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Nicolás Herranz, Jesús Gil
Published April 2, 2018
Citation Information: J Clin Invest. 2018;128(4):1238-1246. https://doi.org/10.1172/JCI95148.
Citation Information: J Clin Invest. 2018;128(4):1238-1246. https://doi.org/10.1172/JCI95148.
Abstract
Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different stresses. By imposing a growth arrest, senescence limits the replication of old or damaged cells. Besides exiting the cell cycle, senescent cells undergo many other phenotypic alterations such as metabolic reprogramming, chromatin rearrangement, or autophagy modulation. In addition, senescent cells produce and secrete a complex combination of factors, collectively referred as the senescence-associated secretory phenotype, that mediate most of their non–cell-autonomous effects. Because senescent cells influence the outcome of a variety of physiological and pathological processes, including cancer and age-related diseases, pro-senescent and anti-senescent therapies are actively being explored. In this Review, we discuss the mechanisms regulating different aspects of the senescence phenotype and their functional implications. This knowledge is essential to improve the identification and characterization of senescent cells in vivo and will help to develop rational strategies to modulate the senescence program for therapeutic benefit.
Authors
Nicolás Herranz, Jesús Gil
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Citations to this article (567)
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The EMBO journal | 2024 |
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Kaempferol Synergistically Enhances Cisplatin-induced Apoptosis and Cell Cycle Arrest in Colon Cancer Cells
Haroon M, Kang SC |
Journal of Cancer Prevention | 2024 |
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A new model and precious tool to study molecular mechanisms of macrophage aging.
Smith R, Bassand K, Dussol A, Piesse C, Duplus E, El Hadri K |
Aging | 2024 |
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The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression.
Dasgupta N, Arnold R, Equey A, Gandhi A, Adams PD |
npj aging | 2024 |
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Identification of Cellular Senescence-Related Critical Genes and Molecular Classification and Revealing the Drug-Resistant Therapeutic Effect of IGFBP2 in Chronic Myeloid Leukemia
Xu Y, Yang W, Yao F, Wang Z, Liu J, Huang B, Li X, Zhong F, Wang X |
Journal of Inflammation Research | 2024 |
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IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways.
Siraj Y, Aprile D, Alessio N, Peluso G, Di Bernardo G, Galderisi U |
Cell communication and signaling : CCS | 2024 |
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Can hypoxic exercise retard cellular senescence? A narrative review.
Huang T, Tsang C, Huang J |
European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity | 2024 |
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Identification of senescent cell subpopulations by CITE-seq analysis.
Abdelmohsen K, Mazan-Mamczarz K, Munk R, Tsitsipatis D, Meng Q, Rossi M, Pal A, Shin CH, Martindale JL, Piao Y, Fan J, Yanai H, De S, Beerman I, Gorospe M |
Aging cell | 2024 |
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Cellular senescence in Alzheimer's disease: from physiology to pathology.
Zhu J, Wu C, Yang L |
Translational neurodegeneration | 2024 |
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Cellular Senescence: A Bridge Between Diabetes and Microangiopathy
Liu J, Guo B, Liu Q, Zhu G, Wang Y, Wang N, Yang Y, Fu S |
Biomolecules | 2024 |
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SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina
Suresh S, Karthik G, Ouyang JF, Chrysostomou V, Tang SA, Petretto E, Crowston JG, Bell KC |
NPJ Aging | 2024 |
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Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
Han Z, Wang K, Ding S, Zhang M |
Bone Research | 2024 |
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Molecular Signaling and Clinical Implications in the Human Aging-cancer Cycle
Rezaeian AH, Wei W |
Seminars in cancer biology | 2024 |
|
Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke
Huang Z, Xu P, Hess DC, Zhang Q |
Translational Neurodegeneration | 2024 |
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cGAS/STING signalling pathway in senescence and oncogenesis
Yu L, Liu P |
Seminars in cancer biology | 2024 |
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SRSF1 Is Crucial for Maintaining Satellite Cell Homeostasis During Skeletal Muscle Growth and Regeneration
Wang Z, Peng Q, Zhang Z, You X, Duan H, Sha R, Yuan N, Li Z, Xie Z, Han J, Feng Y |
Journal of Cachexia, Sarcopenia and Muscle | 2024 |
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Unraveling the Guardian: p53’s Multifaceted Role in the DNA Damage Response and Tumor Treatment Strategies
Zhang H, Xu J, Long Y, Maimaitijiang A, Su Z, Li W, Li J |
International Journal of Molecular Sciences | 2024 |
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The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation
Yang H, Chen X, Chen J, Dong Y, Huang Y, Qin L, Tan J, Yi W |
Frontiers in Cell and Developmental Biology | 2024 |
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ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities
Larrea Murillo L, Sugden CJ, Ozsvari B, Moftakhar Z, Hassan GS, Sotgia F, Lisanti MP |
Cells | 2024 |
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Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation
Yu G, Wang Z, Gong A, Fu X, Chen N, Zhou D, Li Y, Liu Z, Tong X |
Antioxidants | 2024 |
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Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity
Weiss AM, Lopez MA II, Rosenberger MG, Kim JY, Shen J, Chen Q, Ung T, Ibeh UM, Knight HR, Rutledge NS, Studnitzer B, Rowan SJ, Esser-Kahn AP |
Journal of medicinal chemistry | 2024 |
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Pathophysiology of vascular ageing and the effect of novel cardio‐renal protective medications in preventing progression of chronic kidney disease in people living with diabetes
Fountoulakis N, Miyamoto Y, Pavkov ME, Karalliedde J, Maltese G |
Diabetic Medicine | 2024 |
|
Senescent T Cells in Age-Related Diseases
Yu PJ, Zhou M, Liu Y, Du J |
Aging and Disease | 2024 |
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Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes
Pangrazzi L, Meryk A |
Biology | 2024 |
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Asparagine prevents intestinal stem cell aging via the autophagy‐lysosomal pathway
Luo T, Zhao L, Feng C, Yan J, Yuan Y, Chen H |
Aging Cell | 2024 |
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Senolytics: charting a new course or enhancing existing anti-tumor therapies?
Czajkowski K, Herbet M, Murias M, Piątkowska-Chmiel I |
Cellular Oncology (Dordrecht, Netherlands) | 2024 |
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Establishment of a novel benign meningioma cell line spontaneously immortalized under hypoxic conditions.
Ishikawa T, Matsuda M, Ishikawa H, Toyomura J, Ohyama A, Sakamoto N, Zaboronok A, Ishikawa E |
Human cell | 2024 |
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PM2.5-induced cellular senescence drives brown adipose tissue impairment in middle-aged mice
Hu R, Fan W, Li S, Zhang G, Zang L, Qin L, Li R, Chen R, Zhang L, Gu W, Zhang Y, Rajagopalan S, Sun Q, Liu C |
Ecotoxicology and environmental safety | 2024 |
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Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants.
Tufail M, Huang YQ, Hu JJ, Liang J, He CY, Wan WD, Jiang CH, Wu H, Li N |
Aging and disease | 2024 |
|
Aging and Autophagy: Roles in Musculoskeletal System Injury
Zhang H, Gu W, Wu G, Yu Y |
Aging and Disease | 2024 |
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Senolytic drugs, Dasatinib and Quercetin, attenuate adipose tissue inflammation and ameliorate metabolic function in old mice
Md Islam, Eric Tuday, John Kim, William Holland, Anthony Donato, Lisa Lesniewski |
Aging Cell | 2023 |
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An ERK5-NRF2 axis mediates senescence-associated stemness and atherosclerosis
Jun-ichi Abe, masaki Imanishi, Shengyu Li, Aijun Zhang, Kyung Ko, Venkata Samanthapudi, Ling-Ling Lee, Anita Deswal, Joerg Herrmann, Steven Lin, Eduardo Chini, Ying Shen, Keri Schadler, Thi-Hong-Minh Nguyen, Anisha Gupte, Cielito Reyes-Gibby, Sai-Ching Yeung, Elizabeth Olmsted-Davis, Nicolas Palaska, John Cooke, Henry Pownall, Momoko Yoshimoto, Keigi Fujiwara, Dale Hamilton, Jared Burks, Guangyu Wang, Nhat-Tu Le, Sivareddy Kotla |
Circulation research | 2023 |
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Senescence-based Colorectal Cancer Subtyping Reveals Distinct Molecular Characteristics and Therapeutic Strategies
Min-Yi Lv, Du Cai, Cheng-Hang Li, Junguo Chen, Guanman Li, Chuling Hu, Baowen Gai, Jiaxin Lei, Ping Lan, Xiaojian Wu, Xiaosheng He, Feng Gao |
MedComm | 2023 |
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Transplanting Old Organs Accelerates Aging in Young Recipients
Jasper Iske, Maximilian Julius Roesel, Andreas Schroeter, Tomohisa Matsunaga, Ryoichi Maenosono, Utkarsh Tripath, Yao Xiao, Yeqi Nian, Barbara Caldarone, Florian Vondran, Peter Sage, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Tamar Pirtskhalava, Tamara Tchkonia, James Kirkland, Hao Zhou, Stefan Tullius |
American Journal of Transplantation | 2023 |
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Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM, Brandão BB, Mann M, Kahn CR |
Nature Communications | 2023 |
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Stability and biosafety of human epidermal stem cell for wound repair: preclinical evaluation
Zhao X, Li X, Wang Y, Guo Y, Huang Y, Lv D, Lei M, Yu S, Luo G, Zhan R |
Stem Cell Research & Therapy | 2023 |
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Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
Muto J, Fukuda S, Watanabe K, Dai X, Tsuda T, Kiyoi T, Kameda K, Kawakami R, Mori H, Shiraishi K, Murakami M, Imamura T, Higashiyama S, Fujisawa Y, Mizukami Y, Sayama K |
Communications biology | 2023 |
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Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H |
Nature Communications | 2023 |
|
Radiation-induced senescence: therapeutic opportunities
Kim JH, Brown SL, Gordon MN |
Radiation oncology (London, England) | 2023 |
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RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
Imanishi T, Unno M, Yoneda N, Motomura Y, Mochizuki M, Sasaki T, Pasparakis M, Saito T |
Science Advances | 2023 |
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A comprehensive overview of cellular senescence from 1990 to 2021: A machine learning-based bibliometric analysis
Li C, Liu Z, Shi R |
Frontiers in Medicine | 2023 |
|
Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain
Pham AM, Ortiz LE, Lukacher AE, Kwun HJ |
Cells | 2023 |
|
Long-Term Cultured Human Glioblastoma Multiforme Cells Demonstrate Increased Radiosensitivity and Senescence-Associated Secretory Phenotype in Response to Irradiation
Alhaddad L, Nofal Z, Pustovalova M, Osipov AN, Leonov S |
International journal of molecular sciences | 2023 |
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Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis
Banerjee P, Gaddam N, Pandita TK, Chakraborty S |
International journal of molecular sciences | 2023 |
|
Transcriptome-Based Traits of Radioresistant Sublines of Non-Small Cell Lung Cancer Cells
Pustovalova M, Malakhov P, Guryanova A, Sorokin M, Suntsova M, Buzdin A, Osipov AN, Leonov S |
International journal of molecular sciences | 2023 |
|
Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction
Zhou H, Zhao C, Wang P, Yang W, Zhu H, Zhang S |
Frontiers in Endocrinology | 2023 |
|
Ferroptosis and Senescence: A Systematic Review
Coradduzza D, Congiargiu A, Chen Z, Zinellu A, Carru C, Medici S |
International journal of molecular sciences | 2023 |
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The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells
Nosrati F, Grillari J, Azarnia M, Nabiuni M, Moghadasali R, Karimzadeh L, Lämmermann I |
Biogerontology | 2023 |
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cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
Schmitz CR, Maurmann RM, Guma FT, Bauer ME, Barbé-Tuana FM |
Frontiers in immunology | 2023 |
|
Could senescence phenotypes strike the balance to promote tumor dormancy?
Chiu FY, Kvadas RM, Mheidly Z, Shahbandi A, Jackson JG |
Cancer metastasis reviews | 2023 |
|
E2F1 inhibits cellular senescence and promotes oxaliplatin resistance in colorectal cancer
Gao H, Zhou F, Li R, Yuan J, Ye L |
Annals of translational medicine | 2023 |
|
Comprehensive genomics analysis of aging related gene signature to predict the prognosis and drug resistance of colon adenocarcinoma
Feng J, Fu F, Nie Y |
Frontiers in pharmacology | 2023 |
|
Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules
Zou W, Lai M, Jiang Y, Mao L, Zhou W, Zhang S, Lai P, Guo B, Wei T, Nie C, Zheng L, Zhang J, Gao X, Zhao X, Xia L, Zou Z, Liu A, Liu S, Cui Z, Bai X |
Advanced Science | 2023 |
|
Tumor senescence leads to poor survival and therapeutic resistance in human breast cancer
Zhai J, Han J, Li C, Lv D, Ma F, Xu B |
Frontiers in Oncology | 2023 |
|
A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
Liu Y, Zhang Q, Ni W, Ji G, Xu H |
Frontiers in Molecular Biosciences | 2023 |
|
NRF2 and the Moirai: Life and Death Decisions on Cell Fates
Yagishita Y, Chartoumpekis DV, Kensler TW, Wakabayashi N |
Antioxidants & Redox Signaling | 2023 |
|
Cytosolic DNA sensors and glial responses to endogenous DNA
Suptela AJ, Marriott I |
Frontiers in immunology | 2023 |
|
Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer’s Disease
Tun X, Wang EJ, Gao Z, Lundberg K, Xu R, Hu D |
International journal of molecular sciences | 2023 |
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SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth
Fard D, Testa E, Panzeri V, Rizzolio S, Bianchetti G, Napolitano V, Masciarelli S, Fazi F, Maulucci G, Scicchitano BM, Sette C, Viscomi MT, Tamagnone L |
Cellular and Molecular Life Sciences | 2023 |
|
The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks
Pereira QC, dos Santos TW, Fortunato IM, Ribeiro ML |
International journal of molecular sciences | 2023 |
|
Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases.
Lin MJ, Hu SL, Tian Y, Zhang J, Liang N, Sun R, Gong SX, Wang AP |
Journal of Cardiovascular Translational Research | 2023 |
|
Predictive investigation of idiopathic pulmonary fibrosis subtypes based on cellular senescence-related genes for disease treatment and management
Yang C, Han Z, Zhan W, Wang Y, Feng J |
Frontiers in Genetics | 2023 |
|
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Tan J, Wei J, Lu H |
Inflammation | 2023 |
|
Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy
Ma M, Wei N, Yang J, Ding T, Song A, Chen L, Zheng S, Jin H |
Pharmaceutical Biology | 2023 |
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LncRNA AC006064.4-201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1.
Shen P, Gao J, Huang S, You C, Wang H, Chen P, Yao T, Gao T, Zhou B, Shen S, Zhao X, Ma J |
Biomarker Research | 2023 |
|
DNA Damage-Mediated Neurotoxicity in Parkinson's Disease.
Wang ZX, Li YL, Pu JL, Zhang BR |
International journal of molecular sciences | 2023 |
|
Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.
Al-Mansour F, Alraddadi A, He B, Saleh A, Poblocka M, Alzahrani W, Cowley S, Macip S |
Aging | 2023 |
|
Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities
Silwal P, Nguyen-Thai AM, Mohammad HA, Wang Y, Robbins PD, Lee JY, Vo NV |
Biomolecules | 2023 |
|
Senescent epithelial cells remodel the microenvironment for the progression of oral submucous fibrosis through secreting TGF-β1
Wang Z, Han Y, Peng Y, Shao S, Nie H, Xia K, Xiong H, Su T |
PeerJ | 2023 |
|
Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells
Ramadhiani R, Ikeda K, Miyagawa K, Ryanto GR, Tamada N, Suzuki Y, Kirita Y, Matoba S, Hirata KI, Emoto N |
iScience | 2023 |
|
Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer?
Fettucciari K, Fruganti A, Stracci F, Spaterna A, Marconi P, Bassotti G |
International journal of molecular sciences | 2023 |
|
Cellular senescence-related gene signature as a valuable predictor of prognosis in hepatocellular carcinoma
Zhang S, Zheng Y, Li X, Zhang S, Hu H, Kuang W |
Aging | 2023 |
|
Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations
Wechter N, Rossi M, Anerillas C, Tsitsipatis D, Piao Y, Fan J, Martindale JL, De S, Mazan-Mamczarz K, Gorospe M |
Aging | 2023 |
|
A novel anti-HBV agent, E-CFCP, restores Hepatitis B virus (HBV)-induced senescence-associated cellular marker perturbation in human hepatocytes.
Takamatsu Y, Hayashi S, Kumamoto H, Imoto S, Tanaka Y, Mitsuya H, Higashi-Kuwata N |
Virus Research | 2023 |
|
Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats.
Ansari A, Walton SL, Denton KM |
Biology of sex differences | 2023 |
|
Senescence: a double-edged sword in beta-cell health and failure?
Varghese SS, Dhawan S |
Frontiers in Endocrinology | 2023 |
|
A senescence-associated signature refines the classification of different modification patterns and characterization of tumor immune microenvironment infiltration in triple-negative breast cancer
Huang R, Wang H, Hong J, Wang Z, Wu J, Huang O, He J, Chen W, Li Y, Chen X, Shen K |
Frontiers in pharmacology | 2023 |
|
Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration
Xu J, Shao T, Lou J, Zhang J, Xia C |
Frontiers in pharmacology | 2023 |
|
An Integrated View of Stressors as Causative Agents in OA Pathogenesis
Floramo JS, Molchanov V, Liu H, Liu Y, Craig SE, Yang T |
Biomolecules | 2023 |
|
Dermal Fibroblasts as the Main Target for Skin Anti-Age Correction Using a Combination of Regenerative Medicine Methods
Zorina A, Zorin V, Isaev A, Kudlay D, Vasileva M, Kopnin P |
Current issues in molecular biology | 2023 |
|
NatB Catalytic Subunit Depletion Disrupts DNA Replication Initiation Leading to Senescence in MEFs
Elurbide J, Carte B, Guedes J, Aldabe R |
International journal of molecular sciences | 2023 |
|
Studying Hepatic Stellate Cell Senescence.
Serna-Salas SA, Soto-Gámez AA, Wu Z, Klaver M, Moshage H |
Methods in molecular biology (Clifton, N.J.) | 2023 |
|
SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence.
Lee SH, Yang JH, Park UH, Choi H, Kim YS, Yoon BE, Han HJ, Kim HT, Um SJ, Kim EJ |
Experimental & molecular medicine | 2023 |
|
Understanding cardiac senescence one cell type at a time
Sen P, Gurha P |
2023 | |
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Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex.
Kandhaya-Pillai R, Miro-Mur F, Alijotas-Reig J, Tchkonia T, Schwartz S, Kirkland JL, Oshima J |
Aging | 2023 |
|
Discovery of senolytics using machine learning
Smer-Barreto V, Quintanilla A, Elliott RJ, Dawson JC, Sun J, Campa VM, Lorente-Macías Á, Unciti-Broceta A, Carragher NO, Acosta JC, Oyarzún DA |
Nature Communications | 2023 |
|
Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice
Lu KJ, Sheu JR, Teng RD, Jayakumar T, Chung CL, Hsieh CY |
International journal of biological sciences | 2023 |
|
Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head
Li Y, Zhou Z, Xu S, Jiang J, Xiao J |
Medical science monitor : international medical journal of experimental and clinical research | 2023 |
|
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases
Knopp RC, Erickson MA, Rhea EM, Reed MJ, Banks WA |
Experimental Biology and Medicine | 2023 |
|
Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti‐tumour properties
Alessio N, Acar MB, Squillaro T, Aprile D, Ayaz\u2010Güner Ş, Di Bernardo G, Peluso G, Özcan S, Galderisi U |
Cell Proliferation | 2023 |
|
Induction of Senescence by Loss of Gata4 in Cardiac Fibroblasts
Zhang Z, Shayani G, Xu Y, Kim A, Hong Y, Feng H, Zhu H |
Cells | 2023 |
|
Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract
Choi EL, Taheri N, Chandra A, Hayashi Y |
International journal of molecular sciences | 2023 |
|
Mapping cellular senescence networks in human diabetic foot ulcers.
Yu GT, Monie DD, Khosla S, Tchkonia T, Kirkland JL, Wyles SP |
GeroScience | 2023 |
|
Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted
He YH, Pan JX, Xu LM, Gu T, Chen YW |
World journal of hepatology | 2023 |
|
Future Data Points to Implement in Adult Spinal Deformity Assessment for Artificial Intelligence Modeling Prediction: The Importance of the Biological Dimension.
Haddad S, Pizones J, Raganato R, Safaee MM, Scheer JK, Pellisé F, Ames CP |
2023 | |
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Senescent CD8(+) T cells acquire NK cell-like innate functions to promote antitumor immunity.
Kakuda T, Suzuki J, Matsuoka Y, Kikugawa T, Saika T, Yamashita M |
Cancer Science | 2023 |
|
The Delayed Effects of Acute Radiation Exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures
Wu T, Orschell CM |
International Journal of Radiation Biology | 2023 |
|
Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of alveolar macrophages
Wu Y, Hu SS, Zhang R, Goplen NP, Gao X, Narasimhan H, Shi A, Chen Y, Li Y, Zang C, Dong H, Braciale TJ, Zhu B, Sun J |
iScience | 2023 |
|
Supersulphides provide airway protection in viral and chronic lung diseases.
Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H, Akaike T |
Nature Communications | 2023 |
|
Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis
Bateman G, Guo-Parke H, Rodgers AM, Linden D, Bailey M, Weldon S, Kidney JC, Taggart CC |
Biomedicines | 2023 |
|
Research Progress on the Anti-Aging Potential of the Active Components of Ginseng
Su J, Su Q, Hu S, Ruan X, Ouyang S |
Nutrients | 2023 |
|
Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics
Gao Y, Wu T, Tang X, Wen J, Zhang Y, Zhang J, Wang S |
GeroScience | 2023 |
|
A rationally designed fluorescence probe achieves highly specific and long‐term detection of senescence in vitro and in vivo
Hu L, Dong C, Wang Z, He S, Yang Y, Zi M, Li H, Zhang Y, Chen C, Zheng R, Jia S, Liu J, Zhang X, He Y |
Aging Cell | 2023 |
|
Functional Diversity of Mammalian Small Heat Shock Proteins: A Review
Gu C, Fan X, Yu W |
Cells | 2023 |
|
Cellular senescence induction leads to progressive cell death via the INK4a‐RB pathway in naked mole‐rats
Kawamura Y, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T, Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K |
The EMBO Journal | 2023 |
|
Senescence-related gene c-Myc affects bladder cancer cell senescence by interacting with HSP90B1 to regulate cisplatin sensitivity
Wang Y, Zhu H, Xu H, Qiu Y, Zhu Y, Wang X |
Aging | 2023 |
|
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes.
Venz R, Goyala A, Soto-Gamez A, Yenice T, Demaria M, Ewald CY |
GeroScience | 2023 |
|
Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.
Zhang Y, Liu M, Xie R |
BMC Public Health | 2023 |
|
Contribution of viral and bacterial infections to senescence and immunosenescence
Reyes A, Ortiz G, Duarte LF, Fernández C, Hernández-Armengol R, Palacios PA, Prado Y, Andrade CA, Rodriguez-Guilarte L, Kalergis AM, Simon F, Carreño LJ, Riedel CA, Cáceres M, González PA |
Frontiers in Cellular and Infection Microbiology | 2023 |
|
A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks
Sakai C, Ueda K, Goda K, Fujita R, Maeda J, Nakayama S, Sotomaru Y, Tashiro S, Yoshizumi M, Ishida T, Ishida M |
Scientific Reports | 2023 |
|
Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics
Oguma Y, Alessio N, Aprile D, Dezawa M, Peluso G, Di Bernardo G, Galderisi U |
Cell communication and signaling : CCS | 2023 |
|
Neutrophil extracellular traps and long COVID
Shafqat A, Omer MH, Albalkhi I, Alabdul Razzak G, Abdulkader H, Abdul Rab S, Sabbah BN, Alkattan K, Yaqinuddin A |
Frontiers in immunology | 2023 |
|
Parkinson’s Disease: A Tale of Many Players
Pauwels EK, Boer GJ |
Medical Principles and Practice | 2023 |
|
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies.
Giunta S, Xia S, Pelliccioni G, Olivieri F |
GeroScience | 2023 |
|
Immunohistochemical Study of Airways Fibrous Remodeling in Smoking Mice
Balzano E, De Cunto G, Goracci C, Bartalesi B, Cavarra E, Lungarella G, Lucattelli M |
Journal of Histochemistry & Cytochemistry | 2023 |
|
The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential
Zhang J, Zhang L, Chen Y, Fang X, Li B, Mo C |
Frontiers in immunology | 2023 |
|
Identification of cellular senescence-related signature for predicting prognosis and therapeutic response of acute myeloid leukemia
Zhong F, Yang Y, Yao F, Liu J, Yu X, Wang XL, Huang B, Wang XZ |
Aging | 2023 |
|
Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells
Ghislanzoni S, Kang JW, Bresci A, Masella A, Kobayashi-Kirschvink KJ, Polli D, Bongarzone I, So PT |
Biosensors | 2023 |
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Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources
Song L, Zhang S |
Biomolecules | 2023 |
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Mid-old cells are a potential target for anti-aging interventions in the elderly
Kim YH, Lee YK, Park SS, Park SH, Eom SY, Lee YS, Lee WJ, Jang J, Seo D, Kang HY, Kim JC, Lim SB, Yoon G, Kim HS, Kim JH, Park TJ |
Nature Communications | 2023 |
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Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells
Li W, Kawaguchi K, Tanaka S, He C, Maeshima Y, Suzuki E, Toi M |
Communications biology | 2023 |
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Construction and evaluation of a novel prognostic risk model of aging-related genes in bladder cancer
Wang D, Ning H, Wu H, Song Y, Chu Y, Liu F, Zhao Z, Wu F, Lyu J |
Current Urology | 2023 |
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Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles
FUJIOKA Y, OTANI K, KODAMA T, OKADA M, YAMAWAKI H |
Journal of Veterinary Medical Science | 2023 |
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Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus.
Ijima S, Saito Y, Yamamoto S, Nagaoka K, Iwamoto T, Kita A, Miyajima M, Sato T, Miyazaki A, Chikenji TS |
Immunity & ageing : I & A | 2023 |
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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J |
Nature Cell Biology | 2023 |
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Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury.
Fuentes-Flores A, Geronimo-Olvera C, Girardi K, Necuñir-Ibarra D, Patel SK, Bons J, Wright MC, Geschwind D, Hoke A, Gomez-Sanchez JA, Schilling B, Rebolledo DL, Campisi J, Court FA |
EMBO Molecular Medicine | 2023 |
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Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives.
Jo MJ, Lee JK, Kim JE, Ko GJ |
International journal of molecular sciences | 2023 |
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Accumulation of senescent cells in the stroma of aged mouse ovary
MARUYAMA N, FUKUNAGA I, KOGO T, ENDO T, FUJII W, KANAI-AZUMA M, NAITO K, SUGIURA K |
Journal of Reproduction and Development | 2023 |
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Cellular microenvironment: a key for tuning mesenchymal stem cell senescence
Sun W, Lv J, Guo S, Lv M |
Frontiers in Cell and Developmental Biology | 2023 |
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Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
Kumar A, Thirumurugan K |
Cell cycle (Georgetown, Tex.) | 2023 |
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Toxicology of pharmaceutical and nutritional longevity compounds
Kahraman C, Kaya Bilecenoglu D, Sabuncuoglu S, Cankaya IT |
Expert Reviews in Molecular Medicine | 2023 |
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The potential use of ascorbic acid to recover the cellular senescence of lipopolysaccharide-induced human apical papilla cells: an in vitro study.
Teawcharoensopa C, Srisuwan T |
Clinical Oral Investigations | 2023 |
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Autophagy-related 7 proteindependent autophagy mediates resveratrol-caused upregulation of mitochondrial biogenesis and steroidogenesis in aged Leydig cell.
Lin F, Zhang S, Zhu X, Lv Z |
Molecular Biology Reports | 2023 |
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NAD metabolism: Role in senescence regulation and aging.
Chini CCS, Cordeiro HS, Tran NLK, Chini EN |
Aging Cell | 2023 |
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Discovery of a 4-Hydroxy-3'-Trifluoromethoxy-Substituted Resveratrol Derivative as an Anti-Aging Agent.
Liang Y, Chen X, Teng Z, Wang X, Yang J, Liu G |
Molecules (Basel, Switzerland) | 2023 |
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A novel biomarker of fibrofatty replacement in dystrophinopathies identified by integrating transcriptome, magnetic resonance imaging, and pathology data
Xie Z, Liu C, Sun C, Lu Y, Wu S, Liu Y, Wang Q, Wan Y, Wang Y, Yu M, Meng L, Deng J, Zhang W, Wang Z, Yang C, Yuan Y, Xie Z |
Journal of Cachexia, Sarcopenia and Muscle | 2023 |
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A mixed antioxidant supplement improves cognitive function, and coordination in aged mice
Fukui K, You F, Kato Y, Yuzawa S, Kishimoto A, Hara T, Kanome Y, Harakawa Y, Yoshikawa T, Inufusa H |
Journal of Clinical Biochemistry and Nutrition | 2023 |
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Hematopoietic aging: Cellular, molecular, and related mechanisms
Ye L, Tian C, Li Y, Pan H, Hu J, Shu L, Pan X |
Chinese Medical Journal | 2023 |
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Senescence and Immunotherapy: Redundant Immunomodulatory Pathways Promote Resistance
Oesterreich S, Aird KM |
Cancer immunology research | 2023 |
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Cellular senescence exacerbates features of aging in the eyes
Kitazawa K, Numa K, Patel SK, King CD, Matsumoto A, Sotozono C, Desprez PY, Schilling B, Campisi J |
Aging biology | 2023 |
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Major depression, physical health and molecular senescence markers abnormalities.
Seitz-Holland J, Mulsant BH, Reynolds CF 3rd, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Lenze EJ, Diniz BS, Seitz-Holland J, Mulsant BH, Reynolds CF 3rd, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Lenze EJ, Diniz BS |
Nature. Mental health | 2023 |
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JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice
Cristina Rivellini, Emanuela Porrello, Giorgia Dina, Simona Mrakic-Sposta, Alessandra Vezzoli, Marco Bacigaluppi, Giorgia Serena Gullotta, Linda Chaabane, Letizia Leocani, Silvia Marenna, Emanuela Colombo, Cinthia Farina, Jia Newcombe, Klaus-Armin Nave, Ruggero Pardi, Angelo Quattrini, Stefano Previtali |
Journal of Clinical Investigation | 2022 |
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Age-associated callus senescent cells produce TGF beta1 that inhibits fracture healing in aged mice
Jiatong Liu, Jun Zhang, Xi Lin, Brendan Boyce, Hengwei Zhang, Lianping Xing |
Journal of Clinical Investigation | 2022 |
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Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2
Naiyuan Cheng, Ki-Hyun Kim, Lester F. Lau |
JCI Insight | 2022 |
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The Achilles heel of cancer survivors: fundamentals of accelerated cellular senescence
Shameel Shafqat, Evelyn Arana Chicas, Areez Shafqat, Shahrukh Hashmi |
Journal of Clinical Investigation | 2022 |
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Connecting Aging Biology and Inflammation in the Omics Era
Keenan A Walker, Nathan Basisty, David M Wilson, III, Luigi Ferrucci |
Journal of Clinical Investigation | 2022 |
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Cellular Senescence: A Key Therapeutic Target in Aging and Diseases
Lei Zhang, Louise Pitcher, Matthew Yousefzadeh, Laura Niedernhofer, Paul Robbins, Yi Zhu |
Journal of Clinical Investigation | 2022 |
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Protective roles of cytoplasmic p21Cip1/Waf1 in senolysis and ferroptosis of lung adenocarcinoma cells
Akira Koyanagi, Hotoshi Kotani, Yuichi Iida, Ryosuke Tanino, Irna Kartika, Koji Kishimoto, Mamoru Harada |
Cell Proliferation | 2022 |
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Blockade of nuclear β-catenin signaling via direct targeting of RanBP3 with NU2058 suppress colorectal tumorigenesis
Can-Can Zheng, Long Liao, Ya-Ping Liu, Yan-Ming Yang, Yan He, Guo-Geng Zhang, Shu-Jun Li, Ting Liu, Xin-Ke Zhou, Bin Li |
Advanced Science | 2022 |
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transcriptomic analysis and functional studies reveal that senescence plays a role in Myotonic Dystrophy type 1
Mikel García-Puga, Ander Saenz-Antoñanzas, gorka gerenu, Alex Arrieta, roberto fERNANDEZ-TORRON, MIREN ZULAICA, AMETS SAENZ, Joseba Elizazu, Gisela Nogales-Gadea, Shahinaz M Gadalla, Marcos J. Araúzo-Bravo, Adolfo Lopez de Munain, Ander Matheu |
JCI Insight | 2022 |
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Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential
Y He, W Xie, H Li, H Jin, Y Zhang, Y Li |
Frontiers in Cell and Developmental Biology | 2022 |
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Development of human alveolar epithelial cell models to study distal lung biology and disease
E Tran, T Shi, X Li, A Chowdhury, D Jiang, Y Liu, H Wang, C Yan, W Wallace, R Lu, A Ryan, C Marconett, B Zhou, Z Borok, I Offringa |
iScience | 2022 |
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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
L Hu, H Li, M Zi, W Li, J Liu, Y Yang, D Zhou, Q Kong, Y Zhang, Y He |
Frontiers in Cell and Developmental Biology | 2022 |
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Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
A Bleve, F Motta, B Durante, C Pandolfo, C Selmi, A Sica |
Clinical Reviews in Allergy & Immunology | 2022 |
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TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence
L Fang, D Li, J Yin, H Pan, H Ye, J Bowman, B Capaldo, K Kelly |
Cancer Gene Therapy | 2022 |
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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Y Wu, S Shen, Y Shi, N Tian, Y Zhou, X Zhang |
Frontiers in Bioengineering and Biotechnology | 2022 |
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The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Y Sun, X Wang, T Liu, X Zhu, X Pan |
Cell & Bioscience | 2022 |
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Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs
N Kudlova, J Sanctis, M Hajduch |
International journal of molecular sciences | 2022 |
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Cellular senescence and acute kidney injury
X Lin, H Jin, Y Chai, S Shou |
Pediatric Nephrology | 2022 |
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The Mechanism of Bone Remodeling After Bone Aging
H Fang, Z Deng, J Liu, S Chen, Z Deng, W Li |
Clinical Interventions in Aging | 2022 |
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miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing
W He, M Yang, Y Jiang, C He, Y Sun, L Liu, M Huang, Y Jiao, K Chen, J Hou, M Huang, Y Xu, X Feng, Y Liu, Q Guo, H Peng, Y Huang, T Su, Y Xiao, Y Li, C Zeng, G Lei, X Luo, C Li |
Cell Death and Disease | 2022 |
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Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization
Z Song, B Li, M Li, J Luo, Y Hong, Y He, S Chen, Z Yang, C Liang, Z Yang |
International journal of molecular sciences | 2022 |
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Cell senescence and malignant transformation in the inherited bone marrow failure syndromes: Overlapping pathophysiology with therapeutic implications
E Groarke, R Calado, J Liu |
Seminars in Hematology | 2022 |
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Endothelial Senescence: A New Age in Pulmonary Hypertension
M Culley, S Chan |
Circulation research | 2022 |
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Cellular Senescence and Aging in Myotonic Dystrophy
Y Hasuike, H Mochizuki, M Nakamori |
International journal of molecular sciences | 2022 |
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Phosphate Metabolism: From Physiology to Toxicity
M Razzaque |
2022 | |
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Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease
S Miller, C Campbell, H Jimenez-Corea, G Wu, R Logan |
Frontiers in neuroscience | 2022 |
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Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer
EO Nwafor, P Lu, Y Zhang, R Liu, H Peng, B Xing, Y Liu, Z Li, K Zhang, Y Zhang, Z Liu |
Translational oncology | 2022 |
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Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities
R Sharma |
Probiotics and Antimicrobial Proteins | 2022 |
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RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression
X Liu, J Chen, X Long, J Lan, X Liu, M Zhou, S Zhang, J Zhou |
Cell Death and Disease | 2022 |
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Platelet Lysate for Mesenchymal Stromal Cell Culture in the Canine and Equine Species: Analogous but Not the Same
A Hagen, H Holland, V Brandt, C Doll, T Häußler, M Melzer, J Moellerberndt, H Lehmann, J Burk |
Animals | 2022 |
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Editorial: Apoptosis and Senescence in Vertebrate Development
W Knabe, S Washausen |
Frontiers in Cell and Developmental Biology | 2022 |
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Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence
Q Li, Y Deng, L Liu, C Zhang, Y Cai, T Zhang, M Han, G Xu |
Frontiers in immunology | 2022 |
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Targeting regulation of ATP synthase 5 alpha/beta dimerization alleviates senescence
Y Lee, D Choi, G Jang, J Park, E Song, H Lee, M Kuk, J Joo, S Ahn, Y Byun, J Park |
Aging | 2022 |
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miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells
W da Silveira, L Renaud, E Hazard, G Hardiman |
Genes & development | 2022 |
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Impaired differentiation of small airway basal stem/progenitor cells in people living with HIV
N Chung, K Khan, M Andreoli, R Kaner, S OBeirne, R Crystal |
Scientific Reports | 2022 |
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Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization
D Romaniello, V Gelfo, F Pagano, E Ferlizza, M Sgarzi, M Mazzeschi, A Morselli, C Miano, G DUva, M Lauriola |
Cellular & Molecular Biology Letters | 2022 |
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Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells
P Chaturvedi, V George, N Shrestha, M Wang, M Dee, X Zhu, B Liu, J Egan, F D'Eramo, C Spanoudis, V Gallo, C Echeverri, L You, L Kong, B Fang, E Jeng, P Rhode, H Wong |
Molecular Therapy | 2022 |
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ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics
R Spinelli, P Florese, L Parrillo, F Zatterale, M Longo, V DEsposito, A Desiderio, A Nerstedt, B Gustafson, P Formisano, C Miele, G Raciti, R Napoli, U Smith, F Beguinot |
Aging Cell | 2022 |
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Lipids as Regulators of Cellular Senescence
S Hamsanathan, A Gurkar |
Frontiers in physiology | 2022 |
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Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype
S Ryu, M Jung, C Kim, H Kang, S Han, S Cha, S Jeong, E Lee |
Cell Death and Disease | 2022 |
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Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells
T Murakami, N Inagaki, H Kondoh |
Frontiers in Endocrinology | 2022 |
|
Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging
I Mora, L Arola, A Caimari, X Escoté, F Puiggròs |
International journal of molecular sciences | 2022 |
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Vegetables and Their Bioactive Compounds as Anti-Aging Drugs
H Mechchate, A Allam, N Omari, N Hachlafi, M Shariati, P Wilairatana, M Mubarak, A Bouyahya |
Molecules (Basel, Switzerland) | 2022 |
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Mesenchymal Stem/Stromal Cell Senescence: Hallmarks, Mechanisms, and Combating Strategies
Z Weng, Y Wang, T Ouchi, H Liu, X Qiao, C Wu, Z Zhao, L Li, B Li |
Stem Cells Translational Medicine | 2022 |
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SIRT7 in the aging process
F Lagunas-Rangel |
Cellular and Molecular Life Sciences | 2022 |
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RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence
Y Sun, X Yu, X Gao, C Zhang, H Sun, K Xu, D Wei, Q Wang, H Zhang, Y Shi, L Li, X He |
Cell & Bioscience | 2022 |
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Isatis tinctoria L. Leaf Extract Inhibits Replicative Senescence in Dermal Fibroblasts by Regulating mTOR-NF-κB-SASP Signaling
J Woo, S Shin, H Ji, D Ryu, E Cho, Y Kim, J Kim, D Park, E Jung |
Nutrients | 2022 |
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Skin Cancer-Associated S. aureus Strains Can Induce DNA Damage in Human Keratinocytes by Downregulating DNA Repair and Promoting Oxidative Stress
A Krueger, A Mohamed, C Kolka, T Stoll, J Zaugg, R Linedale, M Morrison, H Soyer, P Hugenholtz, I Frazer, M Hill |
Cancers | 2022 |
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Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro
T Zimmermann, M Pommer, V Kluge, C Chiheb, S Muehlich, A Bosserhoff |
Cells | 2022 |
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Cellular Senescence in Aging Lungs and Diseases
Aghali A, Koloko Ngassie ML, Pabelick CM, Prakash YS |
Cells | 2022 |
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Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging
Zorina A, Zorin V, Kudlay D, Kopnin P |
International journal of molecular sciences | 2022 |
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Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease
Pedroza-Diaz J, Arroyave-Ospina JC, Serna Salas S, Moshage H |
Antioxidants | 2022 |
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miR-181b regulates vascular endothelial aging by modulating a MAP3K3 signaling pathway
Zhou H, Yang D, Cheng HS, McCoy MG, Pérez-Cremades D, Haemmig S, Wong D, Chen L, Feinberg MW |
The FASEB Journal | 2022 |
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DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes
Brawerman G, Pipella J, Thompson PJ |
Molecular Metabolism | 2022 |
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Retrotransposons as a Source of DNA Damage in Neurodegeneration
Peze-Heidsieck E, Bonnifet T, Znaidi R, Ravel-Godreuil C, Massiani-Beaudoin O, Joshi RL, Fuchs J |
Frontiers in aging neuroscience | 2022 |
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An Aging and Senescence-Related Gene Signature for Prognosis Prediction in Clear Cell Renal Cell Carcinoma
Li J, Gui C, Yao H, Luo C, Song H, Lin H, Xu Q, Chen X, Huang Y, Luo J, Chen W |
Frontiers in Genetics | 2022 |
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Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence
Gao Y, Kamogashira T, Fujimoto C, Iwasaki S, Yamasoba T |
2022 | |
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Single-cell analysis reveals the Comma-1D cell line as a unique model for mammary gland development and breast cancer
Werner RL, Nekritz EA, Yan KK, Ju B, Shaner B, Easton J, Yu J, Silva J |
Journal of cell science | 2022 |
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Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition
Rahman M, Olson I, Mansour M, Carlstrom LP, Sutiwisesak R, Saber R, Rajani K, Warrington AE, Howard A, Schroeder M, Chen S, Decker PA, Sananikone EF, Zhu Y, Tchkonia T, Parney IF, Burma S, Brown D, Rodriguez M, Sarkaria JN, Kirkland JL, Burns TC |
Molecular cancer research : MCR | 2022 |
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TLR4 Modulates Senescence and Paracrine Action in Placental Mesenchymal Stem Cells via Inhibiting Hedgehog Signaling Pathway in Preeclampsia
Zhong Y, Zhang Y, Liu W, Zhao Y, Zou L, Liu X |
Oxidative medicine and cellular longevity | 2022 |
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Eugenol and carvacrol attenuate brain d-galactose-induced aging-related oxidative alterations in rats
El-Far AH, Mohamed HH, Elsabagh DA, Mohamed SA, Noreldin AE, Al Jaouni SK, Alsenosy AA |
Environmental Science and Pollution Research | 2022 |
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Cellular Senescence and Ageing: Mechanisms and Interventions
Mylonas A, O\u2019Loghlen A |
2022 | |
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Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
Inci N, Kamali D, Akyildiz EO, Tahir Turanli E, Bozaykut P |
2022 | |
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EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263
Abdelgawad IY, Agostinucci K, Ismail SG, Grant MK, Zordoky BN |
Cells | 2022 |
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A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
Muralikrishnan V, Fang F, Given TC, Podicheti R, Chtcherbinine M, Metcalfe TX, Sriramkumar S, O\u2019Hagan HM, Hurley TD, Nephew KP |
Cancers | 2022 |
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Senescence in osteoarthritis: from mechanism to potential treatment
Liu Y, Zhang Z, Li T, Xu H, Zhang H |
Arthritis Research & Therapy | 2022 |
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Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression.
Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD |
Cell Death and Disease | 2022 |
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The senescence-associated secretory phenotype in ovarian cancer dissemination.
Veenstra JP, Bittencourt LFF, Aird KM |
American journal of physiology. Cell physiology | 2022 |
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Editorial: Editor's Pick 2021: Highlights in Cell Death and Survival.
He YW, Walsh CM |
Frontiers in Cell and Developmental Biology | 2022 |
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Beyond Moco Biosynthesis-Moonlighting Roles of MoaE and MOCS2.
Suganuma T |
Molecules (Basel, Switzerland) | 2022 |
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New Horizons in the Treatment of Age-Associated Obesity, Sarcopenia and Osteoporosis.
Kalinkovich A, Becker M, Livshits G |
Drugs & Aging | 2022 |
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Exploring the fuzzy border between senolytics and senomorphics with chemoinformatics and systems pharmacology.
Olascoaga-Del Angel KS, Gutierrez H, Königsberg M, Pérez-Villanueva J, López-Diazguerrero NE |
Biogerontology | 2022 |
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TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis.
Bae EJ, Choi M, Kim JT, Kim DK, Jung MK, Kim C, Kim TK, Lee JS, Jung BC, Shin SJ, Rhee KH, Lee SJ |
Experimental & molecular medicine | 2022 |
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ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels.
Hao X, Shiromoto Y, Sakurai M, Towers M, Zhang Q, Wu S, Havas A, Wang L, Berger S, Adams PD, Tian B, Nishikura K, Kossenkov AV, Liu P, Zhang R |
Nature Cell Biology | 2022 |
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Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin.
Lee H, Lee HY, Chae JB, Park CW, Kim C, Ryu JH, Jang J, Kim N, Chung H |
2022 | |
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Defective bone repletion in aged Balb/cBy mice was caused by impaired osteoblastic differentiation.
Sheng MH, Lau KW, Rundle CH, Alsunna A, Wilson SM, Baylink DJ |
Journal of Bone and Mineral Metabolism | 2022 |
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Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents.
Park M, Na J, Kwak SY, Park S, Kim H, Lee SJ, Jang WS, Lee SB, Jang WI, Jang H, Shim S |
International journal of molecular sciences | 2022 |
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Mammalian Resilience Revealed by a Comparison of Human Diseases and Mouse Models Associated With DNA Helicase Deficiencies
Kohzaki M |
Frontiers in Molecular Biosciences | 2022 |
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A risk model of 10 aging-related genes for predicting survival and immune response in triple-negative breast cancer.
Yang X, Sun Y, Liu X, Jiang Z |
Cancer Medicine | 2022 |
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PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
Tsuru A, Yoshie M, Kojima J, Yonekawa R, Azumi M, Kusama K, Nishi H, Tamura K |
Biomolecules | 2022 |
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Functional properties of equine adipose-derived mesenchymal stromal cells cultured with equine platelet lysate
Hagen A, Niebert S, Brandt VP, Holland H, Melzer M, Wehrend A, Burk J |
Frontiers in Veterinary Science | 2022 |
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Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis
García-Martínez BI, Ruiz-Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VM |
Molecules (Basel, Switzerland) | 2022 |
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Senescence of alveolar epithelial cells impacts initiation and chronic phases of murine fibrosing interstitial lung disease.
Yamada Z, Nishio J, Motomura K, Mizutani S, Yamada S, Mikami T, Nanki T |
Frontiers in immunology | 2022 |
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Spindle and Kinetochore-associated Family Genes are Prognostic and Predictive Biomarkers in Hepatocellular Carcinoma
Cai C, Zhang Y, Hu X, Yang S, Ye J, Wei Z, Chu T |
Journal of Clinical and Translational Hepatology | 2022 |
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Identification of senescence-related subtypes, establishment of a prognosis model, and characterization of a tumor microenvironment infiltration in breast cancer
Zhou Y, Xiao L, Long G, Cao J, Liu S, Tao Y, Zhou L, Tang J |
Frontiers in immunology | 2022 |
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Indoxyl sulfate impairs in vitro erythropoiesis by triggering apoptosis and senescence
Duangchan T, Rattanasompattikul M, Chitchongyingcharoen N, Mas-Oodi S, Promkan M, Rongkiettechakorn N, Korpraphong S, Supokawej A |
Experimental Biology and Medicine | 2022 |
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Senolytics in the treatment of diabetic retinopathy
Hassan JW, Bhatwadekar AD |
Frontiers in pharmacology | 2022 |
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Transcriptional Heterogeneity of Cellular Senescence in Cancer.
Junaid M, Lee A, Kim J, Park TJ, Lim SB |
Molecules and Cells | 2022 |
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STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells.
Lee JJ, Kim SY, Kim SH, Choi S, Lee B, Shin JS |
Cell Death and Disease | 2022 |
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From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
L'Hôte V, Mann C, Thuret JY |
Open Biology | 2022 |
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Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms
Farooq U, Notani D |
Frontiers in Cell and Developmental Biology | 2022 |
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Potential of Hibiscus sabdariffa L. and Hibiscus Acid to Reverse Skin Aging
Wang D, Nagata M, Matsumoto M, Amen Y, Wang D, Shimizu K |
Molecules (Basel, Switzerland) | 2022 |
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Targeting cellular senescence to combat cancer and ageing
Wang C, Hao X, Zhang R |
Molecular Oncology | 2022 |
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Role of Carbon Monoxide in Oxidative Stress-Induced Senescence in Human Bronchial Epithelium
Cai MY, Yip CY, Pan K, Zhang Y, Chan RW, Chan WY, Ko WH |
Oxidative medicine and cellular longevity | 2022 |
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Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Kyi P, Hendee K, Hunyenyiwa T, Matus K, Mammoto T, Mammoto A |
Frontiers in Medicine | 2022 |
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COVID-19 and cellular senescence
Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S |
Nature reviews. Immunology | 2022 |
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Senescence of Tumor Cells in Anticancer Therapy—Beneficial and Detrimental Effects
Piskorz WM, Cechowska-Pasko M |
International journal of molecular sciences | 2022 |
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Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model
Miller W, Pruett CL, Stone W, Eide C, Riddle M, Popp C, Yousefzadeh M, Lees C, Seelig D, Thompson E, Orr H, Niedernhofer L, Tolar J |
PloS one | 2022 |
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Cellular senescence in ischemia/reperfusion injury
Chen C, Zheng M, Hou H, Fang S, Chen L, Yang J, Yao W, Zhang Q, Hei Z |
Cell Death Discovery | 2022 |
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Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells
Exarchos V, Neuber S, Meyborg H, Giampietro C, Chala N, Moimas S, Hinkov H, Kaufmann F, Pramotton FM, Krüger K, Rodriguez Cetina Biefer H, Cesarovic N, Poulikakos D, Falk V, Emmert MY, Ferrari A, Nazari-Shafti TZ |
Frontiers in Cardiovascular Medicine | 2022 |
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A BDNF-TrkB autocrine loop enhances senescent cell viability
Anerillas C, Herman AB, Munk R, Garrido A, Lam KW, Payea MJ, Rossi M, Tsitsipatis D, Martindale JL, Piao Y, Mazan-Mamczarz K, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M |
Nature Communications | 2022 |
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ACSL1 promotes imatinib-induced chronic myeloid leukemia cell senescence by regulating SIRT1/p53/p21 pathway.
Liu W, Zhu X, Tang L, Shen N, Cheng F, Zou P, You Y, Yuan G, Li Q, Zhu X |
Scientific Reports | 2022 |
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Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation.
Ou B, Liu Y, Gao Z, Xu J, Yan Y, Li Y, Zhang J |
Cell Death and Disease | 2022 |
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Targeting senescence as an anticancer therapy.
Bousset L, Gil J |
Molecular Oncology | 2022 |
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The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells.
Liu X, Shi Q, Choudhry N, Zhang T, Liu H, Zhang S, Zhang J, Yang D |
International journal of molecular sciences | 2022 |
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Establishment and validation of a novel prognostic model for lower-grade glioma based on senescence-related genes
Li J, Wang J, Liu D, Tao C, Zhao J, Wang W |
Frontiers in immunology | 2022 |
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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways.
de Almeida AJPO, de Oliveira JCPL, da Silva Pontes LV, de Souza Júnior JF, Gonçalves TAF, Dantas SH, de Almeida Feitosa MS, Silva AO, de Medeiros IA |
Oxidative medicine and cellular longevity | 2022 |
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Lamin A to Z in normal aging.
Primmer SR, Liao CY, Kummert OMP, Kennedy BK |
Aging | 2022 |
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Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
Zhou S, Zhu J, Zhou PK, Gu Y |
Frontiers in Cell and Developmental Biology | 2022 |
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Targeting Immune Senescence in Atherosclerosis.
Vellasamy DM, Lee SJ, Goh KW, Goh BH, Tang YQ, Ming LC, Yap WH |
International journal of molecular sciences | 2022 |
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Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
Kulkarni A, Muralidharan C, May SC, Tersey SA, Mirmira RG |
Endocrinology | 2022 |
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Polyvascular Disease and the Incidence of Cancer in Patients with Coronary Artery Disease
Suzuki M, Tomoike H, Dai Z, Hosoda T, Sumiyoshi T, Hosoda S, Isobe M |
2022 | |
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Cellular Senescence in Metabolic-Associated Kidney Disease: An Update
Gao P, Zou X, Sun X, Zhang C |
Cells | 2022 |
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In Vitro Study of the Therapeutic Potential of Brown Crude Fucoidans in Osteoarthritis Treatment
Vaamonde-García C, Capelo-Mera E, Flórez-Fernández N, Torres MD, Rivas-Murias B, Mejide-Faílde R, Blanco FJ, Domínguez H |
International journal of molecular sciences | 2022 |
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Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
Torres-Arciga K, Flores-León M, Ruiz-Pérez S, Trujillo-Pineda M, González-Barrios R, Herrera LA |
Frontiers in Genetics | 2022 |
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Novel Role of Mammalian Cell Senescence-Sustenance of Muscle Larvae of Trichinella spp
Dabrowska M, Kępczyńska A, Goździk K, Całka-Kresa M, Skoneczny M, Zieliński Z, Doligalska M, Sikora E |
Oxidative medicine and cellular longevity | 2022 |
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The Senescence-Related Signature Predicts Prognosis and Characterization of Tumor Microenvironment Infiltration in Pancreatic Cancer
Hua H, Zheng C, Fan J, Li X, Xie W, Chen J, Yu C |
BioMed Research International | 2022 |
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Cockroaches: a potential source of novel bioactive molecule(s) for the benefit of human health
Siddiqui R, Elmashak Y, Khan NA |
Applied Entomology and Zoology | 2022 |
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Editorial: Induced cell senescence as a therapeutic strategy for cancer treatment
He K, Lu L, Jian YP, Xu ZX |
Frontiers in Oncology | 2022 |
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Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells
Choudhury D, Rong N, Ikhapoh I, Rajabian N, Tseropoulos G, Wu Y, Mehrotra P, Thiyagarajan R, Shahini A, Seldeen KL, Troen B, Lei P, Andreadis ST |
Cell Reports | 2022 |
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Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation
Khavinson V, Linkova N, Dyatlova A, Kantemirova R, Kozlov K |
Cells | 2022 |
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Genome integrity and inflammation in the nervous system.
Aditi, McKinnon PJ |
DNA repair | 2022 |
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The impact of senescence on muscle wasting in chronic kidney disease
Huang Y, Wang B, Hassounah F, Price SR, Klein J, Mohamed TM, Wang Y, Park J, Cai H, Zhang X, Wang XH |
Journal of Cachexia, Sarcopenia and Muscle | 2022 |
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Targeting Senescent Tendon Stem/Progenitor Cells to Prevent or Treat Age-Related Tendon Disorders.
Wang H, Dai GC, Li YJ, Chen MH, Lu PP, Zhang YW, -Zhang M, Cao MM, Rui YF |
Stem Cell Reviews and Reports | 2022 |
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Exercise, healthy ageing, and the potential role of small extracellular vesicles
McIlvenna LC, Whitham M |
The Journal of Physiology | 2022 |
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Osteoarthritis: Mechanistic Insights, Senescence, and Novel Therapeutic Opportunities
Carpintero-Fernández P, Varela-Eirín M, García-Yuste A, López-Díaz I, Caeiro JR, Mayán MD |
Bioelectricity | 2022 |
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Cellular Senescence in Acute and Chronic Wound Repair.
Wilkinson HN, Hardman MJ |
Cold Spring Harbor perspectives in biology | 2022 |
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Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Miranda K. Culley, Jingsi Zhao, Yi Yin Tai, Ying Tang, Dror Perk, Vinny Negi, Qiujun Yu, Chen-Shan C. Woodcock, Adam Handen, Gil Speyer, Seungchan Kim, Yen-Chun Lai, Taijyu Satoh, Annie M M Watson, Yassmin Al Aaraj, John Sembrat, Mauricio Rojas, Dmitry Goncharov, Elena A. Goncharova, Omar F. Khan, Daniel Anderson, James E Dahlman, Aditi U. Gurkar, Robert Lafyatis, Ahmed U. Fayyaz, Margaret M Redfield, Mark T. Gladwin, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y. Chan |
Journal of Clinical Investigation | 2021 |
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Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population
Daryle DePianto, Jason A. Vander Heiden, Katrina B. Morshead, Kai-Hui Sun, Zora Modrusan, Grace Teng, Paul J. Wolters, Joseph Arron |
JCI Insight | 2021 |
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Metabolic reprogramming during hyperammonemia targets mitochondrial function and post-mitotic senescence
Avinash Kumar, Nicole Welch, Saurabh Mishra, Annette Bellar, Rafaella N. Silva, Ling Li, Shashi S Singh, Mary Sharkoff, Alexis Kerr, Aruna Kumar Chelluboyina, Jinendiran Sekar, Amy Attaway, Charles Hoppel, Belinda Willard, Gangarao Davuluri, Srinivasan Dasarathy |
JCI Insight | 2021 |
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IER2-induced senescence drives melanoma invasion through osteopontin
L Kyjacova, R Saup, K Rönsch, S Wallbaum, S Dukowic-Schulze, A Foss, SD Scherer, M Rothley, A Neeb, N Grau, W Thiele, S Thaler, N Cremers, C Sticht, N Gretz, BK Garvalov, J Utikal, JP Sleeman |
Oncogene | 2021 |
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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
EM Walker, J Cha, X Tong, M Guo, JH Liu, S Yu, D Iacovazzo, F Mauvais-Jarvis, SE Flanagan, M Korbonits, J Stafford, DA Jacobson, R Stein |
Cell Reports | 2021 |
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Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane
G Deevska, PP nd, M Mitov, DA Butterfield, M Nikolova-Karakashian |
Cells | 2021 |
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mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
A Cayo, R Segovia, W Venturini, R Moore-Carrasco, C Valenzuela, N Brown |
International journal of molecular sciences | 2021 |
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Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities
X Sun, MW Feinberg |
Frontiers in physiology | 2021 |
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Chronic Immune Activation and CD4+ T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy
D Wolday, FM Ndungu, GP Gómez-Pérez, TF de Wit |
Frontiers in immunology | 2021 |
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Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging
GR Guimarães, PP Almeida, L de Oliveira Santos, LP Rodrigues, JL de Carvalho, M Boroni |
Cells | 2021 |
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Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
I Colón-Mesa, M Fernández-Galilea, N Sáinz, M Lopez-Yus, JM Artigas, JM Arbonés-Mainar, E Félix-Soriano, X Escoté, MJ Moreno-Aliaga |
International journal of molecular sciences | 2021 |
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Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms
H Lu, W Du, L Ren, M Hamblin, R Becker, Y Chen, Y Fan |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2021 |
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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
X Zhu, Z Chen, W Shen, G Huang, JM Sedivy, H Wang, Z Ju |
Signal Transduction and Targeted Therapy | 2021 |
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Metabolic regulation in the immune response to cancer
Q Wu, X Yu, J Li, S Sun, Y Tu |
2021 | |
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Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis
X Dong, Y Huang, Z Yang, X Chu, J Wu, S Wang, X He, CY Gao, X Chen, K Yang, D Zhang |
Aging Cell | 2021 |
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Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
J Chen, ZX Fan, DC Zhu, YL Guo, K Ye, D Dai, Z Guo, ZQ Hu, Y Miao, Q Qu |
Frontiers in Cell and Developmental Biology | 2021 |
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Paclitaxel Impedes EGFR-mutated PC9 Cell Growth via Reactive Oxygen Species-mediated DNA Damage and EGFR/PI3K/AKT/mTOR Signaling Pathway Suppression
Mohiuddin, K Kasahara |
Cancer genomics & proteomics | 2021 |
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Dietary Anti-Aging Polyphenols and Potential Mechanisms
J Luo, H Si, Z Jia, D Liu |
Antioxidants | 2021 |
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Cellular senescence or stemness: hypoxia flips the coin
D Otero-Albiol, A Carnero |
Journal of Experimental & Clinical Cancer Research | 2021 |
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
R Kumari, P Jat |
Frontiers in Cell and Developmental Biology | 2021 |
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Neuroinflammation in Alzheimer’s Disease
IG Onyango, GV Jauregui, M Čarná, JP Bennett, GB Stokin |
Biomedicines | 2021 |
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Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells
R Arnold, E Vehns, H Randl, K Djabali |
International journal of molecular sciences | 2021 |
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The Hallmarks of Flavonoids in Cancer
LG Ponte, IC Pavan, MC Mancini, LG da Silva, AP Morelli, MB Severino, RM Bezerra, FM Simabuco |
Molecules (Basel, Switzerland) | 2021 |
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uPAR: An Essential Factor for Tumor Development
T Lv, Y Zhao, X Jiang, H Yuan, H Wang, X Cui, J Xu, J Zhao, J Wang |
Journal of Cancer | 2021 |
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Impact of Aging on Liver Cells and Liver Disease: Focus on the Biliary and Vascular Compartments
L Baiocchi, S Glaser, H Francis, L Kennedy, E Felli, G Alpini, J GraciaSancho |
Hepatology Communications | 2021 |
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Senescence under appraisal: hopes and challenges revisited
CS Davan-Wetton, E Pessolano, M Perretti, T Montero-Melendez |
Cellular and Molecular Life Sciences | 2021 |
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Does Subtelomeric Position of COMMD5 Influence Cancer Progression?
CG Campion, T Verissimo, S Cossette, J Tremblay |
Frontiers in Oncology | 2021 |
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Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
KS Lee, S Lin, DA Copland, AD Dick, J Liu |
Journal of Neuroinflammation | 2021 |
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
I Alhallak, KG Wolter, AC Munoz, FA Simmen, RJ Ward, SA Petty, LX Li, RC Simmen |
Journal of Molecular Endocrinology | 2021 |
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Hypothalamic inflammation in metabolic disorders and aging
A Bhusal, H Rahman, K Suk |
Cellular and Molecular Life Sciences | 2021 |
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Cell senescence in neuropathology: A focus on neurodegeneration and tumours
G Carreno, R Guiho, JP MartinezBarbera |
Neuropathology and Applied Neurobiology | 2021 |
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Bcl-xL as a Modulator of Senescence and Aging
C Mas-Bargues, C Borrás, J Viña |
International journal of molecular sciences | 2021 |
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The Jekyll and Hyde of Cellular Senescence in Cancer
D Demirci, B Dayanc, FA Mazi, S Senturk |
Cells | 2021 |
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Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions
U Tripathi, A Misra, T Tchkonia, JL Kirkland |
Mechanisms of Ageing and Development | 2021 |
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TBX2 controls a proproliferative gene expression program in melanoma
S Lu, P Louphrasitthiphol, N Goradia, JP Lambert, J Schmidt, J Chauhan, MG Rughani, L Larue, M Wilmanns, CR Goding |
Genes & development | 2021 |
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Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells
R Elsayed, M Elashiry, Y Liu, A El-Awady, M Hamrick, CW Cutler |
Frontiers in Cellular and Infection Microbiology | 2021 |
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Senescent T cells: a potential biomarker and target for cancer therapy
J Zhang, T He, L Xue, H Guo |
EBioMedicine | 2021 |
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Cellular Senescence: Mechanisms and Therapeutic Potential
Z Liao, HL Yeo, SW Wong, Y Zhao |
Biomedicines | 2021 |
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Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease
C Yan, Z Xu, W Huang |
Aging and disease | 2021 |
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Solid tumours hijack the histone variant network
FG Ghiraldini, D Filipescu, E Bernstein |
Nature Reviews Cancer | 2021 |
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Cellular Senescence in Brain Aging
E Sikora, A Bielak-Zmijewska, M Dudkowska, A Krzystyniak, G Mosieniak, M Wesierska, J Wlodarczyk |
Frontiers in aging neuroscience | 2021 |
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Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity
X Cheng, MS Ali, M Moran, MP Viana, SL Schlichte, MC Zimmerman, O Khalimonchuk, MW Feinberg, X Sun |
Redox Biology | 2021 |
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Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their reparative Potency
XJ Chen, SR Kim, K Jiang, CM Ferguson, H Tang, XY Zhu, A Lerman, A Eirin, LO Lerman |
Hypertension | 2021 |
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Anti-senescent drug screening by deep learning-based morphology senescence scoring
D Kusumoto, T Seki, H Sawada, A Kunitomi, T Katsuki, M Kimura, S Ito, J Komuro, H Hashimoto, K Fukuda, S Yuasa |
Nature Communications | 2021 |
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Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype
X Hao, B Zhao, W Zhou, H Liu, T Fukumoto, D Gabrilovich, R Zhang |
iScience | 2021 |
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Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential
KN Miller, N Dasgupta, T Liu, PD Adams, MG Vizioli |
eLife | 2021 |
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MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy
M Fukuoka, H Fujita, K Numao, Y Nakamura, H Shimizu, M Sekiguchi, H Hohjoh |
2021 | |
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Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells
EM Faulhaber, T Jost, J Symank, J Scheper, F Bürkel, R Fietkau, M Hecht, LV Distel |
Genes & development | 2021 |
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Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo
A Shahini, N Rajabian, D Choudhury, S Shahini, K Vydiam, T Nguyen, J Kulczyk, T Santarelli, I Ikhapoh, Y Zhang, J Wang, S Liu, A Stablewski, R Thiyagarajan, K Seldeen, BR Troen, J Peirick, P Lei, ST Andreadis |
Science Advances | 2021 |
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Iodoacetic Acid, a Water Disinfection Byproduct, Disrupts Hypothalamic, and Pituitary Reproductive Regulatory Factors and Induces Toxicity in the Female Pituitary
RV Gonzalez, KE Weis, AV Gonsioroski, JA Flaws, LT Raetzman |
Toxicological Sciences | 2021 |
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Premature Senescence and Telomere Shortening Induced by Oxidative Stress From Oxalate, Calcium Oxalate Monohydrate, and Urine From Patients With Calcium Oxalate Nephrolithiasis
K Chuenwisad, P More-krong, P Tubsaeng, N Chotechuang, M Srisa-Art, RJ Storer, C Boonla |
Frontiers in immunology | 2021 |
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Testosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence
SM Kang, HS Jung, MJ Kwon, SH Lee, JH Park |
The World Journal of Men's Health | 2021 |
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Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype
C Torres-Querol, P Torres, N Vidal, M Portero-Otín, G Arque, F Purroy |
Scientific Reports | 2021 |
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KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype
B Zhang, Q Long, S Wu, Q Xu, S Song, L Han, M Qian, X Ren, H Liu, J Jiang, J Guo, X Zhang, X Chang, Q Fu, EW Lam, J Campisi, JL Kirkland, Y Sun |
2021 | |
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Evaluation of Pirfenidone and Nintedanib in a Human Lung Model of Fibrogenesis
KM Roach, E Castells, K Dixon, S Mason, G Elliott, H Marshall, MA Poblocka, S Macip, M Richardson, L Khalfaoui, P Bradding |
Frontiers in pharmacology | 2021 |
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DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases
M Nagane, H Yasui, P Kuppusamy, T Yamashita, O Inanami |
Journal of Radiation Research | 2021 |
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Non-Lethal Concentration of MeHg Causes Marked Responses in the DNA Repair, Integrity, and Replication Pathways in the Exposed Human Salivary Gland Cell Line
LS Nogueira, CP Vasconcelos, JR Plaça, GP Mitre, LO Bittencourt, MS da Silva Kataoka, EH de Oliveira, RR Lima |
Frontiers in pharmacology | 2021 |
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Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective
VG Giannakoulis, P Dubovan, E Papoutsi, A Kataki, J Koskinas |
Cancers | 2021 |
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Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
S Rojas-Vázquez, L Blasco-Chamarro, I López-Fabuel, R Martínez-Máñez, I Fariñas |
Frontiers in neuroscience | 2021 |
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Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
M Poblocka, AL Bassey, VM Smith, M Falcicchio, AS Manso, M Althubiti, XB Sheng, A Kyle, R Barber, M Frigerio, S Macip |
Scientific Reports | 2021 |
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Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration
GJ Gillispie, E Sah, S Krishnamurthy, MY Ahmidouch, B Zhang, ME Orr |
Life Sciences | 2021 |
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The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced Inflammation
J Morales-Valencia, G David |
Frontiers in Oncology | 2021 |
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The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration
E Sah, S Krishnamurthy, MY Ahmidouch, GJ Gillispie, C Milligan, ME Orr |
Life Sciences | 2021 |
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ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?
V Stagni, A Ferri, C Cirotti, D Barilà |
Frontiers in Cell and Developmental Biology | 2021 |
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Deletion of Nrip1 delays skin aging by reducing adipose-derived mesenchymal stem cells (ADMSCs) senescence, and maintaining ADMSCs quiescence
Y Hu, Y Zhu, SD Gerber, JM Osland, M Chen, KA Rao, H Gu, R Yuan |
GeroScience | 2021 |
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Suppression of p16 alleviates the senescence-associated secretory phenotype
R Buj, KE Leon, MA Anguelov, KM Aird |
Aging | 2021 |
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Centrosome-phagy: implications for human diseases
Q Wu, X Yu, L Liu, S Sun, S Sun |
Cell & Bioscience | 2021 |
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Patient-Derived Explants of Colorectal Cancer: Histopathological and Molecular Analysis of Long-Term Cultures
S da Mata, T Franchi-Mendes, S Abreu, B Filipe, S Morgado, M Mesquita, C Albuquerque, R Fonseca, VE Santo, ER Boghaert, I Rosa, C Brito |
Cancers | 2021 |
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c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA
B Li, G Zhang, Z Wang, Y Yang, C Wang, D Fang, K Liu, F Wang, Y Mei |
Cell Death and Disease | 2021 |
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Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways
J Calyeca, YI Balderas-Martínez, M Selman, A Pardo |
Aging | 2021 |
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Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging
ME Rouillard, PA Sutter, OR Durham, CM Willis, SJ Crocker |
Aging and disease | 2021 |
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Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma
FY Huang, DK Wong, WK Seto, LY Mak, TT Cheung, MF Yuen |
Cell Death Discovery | 2021 |
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A Senescence-Like Cellular Response Inhibits Bovine Ephemeral Fever Virus Proliferation
YJ Zeng, MK Hsu, CA Tsai, CY Chu, HC Wu, HY Wang |
Human vaccines | 2021 |
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Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway
SQ Zuo, C Li, YL Liu, YH Tan, X Wan, T Xu, Q Li, L Wang, YL Wu, FM Deng, B Tang |
FEBS Open Bio | 2021 |
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Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy
TL White, N Deshpande, V Kumar, AG Gauthier, UV Jurkunas |
Free radical biology & medicine | 2021 |
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Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities
S Oh, DY Kwon, I Choi, YM Kim, JY Lee, J Ryu, H Jeong, MJ Kim, R Song |
ACS Medicinal Chemistry Letters | 2021 |
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A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η5-C5Me4R} Complexes with Variable R Groups
AD Palo, D Draca, MG Murrali, S Zacchini, G Pampaloni, S Mijatovic, D Maksimovic-Ivanic, F Marchetti |
International journal of molecular sciences | 2021 |
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Understanding the Radiobiology of Vestibular Schwannomas to Overcome Radiation Resistance
TP Thielhelm, S Goncalves, SM Welford, EA Mellon, ER Cohen, A Nourbakhsh, C Fernandez-Valle, F Telischi, ME Ivan, CT Dinh |
Cancers | 2021 |
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Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence
H Zheng, X Liang, Q Han, Z Shao, Y Zhang, L Shi, Y Hong, W Li, C Mai, Q Mo, Q Fu, X Ma, F Lin, M Li, B Hu, X Li, Y Zhang |
Journal of nanobiotechnology | 2021 |
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Short-term metformin ingestion by healthy older adults improves myoblast function
ZS Mahmassani, AI McKenzie, JJ Petrocelli, NM de Hart, PT Reidy, DK Fix, PJ Ferrara, K Funai, MJ Drummond |
American journal of physiology. Cell physiology | 2021 |
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m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype
P Liu, F Li, J Lin, T Fukumoto, T Nacarelli, X Hao, AV Kossenkov, MC Simon, R Zhang |
Nature Cell Biology | 2021 |
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Characterization of the SARS-CoV-2 Host Response in Primary Human Airway Epithelial Cells from Aged Individuals
B Subramaniyan, JL Larabee, M Bodas, AR Moore, AW Burgett, DA Myers, C Georgescu, JD Wren, JF Papin, MS Walters |
Viruses | 2021 |
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DNA Damage-Induced Inflammatory Microenvironment and Adult Stem Cell Response
D Cinat, RP Coppes, L Barazzuol |
Frontiers in Cell and Developmental Biology | 2021 |
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CCNB2/SASP/Cathepsin B & PGE2 Axis Induce Cell Senescence Mediated Malignant Transformation
Y Wang, H Zhang, M Wang, J He, H Guo, L Li, J Wang |
International journal of biological sciences | 2021 |
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Stress and Telomere Shortening: Insights from Cellular Mechanisms
J Lin, E Epel |
Ageing Research Reviews | 2021 |
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Senescence as a trade-off between successful land colonisation and longevity: critical review and analysis of a hypothesis
T Bilinski, A Bylak, K Kukuła, R Zadrag-Tecza |
PeerJ | 2021 |
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XPO7 is a tumor suppressor regulating p21 CIP1 -dependent senescence
AJ Innes, B Sun, V Wagner, S Brookes, D McHugh, J Pombo, RM Porreca, G Dharmalingam, S Vernia, J Zuber, JB Vannier, R García-Escudero, J Gil |
Genes & development | 2021 |
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Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging
CC Chao, PW Shen, TY Tzeng, HJ Kung, TF Tsai, YH Wong |
Biomedicines | 2021 |
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Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis
A Mukherjee, MW Epperly, D Shields, W Hou, R Fisher, D Hamade, H Wang, MS Huq, R Bao, T Tabib, D Monier, S Watkins, M Calderon, JS Greenberger |
Cell Death Discovery | 2021 |
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Enhancement of Bone-Forming Ability on Beta-Tricalcium Phosphate by Modulating Cellular Senescence Mechanisms Using Senolytics
X Wang, Y Honda, J Zhao, H Morikuni, A Nishiura, Y Hashimoto, N Matsumoto |
International journal of molecular sciences | 2021 |
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Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma
W Lin, X Wang, Z Xu, Z Wang, T Liu, Z Cao, X Feng, Y Gao, J He |
Cancer Cell International | 2021 |
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Mechanisms and Regulation of Cellular Senescence
L Roger, F Tomas, V Gire |
International journal of molecular sciences | 2021 |
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Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
I Fernández-Duran, A Quintanilla, N Tarrats, J Birch, P Hari, FR Millar, AB Lagnado, V Smer-Barreto, M Muir, VG Brunton, JF Passos, JC Acosta |
Cell Death and Differentiation | 2021 |
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Senescent tumor cells: an overlooked adversary in the battle against cancer
SS Park, YW Choi, JH Kim, HS Kim, TJ Park |
Experimental & molecular medicine | 2021 |
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Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells
J Woo, S Shin, E Cho, D Ryu, D Garandeau, H Chajra, M Fréchet, D Park, E Jung, IV Balalaeva |
PloS one | 2021 |
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Senescent Cells in Cancer: Wanted or Unwanted Citizens
SE Niklander, DW Lambert, KD Hunter |
Cells | 2021 |
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Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification
Lázničková P, Bendíčková K, Kepák T, Frič J |
2021 | |
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Anti-oncogenic PTEN induces ovarian cancer cell senescence by targeting P21.
Ke X, Li L, Li J, Zheng M, Liu P |
Cell biology international | 2021 |
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Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation
Wyles SP, Tchkonia T, Kirkland JL |
Plastic and Reconstructive Surgery | 2021 |
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Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M, Yang H, Xiao Y, Tu T, Tang L, Li X, Zeng J, Zheng X, Zhou S |
Journal of Advanced Research | 2021 |
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细胞衰老与肿瘤治疗
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2021 | |
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Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
B Yu, J Ma, J Li, D Wang, Z Wang, S Wang |
Nature Communications | 2020 |
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CDKL3 promotes osteosarcoma progression by activating Akt/PKB
A He, L Ma, Y Huang, H Zhang, W Duan, Z Li, T Fei, J Yuan, H Wu, L Liu, Y Bai, W Dai, Y Wang, H Li, Y Sun, Y Wang, C Wang, T Yuan, Q Yang, S Tian, M Dong, R Sheng, D Xiang |
Life science alliance | 2020 |
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Non-coding RNAs as Regulators of Cellular Senescence in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease
N Omote, M Sauler |
Frontiers in Medicine | 2020 |
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Biological functions and theranostic potential of HMGB family members in human cancers
L Niu, W Yang, L Duan, X Wang, Y Li, C Xu, C Liu, Y Zhang, W Zhou, J Liu, Q Zhao, Y Han, L Hong, D Fan |
Therapeutic advances in medical oncology | 2020 |
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Autophagy Roles in Genome Maintenance
S Ambrosio, B Majello |
Cancers | 2020 |
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Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
OD Ilie, A Ciobica, S Riga, N Dhunna, J McKenna, I Mavroudis, B Doroftei, AM Ciobanu, D Riga |
MED LITH | 2020 |
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FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake
S Shrestha, W Cho, B Stump, J Imani, AM Lamattina, PH Louis, J Pazzanese, IO Rosas, G Visner, MA Perrella, S El-Chemaly |
Molecular Medicine | 2020 |
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Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?
E Shosha, AY Fouda, SP Narayanan, RW Caldwell, RB Caldwell |
Journal of Clinical Medicine | 2020 |
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The quest to slow ageing through drug discovery
L Partridge, M Fuentealba, BK Kennedy |
Nature Reviews Drug Discovery | 2020 |
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The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence
C Liao, Y Xiao, L Liu |
Cancer management and research | 2020 |
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Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology
S Mühleder, M Fernández-Chacón, I Garcia-Gonzalez, R Benedito |
Cellular and Molecular Life Sciences | 2020 |
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Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions
MH Docherty, DP Baird, J Hughes, DA Ferenbach |
Frontiers in pharmacology | 2020 |
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Cellular senescence and Alzheimer disease: the egg and the chicken scenario
S Saez-Atienzar, E Masliah |
Nature Reviews Neuroscience | 2020 |
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Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
L Wyld, I Bellantuono, T Tchkonia, J Morgan, O Turner, F Foss, J George, S Danson, JL Kirkland |
Cancers | 2020 |
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Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
W Venturini, A Olate-Briones, C Valenzuela, D Méndez, E Fuentes, A Cayo, D Mancilla, R Segovia, NE Brown, R Moore-Carrasco |
International journal of molecular sciences | 2020 |
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Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
J Xu, L Zhou, Y Liu |
Frontiers in pharmacology | 2020 |
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
RD Micco, V Krizhanovsky, D Baker, F dAdda di Fagagna |
Nature Reviews Molecular Cell Biology | 2020 |
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Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria
Y Fan, J Cheng, H Zeng, L Shao |
Frontiers in physiology | 2020 |
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Senescent cells and macrophages: key players for regeneration?
S S., E Emmerson |
Open Biology | 2020 |
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Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
D Gottwald, F Putz, N Hohmann, M Büttner-Herold, M Hecht, R Fietkau, L Distel |
2020 | |
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Unraveling Adipocytes and Cancer Links: Is There a Role for Senescence?
Q Wu, B Li, S Sun, S Sun |
Frontiers in Cell and Developmental Biology | 2020 |
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Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
M Amaya-Montoya, A Pérez-Londoño, V Guatibonza-García, A Vargas-Villanueva, CO Mendivil |
Advances in Therapy | 2020 |
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Similarities and interplay between senescent cells and macrophages
J Behmoaras, J Gil |
The Journal of Cell Biology | 2020 |
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The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases
L Cuollo, F Antonangeli, A Santoni, A Soriani |
Biology : open access journal | 2020 |
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Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts
S An, SY Cho, J Kang, S Lee, HS Kim, DJ Min, ED Son, KH Cho |
Proceedings of the National Academy of Sciences | 2020 |
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Cellular senescence impairs the reversibility of pulmonary arterial hypertension
DE van der Feen, GP Bossers, QA Hagdorn, JR Moonen, K Kurakula, R Szulcek, J Chappell, F Vallania, M Donato, K Kok, JS Kohli, AH Petersen, T van Leusden, M Demaria, MJ Goumans, RA Boer, P Khatri, M Rabinovitch, RM Berger, B Bartelds |
Science Translational Medicine | 2020 |
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Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort
Y Yu, H Singh, K Kwon, T Tsitrin, J Petrini, KE Nelson, R Pieper |
GeroScience | 2020 |
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Molecular basis of ageing in chronic metabolic diseases
R Spinelli, L Parrillo, M Longo, P Florese, A Desiderio, F Zatterale, C Miele, GA Raciti, F Beguinot |
Journal of Endocrinological Investigation | 2020 |
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Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis
H Jin, Y Zhang, D Liu, SS Wang, Q Ding, P Rastogi, M Purvis, A Wang, S Elhadi, C Ren, C Cao, Y Chai, P Igarashi, AM Jetten, D Lu, M Attanasio |
The American Journal of Pathology | 2020 |
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Decreased autophagy and fuel switching occur in a senescent hepatic cell model system
BK Singh, M Tripathi, R Sandireddy, K Tikno, J Zhou, PM Yen |
Aging | 2020 |
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Cellular Senescence in Renal and Urinary Tract Disorders
Y Santin, P Lluel, P Rischmann, X Gamé, J Mialet-Perez, A Parini |
Cells | 2020 |
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FOXO1 deficiency impairs proteostasis in aged T cells
J Jin, X Li, B Hu, C Kim, W Cao, H Zhang, CM Weyand, JJ Goronzy |
Science Advances | 2020 |
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Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
AM Battram, M Bachiller, B Martín-Antonio |
International journal of molecular sciences | 2020 |
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Cigarette smoking induces human CCR6+Th17 lymphocytes senescence and VEGF-A secretion
I Baskara, S Kerbrat, M Dagouassat, HQ Nguyen, M Guillot-Delost, M Surenaud, C Baillou, FM Lemoine, D Morin, J Boczkowski, SL Gouvello |
Scientific Reports | 2020 |
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Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
KE Blokland, SD Pouwels, M Schuliga, DA Knight, JK Burgess |
Clinical Science | 2020 |
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Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer
J Zhou, YY Jiang, HP Wang, H Chen, YC Wu, L Wang, X Pu, G Yue, L Zhang |
Annals of translational medicine | 2020 |
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Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice
RF Loeser, KL Kelley, A Armstrong, JA Collins, BO Diekman, CS Carlson |
Arthritis & Rheumatology | 2020 |
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Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils
M Perego, VA Tyurin, YY Tyurina, J Yellets, T Nacarelli, C Lin, Y Nefedova, A Kossenkov, Q Liu, S Sreedhar, H Pass, J Roth, T Vogl, D Feldser, R Zhang, VE Kagan, DI Gabrilovich |
Science Translational Medicine | 2020 |
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Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD
Q Wang, D Li, J Zhu, M Zhang, H Zhang, G Cao, L Zhu, Q Shi, J Hao, Q Wen, Z Liu, H Yang, Z Yin |
Frontiers in immunology | 2020 |
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Role of p53 in the Regulation of Cellular Senescence
M Mijit, V Caracciolo, A Melillo, F Amicarelli, A Giordano |
Biomolecules | 2020 |
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New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease
X Sun, EN Harris |
American journal of physiology. Cell physiology | 2020 |
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Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND
J Marino, B Wigdahl, MR Nonnemacher |
Frontiers in aging neuroscience | 2020 |
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Senescence in the pathogenesis of age-related macular degeneration
J Blasiak |
Cellular and Molecular Life Sciences | 2020 |
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Galactose‐modified duocarmycin prodrugs as senolytics
A Guerrero, R Guiho, N Herranz, A Uren, DJ Withers, JP MartínezBarbera, LF Tietze, J Gil |
Aging Cell | 2020 |
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Blunting senescence boosts liver regeneration
J Birch, J Gil |
Genes & development | 2020 |
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VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling
J Sun, Q Tang, Y Gao, W Zhang, Z Zhao, F Yang, X Hu, D Zhang, Y Wang, H Zhang, B Song, B Zhang, H Wang |
Journal of Experimental & Clinical Cancer Research | 2020 |
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A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity
Z Tavarez-Santamaría, NJ Jacobo-Herrera, L Rocha-Zavaleta, A Zentella-Dehesa, B del Carmen Couder-García, M Martínez-Vázquez |
Molecules (Basel, Switzerland) | 2020 |
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Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells
H Wang, Z Wang, Y Huang, Y Zhou, X Sheng, Q Jiang, Y Wang, P Luo, M Luo, C Shi |
Frontiers in Oncology | 2020 |
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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
MG Vizioli, T Liu, KN Miller, NA Robertson, K Gilroy, AB Lagnado, A Perez-Garcia, C Kiourtis, N Dasgupta, X Lei, PJ Kruger, C Nixon, W Clark, D Jurk, TG Bird, JF Passos, SL Berger, Z Dou, PD Adams |
Genes & development | 2020 |
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Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity
JA Berlanga-Acosta, GE Guillén-Nieto, N Rodríguez-Rodríguez, Y Mendoza-Mari, ML Bringas-Vega, JO Berlanga-Saez, DG del Barco Herrera, I Martinez-Jimenez, S Hernandez-Gutierrez, PA Valdés-Sosa |
Frontiers in Endocrinology | 2020 |
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Presbycusis: An Update on Cochlear Mechanisms and Therapies
J Wang, JL Puel |
Journal of Clinical Medicine | 2020 |
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Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease
E Cianflone, M Torella, F Biamonte, AD Angelis, K Urbanek, FS Costanzo, M Rota, GM Ellison-Hughes, D Torella |
Cells | 2020 |
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Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges
X Zhou, Y Hong, H Zhang, X Li |
Frontiers in Cell and Developmental Biology | 2020 |
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Biological Aging Marker p16INK4a in T Cells and Breast Cancer Risk
J Shen, R Song, BF Fuemmeler, KP McGuire, WH Chow, H Zhao |
Cancers | 2020 |
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Construction of a disease‐specific lncRNA‐miRNA‐mRNA regulatory network reveals potential regulatory axes and prognostic biomarkers for hepatocellular carcinoma
Q Zhang, L Sun, Q Zhang, W Zhang, W Tian, M Liu, Y Wang |
Cancer Medicine | 2020 |
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Regulation of senescence traits by MAPKs
C Anerillas, K Abdelmohsen, M Gorospe |
GeroScience | 2020 |
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Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells
J Adamczyk-Grochala, A Lewinska |
Cells | 2020 |
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Functional Determinants of Cell Cycle Plasticity and Sensitivity to CDK4/6 Inhibition
V Kumarasamy, P Vail, R Nambiar, AK Witkiewicz, ES Knudsen |
Cancer research | 2020 |
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T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice
WH Hsu, YJ Shiao, YM Chao, YJ Huang, YL Lin |
Aging | 2020 |
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Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26
C Jin, Y Li, Y Su, Z Guo, X Wang, S Wang, F Zhang, Z Zhang, J Shao, S Zheng |
Cell Death and Disease | 2020 |
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Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?
NJ Queen, QN Hassan, L Cao |
Frontiers in neuroscience | 2020 |
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
B Zhao, P Liu, T Fukumoto, T Nacarelli, N Fatkhutdinov, S Wu, J Lin, KM Aird, HY Tang, Q Liu, DW Speicher, R Zhang |
Nature Communications | 2020 |
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Cellular and molecular mechanisms of xenobiotics-induced premature senescence
Y Liang, N Liang, L Yin, F Xiao |
Toxicology Research | 2020 |
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Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy
Y Liu, Q Chen |
Current Molecular Biology Reports | 2020 |
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Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome
R Habib, R Kim, H Neitzel, I Demuth, K Chrzanowska, E Seemanova, R Faber, M Digweed, R Voss, K Jäger, K Sperling, M Walter |
Aging | 2020 |
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Hepatocellular Senescence: Immunosurveillance and Future Senescence-Induced Therapy in Hepatocellular Carcinoma
P Liu, Q Tang, M Chen, W Chen, Y Lu, Z Liu, Z He |
Frontiers in Oncology | 2020 |
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Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
I Olan, AJ Parry, S Schoenfelder, M Narita, Y Ito, AS Chan, GS Slater, D Bihary, M Bando, K Shirahige, H Kimura, SA Samarajiwa, P Fraser, M Narita |
Nature Communications | 2020 |
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Nontraditional systems in aging research: an update
J Mikuła-Pietrasik, M Pakuła, M Markowska, P Uruski, L Szczepaniak-Chicheł, A Tykarski, K Książek |
Cellular and Molecular Life Sciences | 2020 |
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Rapid senescence‐like response after acute injury
X Chu, J Wen, RP Raju |
Aging Cell | 2020 |
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Differential Gene Set Enrichment Analysis: a statistical approach to quantify the relative enrichment of two gene sets
JH Joly, WE Lowry, NA Graham, L Cowen |
Bioinformatics | 2020 |
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Signature changes in the expressions of protein-coding genes, lncRNAs, and repeat elements in early and late cellular senescence
G KARAKÜLAH, C YANDIM |
2020 | |
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Satellite cell‐specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration
JH Bae, M Hong, HJ Jeong, H Kim, SJ Lee, D Ryu, GU Bae, SC Cho, YS Lee, RS Krauss, JS Kang |
Journal of Cachexia, Sarcopenia and Muscle | 2020 |
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A preview of selected articles
Atkinson SP |
Stem Cells Translational Medicine | 2020 |
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Molecular and cellular paradigms of multidrug resistance in cancer
Vaidya FU, Sufiyan Chhipa A, Mishra V, Gupta VK, Rawat SG, Kumar A, Pathak C |
EMBO reports | 2020 |
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Epithelial innate immunity mediates tubular cell senescence after kidney injury
Heng Jin, Yan Zhang, Qiong Ding, Shan Shan Wang, Prerna Rastogi, Dao-Fu Dai, Dongmei Lu, Dingxiao Liu, Madison Purvis, Chao Cao, Angela Wang, Chongyu Ren, Sarah Elhadi, Ming Chang Hu, Yanfen Chai, Diana Zepeda-Orozco, Judith Campisi, Massimo Attanasio |
JCI Insight | 2019 |
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Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes following acute traumatic brain injury in mice
RM Ritzel, SJ Doran, EP Glaser, VE Meadows, AI Faden, BA Stoica, DJ Loane |
Neurobiology of Aging | 2019 |
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Hepatic senescence, the good and the bad
N Huda, G Liu, H Hong, S Yan, B Khambu, XM Yin |
World journal of gastroenterology : WJG | 2019 |
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NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
D Kabacaoglu, DA Ruess, J Ai, H Algül |
Cancers | 2019 |
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Vascular Diseases and Gangliosides
N Sasaki, M Toyoda |
International journal of molecular sciences | 2019 |
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Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion
H Niu, L Qian, B Sun, W Liu, F Wang, Q Wang, X Ji, Y Luo, EU Nesa, H Lou, H Yuan |
Acta pharmaceutica Sinica. B | 2019 |
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Cardiac glycosides are broad-spectrum senolytics
A Guerrero, N Herranz, B Sun, V Wagner, S Gallage, R Guiho, K Wolter, J Pombo, EE Irvine, AJ Innes, J Birch, J Glegola, S Manshaei, D Heide, G Dharmalingam, J Harbig, A Olona, J Behmoaras, D Dauch, AG Uren, L Zender, S Vernia, JP Martínez-Barbera, M Heikenwalder, DJ Withers, J Gil |
2019 | |
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The complement system in liver diseases: Evidence-based approach and therapeutic options
T Lung, B Sakem, L Risch, R Würzner, G Colucci, A Cerny, U Nydegger |
2019 | |
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Radiation-induced astrocyte senescence is rescued by Δ133p53
C Turnquist, JA Beck, I Horikawa, IE Obiorah, NV Muhlinen, B Vojtesek, DP Lane, C Grunseich, JJ Chahine, HM Ames, DD Smart, BT Harris, CC Harris |
Neuro-Oncology | 2019 |
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Measuring biological aging in humans: A quest
L Ferrucci, M GonzalezFreire, E Fabbri, E Simonsick, T Tanaka, Z Moore, S Salimi, F Sierra, R Cabo |
Aging Cell | 2019 |
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Cell Senescence in Lupus
L Gao, M Slack, A McDavid, J Anolik, RJ Looney |
Current Rheumatology Reports | 2019 |
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The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
P Hari, FR Millar, N Tarrats, J Birch, A Quintanilla, CJ Rink, I Fernández-Duran, M Muir, AJ Finch, VG Brunton, JF Passos, JP Morton, L Boulter, JC Acosta |
Science Advances | 2019 |
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The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
R Samarakoon, SP Higgins, CE Higgins, PJ Higgins |
Biomolecules | 2019 |
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Dissecting Aging and Senescence—Current Concepts and Open Lessons
Schmeer, Kretz, Wengerodt, Stojiljkovic, Witte |
Cells | 2019 |
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SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
CA Valenzuela, R Quintanilla, A Olate-Briones, W Venturini, D Mancilla, A Cayo, R Moore-Carrasco, NE Brown |
International journal of molecular sciences | 2019 |
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Senescent cells feed on their neighbours
M Overholtzer |
Nature | 2019 |
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Cellular senescence: a promising strategy for cancer therapy
Lee S, Lee JS |
BMB Reports | 2019 |
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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
A Georgilis, S Klotz, CJ Hanley, N Herranz, B Weirich, B Morancho, AC Leote, L D'Artista, S Gallage, M Seehawer, T Carroll, G Dharmalingam, KB Wee, M Mellone, J Pombo, D Heide, E Guccione, J Arribas, NL Barbosa-Morais, M Heikenwalder, GJ Thomas, L Zender, J Gil |
Cancer Cell | 2018 |
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Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases
NK Karamanos, AD Theocharis, T Neill, RV Iozzo |
Matrix biology : journal of the International Society for Matrix Biology | 2018 |
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TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling
Z Hou, K Guo, X Sun, F Hu, Q Chen, X Luo, G Wang, J Hu, L Sun |
Molecular Cancer | 2018 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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