Blood vessels have a unified mission to circulate blood throughout the body; however, they have additional diverse and specialized roles in various organs. For example, in the liver, discontinuous sinusoids, which are fenestrated capillaries with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules to highly metabolic hepatocytes. During embryonic development, discontinuous sinusoids also allow circulating hematopoietic progenitor and stem cells to populate the liver and promote blood cell differentiation. In this issue of the
Courtney T. Griffin, Siqi Gao
Title and authors | Publication | Year |
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Bioengineering vascularization
Landau S, Okhovatian S, Zhao Y, Liu C, Shakeri A, Wang Y, Ramsay K, Kieda J, Jiang R, Radisic M |
Development (Cambridge, England) | 2024 |
Pharmacokinetics of Biopharmaceuticals: Their Critical Role in Molecular Design
Ogihara T, Mizoi K, Ishii-Watabe A |
Biomedicines | 2023 |
Endothelial CD34 expression and regulation of immune cell response in-vitro.
Arakelian L, Lion J, Churlaud G, Bargui R, Thierry B, Mutabazi E, Bruneval P, Alberdi AJ, Doliger C, Veyssiere M, Larghero J, Mooney N |
Scientific Reports | 2023 |
Systemic mapping of organ plasma extravasation at multiple stages of chronic heart failure
Kitzerow O, Suder P, Shukry M, Lisco SJ, Zucker IH, Wang HJ |
Frontiers in physiology | 2023 |
Endothelial Cell Metabolism in Vascular Functions
A Filippini, L Tamagnone, A DAlessio |
Cancers | 2022 |
Therapeutic Effect of Polymeric Nanomicelles Formulation of LY2157299-Galunisertib on CCl4-Induced Liver Fibrosis in Rats
Panzarini E, Leporatti S, Tenuzzo BA, Quarta A, Hanafy NA, Giannelli G, Moliterni C, Vardanyan D, Sbarigia C, Fidaleo M, Tacconi S, Dini L |
Journal of Personalized Medicine | 2022 |
Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C–CDH5 inhibition
Sung DC, Chen M, Dominguez MH, Mahadevan A, Chen X, Yang J, Gao S, Ren AA, Tang AT, Mericko P, Patton R, Lee M, Jannaway M, Nottebaum A, Vestweber D, Scallan JP, Kahn ML |
2022 | |
Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis
W de Haan, W Dheedene, K Apelt, S Décombas-Deschamps, S Vinckier, S Verhulst, A Conidi, T Deffieux, M Staring, P Vandervoort, E Caluwé, M Lox, I Mannaerts, T Takagi, J Jaekers, G Berx, J Haigh, B Topal, A Zwijsen, Y Higashi, L van Grunsven, W van IJcken, E Mulugeta, M Tanter, F Lebrin, D Huylebroeck, A Luttun |
Cardiovascular Research | 2021 |
The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
C Peghaire, NP Dufton, M Lang, II Salles-Crawley, J Ahnström, V Kalna, C Raimondi, C Pericleous, L Inuabasi, R Kiseleva, VR Muzykantov, JC Mason, GM Birdsey, AM Randi |
Nature Communications | 2019 |
Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells
J Tee, L Ng, H Koh, D Leong, H Ho |
International journal of molecular sciences | 2018 |