Commentary 10.1172/JCI91880

How does leptin restore euglycemia in insulin-deficient diabetes?

Douglas Oberlin and Christoph Buettner

Department of Medicine and Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Address correspondence to: Christoph Buettner, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, New York 10029, USA. Phone: 212.241.3425; E-mail: christoph.buettner@mssm.edu.

Find articles by Oberlin, D. in: JCI | PubMed | Google Scholar

Department of Medicine and Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Address correspondence to: Christoph Buettner, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, New York 10029, USA. Phone: 212.241.3425; E-mail: christoph.buettner@mssm.edu.

Find articles by Buettner, C. in: JCI | PubMed | Google Scholar

First published January 23, 2017 - More info

Published in Volume 127, Issue 2 (February 1, 2017)
J Clin Invest. 2017;127(2):450–453. doi:10.1172/JCI91880.
Copyright © 2017, American Society for Clinical Investigation

First published January 23, 2017

See the related article at Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis.

Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.

Preview pages

Reset
Page preview
451 Page 450 Back

Continue reading with a subscription.

A subscription is required for you to read this article in full. If you are a subscriber, you may sign in to continue reading.

Already subscribed?

Click here to sign into your account.

Don't have a subscription?

Please select one of the subscription options, which includes a low-cost option just for this article.

At an institution or library?

If you are at an institution or library and believe you should have access, please check with your librarian or administrator (more information).

Problems?

Please try these troubleshooting tips.

  • Purchase this article
  • $10
  • Purchasing this article will give you full access for the calendar year.
  • Purchase article
  • Purchase Site Pass
  • $25
  • This will give you access to every article on the site for 24 hours.
  • Order site pass
  • Online subscription
  • $95
  • Individual online subscriptions give you full online access for the calendar year.
  • Order Online
  • Print subscription
  • $795
  • Individual print subscriptions give you the print journal and full online access for the year.
  • Print + Online
  • JCI This Month subscription
  • $125
  • JCI This Month is a 16- to 20-page overview of the articles published each month
  • Subscribing to JCI This Month also gives subscribers full online access for the calendar year.
  • *Price outside U.S. and Canada: $225.
  • JCI This Month + Online
Advertisement