Usage Information

Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease
Elizabeth Parks, … , Hannele Yki-Järvinen, Meredith Hawkins
Elizabeth Parks, … , Hannele Yki-Järvinen, Meredith Hawkins
Published January 23, 2017
Citation Information: J Clin Invest. 2017;127(2):454-456. https://doi.org/10.1172/JCI92407.
View: Text | PDF
Commentary

Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.

Authors

Elizabeth Parks, Hannele Yki-Järvinen, Meredith Hawkins

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 787 1,082
PDF 104 37
Figure 96 7
Citation downloads 73 0
Totals 1,060 1,126
Total Views 2,186
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement