progressively increasing mean age. These fractions were obtained by ultracentrifugation on a discontinuous density gradient of erythrocyte suspensions free of contaminating platelets and leukocytes.

Authors

Sergio Piomelli, Laurence M. Corash, Deatra D. Davenport, Janet Miraglia, Edward L. Amorosi

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