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Xing Fu, … , Burns C. Blaxall, Jeffery D. Molkentin
Published April 16, 2018
Citation Information: J Clin Invest. 2018;128(5):2127-2143. https://doi.org/10.1172/JCI98215.
Citation Information: J Clin Invest. 2018;128(5):2127-2143. https://doi.org/10.1172/JCI98215.
Abstract
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation. Fibroblasts were activated and highly proliferative, reaching a maximum rate within 2 to 4 days after infarction injury, at which point they expanded 3.5-fold and were maintained long term. By 3 to 7 days, these cells differentiated into myofibroblasts that secreted abundant extracellular matrix proteins and expressed smooth muscle α-actin to structurally support the necrotic area. By 7 to 10 days, myofibroblasts lost proliferative ability and smooth muscle α-actin expression as the collagen-containing extracellular matrix and scar fully matured. However, these same lineage-traced initial fibroblasts persisted within the scar, achieving a new molecular and stable differentiated state referred to as a matrifibrocyte, which was also observed in the scars of human hearts. These cells express common and unique extracellular matrix and tendon genes that are more specialized to support the mature scar.
Authors
Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G. Boyer, Ronald J. Vagnozzi, Bryan D. Maliken, Michelle A. Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C. Blaxall, Jeffery D. Molkentin
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Citations to this article (362)
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Ackerman JE, Adjei-Sowah E, Korcari A, Muscat SN, Nichols AE, Buckley MR, Loiselle AE |
2023 | |
|
The heterocellular heart: identities, interactions, and implications for cardiology
Lother A, Kohl P |
Basic Research in Cardiology | 2023 |
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Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair
Zhu D, Liu S, Huang K, Li J, Mei X, Li Z, Cheng K |
European Heart Journal | 2023 |
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YAP/TAZ: Molecular pathway and disease therapy
Wei Y, Hui VL, Chen Y, Han R, Han X, Guo Y |
2023 | |
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Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.
Simonson B, Chaffin M, Hill MC, Atwa O, Guedira Y, Bhasin H, Hall AW, Hayat S, Baumgart S, Bedi KC Jr, Margulies KB, Klattenhoff CA, Ellinor PT |
Cell Reports | 2023 |
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Animal models to study cardiac regeneration.
Weinberger M, Riley PR |
Nature reviews. Cardiology | 2023 |
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Transcription factor EB (TFEB) improves ventricular remodeling after myocardial infarction by inhibiting Wnt/β-catenin signaling pathway
Liu C, Zhou D, Zhang Q, Wei H, Lu Y, Li B, Zhan H, Cheng J, Wang C, Yang Y, Li S, Hu C, Liao X |
PeerJ | 2023 |
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Understanding Fibroblast Heterogeneity in Form and Function
Parker JB, Valencia C, Akras D, DiIorio SE, Griffin MF, Longaker MT, Wan DC |
Biomedicines | 2023 |
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Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis.
Umbarkar P, Ejantkar S, Ruiz Ramirez SY, Toro Cora A, Zhang Q, Tousif S, Lal H |
Basic Research in Cardiology | 2023 |
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miRNAs Epigenetic Tuning of Wall Remodeling in the Early Phase after Myocardial Infarction: A Novel Epidrug Approach
Salvatori F, D\u2019Aversa E, Serino ML, Singh AV, Secchiero P, Zauli G, Tisato V, Gemmati D |
International journal of molecular sciences | 2023 |
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Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice
Künzel SR, Winter L, Hoffmann M, Kant TA, Thiel J, Kronstein\u2010Wiedemann R, Klapproth E, Lorenz K, El\u2010Armouche A, Kämmerer S |
Physiological Reports | 2023 |
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Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition
Nguyen MT, Imanishi M, Li S, Chau K, Banerjee P, Velatooru LR, Ko KA, Samanthapudi VS, Gi YJ, Lee LL, Abe RJ, McBeath E, Deswal A, Lin SH, Palaskas NL, Dantzer R, Fujiwara K, Borchrdt MK, Turcios EB, Olmsted-Davis EA, Kotla S, Cooke JP, Wang G, Abe JI, Le NT |
Frontiers in Cardiovascular Medicine | 2023 |
|
Cardiac Fibrosis Mitigated by an Endogenous Negative Regulator of HDAC
Lazaropoulos MP, Elrod JW |
Circulation research | 2023 |
|
Epigenetic Regulation of Fibroblasts and Crosstalk between Cardiomyocytes and Non-Myocyte Cells in Cardiac Fibrosis
Chu L, Xie D, Xu D |
Biomolecules | 2023 |
|
Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes
Burgon PG, Weldrick JJ, Talab OM, Nadeer M, Nomikos M, Megeney LA |
Cells | 2023 |
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Highlighting Fibroblasts Activation in Fibrosis: The State-of-The-Art Fibroblast Activation Protein Inhibitor PET Imaging in Cardiovascular Diseases
Cui Y, Wang Y, Wang S, Du B, Li X, Li Y |
Journal of Clinical Medicine | 2023 |
|
Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction
Sasaki T, Kuse Y, Nakamura S, Shimazawa M, Hara H |
FASEB bioAdvances | 2023 |
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Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury
Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G |
2023 | |
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Protective effects of macrophage-specific integrin α5 in myocardial infarction are associated with accentuated angiogenesis
Li R, Chen B, Kubota A, Hanna A, Humeres C, Hernandez SC, Liu Y, Ma R, Tuleta I, Huang S, Venugopal H, Zhu F, Su K, Li J, Zhang J, Zheng D, Frangogiannis NG |
Nature Communications | 2023 |
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IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling
Siamwala JH, Pagano FS, Dubielecka PM, Ivey MJ, Guirao-Abad JP, Zhao A, Chen S, Granston H, Jeong JY, Rounds S, Kanisicak O, Sadayappan S, Gilbert RJ |
Communications biology | 2023 |
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Identifying the Interaction Between Tuberculosis and SARS-CoV-2 Infections via Bioinformatics Analysis and Machine Learning.
Huang ZM, Kang JQ, Chen PZ, Deng LF, Li JX, He YX, Liang J, Huang N, Luo TY, Lan QW, Chen HK, Guo XG |
Biochemical Genetics | 2023 |
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Harnessing stem cell and lineage reprogramming technology to treat cardiac fibrosis.
Zeng N, Tang W, Wu Y, Fan H, Xie S, Cao N |
2023 | |
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Perish in the Attempt: Regulated Cell Death in Regenerative and Nonregenerative Tissue.
Li S, Tao G |
Antioxidants & Redox Signaling | 2023 |
|
Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells.
Fernandes I, Funakoshi S, Hamidzada H, Epelman S, Keller G |
Nature Communications | 2023 |
|
Fibroblasts, myofibroblasts and cardiac arrhythmias
Frangogiannis NG |
2023 | |
|
The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence
Hui W, Song T, Yu L, Chen X |
Antioxidants | 2023 |
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Fibroblast Reprogramming in Cardiac Repair
Wang Q, Spurlock B, Liu J, Qian L |
JACC: Basic to Translational Science | 2023 |
|
Cardiac Maturation
Sakamoto T, Kelly DP |
Journal of Molecular and Cellular Cardiology | 2023 |
|
Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.
Ackerman JE, Muscat SN, Adjei-Sowah E, Korcari A, Nichols AEC, Buckley MR, Loiselle AE |
Matrix biology : journal of the International Society for Matrix Biology | 2023 |
|
Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside.
Xu X, Hua X, Mo H, Hu S, Song J |
Basic Research in Cardiology | 2023 |
|
Fibroblasts and immune cells: at the crossroad of organ inflammation and fibrosis
Smolgovsky S, Theall B, Wagner N, Alcaide P |
American journal of physiology. Heart and circulatory physiology | 2023 |
|
MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training
Improta-Caria AC, Rodrigues LF, Joaquim VH, De Sousa RA, Fernandes T, Oliveira EM |
American journal of physiology. Heart and circulatory physiology | 2023 |
|
Smad7 effects on TGF-beta and Erbb2 restrain myofibroblast activation, and protect from post-infarction heart failure
Claudio Humeres, Arti V Shinde, Anis Hanna, Linda Alex, Silvia C Hernandez, Ruoshui Li, Bijun Chen, Simon J Conway, Nikolaos G Frangogiannis |
Journal of Clinical Investigation | 2022 |
|
MiR-181b targets semaphorin 3a to mediate TGF-β-induced endothelial-to-mesenchymal transition related to atrial fibrillation
Ying-Ju Lai, Feng-Chun Tsai, Gwo-Jyh Chang, Shang-Hung Chang, Chung-Chi Huang, Wei-Jan Chen, Yung-Hsin Yeh |
Journal of Clinical Investigation | 2022 |
|
Dendritic cell-derived epiregulin maintains scleroderma skin and lung fibrosis
Ian Odell, Holly Steach, Stephen Gauld, Tracy Carr, Joseph Wetter, Lucy Phillips, Monique Hinchcliff, Richard Flavell |
Science Immunology | 2022 |
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Consequences of fibroblast ablation in adult murine hearts
Jill T. Kuwabara, Sumit Bhutada, Vikram Shettigar, Greg S Gojanovich, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark Ziolo, Suneel Apte, Michelle D. Tallquist |
eLife | 2022 |
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Thymosin beta 4 and prothymosin alpha promote cardiac regeneration post-ischemic injury in mice
Monika Gladka, Anne Johansen, Sebastiaan Kampen, Marijn Peters, Bas Molenaar, Danielle Versteeg, Lieneke Kooijman, Mauro Giacca, Eva Rooij |
Cardiovascular Research | 2022 |
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Novel Techniques Targeting Fibroblasts after Ischemic Heart Injury
S Cakir, K Whitehead, H Hendricks, L de Castro Brás |
Cells | 2022 |
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A New Hypothetical Concept in Metabolic Understanding of Cardiac Fibrosis: Glycolysis Combined with TGF-β and KLF5 Signaling
T Methatham, R Nagai, K Aizawa |
International journal of molecular sciences | 2022 |
|
Fibro-fatty remodelling in arrhythmogenic cardiomyopathy
A Kohela, E van Rooij |
Basic Research in Cardiology | 2022 |
|
Wnt Site Signaling Inhibitor Secreted Frizzled‐Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction–Induced Endothelial‐to‐Mesenchymal Transition
Z Alvandi, Y Nagata, L Passos, A Gheinani, J Guerrero, J WylieSears, D Romero, B Morris, S Sullivan, K Yaghoubian, A Alvandi, R Adam, E Aikawa, R Levine, J Bischoff |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2022 |
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Fibroblast activation protein imaging in reperfused ST-elevation myocardial infarction: comparison with cardiac magnetic resonance imaging
B Xie, J Wang, , X Guo, BX Chen, L Li, C Hua, S Zhao, P Su, M Chen, MF Yang |
European Journal of Nuclear Medicine and Molecular Imaging | 2022 |
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Identification of macrophages in normal and injured mouse tissues using reporter lines and antibodies
B Chen, R Li, A Kubota, L Alex, N Frangogiannis |
Scientific Reports | 2022 |
|
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction
H Venugopal, A Hanna, C Humeres, N Frangogiannis |
Cells | 2022 |
|
Transforming growth factor-β in myocardial disease
NG Frangogiannis |
Nature Reviews Cardiology | 2022 |
|
Signaling pathways and targeted therapy for myocardial infarction
Q Zhang, L Wang, S Wang, H Cheng, L Xu, G Pei, Y Wang, C Fu, Y Jiang, C He, Q Wei |
Signal Transduction and Targeted Therapy | 2022 |
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MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing
D Bugg, L Bailey, R Bretherton, K Beach, I Reichardt, K Robeson, A Reese, J Gunaje, G Flint, C DeForest, A Stempien-Otero, J Davis |
Cell Stem Cell | 2022 |
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Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
L López-Muneta, J Linares, O Casis, L Martínez-Ibáñez, A Miqueo, J Bezunartea, A de la Nava, M Gallego, M Fernández-Santos, J Rodriguez-Madoz, X Aranguren, F Fernández-Avilés, J Segovia, F Prósper, X Carvajal-Vergara |
Frontiers in Cell and Developmental Biology | 2022 |
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Actin Alpha 2 Downregulation Inhibits Neural Stem Cell Proliferation and Differentiation into Neurons through Canonical Wnt/β-Catenin Signaling Pathway
J Zhang, Q Hu, X Jiang, S Wang, X Zhou, Y Lu, X Huang, H Duan, T Zhang, H Ge, A Yu, V Mendoza-Núñez |
Oxidative Medicine & Cellular Longevity | 2022 |
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Atomic Force Microscopy (AFM) Applications in Arrhythmogenic Cardiomyopathy
B Peña, M Adbel-Hafiz, M Cavasin, L Mestroni, O Sbaizero |
International journal of molecular sciences | 2022 |
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Enhanced NCLX-dependent mitochondrial Ca2+ efflux attenuates pathological remodeling in heart failure
J Garbincius, T Luongo, P Jadiya, A Hildebrand, D Kolmetzky, A Mangold, R Roy, J Ibetti, M Nwokedi, W Koch, J Elrod |
Journal of Molecular and Cellular Cardiology | 2022 |
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Mapping the cardiac vascular niche in heart failure
F Peisker, M Halder, J Nagai, S Ziegler, N Kaesler, K Hoeft, R Li, E Bindels, C Kuppe, J Moellmann, M Lehrke, C Stoppe, M Schaub, R Schneider, I Costa, R Kramann |
Nature Communications | 2022 |
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Smad-dependent pathways in the infarcted and failing heart
Humeres C, Venugopal H, Frangogiannis NG |
Current Opinion in Pharmacology | 2022 |
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Fibrotic Signaling in Cardiac Fibroblasts and Vascular Smooth Muscle Cells: The Dual Roles of Fibrosis in HFpEF and CAD
Bachmann JC, Baumgart SJ, Uryga AK, Bosteen MH, Borghetti G, Nyberg M, Herum KM |
Cells | 2022 |
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Mesenchymal Stem/Stromal Cells in Progressive Fibrogenic Involvement and Anti-Fibrosis Therapeutic Properties
Li C, Wang B |
Frontiers in Cell and Developmental Biology | 2022 |
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Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids
Wintzinger M, Panta M, Miz K, Prabakaran AD, Durumutla HB, Sargent M, Peek CB, Bass J, Molkentin JD, Quattrocelli M |
Molecular Metabolism | 2022 |
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Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivo
Herum KM, Weng G, Kahnert K, Waikel R, Milburn G, Conger A, Anaya P, Campbell KS, Lundby A, Won KJ, Brakebusch C |
2022 | |
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Uniting Disciplines to Develop Therapeutics: Targeted mRNA Lipid Nanoparticles Reprogram the Immune System In Vivo to Treat Heart Disease
Rurik JG, Epstein JA |
DNA and Cell Biology | 2022 |
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TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation?
Saljic A, Grandi E, Dobrev D |
Journal of Clinical Investigation | 2022 |
|
Manipulating Cardiomyocyte Plasticity for Heart Regeneration
Ko T, Nomura S |
Frontiers in Cell and Developmental Biology | 2022 |
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Canadian Contributions in Fibroblast Biology
Al-Hattab DS, Chattopadhyaya S, Czubryt MP |
Cells | 2022 |
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Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
Koenig AL, Shchukina I, Amrute J, Andhey PS, Zaitsev K, Lai L, Bajpai G, Bredemeyer A, Smith G, Jones C, Terrebonne E, Rentschler SL, Artyomov MN, Lavine KJ |
2022 | |
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Heterogeneity of the NIH3T3 Fibroblast Cell Line.
Rahimi AM, Cai M, Hoyer-Fender S |
Cells | 2022 |
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Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo.
Miller JM, Meki MH, Elnakib A, Ou Q, Abouleisa RRE, Tang XL, Salama ABM, Gebreil A, Lin C, Abdeltawab H, Khalifa F, Hill BG, Abi-Gerges N, Bolli R, El-Baz AS, Giridharan GA, Mohamed TMA |
2022 | |
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Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis.
Bobowski-Gerard M, Boulet C, Zummo FP, Dubois-Chevalier J, Gheeraert C, Bou Saleh M, Strub JM, Farce A, Ploton M, Guille L, Vandel J, Bongiovanni A, Very N, Woitrain E, Deprince A, Lalloyer F, Bauge E, Ferri L, Ntandja-Wandji LC, Cotte AK, Grangette C, Vallez E, Cianférani S, Raverdy V, Caiazzo R, Gnemmi V, Leteurtre E, Pourcet B, Paumelle R, Ravnskjaer K, Lassailly G, Haas JT, Mathurin P, Pattou F, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J |
Nature Communications | 2022 |
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Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart.
Umbarkar P, Tousif S, Singh AP, Anderson JC, Zhang Q, Tallquist MD, Woodgett J, Lal H |
Circulation research | 2022 |
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Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
Sun C, Tian X, Jia Y, Yang M, Li Y, Fernig DG |
Open Biology | 2022 |
|
PU.1 inhibition does not attenuate cardiac function deterioration or fibrosis in a murine model of myocardial infarction.
Nong Y, Guo Y, Ou Q, Gumpert A, Tomlin A, Zhu X, Bolli R |
Molecular and Cellular Biochemistry | 2022 |
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Mammalian organ regeneration in spiny mice.
Okamura DM, Nguyen ED, Collins SJ, Yoon K, Gere JB, Weiser-Evans MCM, Beier DR, Majesky MW |
Journal of Muscle Research and Cell Motility | 2022 |
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Limb-Bud and Heart (LBH) Upregulation in Cardiomyocytes under Hypoxia Promotes the Activation of Cardiac Fibroblasts via Exosome Secretion.
Xu Y, Wu A, Chen J, Song X, Chen M, Liu Q |
Mediators of Inflammation | 2022 |
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Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
Piątek-Matuszak P, Pasławski R, Pasławska U, Kiczak L, Płóciennik M, Janiszewski A, Michałek M, Gwizdała A, Kaźmierczak J, Gorący J |
Journal of Clinical Medicine | 2022 |
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Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction
Fang J, Zhang Y, Chen D, Zheng Y, Jiang J |
International Journal of Nanomedicine | 2022 |
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Macrophages in myocardial infarction.
Kubota A, Frangogiannis NG |
American journal of physiology. Cell physiology | 2022 |
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Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction.
Spiroski AM, McCracken IR, Thomson A, Magalhaes-Pinto M, Lalwani MK, Newton KJ, Miller E, Bénézech C, Hadoke P, Brittan M, Mountford JC, Beqqali A, Gray GA, Baker AH |
Frontiers in Cardiovascular Medicine | 2022 |
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Comparative Evaluation of Inducible Cre Mouse Models for Fibroblast Targeting in the Healthy and Infarcted Myocardium.
Aguado-Alvaro LP, Garitano N, Abizanda G, Larequi E, Prosper F, Pelacho B |
Biomedicines | 2022 |
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Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models
Saleh KK, Xi H, Switzler C, Skuratovsky E, Romero MA, Chien P, Gibbs D, Gane L, Hicks MR, Spencer MJ, Pyle AD |
iScience | 2022 |
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Non-cardiomyocytes in the heart in embryo development, health, and disease, a single-cell perspective
Ding S, Zhang X, Qiu H, Wo J, Zhang F, Na J |
Frontiers in Cell and Developmental Biology | 2022 |
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Connexin43 in Post-Surgical Peritoneal Adhesion Formation.
Chua JW, Thangaveloo M, Lim DXE, Madden LE, Phillips ARJ, Becker DL |
2022 | |
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Progression to lung fibrosis in severe COVID-19 patients: A morphological and transcriptomic study in postmortem samples.
Pérez-Mies B, Caniego-Casas T, Bardi T, Carretero-Barrio I, Benito A, García-Cosío M, González-García I, Pizarro D, Rosas M, Cristóbal E, Ruano Y, Garrido MC, Rigual-Bobillo J, de Pablo R, Galán JC, Pestaña D, Palacios J |
Frontiers in Medicine | 2022 |
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Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway
Han X, Yang Y, Zhang M, Li L, Xue Y, Jia Q, Wang X, Guan S |
Drug design, development and therapy | 2022 |
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Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
Atchison DK, O'Connor CL, Converso-Baran K, Bergin IL, Zhang H, Wang Y, Hartman JR, Ju W, Smrcka AV, Ganesh SK, Bitzer M |
American journal of physiology. Heart and circulatory physiology | 2022 |
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Defining the timeline of periostin upregulation in cardiac fibrosis following acute myocardial infarction in mice.
Gil H, Goldshtein M, Etzion S, Elyagon S, Hadad U, Etzion Y, Cohen S |
Scientific Reports | 2022 |
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Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction
Moggio A, Schunkert H, Kessler T, Sager HB |
International journal of molecular sciences | 2022 |
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Transcriptome analysis of a dog model of congestive heart failure shows that collagen-related 2-oxoglutarate-dependent dioxygenases contribute to heart failure.
Isono T, Matsumoto T, Suzaki M, Kubota S, Kageyama S, Kawauchi A, Wada A |
Scientific Reports | 2022 |
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Hippo-Yap signaling in cardiac and fibrotic remodeling
Del Re DP |
Current Opinion in Physiology | 2022 |
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Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression.
Wang B, Tan Y, Zhang Y, Zhang S, Duan X, Jiang Y, Li T, Zhou Q, Liu X, Zhan Z |
Experimental & molecular medicine | 2022 |
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Intercellular model predicts mechanisms of inflammation-fibrosis coupling after myocardial infarction.
Chowkwale M, Lindsey ML, Saucerman JJ |
The Journal of Physiology | 2022 |
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Transcriptional regulation of cardiac fibroblast phenotypic plasticity
Burgos Villar KN, Liu X, Small EM |
Current Opinion in Physiology | 2022 |
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Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues
Dooling LJ, Saini K, Anlaş AA, Discher DE |
Matrix biology : journal of the International Society for Matrix Biology | 2022 |
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Single-cell transcriptomics for the assessment of cardiac disease.
Miranda AMA, Janbandhu V, Maatz H, Kanemaru K, Cranley J, Teichmann SA, Hübner N, Schneider MD, Harvey RP, Noseda M |
Nature reviews. Cardiology | 2022 |
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Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice
Maroney SA, Siebert AE, Martinez ND, Rasmussen M, Peterson JA, Weiler H, Lincoln J, Mast AE |
Journal of Thrombosis and Haemostasis | 2022 |
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Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction
Li Y, Li C, Liu Q, Wang L, Bao AX, Jung JP, Dodlapati S, Sun J, Gao P, Zhang X, Francis J, Molkentin JD, Fu X |
Journal of Molecular and Cellular Cardiology | 2022 |
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Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis.
Tsai CR, Martin JF |
Current topics in developmental biology | 2022 |
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The role of interleukin-33 in organ fibrosis.
Di Carmine S, Scott MM, McLean MH, McSorley HJ |
2022 | |
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Fibroblasts orchestrate cellular crosstalk in the heart through the ECM
Bowers SL, Meng Q, Molkentin JD |
2022 | |
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Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
Yamada S, Ko T, Hatsuse S, Nomura S, Zhang B, Dai Z, Inoue S, Kubota M, Sawami K, Yamada T, Sassa T, Katagiri M, Fujita K, Katoh M, Ito M, Harada M, Toko H, Takeda N, Morita H, Aburatani H, Komuro I |
Nature Cardiovascular Research | 2022 |
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AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism
C Dufeys, EP Daskalopoulos, D Castanares-Zapatero, SJ Conway, A Ginion, C Bouzin, J Ambroise, B Bearzatto, JL Gala, S Heymans, AP Papageorgiou, S Vinckier, J Cumps, JL Balligand, M Vanhaverbeke, P Sinnaeve, S Janssens, L Bertrand, C Beauloye, S Horman |
Basic Research in Cardiology | 2021 |
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Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
LS Tombor, D John, SF Glaser, G Luxán, E Forte, M Furtado, N Rosenthal, N Baumgarten, MH Schulz, J Wittig, EM Rogg, Y Manavski, A Fischer, M Muhly-Reinholz, K Klee, M Looso, C Selignow, T Acker, SI Bibli, I Fleming, R Patrick, RP Harvey, WT Abplanalp, S Dimmeler |
Nature Communications | 2021 |
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The Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease
S Islam, KI Boström, DD Carlo, CA Simmons, Y Tintut, Y Yao, JJ Hsu |
Frontiers in physiology | 2021 |
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Mechano-chemo signaling interactions modulate matrix production by cardiac fibroblasts
JD Rogers, JW Holmes, JJ Saucerman, WJ Richardson |
2021 | |
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Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension
A Hanna, AV Shinde, R Li, L Alex, C Humeres, P Balasubramanian, NG Frangogiannis |
Matrix biology : journal of the International Society for Matrix Biology | 2021 |
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Diabetic fibrosis
I Tuleta, NG Frangogiannis |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2021 |
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Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved
B Delgado-Valero, V Cachofeiro, E Martínez-Martínez |
Cells | 2021 |
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Cellular and molecular pathobiology of heart failure with preserved ejection fraction
S Mishra, DA Kass |
Nature Reviews Cardiology | 2021 |
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Strontium ions protect hearts against myocardial ischemia/reperfusion injury
M Xing, Y Jiang, W Bi, L Gao, YL Zhou, SL Rao, LL Ma, ZW Zhang, HT Yang, J Chang |
Science Advances | 2021 |
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Controlling cardiac fibrosis through fibroblast state space modulation
IM Reichardt, KZ Robeson, M Regnier, J Davis |
Cellular Signalling | 2021 |
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Transcription Factor-7-Like-2 (TCF7L2) in Atherosclerosis: A Potential Biomarker and Therapeutic Target
J Li, L Zhou, X Ouyang, P He |
Frontiers in Cardiovascular Medicine | 2021 |
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Mechanisms of Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models
P Umbarkar, S Ejantkar, S Tousif, H Lal |
Cells | 2021 |
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Ca2+/calmodulin kinase II–dependent regulation of βIV-spectrin modulates cardiac fibroblast gene expression, proliferation, and contractility
DM Nassal, NJ Patel, SD Unudurthi, R Shaheen, J Yu, PJ Mohler, TJ Hund |
The Journal of biological chemistry | 2021 |
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Cell type–specific microRNA therapies for myocardial infarction
B Liu, B Wang, X Zhang, R Lock, T Nash, G Vunjak-Novakovic |
Science Translational Medicine | 2021 |
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NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C hi monocytes in pressure-overloaded hearts
H Abe, Y Tanada, S Omiya, MN Podaru, T Murakawa, J Ito, AM Shah, SJ Conway, M Ono, K Otsu |
Science signaling | 2021 |
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Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level
M Rao, X Wang, G Guo, L Wang, S Chen, P Yin, K Chen, L Chen, Z Zhang, X Chen, X Hu, S Hu, J Song |
Basic Research in Cardiology | 2021 |
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Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response
AC Silva, C Pereira, AC Fonseca, P Pinto-do-Ó, DS Nascimento |
Frontiers in Cell and Developmental Biology | 2021 |
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Epicardial Contribution to the Developing and Injured Heart: Exploring the Cellular Composition of the Epicardium
TJ Streef, AM Smits |
Frontiers in Cardiovascular Medicine | 2021 |
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Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction
QJ Zhang, Y He, Y Li, H Shen, L Lin, M Zhu, Z Wang, X Luo, J Hill, D Cao, RL Luo, R Zou, J McAnally, J Liao, P Bajona, Q Zang, Y Yu, ZP Liu |
Circulation research | 2021 |
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Cadherin-11 and cardiac fibrosis: A common target for a common pathology
LA Riley, WD Merryman |
Cellular Signalling | 2021 |
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Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury
H Zhao, Y Zhang, X Xu, Q Sun, C Yang, H Wang, J Yang, Y Yang, X Yang, Y Liu, Y Zhao |
Frontiers in Cell and Developmental Biology | 2021 |
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The bright side of fibroblasts: molecular signature and regenerative cues in major organs
RN Gomes, F Manuel, DS Nascimento |
npj Regenerative Medicine | 2021 |
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Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin
RM Burke, RA Dirkx, P Quijada, JK Lighthouse, A Mohan, M OBrien, W Wojciechowski, CF Woeller, RP Phipps, JD Alexis, JM Ashton, EM Small |
Circulation research | 2021 |
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Understanding the Adult Mammalian Heart at Single-Cell RNA-Seq Resolution
E Marín-Sedeño, XM de Morentin, JM Pérez-Pomares, D Gómez-Cabrero, A Ruiz-Villalba |
Frontiers in Cell and Developmental Biology | 2021 |
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Limb-bud and Heart (LBH) mediates proliferation, fibroblast-to-myofibroblast transition and EMT-like processes in cardiac fibroblasts
A wu, L Zhang, J Chen, H Li, P Yang, M Chen, Q Liu |
Molecular and Cellular Biochemistry | 2021 |
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Long noncoding RNA Cfast regulates cardiac fibrosis
F Zhang, X Fu, M Kataoka, N Liu, Y Wang, F Gao, T Liang, X Dong, J Pei, X Hu, W Zhu, H Yu, DB Cowan, X Hu, ZP Huang, J Wang, DZ Wang, J Chen |
Molecular Therapy — Nucleic Acids | 2021 |
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Ventricular Arrhythmias in Ischemic Cardiomyopathy—New Avenues for Mechanism-Guided Treatment
M Amoni, E Dries, S Ingelaere, D Vermoortele, HL Roderick, P Claus, R Willems, KR Sipido |
Cells | 2021 |
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M Lindsey, K Brunt, J Kirk, P Kleinbongard, J Calvert, L de Castro Brás, K DeLeon-Pennell, D Re, N Frangogiannis, S Frantz, R Gumina, G Halade, S Jones, R Ritchie, F Spinale, E Thorp, C Ripplinger, Z Kassiri |
American journal of physiology. Heart and circulatory physiology | 2021 |
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Transient ACE (Angiotensin-Converting Enzyme) Inhibition Suppresses Future Fibrogenic Capacity and Heterogeneity of Cardiac Fibroblast Subpopulations
AM Garvin, MD Both, JS Talboom, ML Lindsey, MJ Huentelman, TM Hale |
Hypertension | 2021 |
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Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac Fibroblasts
SY Shi, X Luo, TM Yamawaki, CM Li, B Ason, MB Furtado |
Current Cardiology Reports | 2021 |
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Cardiac Fibrosis and Fibroblasts
H Kurose |
Cells | 2021 |
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Role of PI3K/Akt signaling pathway in cardiac fibrosis
W Qin, L Cao, IY Massey |
Molecular and Cellular Biochemistry | 2021 |
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Fibroblasts: Origins, definitions, and functions in health and disease
MV Plikus, X Wang, S Sinha, E Forte, SM Thompson, EL Herzog, RR Driskell, N Rosenthal, J Biernaskie, V Horsley |
Cell | 2021 |
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Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism
AJ Mouton, ER Flynn, SP Moak, NM Aitken, AC Omoto, X Li, AA da Silva, Z Wang, JM do Carmo, JE Hall |
Journal of Molecular and Cellular Cardiology | 2021 |
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Cardiac Fibroblasts and Myocardial Regeneration
W Chen, W Bian, Y Zhou, J Zhang |
Frontiers in Bioengineering and Biotechnology | 2021 |
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Identification of the distinctive role of DPT in dilated cardiomyopathy: a study based on bulk and single-cell transcriptomic analysis
Y Lu, Q Wu, J Liao, S Zhang, K Lu, S Yang, Y Wu, Q Dong, J Yuan, N Zhao, Y Du |
Annals of translational medicine | 2021 |
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RAS inhibition in resident fibroblast biology
AM Garvin, BS Khokhar, MP Czubryt, TM Hale |
Cellular Signalling | 2021 |
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Modulation of Cardiac Fibrosis in and Beyond Cells
D Fan, Z Kassiri |
Frontiers in Molecular Biosciences | 2021 |
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Repurposing Nintedanib for pathological cardiac remodeling and dysfunction
P Umbarkar, AP Singh, S Tousif, Q Zhang, P Sethu, H Lal |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2021 |
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Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
CM Brewer, BR Nelson, P Wakenight, SJ Collins, DM Okamura, XR Dong, WM Mahoney, A McKenna, J Shendure, A Timms, KJ Millen, MW Majesky |
Developmental Cell | 2021 |
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Fibroblast Memory in Development, Homeostasis and Disease
T Kirk, A Ahmed, E Rognoni |
Cells | 2021 |
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Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
MM Gladka, A Kohela, B Molenaar, D Versteeg, L Kooijman, J Monshouwer-Kloots, V Kremer, HR Vos, MM Huibers, JJ Haigh, D Huylebroeck, RA Boon, M Giacca, E van Rooij |
Nature Communications | 2021 |
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Editorial: Cardiac Fibrosis, From Lineage Tracing to Therapeutic Application
C de Lucia, M Wallner, D Corradi, G Pironti |
Frontiers in physiology | 2021 |
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A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-α (FAPα)
JM Kelly, TM Jeitner, S Ponnala, C Williams, A Nikolopoulou, SG DiMagno, JW Babich |
Molecular Imaging and Biology | 2021 |
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A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity
C Liu, P Medina, D Thomas, IY Chen, K Sallam, D Sayed, N Sayed |
2021 | |
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Inhibition of CREB-CBP Signaling Improves Fibroblast Plasticity for Direct Cardiac Reprogramming
E Bektik, Y Sun, AT Dennis, P Sakon, D Yang, I Deschênes, JD Fu |
Cells | 2021 |
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Interaction of Obesity and Hypertension on Cardiac Metabolic Remodeling and Survival Following Myocardial Infarction
AJ Mouton, ER Flynn, SP Moak, X Li, AA da Silva, Z Wang, JM do Carmo, ME Hall, JE Hall |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2021 |
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Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts
A Kalyanasundaram, N Li, ML Gardner, EJ Artiga, BJ Hansen, A Webb, MA Freitas, M Pietrzak, BA Whitson, NA Mokadam, PM Janssen, PJ Mohler, VV Fedorov |
Circulation | 2021 |
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Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart
RJ Vagnozzi, RK Kasam, MA Sargent, JD Molkentin |
Circulation | 2021 |
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Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration
S Allanki, B Strilic, L Scheinberger, YL Onderwater, A Marks, S Günther, J Preussner, K Kikhi, M Looso, DY Stainier, S Reischauer |
Science Advances | 2021 |
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The C0-C1f Region of Cardiac Myosin Binding Protein-C Induces Pro-Inflammatory Responses in Fibroblasts via TLR4 Signaling
A Yogeswaran, C Troidl, JW McNamara, J Wilhelm, T Truschel, L Widmann, M Aslam, CW Hamm, S Sadayappan, C Lipps |
Cells | 2021 |
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Translational perspectives on cardiac reprogramming
YJ Nam |
Seminars in Cell & Developmental Biology | 2021 |
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SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation
NM Landry, SG Rattan, KL Filomeno, TW Meier, SC Meier, SJ Foran, CF Meier, N Koleini, RR Fandrich, E Kardami, TA Duhamel, IM Dixon |
Basic Research in Cardiology | 2021 |
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Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction
X Luo, J Yin, D Dwyer, T Yamawaki, H Zhou, H Ge, CY Han, A Shkumatov, K Snyder, B Ason, CM Li, O Homann, M Stolina |
Scientific Reports | 2021 |
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Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes
L Wang, Y Yang, H Ma, Y Xie, J Xu, D Near, H Wang, T Garbutt, Y Li, J Liu, L Qian |
Cardiovascular Research | 2021 |
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Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration
S Liu, L Tang, X Zhao, B Nguyen, TR Heallen, M Li, J Wang, J Wang, JF Martin |
Circulation research | 2021 |
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Local Preirradiation of Infarcted Cardiac Tissue Substantially Enhances Cell Engraftment
G Abizanda, L López-Muneta, J Linares, LI Ramos, A Baraibar-Churio, M Bobadilla, E Iglesias, G Coppiello, P Ripalda-Cemboráin, XL Aranguren, F Prósper, A Pérez-Ruiz, X Carvajal-Vergara |
International journal of molecular sciences | 2021 |
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Inflammation‐induced left ventricular fibrosis is partially mediated by tumor necrosis factor‐α
A Manilall, L Mokotedi, S Gunter, RL Roux, S Fourie, CA Flanagan, AM Millen |
Physiological Reports | 2021 |
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Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair
B Molenaar, LT Timmer, M Droog, I Perini, D Versteeg, L Kooijman, J Monshouwer-Kloots, H de Ruiter, MM Gladka, E van Rooij |
2021 | |
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Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction
H Esmaeili, C Li, X Fu, JP Jung |
Frontiers in Bioengineering and Biotechnology | 2021 |
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Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice
A Baraibar-Churio, M Bobadilla, FJ Machado, N Sáinz, C Roncal, G Abizanda, F Prósper, J Orbe, A Pérez-Ruiz |
Life Sciences | 2021 |
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Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
D Fischesser, E Meyer, M Sargent, J Molkentin |
Journal of visualized experiments : JoVE | 2021 |
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Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion
L Valls-Lacalle, L Puertas-Umbert, S Varona, J Martínez-González, C Rodríguez, A Rodríguez-Sinovas |
Antioxidants | 2021 |
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Artificial Intelligence Based Framework to Quantify the Cardiomyocyte Structural Integrity in Heart Slices
H Abdeltawab, F Khalifa, K Hammouda, J Miller, M Meki, Q Ou, A El-Baz, T Mohamed |
Cardiovascular Engineering and Technology | 2021 |
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Altered Expression of ORAI and STIM Isoforms in Activated Human Cardiac Fibroblasts
R Čendula, N Chomaničová, A Adamičková, A Gažová, J Kyselovič, M Máťuš |
Physiological research / Academia Scientiarum Bohemoslovaca | 2021 |
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Electroconductive biomaterials for cardiac tissue engineering
H Esmaeili, A Patino-Guerrero, M Hasany, M Ansari, A Memic, A Dolatshahi-Pirouz, M Nikkhah |
Acta Biomaterialia | 2021 |
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Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics
Misra A, Baker CD, Pritchett EM, Burgos Villar KN, Ashton JM, Small EM |
Journal of Cardiovascular Development and Disease | 2021 |
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Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction.
Liu S, Li K, Wagner Florencio L, Tang L, Heallen TR, Leach JP, Wang Y, Grisanti F, Willerson JT, Perin EC, Zhang S, Martin JF |
Science Translational Medicine | 2021 |
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The landscape of accessible chromatin in quiescent cardiac fibroblasts and cardiac fibroblasts activated after myocardial infarction.
Li C, Sun J, Liu Q, Dodlapati S, Ming H, Wang L, Li Y, Li R, Jiang Z, Francis J, Fu X |
Epigenetics : official journal of the DNA Methylation Society | 2021 |
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A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction
LK Mullany, AD Rohira, JP Leach, JH Kim, TO Monroe, AR Ortiz, B Stork, MW Gaber, P Sarkar, AG Sikora, TK Rosengart, B York, Y Song, CC Dacso, DM Lonard, JF Martin, BW OMalley |
Proceedings of the National Academy of Sciences | 2020 |
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Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family
LK Mullany, DM Lonard, BW OMalley |
Endocrinology | 2020 |
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The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition
SF Glaser, AW Heumüller, L Tombor, P Hofmann, M Muhly-Reinholz, A Fischer, S Günther, KE Kokot, H Okada, D Hassel, S Kumar, H Jo, RA Boon, W Abplanalp, D John, JN Boeckel, S Dimmeler |
Proceedings of the National Academy of Sciences | 2020 |
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Regulators of cardiac fibroblast cell state
R Bretherton, D Bugg, E Olszewski, J Davis |
Matrix biology : journal of the International Society for Matrix Biology | 2020 |
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Role of the Renin–Angiotensin–Aldosterone System in Dystrophin-Deficient Cardiomyopathy
M Rodriguez-Gonzalez, M Lubian-Gutierrez, HM Cascales-Poyatos, AA Perez-Reviriego, A Castellano-Martinez |
International journal of molecular sciences | 2020 |
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Extracellular Matrix in Ischemic Heart Disease, Part 4/4
NG Frangogiannis, JC Kovacic |
Journal of the American College of Cardiology | 2020 |
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Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
JE Londoño, A Marx, AE Kraft, A Schürger, C Richter, A Dietrich, P Lipp, L Birnbaumer, M Freichel |
Cells | 2020 |
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Vascular Homeostasis and Inflammation in Health and Disease—Lessons from Single Cell Technologies
O Bondareva, BN Sheikh |
International journal of molecular sciences | 2020 |
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Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
TK Hughes, MH Wadsworth, TM Gierahn, T Do, D Weiss, PR Andrade, F Ma, BJ de Andrade Silva, S Shao, LC Tsoi, J Ordovas-Montanes, JE Gudjonsson, RL Modlin, JC Love, AK Shalek |
Immunity | 2020 |
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Cardiac fibrosis
NG Frangogiannis |
Cardiovascular Research | 2020 |
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The Future of Direct Cardiac Reprogramming: Any GMT Cocktail Variety?
L López-Muneta, J Miranda-Arrubla, X Carvajal-Vergara |
International journal of molecular sciences | 2020 |
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Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype
Y Liao, H Li, H Cao, Y Dong, L Gao, Z Liu, J Ge, H Zhu |
Protein & Cell | 2020 |
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Growth factor therapy for cardiac repair: an overview of recent advances and future directions
SJ White, JJ Chong |
Biophysical Reviews | 2020 |
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The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function
SP Levick, A Widiapradja |
International journal of molecular sciences | 2020 |
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Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
J Alam, M Musiime, A Romaine, M Sawant, AO Melleby, N Lu, B Eckes, G Christensen, D Gullberg |
2020 | |
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Leukocyte-Dependent Regulation of Cardiac Fibrosis
AD Okyere, DG Tilley |
Frontiers in physiology | 2020 |
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Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances
X Fu, Q Liu, C Li, Y Li, L Wang |
Frontiers in physiology | 2020 |
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Knock‐out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post‐myocardial infarction
HF Song, S He, SH Li, J Wu, W Yin, Z Shao, G Du, J Wu, J Li, RD Weisel, S Verma, J Xie, RK Li |
Journal of Cellular and Molecular Medicine | 2020 |
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Emerging therapeutic targets for cardiac arrhythmias: Role of STAT3 in regulating cardiac fibroblast function
NJ Patel, DM Nassal, D Gratz, TJ Hund |
Expert Opinion on Therapeutic Targets | 2020 |
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Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution
Z Wang, M Cui, AM Shah, W Tan, N Liu, R Bassel-Duby, EN Olson |
Cell Reports | 2020 |
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The Role of the Epicardium During Heart Development and Repair
P Quijada, MA Trembley, EM Small |
Circulation research | 2020 |
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Recapturing embryonic potential in the adult epicardium: Prospects for cardiac repair
AN Redpath, N Smart |
Stem Cells Translational Medicine | 2020 |
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Fibroblast contributions to ischemic cardiac remodeling
RM Burke, KN Villar, EM Small |
Cellular Signalling | 2020 |
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Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease
TJ Shaw, E Rognoni |
Current Rheumatology Reports | 2020 |
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Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation
AA Gibb, MP Lazaropoulos, JW Elrod |
Circulation research | 2020 |
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Adding insult to injury - Inflammation at the heart of cardiac fibrosis
S Smolgovsky, U Ibeh, TP Tamayo, P Alcaide |
Cellular Signalling | 2020 |
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Single-Cell RNA-seq Analysis Reveals a Crucial Role for Collagen Triple Helix Repeat Containing 1 (CTHRC1) Cardiac Fibroblasts after Myocardial Infarction
A Ruiz-Villalba, JP Romero, SC Hernandez, A Vilas-Zornoza, N Fortelny, L Castro-Labrador, PS Martin-Uriz, E Lorenzo-Vivas, P García-Olloqui, M Palacios, JJ Gavira, G Bastarrika, S Janssens, M Wu, E Iglesias, G Abizanda, XM de Morentin, M Lasaga, N Planell, C Bock, D Alignani, G Medal, B Pelacho, I Prudovsky, YR Jin, S Ryzhov, H Yin, D Gomez-Cabrero, V Lindner, D Lara-Astiaso, F Prósper |
Circulation | 2020 |
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The Roles of Noncardiomyocytes in Cardiac Remodeling
D Yang, HQ Liu, FY Liu, N Tang, Z Guo, SQ Ma, P An, MY Wang, HM Wu, Z Yang, D Fan, QZ Tang |
International journal of biological sciences | 2020 |
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Chemokines in Myocardial Infarction
B Chen, NG Frangogiannis |
Journal of Cardiovascular Translational Research | 2020 |
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CXADR‐like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction
X Han, ZA Zhao, S Yan, W Lei, H Wu, XA Lu, Y Chen, J Li, Y Wang, M Yu, Y Wang, Y Zheng, H Wang, Z Shen, S Hu |
Journal of Cellular and Molecular Medicine | 2020 |
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The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease
J Liu, J Wu, L Li, T Li, J Wang |
Frontiers in pharmacology | 2020 |
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Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals
D Bugg, R Bretherton, P Kim, E Olszewski, A Nagle, AE Schumacher, N Chu, J Gunaje, CA DeForest, K Stevens, DH Kim, J Davis |
Circulation research | 2020 |
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microRNA-221 Inhibits Latent TGF-β1 Activation through Targeting Thrombospondin-1 to Attenuate Kidney Failure-Induced Cardiac Fibrosis
Y Zhou, DY Ng, AM Richards, P Wang |
Molecular Therapy — Nucleic Acids | 2020 |
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Targeted Injection of a Truncated Form of Tissue Inhibitor of Metalloproteinase 3 Alters Post–Myocardial Infarction Remodeling
DC Lobb, H Doviak, GL Brower, E Romito, JW ONeill, S Smith, JA Shuman, PD Freels, KN Zellars, LA Freeburg, AY Khakoo, TW Lee, FG Spinale |
The Journal of pharmacology and experimental therapeutics | 2020 |
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The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts
WT Stauffer, EA Blackwood, K Azizi, RJ Kaufman, CC Glembotski |
International journal of molecular sciences | 2020 |
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Cardiac fibroblast activation during myocardial infarction wound healing
MJ Daseke, MA Tenkorang, U Chalise, SR Konfrst, ML Lindsey |
Matrix biology : journal of the International Society for Matrix Biology | 2020 |
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Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts
SD Stojanović, M Fuchs, J Fiedler, K Xiao, A Meinecke, A Just, A Pich, T Thum, M Kunz |
International journal of molecular sciences | 2020 |
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High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy
MA McLellan, DA Skelly, MS Dona, GT Squiers, GE Farrugia, TL Gaynor, CD Cohen, R Pandey, H Diep, A Vinh, NA Rosenthal, AR Pinto |
Circulation | 2020 |
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Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction
T Razin, N Melamed-Book, J Argaman, I Galin, Y Lowy, E Anuka, N Naftali-Shani, M Kandel-Kfir, BP Garfinkel, S Brielle, Z Granot, RN Apte, SJ Conway, JD Molkentin, Y Kamari, J Leor, J Orly |
Journal of Molecular and Cellular Cardiology | 2020 |
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The therapeutic potential of mesenchymal stem cells for cardiovascular diseases
Y Guo, Y Yu, S Hu, Y Chen, Z Shen |
Cell Death and Disease | 2020 |
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Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases
Y Liu, JW Song, JY Lin, R Miao, JC Zhong |
Cardiovascular Toxicology | 2020 |
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Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice
E Forte, DA Skelly, M Chen, S Daigle, KA Morelli, O Hon, VM Philip, MW Costa, NA Rosenthal, MB Furtado |
Cell Reports | 2020 |
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Transcriptional and Cellular Diversity of the Human Heart
NR Tucker, M Chaffin, SJ Fleming, AW Hall, VA Parsons, KC Bedi, AD Akkad, CN Herndon, A Arduini, I Papangeli, C Roselli, F Aguet, SH Choi, KG Ardlie, M Babadi, KB Margulies, CM Stegmann, PT Ellinor |
Circulation | 2020 |
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Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis
DM Barbosa, P Fahlbusch, DH de Wiza, S Jacob, U Kettel, H Al-Hasani, M Krüger, DM Ouwens, S Hartwig, S Lehr, J Kotzka, B Knebel |
Scientific Reports | 2020 |
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A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation
L Hortells, I Valiente-Alandi, ZM Thomas, EJ Agnew, DJ Schnell, AJ York, RJ Vagnozzi, EC Meyer, JD Molkentin, KE Yutzey |
Proceedings of the National Academy of Sciences | 2020 |
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Heart-derived fibroblasts express LYPD-1 and negatively regulate angiogenesis in rat
S Sakamoto, K Matsuura, S Masuda, N Hagiwara, T Shimizu |
Regenerative Therapy | 2020 |
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Integrative Bioinformatic Analyses of Global Transcriptome Data Decipher Novel Molecular Insights into Cardiac Anti-Fibrotic Therapies
M Fuchs, FP Kreutzer, LA Kapsner, S Mitzka, A Just, F Perbellini, CM Terracciano, K Xiao, R Geffers, C Bogdan, HU Prokosch, J Fiedler, T Thum, M Kunz |
International journal of molecular sciences | 2020 |
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Comparative analysis of adeno-associated virus serotypes for gene transfer in organotypic heart slices
Z Liu, K Klose, S Neuber, M Jiang, M Gossen, C Stamm |
Journal of Translational Medicine | 2020 |
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The Histamine 3 Receptor Is Expressed in the Heart and Its Activation Opposes Adverse Cardiac Remodeling in the Angiotensin II Mouse Model
SL McCaffrey, G Lim, M Bullock, AO Kasparian, R Clifton-Bligh, WB Campbell, A Widiapradja, SP Levick |
International journal of molecular sciences | 2020 |
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Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity
JM Miller, MH Meki, Q Ou, SA George, A Gams, RR Abouleisa, XL Tang, BM Ahern, GA Giridharan, A El-Baz, BG Hill, J Satin, DJ Conklin, J Moslehi, R Bolli, AJ Ribeiro, IR Efimov, TM Mohamed |
Toxicology and Applied Pharmacology | 2020 |
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Characterization of fibrillar collagen isoforms in infarcted mouse hearts using second harmonic generation imaging
SP Sahu, Q Liu, A Prasad, SM Hasan, Q Liu, MX Rodriguez, O Mukhopadhyay, D Burk, J Francis, S Mukhopadhyay, X Fu, MR Gartia |
Biomedical Optics Express | 2020 |
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Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering
G Garoffolo, S Ferrari, S Rizzi, M Barbuto, G Bernava, M Pesce |
Biomolecules | 2020 |
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Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data
R Patrick, DT Humphreys, V Janbandhu, A Oshlack, JW Ho, RP Harvey, KK Lo |
Genome biology | 2020 |
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NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival
KT Best, AE Nichols, E Knapp, WC Hammert, C Ketonis, JH Jonason, HA Awad, AE Loiselle |
Science signaling | 2020 |
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The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures
Y Huang, Y Wang, X Wang, L Lin, P Wang, J Sun, L Jiang |
Medical science monitor : international medical journal of experimental and clinical research | 2020 |
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Slicing and Culturing Pig Hearts under Physiological Conditions
Q Ou, RR Abouleisa, XL Tang, HR Juhardeen, MH Meki, JM Miller, G Giridharan, A El-Baz, R Bolli, TM Mohamed |
Journal of visualized experiments : JoVE | 2020 |
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Long Noncoding RNAs in Cardiac Development.
Alexanian M, Ounzain S |
Cold Spring Harbor perspectives in biology | 2020 |
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Cardiac Fibroblast Diversity.
Tallquist MD |
Annual Review of Physiology | 2020 |
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Cell-specific ablation of Hsp47 defines the collagen producing cells in the injured heart
Hadi Khalil, Onur kanisicak, Ronald J. Vagnozzi, Anne Katrine Johansen, Bryan D. Maliken, Vikram Prasad, Justin Boyer, Matthew J Brody, Tobias Schips, Katja Kilian, Robert N Correll, Kunito Kawasaki, Kazuhiro Nagata, Jeffery D. Molkentin |
JCI Insight | 2019 |
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Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation
Gesine M Scharf, Katja Kilian, Julio Cordero, Yong Wang, Andrea Grund, Melanie Hofmann, Natali Froese, Xue Wang, Andreas Kispert, Ralf Kist, Simon J Conway, Robert Geffers, Kai C Wollert, Gergana Dobreva, Johann Bauersachs, Joerg Heineke |
JCI Insight | 2019 |
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βIV-spectrin/STAT3 complex regulates fibroblast phenotype, fibrosis and cardiac function
Nehal J. Patel, Drew M. Nassal, Amara Greer-Short, Sathya Unudurthi, Benjamin W Scandling, Daniel Gratz, Xianyao Xu, Anuradha Kalyanasundaram, Vadim V. Fedorov, Federica Accornero, Peter J. Mohler, Keith J Gooch, Thomas J Hund |
JCI Insight | 2019 |
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