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RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
Nadine Haase, … , Babbette LaMarca, Ralf Dechend
Nadine Haase, … , Babbette LaMarca, Ralf Dechend
Published April 27, 2020
Citation Information: J Clin Invest. 2020;130(6):2928-2942. https://doi.org/10.1172/JCI99417.
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Research Article Reproductive biology Article has an altmetric score of 45

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models

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Abstract

Authors

Nadine Haase, Donald J. Foster, Mark W. Cunningham, Julia Bercher, Tuyen Nguyen, Svetlana Shulga-Morskaya, Stuart Milstein, Sarfraz Shaikh, Jeff Rollins, Michaela Golic, Florian Herse, Kristin Kräker, Ivo Bendix, Meray Serdar, Hanna Napieczynska, Arnd Heuser, Alexandra Gellhaus, Kristin Thiele, Gerd Wallukat, Dominik N. Müller, Babbette LaMarca, Ralf Dechend

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Figure 9

Administration of rAgt siRNA to RUPP rats blunts the increase in blood pressure and prevents a decrease in fetal weights.

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Administration of rAgt siRNA to RUPP rats blunts the increase in blood p...
(A) MAP was reduced in rAgt-targeting siRNA–treated RUPP rats (n = 7) compared with untreated RUPP rats (n = 6), and unchanged in NP rats treated with rAgt-targeting siRNA (n = 7) compared with untreated NP rats (n = 7) (*P < 0.05, **P < 0.01, ***P < 0.001; 1-way ANOVA with Tukey’s post hoc test; mean ± SEM). (B) Albuminuria was not observed in the RUPP model, and no differences could be detected between rAgt-targeting siRNA–treated rats and untreated rats (NP n = 11, NP [rAgt RNAi] n = 8, RUPP n = 11, RUPP [rAgt RNAi] n = 9; mean ± SEM). (C) Fetal weights were decreased in response to placental ischemia in untreated RUPP rats (n = 6) compared with untreated NP rats (n = 7) and NP rats treated with rAgt-targeting siRNA (n = 7); however, the application of rAgt-targeting siRNA to RUPP rats (n = 7) ameliorated the decrease in fetal weight (*P < 0.05, **P < 0.01; 1-way ANOVA with Tukey’s post hoc test; mean ± SEM). (D) Fetal brain/liver weight ratios were increased in untreated RUPP (n = 6) compared with untreated (n = 7) and treated rAgt-targeting siRNA–treated (n = 7) NP rats. Administration of rAgt-targeting siRNA to RUPP rats (n = 7) reduced the fetal brain/liver weight ratio (*P < 0.05, **P < 0.01, ***P < 0.001; 1-way ANOVA with Tukey’s post hoc test; mean ± SEM).

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