Go to
JCI Insight
Citations to this article
Alberto Pugliese
Published August 1, 2017
Citation Information: J Clin Invest. 2017;127(8):2881-2891. https://doi.org/10.1172/JCI94549.
Citation Information: J Clin Invest. 2017;127(8):2881-2891. https://doi.org/10.1172/JCI94549.
Abstract
Type 1 diabetes (T1D) is a chronic autoimmune disease that causes severe loss of pancreatic β cells. Autoreactive T cells are key mediators of β cell destruction. Studies of organ donors with T1D that have examined T cells in pancreas, the diabetogenic insulitis lesion, and lymphoid tissues have revealed a broad repertoire of target antigens and T cell receptor (TCR) usage, with initial evidence of public TCR sequences that are shared by individuals with T1D. Neoepitopes derived from post-translational modifications of native antigens are emerging as novel targets that are more likely to evade self-tolerance. Further studies will determine whether T cell responses to neoepitopes are major disease drivers that could impact prediction, prevention, and therapy. This Review provides an overview of recent progress in our knowledge of autoreactive T cells that has emerged from experimental and clinical research as well as pathology investigations.
Authors
Alberto Pugliese
Total citations by year
Citation information
Citations to this article (200)
| Title and authors | Publication | Year |
|---|---|---|
|
PINK1 is a target of T cell responses in Parkinson's disease
Gregory P Williams, Antoine Freuchet, Tanner Michaelis, April Frazier, Ngan Tran, João Rodrigues Lima-Junior, Elizabeth J Phillips, Simon Mallal, Irene Litvan, Jennifer G Goldman, Roy Alcalay, John Sidney, David Sulzer, Alessandro Sette, Cecilia S Lindestam Arlehamn |
Journal of Clinical Investigation | 2025 |
|
From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes
Blok L, Hanssen N, Nieuwdorp M, Rampanelli E |
Metabolites | 2025 |
|
Insulitis and aging: Immune cell dynamics in Langerhans islets
Jelleschitz J, Heider S, Kehm R, Baumgarten P, Ott C, Schnell V, Grune T, Höhn A |
Redox Biology | 2025 |
|
Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations
Zhao R, Su Z, Gu J, Zhao H, Bian L, Jiang Y, Cai Y, Yang T, Gu Y, Xu X |
BMC Medicine | 2025 |
|
Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression
van der Heide V, McArdle S, Nelson MS, Cerosaletti K, Gnjatic S, Mikulski Z, Posgai AL, Kusmartseva I, Atkinson M, Homann D |
bioRxiv | 2025 |
|
Cleavage of protein kinase c δ by caspase-3 mediates pro-inflammatory cytokine-induced apoptosis in pancreatic islets
Jillian Collins, Robert Piscopio, Mary Reyland, Chelsea G Johansen, Richard Benninger, Nikki Farnsworth |
The Journal of biological chemistry | 2024 |
|
Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children.
Bruzzaniti S, Piemonte E, Bruzzese D, Lepore MT, Strollo R, Izzo L, Di Candia F, Franzese A, Bifulco M, Mozzillo E, Ludvigsson J, Matarese G, Galgani M |
Diabetologia | 2024 |
|
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.
Coomans de Brachène A, Alvelos MI, Szymczak F, Zimath PL, Castela A, Marmontel de Souza B, Roca Rivada A, Marín-Cañas S, Yi X, Op de Beeck A, Morgan NG, Sonntag S, Jawurek S, Title AC, Yesildag B, Pattou F, Kerr-Conte J, Montanya E, Nacher M, Marselli L, Marchetti P, Richardson SJ, Eizirik DL |
Diabetologia | 2024 |
|
PINK1 is a target of T cell responses in Parkinson’s disease
Williams GP, Michaelis T, Lima-Junior JR, Frazier A, Tran NK, Phillips EJ, Mallal SA, Litvan I, Goldman JG, Alcalay RN, Sidney J, Sulzer D, Sette A, Lindestam Arlehamn CS |
2024 | |
|
Novel lipid mediator 7S,14R-docosahexaenoic acid: biogenesis and harnessing mesenchymal stem cells to ameliorate diabetic mellitus and retinal pericyte loss
Lu Y, Tian H, Peng H, Wang Q, Bunnell BA, Bazan NG, Hong S |
Frontiers in Cell and Developmental Biology | 2024 |
|
Refined protocol for newly onset identification in non-obese diabetic mice: an animal-friendly, cost-effective, and efficient alternative
Liao CC, Hsieh CC, Shia WC, Chou MY, Huang CC, Lin JH, Lee SH, Sung HH |
Laboratory animal research | 2024 |
|
Factors Governing B Cell Recognition of Autoantigen and Function in Type 1 Diabetes.
Bass LE, Bonami RH |
2024 | |
|
De novo identification of CD4(+) T cell epitopes.
Zdinak PM, Trivedi N, Grebinoski S, Torrey J, Martinez EZ, Martinez S, Hicks L, Ranjan R, Makani VKK, Roland MM, Kublo L, Arshad S, Anderson MS, Vignali DAA, Joglekar AV |
Nature Methods | 2024 |
|
Immunopeptidome mining reveals a novel ERS-induced target in T1D.
Wang L, Yang S, Zhu G, Li J, Meng G, Chen X, Zhang M, Wang S, Li X, Pan Y, Huang Y, Wang L, Wu Y |
Cellular & molecular immunology | 2024 |
|
Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection
Yang K, Zhang Y, Ding J, Li Z, Zhang H, Zou F |
Frontiers in Endocrinology | 2024 |
|
Identification of functional enhancer variants associated with type I diabetes in CD4+ T cells
Mishra A, Jajodia A, Weston E, Jayavelu ND, Garcia M, Hossack D, Hawkins RD |
Frontiers in immunology | 2024 |
|
CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity
Srivastava N, Hu H, Peterson OJ, Vomund AN, Stremska M, Zaman M, Giri S, Li T, Lichti CF, Zakharov PN, Zhang B, Abumrad NA, Chen YG, Ravichandran KS, Unanue ER, Wan X |
Immunity | 2024 |
|
Lowering an ER stress-regulated long noncoding RNA protects mice from diabetes and isolated pancreatic islets from cell death
Kato M, Abdollahi M, Omori K, Malek V, Lanting L, Kandeel F, Rawson J, Tsark W, Zhang L, Wang M, Tunduguru R, Natarajan R |
Molecular therapy. Nucleic acids | 2024 |
|
Association of the apoptotic markers Apo1/Fas and cCK-18 and the adhesion molecule ICAM-1 with Type 1 diabetes mellitus in children and adolescents.
Kostopoulou E, Katsa ME, Ioannidis A, Foti M, Dimopoulos I, Spiliotis BE, Rojas Gil AP |
BMC Pediatrics | 2024 |
|
Distinct localization, transcriptional profiles, and functionality in early life tonsil regulatory T cells
Verma S, Bradley MC, Gray J, Dogra P, Caron DP, Maurrasse S, Grunstein E, Waldman E, Jang M, Pethe K, Farber DL, Connors TJ |
Journal of immunology (Baltimore, Md. : 1950) | 2024 |
|
Molecular mimicry in multisystem inflammatory syndrome in children.
Bodansky A, Mettelman RC, Sabatino JJ Jr, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu DJL, Pogorelyy MV, Awad W, Kirk AM, Asaki J, Pluvinage JV, Wilson MR, Zambrano LD, Campbell AP, Thomas PG, Randolph AG, Anderson MS, DeRisi JL |
Nature | 2024 |
|
Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes
Roy S, Pokharel P, Piganelli JD |
Molecular Metabolism | 2024 |
|
Antigen-specific T cell responses in autoimmune diabetes
Dwyer AJ, Shaheen ZR, Fife BT |
Frontiers in Immunology | 2024 |
|
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases
Yang SN, Shi Y, Berggren PO |
Physiological Reviews | 2024 |
|
Potential contribution of gut microbiota in the development of autoantibodies in T1D children carrying HLA-DRB1/DQB1 risk alleles: an experimental and in silico analysis.
Shirizadeh A, Razavi Z, Saeedi V, Behzad M, Faradmal J, Solgi G |
Immunogenetics | 2024 |
|
Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes
Sharma R, Amdare NP, Ghosh A, Schloss J, Sidney J, Garforth SJ, Lopez Y, Celikgil A, Sette A, Almo SC, DiLorenzo TP |
The Journal of Biological Chemistry | 2024 |
|
Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes
Kakabadse D, Chen D, Fishman S, Weinstein-Marom H, Davies J, Wen L, Gross G, Wong FS |
Frontiers in Immunology | 2024 |
|
Differential lipid signaling from CD4+ and CD8+ T cells contributes to type 1 diabetes development
White TD, Almutairi A, Gai-Tusing Y, Stephenson DJ, Stephenson BD, Chalfant CE, Lei X, Lu B, Hammock BD, DiLorenzo TP, Ramanadham S |
Frontiers in Immunology | 2024 |
|
Engineered tools to study endocrine dysfunction of pancreas
Alver CG, Dominguez-Bendala J, Agarwal A |
Biophysics Reviews | 2024 |
|
Clinical importance of cytokine (IL-6, IL-8, and IL-10) and vitamin D levels among patients with Type-1 diabetes
Syed Khaja AS, Binsaleh NK, Beg MM, Ashfaq F, Khan MI, Almutairi MG, Qanash H, Saleem M, Ginawi IA |
Scientific Reports | 2024 |
|
Charting Peptide Shared Sequences Between 'Diabetes-Viruses' and Human Pancreatic Proteins, Their Structural and Autoimmune Implications.
James SA, Joshua IA |
Bioinformatics and biology insights | 2024 |
|
Life history of a brain autoreactive T cell: From thymus through intestine to blood-brain barrier and brain lesion
Kawakami N, Wekerle H |
Neurotherapeutics | 2024 |
|
Changes in CD4+CD25HIGH T cells and TGFβ1 levels in different stages of adult-onset type 1 diabetes
Miličić T, Jotić A, Marković I, Popadić D, Lalić K, Uskoković V, Lukić L, Maćešić M, Stanarčić J, Stoiljković M, Milovančević M, Rafailović Đ, Božović A, Radisavljević N, Lalić NM |
Journal of Medical Biochemistry | 2024 |
|
Single-cell analysis reveals islet autoantigen’s immune activation in type 1 diabetes patients
Okamura T, Kitagawa N, Kitagawa N, Sakai K, Sumi M, Kobayashi G, Imai D, Matsui T, Hamaguchi M, Fukui M |
Journal of Clinical Biochemistry and Nutrition | 2024 |
|
Responders to low-dose ATG suppress Th1 effectors and enhance neutrophil activation in type 1 diabetes
Laura Jacobsen, Kirsten Diggins, Lori Blanchfield, James McNichols, Daniel Perry, Jason Brant, Xiaoru Dong, Rhonda Bacher, Vivian Gersuk, Desmond Schatz, Mark Atkinson, Clayton Mathews, Michael Haller, S. Long, Peter Linsley, Todd Brusko |
JCI Insight | 2023 |
|
Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection and cystic fibrosis-related diabetes
Ruchi Yadav, Quan-Zhen Li, Louis S. Bridges, J. Kahlenberg, Hanwen Huang, Arlene Stecenko, Balázs Rada |
Frontiers in immunology | 2023 |
|
Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis
Moon JS, Younis S, Ramadoss NS, Iyer R, Sheth K, Sharpe O, Rao NL, Becart S, Carman JA, James EA, Buckner JH, Deane KD, Holers VM, Goodman SM, Donlin LT, Davis MM, Robinson WH |
Nature Communications | 2023 |
|
Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases
Prinz JC |
Frontiers in immunology | 2023 |
|
Effect of Epstein–Barr Virus Infection on Selected Immunological Parameters in Children with Type 1 Diabetes
Klatka M, Rysz I, Hymos A, Polak A, Mertowska P, Mertowski S, Smolak K, Grywalska E |
International journal of molecular sciences | 2023 |
|
The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population.
Al-Balushi M, Al-Badi S, Al-Yaarubi S, Al-Riyami H, Al-Shidhani A, Al-Hinai S, Alshirawi A, Hasson S, Said E, Al-Jabri A, Al Ansari A |
Sultan Qaboos University medical journal | 2023 |
|
Peripheral blood mononuclear cells reactivity in recent-onset type I diabetes patients is directed against the leader peptide of preproinsulin, GAD65271-285 and GAD65431-450
Jores RD, Baldera D, Schirru E, Muntoni S, Rossino R, Manchinu MF, Marongiu MF, Caria CA, Ripoli C, Ricciardi MR, Cucca F, Congia M |
Frontiers in immunology | 2023 |
|
Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases.
Räisänen L, Viljakainen H, Kolho KL |
Frontiers in Pediatrics | 2023 |
|
The regulation of self-tolerance and the role of inflammasome molecules
Ke Q, Greenawalt AN, Manukonda V, Ji X, Tisch RM |
Frontiers in immunology | 2023 |
|
Acthar Gel Inhibits the Activation of CD4(+) and CD8(+) T Cells.
Wright D, Hayes K |
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research | 2023 |
|
Pre-Diagnostic Saliva Microbiota of School-Aged Children Who Developed Type 1 Diabetes or Inflammatory Bowel Diseases
Räisänen L, Agrawal N, Mathew B, Kääriäinen S, Kolho KL, Viljakainen H |
International journal of molecular sciences | 2023 |
|
Advanced Delivery Strategies for Immunotherapy in Type I Diabetes Mellitus
Huang M, Chen W, Wang M, Huang Y, Liu H, Ming Y, Chen Y, Tang Z, Jia B |
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy | 2023 |
|
Epstein-Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism.
Thomas OG, Rickinson A, Palendira U |
IBMS BoneKEy | 2023 |
|
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
Thomas OG, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Guerreiro-Cacais AO, Grönlund H, Olsson T, Kockum I |
Science Advances | 2023 |
|
First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes.
Van Rampelbergh J, Achenbach P, Leslie RD, Ali MA, Dayan C, Keymeulen B, Owen KR, Kindermans M, Parmentier F, Carlier V, Ahangarani RR, Gebruers E, Bovy N, Vanderelst L, Van Mechelen M, Vandepapelière P, Boitard C |
BMC Medicine | 2023 |
|
Generation of Chimeric Antigen Receptors against Tetraspanin 7
Pieper T, Roth KD, Glaser V, Riet T, Buitrago-Molina LE, Hagedorn M, Lieber M, Hust M, Noyan F, Jaeckel E, Hardtke-Wolenski M |
Cells | 2023 |
|
Monitoring immunomodulation strategies in type 1 diabetes
Krishnamurthy B, Lacorcia M, Kay TW, Thomas HE, Mannering SI |
Frontiers in immunology | 2023 |
|
Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood
Benaglio P, Newsome J, Han JY, Chiou J, Aylward A, Corban S, Miller M, Okino ML, Kaur J, Preissl S, Gorkin DU, Gaulton KJ |
PLoS genetics | 2023 |
|
SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice
Sui M, Li T, Lu H, Li Y, Huang J, Zhang P, Wang S, Zeng L |
Stem Cell Research & Therapy | 2023 |
|
Mitochondrial Control for Healthy and Autoimmune T Cells
Jia L, Zhang L, Liu M, Ji H, Wen Z, Wang C |
Cells | 2023 |
|
HLA-DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients.
Chuzho N, Mishra N, Tandon N, Kanga U, Mishra G, Sharma A, Mehra NK, Kumar N |
Journal of Diabetes | 2023 |
|
Tryptophan metabolism promotes immune evasion in human pancreatic β cells
Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R |
EBioMedicine | 2023 |
|
IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.
Thomaidou S, Munoz Garcia A, de Lange S, Gan J, van der Slik AR, Hoeben RC, Roep BO, Carlotti F, Zaldumbide A |
Diabetologia | 2023 |
|
Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes.
Sun F, Yang CL, Wang FX, Rong SJ, Luo JH, Lu WY, Yue TT, Wang CY, Liu SW |
Cell & Bioscience | 2023 |
|
Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice
Chen D, Kakabadse D, Fishman S, Weinstein-Marom H, Davies J, Boldison J, Thayer TC, Wen L, Gross G, Wong FS |
Frontiers in immunology | 2023 |
|
The beta cell-immune cell interface in type 1 diabetes (T1D)
James EA, Joglekar AV, Linnemann AK, Russ HA, Kent SC |
Molecular Metabolism | 2023 |
|
Mimicking the brain: Epstein-Barr virus and foreign agents as drivers of neuroimmune attack in multiple sclerosis
Thomas OG, Olsson T |
Frontiers in immunology | 2023 |
|
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu Y, Hu Q, Li Y, Lu L, Xiang Z, Yin Z, Kabelitz D, Wu Y |
Signal Transduction and Targeted Therapy | 2023 |
|
Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells
Ye C, Clements SA, Gu W, Geurts AM, Mathews CE, Serreze DV, Chen YG, Driver JP |
Proceedings of the National Academy of Sciences | 2023 |
|
Autoimmune diseases: targets, biology, and drug discovery.
Li SJ, Wu YL, Chen JH, Shen SY, Duan J, Xu HE |
Acta Pharmacologica Sinica | 2023 |
|
Chimeric Antigen Receptor (CAR)-Based Cell Therapy for Type 1 Diabetes Mellitus (T1DM); Current Progress and Future Approaches.
Mohammadi V, Maleki AJ, Nazari M, Siahmansouri A, Moradi A, Elahi R, Esmaeilzadeh A |
Stem Cell Reviews and Reports | 2023 |
|
Teplizumab in Type 1 Diabetes Mellitus: An Updated Review
Thakkar S, Chopra A, Nagendra L, Kalra S, Bhattacharya S |
2023 | |
|
Benefits and risks of drug combination therapy for diabetes mellitus and its complications: a comprehensive review
Xie X, Wu C, Hao Y, Wang T, Yang Y, Cai P, Zhang Y, Huang J, Deng K, Yan D, Lin H |
Frontiers in Endocrinology | 2023 |
|
Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
Chandan Sona, Yu-Te Yeh, Andreas Patsalos, Laszlo Halasz, Xin Yan, Natalia L. Kononenko, Laszlo Nagy, Matthew N. Poy |
JCI Insight | 2022 |
|
Rational construction of controllable autoimmune diabetes model depicting clinical features
F Yu, X Zhou, X Jin, S Zhao, G Zhao, S Jiang, S Geng, B Wang, P Fiorina |
PloS one | 2022 |
|
Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes
A Mitchell, A Michels |
International journal of molecular sciences | 2022 |
|
Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu |
Theranostics | 2022 |
|
The impact of the gut microbiome on extra-intestinal autoimmune diseases
E Miyauchi, C Shimokawa, A Steimle, M Desai, H Ohno |
Nature Reviews Immunology | 2022 |
|
Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse
B Jamison, J DiLisio, K Beard, T Neef, B Bradley, J Goodman, R Gill, S Miller, R Baker, K Haskins |
Diabetes | 2022 |
|
Nanotechnology in Immunotherapy for Type 1 Diabetes: Promising Innovations and Future Advances
S Nigam, J Bishop, H Hayat, T Quadri, H Hayat, P Wang |
Pharmaceutics | 2022 |
|
Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells
M Khilji, P Faridi, E Pinheiro-Machado, C Hoefner, T Dahlby, R Aranha, S Buus, M Nielsen, J Klusek, T Mandrup-Poulsen, K Pandey, A Purcell, M Marzec |
Biomedicines | 2022 |
|
Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand
W Yang, A Denger, C Diener, F Küppers, L Soriano-Baguet, G Schäfer, A Yanamandra, R Zhao, A Knörck, E Schwarz, M Hart, F Lammert, L Roma, D Brenner, G Christidis, V Helms, E Meese, M Hoth, B Qu |
Frontiers in immunology | 2022 |
|
NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes
P Xiao, T Takiishi, N Violato, G Licata, F Dotta, G Sebastiani, L Marselli, S Singh, M Sze, G Loo, E Dejardin, E Gurzov, A Cardozo |
Cell Death and Disease | 2022 |
|
Posttranslational modifications in diabetes: Mechanisms and functions
A Hu, H Zou, B Chen, J Zhong |
Reviews in Endocrine and Metabolic Disorders | 2022 |
|
Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes
Artzy-Schnirman A, Abu-Shah E, Chandrawati R, Altman E, Yusuf N, Wang ST, Ramos J, Hansel CS, Haus-Cohen M, Dahan R, Arif S, Dustin ML, Peakman M, Reiter Y, Stevens MM |
Nano letters | 2022 |
|
Activation of T cell checkpoint pathways during β-cell antigen presentation by engineered dendritic cells promotes protection from type 1 diabetes
Gudi RR, Perez N, Karumuthil-Melethil S, Li G, Vasu C |
Immunology | 2022 |
|
From Disease and Patient Heterogeneity to Precision Medicine in Type 1 Diabetes
den Hollander NH, Roep BO |
Frontiers in Medicine | 2022 |
|
Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges
Silva IB, Kimura CH, Colantoni VP, Sogayar MC |
Stem Cell Research & Therapy | 2022 |
|
The Contribution of Neutrophils and NETs to the Development of Type 1 Diabetes
Petrelli A, Popp SK, Fukuda R, Parish CR, Bosi E, Simeonovic CJ |
Frontiers in immunology | 2022 |
|
Environmental Triggering of Type 1 Diabetes Autoimmunity
Houeiss P, Luce S, Boitard C |
Frontiers in Endocrinology | 2022 |
|
A Comprehensive Review of the Evolution of Insulin Development and Its Delivery Method
Sugumar V, Ang KP, Alshanon AF, Sethi G, Yong PV, Looi CY, Wong WF |
Pharmaceutics | 2022 |
|
A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes
Girdhar K, Huang Q, Chow IT, Vatanen T, Brady C, Raisingani A, Autissier P, Atkinson MA, Kwok WW, Kahn CR, Altindis E |
Proceedings of the National Academy of Sciences | 2022 |
|
Antibiotic exposures and the development of pediatric autoimmune diseases: a register-based case-control study.
Räisänen LK, Kääriäinen SE, Sund R, Engberg E, Viljakainen HT, Kolho KL |
Pediatric Research | 2022 |
|
Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.
Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL |
Science Advances | 2022 |
|
How dysregulation of the immune system promotes diabetes mellitus and cardiovascular risk complications
Girard D, Vandiedonck C |
Frontiers in Cardiovascular Medicine | 2022 |
|
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC |
International journal of molecular sciences | 2022 |
|
Evaluating T cell responses prior to the onset of type 1 diabetes
Arif S, Yusuf N, Domingo\u2010Vila C, Liu Y, Bingley PJ, Peakman M |
Diabetic Medicine | 2022 |
|
T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis.
Garrido-Mesa J, Brown MA |
Current Rheumatology Reports | 2022 |
|
Narcolepsy and H1N1 influenza immunology a decade later: What have we learned?
Buonocore SM, van der Most RG |
Frontiers in immunology | 2022 |
|
Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development
Du C, Whiddett RO, Buckle I, Chen C, Forbes JM, Fotheringham AK |
Cells | 2022 |
|
Pathophysiology of Type 1 Diabetes and Gut Microbiota Role
Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L |
International journal of molecular sciences | 2022 |
|
Effect of polycyclic aromatic hydrocarbons on immunity
Yu YY, Jin H, Lu Q |
2022 | |
|
Engineered Extracellular Vesicles in Treatment of Type 1 Diabetes Mellitus: A Prospective Review
Raghav A, Ashraf H, Jeong GB |
Biomedicines | 2022 |
|
Regulation of Myeloid Dendritic Cells by Synthetic and Natural Compounds for the Treatment of Rheumatoid Arthritis.
Umbreen H, Zhang X, Tang KT, Lin CC |
International journal of molecular sciences | 2022 |
|
A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathy
Y Wang, Z Chen, T Wang, H Guo, Y Liu, N Dang, S Hu, L Wu, C Zhang, K Ye, B Shi |
Cellular and Molecular Immunology | 2021 |
|
T-cell responses to hybrid insulin peptides prior to type 1 diabetes development
AM Mitchell, AA Alkanani, KA McDaniel, L Pyle, K Waugh, AK Steck, M Nakayama, L Yu, PA Gottlieb, MJ Rewers, AW Michels |
Proceedings of the National Academy of Sciences | 2021 |
|
Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes
BS Kong, SH Min, C Lee, YM Cho |
Cell Reports | 2021 |
|
The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes
M Clark, CJ Kroger, Q Ke, RM Tisch |
Frontiers in immunology | 2021 |
|
Evolving Antibody Therapies for the Treatment of Type 1 Diabetes
Q Ke, CJ Kroger, M Clark, RM Tisch |
Frontiers in immunology | 2021 |
|
The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes
RC Sharp, ME Brown, MR Shapiro, AL Posgai, TM Brusko |
Frontiers in immunology | 2021 |
|
Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children
A Torun, A Hupalowska, P Trzonkowski, J Kierkus, B Pyrzynska |
Frontiers in immunology | 2021 |
|
The dark side of insulin: A primary autoantigen and instrument of self-destruction in type 1 diabetes
LC Harrison |
Molecular Metabolism | 2021 |
|
Peripheral autoreactive CD8 T‐cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes
JD Wesley, S Pfeiffer, D Schneider, D Friedrich, N Perdue, B SehestedHansen, W Hagopian, MG Herrath |
IBMS BoneKEy | 2021 |
|
Noncontiguous T cell epitopes in autoimmune diabetes: From mice to men and back again
N Amdare, AW Purcell, TP DiLorenzo |
The Journal of biological chemistry | 2021 |
|
Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis
LE Buitrago-Molina, J Dywicki, F Noyan, M Trippler, J Pietrek, J Schlue, MP Manns, H Wedemeyer, E Jaeckel, M Hardtke-Wolenski |
Biomedicines | 2021 |
|
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
JL Collier, SA Weiss, KE Pauken, DR Sen, AH Sharpe |
Nature Immunology | 2021 |
|
Neuro-immune-metabolism: The Tripod system of Homeostasis
D Deshpande, L Fuchs, CS Klose |
Immunology Letters | 2021 |
|
ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis
T Marchini, S Hansen, D Wolf |
Cells | 2021 |
|
The Impact of the Ca2+-Independent Phospholipase A2β (iPLA2β) on Immune Cells
TD White, A Almutairi, YG Tusing, X Lei, S Ramanadham |
Biomolecules | 2021 |
|
Current and future therapies for type 1 diabetes
BJ von Scholten, FF Kreiner, SC Gough, M von Herrath |
Diabetologia | 2021 |
|
Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease
LH Armitage, MA Wallet, CE Mathews |
Frontiers in immunology | 2021 |
|
Novel Immunomodulatory Approaches for Porcine Islet Xenotransplantation
SH Hong, HJ Kim, SJ Kang, CG Park |
Current Diabetes Reports | 2021 |
|
High Density Lipoproteins and Diabetes
BJ Cochran, KL Ong, B Manandhar, KA Rye |
Cells | 2021 |
|
Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases
H Wiendl, CC Gross, J Bauer, D Merkler, A Prat, R Liblau |
Nature Reviews Neurology | 2021 |
|
NK Cells in Autoimmune Diseases: Protective or Pathogenic?
M Liu, S Liang, C Zhang |
Frontiers in immunology | 2021 |
|
The β Cell in Diabetes: Integrating Biomarkers With Functional Measures
S Kahn, Y Chen, N Esser, A Taylor, D van Raalte, S Zraika, C Verchere |
Endocrine reviews | 2021 |
|
Insulin Receptor–Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice
N Nandedkar-Kulkarni, E Esakov, B Gregg, MA Atkinson, DG Rogers, JD Horner, K Singer, SK Lundy, JL Felton, T Al-Huniti, AN Kalinoski, MP Morran, NK Gupta, JD Bretz, S Balaji, T Chen, MF McInerney |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
|
Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum
A Carré, R Mallone |
Frontiers in immunology | 2021 |
|
Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets
T Rodriguez-Calvo, JD Johnson, L Overbergh, JL Dunne |
Frontiers in immunology | 2021 |
|
Induction of Antigen-Specific Tolerance in Autoimmune Diabetes with Nanoparticles Containing Hybrid Insulin Peptides
JE DiLisio, K Haskins |
Biomedicines | 2021 |
|
Stem Cells as a Source of Pancreatic Cells for Production of 3D Bioprinted Bionic Pancreas in the Treatment of Type 1 Diabetes
M Wszoła, D Nitarska, P Cywoniuk, M Gomółka, M Klak |
Cells | 2021 |
|
Targeting Mitochondrial-Derived Reactive Oxygen Species in T Cell-Mediated Autoimmune Diseases
MD Chávez, HM Tse |
Frontiers in immunology | 2021 |
|
Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease
G Amodio, A Mandelli, R Curto, PM Rancoita, A Stabilini, R Bonfanti, M de Pellegrin, E Bosi, CD Serio, M Battaglia, S Gregori |
Frontiers in immunology | 2021 |
|
Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis
E Toren, KL Burnette, RR Banerjee, CS Hunter, HM Tse |
Frontiers in immunology | 2021 |
|
New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
C Bender, S Rajendran, MG von Herrath |
Frontiers in Endocrinology | 2021 |
|
Immunological Monitoring in Beta Cell Replacement: Towards a Pathophysiology-Guided Implementation of Biomarkers
F Buron, S Reffet, L Badet, E Morelon, O Thaunat |
Current Diabetes Reports | 2021 |
|
A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation
SS Kim, AD Hudgins, J Yang, Y Zhu, Z Tu, MG Rosenfeld, TP DiLorenzo, Y Suh, P Fiorina |
PloS one | 2021 |
|
Understanding and treating the inflammatory adverse events of cancer immunotherapy
M Dougan, AM Luoma, SK Dougan, KW Wucherpfennig |
Cell | 2021 |
|
T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes
JP Mordes, L Cort, Z Liu, R Eberwine, EP Blankenhorn, BG Pierce |
Genes & development | 2021 |
|
Perinatal risk factors for pediatric onset type 1 diabetes, autoimmune thyroiditis, juvenile idiopathic arthritis, and inflammatory bowel diseases
L Räisänen, H Viljakainen, C Sarkkola, KL Kolho |
European Journal of Pediatrics | 2021 |
|
Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
N Page, S Lemeille, I Vincenti, B Klimek, A Mariotte, I Wagner, GD Liberto, J Kaye, D Merkler |
Nature Communications | 2021 |
|
Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study
Barbara M Brooks-Worrell, Ashley H Tjaden, Sharon L Edelstein, Brenda Palomino, Kristina M Utzschneider, Silva Arslanian, Kieren J Mather, Thomas A Buchanan, Kristen J Nadeau, Karen Atkinson, Elena Barengolts, Steven E Kahn, Jerry P Palmer, |
Frontiers in immunology | 2021 |
|
Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2
Y Guo, J Li, S Fan, Q Hu |
Cell Death Discovery | 2021 |
|
HLA Allele-Specific Quantitative Profiling of Type 1 Diabetic B Lymphocyte Immunopeptidome
P Sudhir, T Lin, Q Zhang |
Journal of Proteome Research | 2021 |
|
Type I IFN–Driven Immune Cell Dysregulation in Rat Autoimmune Diabetes
N Qaisar, A Arowosegbe, A Derr, A Kucukural, B Satish, R Racicot, Z Guo, M Trombly, J Wang |
ImmunoHorizons | 2021 |
|
Insulin Immunotherapy for Pre-Type 1 Diabetes
Jacobsen LM, Schatz DA |
Current opinion in endocrinology, diabetes, and obesity | 2021 |
|
Lipid mediators and biomarkers associated with type 1 diabetes development
Alexander Nelson, Daniel Stephenson, Robert N. Bone, Christopher Cardona, Margaret Park, Ying G. Tusing, Xiaoyong Lei, George Kokotos, Christina L. Graves, Clayton E. Mathews, Joanna Kramer, Martin J. Hessner, Charles E. Chalfant, Sasanka Ramanadham |
JCI Insight | 2020 |
|
Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development
SI Blum, HM Tse |
Microorganisms | 2020 |
|
Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability
J Zhang, L Chen, F Wang, Y Zou, J Li, J Luo, F Khan, F Sun, Y Li, J Liu, Z Chen, S Zhang, F Xiong, Q Yu, J Li, K Huang, BL Adam, Z Zhou, DL Eizirik, P Yang, CY Wang |
Diabetologia | 2020 |
|
The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
C Bender, T Rodriguez-Calvo, N Amirian, KT Coppieters, MG von Herrath |
Science Advances | 2020 |
|
Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism
C Campbell, A Rudensky |
Cell Metabolism | 2020 |
|
The Role of Inflammation in Diabetic Retinopathy
JV Forrester, L Kuffova, M Delibegovic |
Frontiers in immunology | 2020 |
|
Type 1 diabetes progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T-cell effector functions
G Terrazzano, S Bruzzaniti, V Rubino, M Santopaolo, AT Palatucci, A Giovazzino, CL Rocca, P de Candia, A Puca, F Perna, C Procaccini, VD Rosa, C Porcellini, SD Simone, V Fattorusso, A Porcellini, E Mozzillo, R Troncone, A Franzese, J Ludvigsson, G Matarese, G Ruggiero, M Galgani |
Nature metabolism | 2020 |
|
A randomized controlled trial with a delayed‐type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man
M Saghari, P Gal, D Ziagkos, J Burggraaf, JF Powell, N Brennan, R Rissmann, MB Doorn, M Moerland |
British Journal of Clinical Pharmacology | 2020 |
|
Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes
MM Zorro, R Aguirre-Gamboa, T Mayassi, C Ciszewski, D Barisani, S Hu, RK Weersma, S Withoff, Y Li, C Wijmenga, B Jabri, IH Jonkers |
Journal of Autoimmunity | 2020 |
|
A personalised approach for identifying disease-relevant pathways in heterogeneous diseases
J Somani, S Ramchandran, H Lähdesmäki |
npj Systems Biology and Applications | 2020 |
|
Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection
P Akhbari, SJ Richardson, NG Morgan |
Microorganisms | 2020 |
|
Double-negative T cells in autoimmune diseases
H Li, GC Tsokos |
Current Opinion in Rheumatology | 2020 |
|
Fasciola hepatica-Derived Molecules as Regulators of the Host Immune Response
S Ryan, J Shiels, CC Taggart, JP Dalton, S Weldon |
Frontiers in immunology | 2020 |
|
Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells
S Sinha, PS Renavikar, MP Crawford, SM Steward-Tharp, A Brate, E Tsalikian, M Tansey, ET Shivapour, T Cho, J Kamholz, NJ Karandikar, JR Lees |
PloS one | 2020 |
|
Rapid onset type 1 diabetes with anti-PD-1 directed therapy
K Yun, G Daniels, K Gold, K Mccowen, SP Patel |
Oncotarget | 2020 |
|
Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells
NC Leite, E Sintov, TB Meissner, MA Brehm, DL Greiner, DM Harlan, DA Melton |
Cell Reports | 2020 |
|
T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
EA James, R Mallone, SC Kent, TP DiLorenzo |
Diabetes | 2020 |
|
α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
CS Arlehamn, R Dhanwani, J Pham, R Kuan, A Frazier, JR Dutra, E Phillips, S Mallal, M Roederer, KS Marder, AW Amara, DG Standaert, JG Goldman, I Litvan, B Peters, D Sulzer, A Sette |
Nature Communications | 2020 |
|
Can cinnamon spice down autoimmune diseases?
Pahan S, Pahan K |
Journal of clinical & experimental immunology | 2020 |
|
Exercise and Type 1 Diabetes.
Lu X, Zhao C |
Advances in experimental medicine and biology | 2020 |
|
Hybrid lipids, peptides, and lymphocytes: new era in type 1 diabetes research
Abdel Rahim Hamad, Mohanraj Sadasivam, Hamid Rabb |
Journal of Clinical Investigation | 2019 |
|
On the mark: genetically engineered immunotherapies for autoimmunity
CT Ellebrecht, DK Lundgren, AS Payne |
Current Opinion in Immunology | 2019 |
|
The eye as a novel imaging site in diabetes research
SN Yang, PO Berggren |
Pharmacology & Therapeutics | 2019 |
|
Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes
J Schloss, R Ali, J Babad, I Guerrero-Ros, J Pongsachai, LZ He, T Keler, TP DiLorenzo |
ImmunoHorizons | 2019 |
|
Viral Hormones: Expanding Dimensions in Endocrinology
Q Huang, CR Kahn, E Altindis |
Endocrinology | 2019 |
|
Antigen-specific therapeutic approaches for autoimmunity
P Serra, P Santamaria |
Nature Biotechnology | 2019 |
|
Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity
KS Foo, AA Skowronski, D Baum, R Firdessa-Fite, S Thams, L Shang, RJ Creusot, CA LeDuc, D Egli, RL Leibel |
Scientific Reports | 2019 |
|
Replacing murine insulin 1 with human insulin protects NOD mice from diabetes
CM Elso, NA Scott, L Mariana, EI Masterman, AP Sutherland, HE Thomas, SI Mannering, MG von Herrath |
PloS one | 2019 |
|
Translational Approaches Targeting Ceramide Generation From Sphingomyelin in T Cells to Modulate Immunity in Humans
C Hollmann, T Wiese, F Dennstädt, J Fink, J Schneider-Schaulies, N Beyersdorf |
Frontiers in immunology | 2019 |
|
Rationally designed small molecules to prevent type 1 diabetes:
DA Ostrov, PA Gottlieb, AW Michels |
Current opinion in endocrinology, diabetes, and obesity | 2019 |
|
A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells
M Bettini, MA Scavuzzo, B Liu, E Kolawole, L Guo, BD Evavold, M Borowiak, ML Bettini |
Diabetes | 2019 |
|
STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia
Q Weng, M Zhao, J Zheng, L Yang, Z Xu, Z Zhang, J Wang, J Wang, B Yang, QR Lu, M Ying, Q He |
Cell Death and Differentiation | 2019 |
|
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity
A Jain, RA Irizarry-Caro, MM McDaniel, AS Chawla, KR Carroll, GR Overcast, NH Philip, A Oberst, AV Chervonsky, JD Katz, C Pasare |
Nature Immunology | 2019 |
|
Extracellular Vesicles in Type 1 Diabetes: Messengers and Regulators
S Negi, AK Rutman, S Paraskevas |
Current Diabetes Reports | 2019 |
|
HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
MA Russell, SD Redick, DM Blodgett, SJ Richardson, P Leete, L Krogvold, K Dahl-Jørgensen, R Bottino, M Brissova, JM Spaeth, JA Babon, R Haliyur, AC Powers, C Yang, SC Kent, AG Derr, A Kucukural, MG Garber, NG Morgan, DM Harlan |
Diabetes | 2019 |
|
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes
JL Dunne, SJ Richardson, MA Atkinson, ME Craig, K Dahl-Jørgensen, M Flodström-Tullberg, H Hyöty, RA Insel, Å Lernmark, RE Lloyd, NG Morgan, A Pugliese |
Diabetologia | 2019 |
|
Mass Cytometry Identifies Distinct Subsets of Regulatory T Cells and Natural Killer Cells Associated With High Risk for Type 1 Diabetes
H Barcenilla, L Åkerman, M Pihl, J Ludvigsson, R Casas |
Frontiers in immunology | 2019 |
|
Type 1 diabetic mellitus patients with increased atherosclerosis risk display decreased CDKN2A/2B/2BAS gene expression in leukocytes
S Martínez-Hervás, V Sánchez-García, A Herrero-Cervera, Á Vinué, JT Real, JF Ascaso, DJ Burks, H González-Navarro |
Journal of Translational Medicine | 2019 |
|
Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys
A Domon, K Katayama, Y Tochigi, H Suzuki |
Journal of Diabetes Research | 2019 |
|
Hybrid insulin peptides are neo-epitopes for CD4 T cells in autoimmune diabetes:
RL Baker, BL Jamison, K Haskins |
Current opinion in endocrinology, diabetes, and obesity | 2019 |
|
Characterization of IL-17-producing T helper cells-like autoreactive T cells in aged mice
T Uematsu, T Fujita, N Kobayashi |
Experimental Animals | 2019 |
|
Reconstruction of Cell-type-Specific Interactomes at Single-Cell Resolution
S Mohammadi, J Davila-Velderrain, M Kellis |
Cell Systems | 2019 |
|
A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40
A Spyrantis, J Krieger, K Stifter, BO Boehm, R Schirmbeck |
Cellular and Molecular Immunology | 2019 |
|
Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes
CJ Kroger, M Clark, Q Ke, RM Tisch |
Frontiers in immunology | 2018 |
|
The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future
YG Chen, CE Mathews, JP Driver |
Frontiers in Endocrinology | 2018 |
|
Pancreas Pathology During the Natural History of Type 1 Diabetes
T Rodriguez-Calvo, SJ Richardson, A Pugliese |
Current Diabetes Reports | 2018 |
|
Abnormal T Cell Frequencies, Including Cytomegalovirus-Associated Expansions, Distinguish Seroconverted Subjects at Risk for Type 1 Diabetes
RZ Harms, KM Lorenzo-Arteaga, KR Ostlund, VB Smith, LM Smith, P Gottlieb, N Sarvetnick |
Frontiers in immunology | 2018 |
|
Of mice and men: models and mechanisms of diabetic cardiomyopathy
C Riehle, J Bauersachs |
Basic Research in Cardiology | 2018 |
|
Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases
Y Tai, Q Wang, H Korner, L Zhang, W Wei |
Frontiers in pharmacology | 2018 |
|
Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation
X Wan, ER Unanue |
2018 | |
|
MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice
M Zhang, JJ Racine, Q Lin, Y Liu, S Tang, Q Qin, T Qi, AD Riggs, D Zeng |
Proceedings of the National Academy of Sciences | 2018 |
|
The Aryl Hydrocarbon Receptor as an Immune-Modulator of Atmospheric Particulate Matter-Mediated Autoimmunity
CA O'Driscoll, JD Mezrich |
Frontiers in immunology | 2018 |
|
Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
CJ Simeonovic, SK Popp, LM Starrs, DJ Brown, AF Ziolkowski, B Ludwig, SR Bornstein, JD Wilson, A Pugliese, TW Kay, HE Thomas, T Loudovaris, FJ Choong, C Freeman, CR Parish, P Fiorina |
PloS one | 2018 |
|
RepSeq Data Representativeness and Robustness Assessment by Shannon Entropy
W Chaara, A Gonzalez-Tort, LM Florez, D Klatzmann, E Mariotti-Ferrandiz, A Six |
Frontiers in immunology | 2018 |
|
Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes
SI Mannering, AR Carluccio, CM Elso |
Diabetologia | 2018 |
|
Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications
J Sidney, JL Vela, D Friedrich, R Kolla, M von Herrath, JD Wesley, A Sette |
BMC Immunology | 2018 |
|
TCRmodel: high resolution modeling of T cell receptors from sequence
R Gowthaman, BG Pierce |
Nucleic Acids Research | 2018 |
|
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
M Buitinga, A Callebaut, FM Sodré, I Crèvecoeur, G Blahnik-Fagan, ML Yang, M Bugliani, D Arribas-Layton, M Marré, DP Cook, E Waelkens, R Mallone, JD Piganelli, P Marchetti, MJ Mamula, R Derua, EA James, C Mathieu, L Overbergh |
Diabetes | 2018 |
|
Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
AK Bhandage, Z Jin, SV Korol, AS Tafreshiha, P Gohel, C Hellgren, D Espes, PO Carlsson, I Sundström-Poromaa, B Birnir, IB Hogue |
PloS one | 2018 |
|
Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response
M Clark, CJ Kroger, RM Tisch |
Frontiers in immunology | 2017 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)