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Citations to this article

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity
Bo Li, … , Mark P. Boldin, Lili Yang
Bo Li, … , Mark P. Boldin, Lili Yang
Published September 5, 2017
Citation Information: J Clin Invest. 2017;127(10):3702-3716. https://doi.org/10.1172/JCI94012.
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Research Article Autoimmunity Immunology Article has an altmetric score of 2

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity

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Abstract

Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive Th17 cells and organ-specific autoimmunity remains largely unknown. Here, we have reported that miR-146a–deficient mice developed more severe experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS). We bred miR-146a–deficient mice with 2D2 T cell receptor–Tg mice to generate 2D2 CD4 T cells that are deficient in miR-146a and specific for myelin oligodendrocyte glycoprotein (MOG), an autoantigen in the EAE model. miR-146a–deficient 2D2 T cells induced more severe EAE and were more prone to differentiate into Th17 cells. Microarray analysis revealed enhancements in IL-6– and IL-21–induced Th17 differentiation pathways in these T cells. Further study showed that miR-146a inhibited the production of autocrine IL-6 and IL-21 in 2D2 T cells, which in turn reduced their Th17 differentiation. Thus, our study identifies miR-146a as an important molecular brake that blocks the autocrine IL-6– and IL-21–induced Th17 differentiation pathways in autoreactive CD4 T cells, highlighting its potential as a therapeutic target for treating autoimmune diseases.

Authors

Bo Li, Xi Wang, In Young Choi, Yu-Chen Wang, Siyuan Liu, Alexander T. Pham, Heesung Moon, Drake J. Smith, Dinesh S. Rao, Mark P. Boldin, Lili Yang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 Total
Citations: 3 7 5 15 19 17 6 7 79
Citation information
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Citations to this article in year 2019 (6)

Title and authors Publication Year
MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy
B Li, C Dasgupta, L Huang, X Meng, L Zhang
Cellular and Molecular Immunology 2019
The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis
A Ahmad, J de Camargo Vieira, AH de Mello, TM de Lima, SK Ariga, DF Barbeiro, HV Barbeiro, B Szczesny, G Törö, N Druzhyna, EB Randi, M Marcatti, T Toliver-Kinsky, A Kiss, L Liaudet, R Salomao, FG Soriano, C Szabo
Pharmacological research : the official journal of the Italian Pharmacological Society 2019
Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis
ZH Li, YF Wang, DD He, XM Zhang, YL Zhou, H Yue, S Huang, Z Fu, LY Zhang, ZQ Mao, S Li, CY Zhang, , J Fu
Aging 2019
Multiple roles of microRNA‑146a in immune responses and hepatocellular carcinoma (Review)
H Wang, X Li, T Li, L Wang, X Wu, J Liu, Y Xu, W Wei
Oncology Letters 2019
Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model
H Mai, W Fan, Y Wang, Y Cai, X Li, F Chen, X Chen, J Yang, P Tang, H Chen, T Zou, T Hong, C Wan, B Zhao, L Cui
Molecular Therapy — Nucleic Acids 2019
Creatine uptake regulates CD8 T cell antitumor immunity
SD Biase, X Ma, , J Yu, YC Wang, DJ Smith, Y Zhou, Z Li, YJ Kim, N Clarke, A To, L Yang
Journal of Experimental Medicine 2019

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