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Usage Information

Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease
Elizabeth Parks, … , Hannele Yki-Järvinen, Meredith Hawkins
Elizabeth Parks, … , Hannele Yki-Järvinen, Meredith Hawkins
Published January 23, 2017
Citation Information: J Clin Invest. 2017;127(2):454-456. https://doi.org/10.1172/JCI92407.
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Commentary

Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.

Authors

Elizabeth Parks, Hannele Yki-Järvinen, Meredith Hawkins

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 784 1,082
PDF 104 37
Figure 96 7
Citation downloads 73 0
Totals 1,057 1,126
Total Views 2,183
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