Citations to this article

How does leptin restore euglycemia in insulin-deficient diabetes?
Douglas Oberlin, Christoph Buettner
Douglas Oberlin, Christoph Buettner
Published January 23, 2017
Citation Information: J Clin Invest. 2017;127(2):450-453. https://doi.org/10.1172/JCI91880.
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How does leptin restore euglycemia in insulin-deficient diabetes?

Abstract

Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.

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Douglas Oberlin, Christoph Buettner

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Citations to this article (7)

Title and authors Publication Year
Leptin in the Commissural Nucleus of the Tractus Solitarius (cNTS) and Anoxic Stimulus in the Carotid Body Chemoreceptors Increases cNTS Leptin Signaling Receptor and Brain Glucose Retention in Rats
M Lemus, C Mojarro, S Montero, M Ramírez-Flores, J Torres-Magallanes, A Maturano-Melgoza, E de Álvarez-Buylla 		Medicina 2022
A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
S Fan, Y Xu, Y Lu, Z Jiang, H Li, JC Morrill, J Cai, Q Wu, Y Xu, M Xue, BR Arenkiel, C Huang, Q Tong 		Nature Communications 2021
Chronic Antidiabetic Actions of Leptin: Evidence From Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor
AA da Silva, JE Hall, X Dai, Z Wang, MC Salgado, JM do Carmo 		Diabetes 2021
Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism
S Pereira, DL Cline, MM Glavas, SD Covey, TJ Kieffer 		Endocrine reviews 2020
The endocrine function of adipose tissues in health and cardiometabolic disease
L Scheja, J Heeren 		Nature Reviews Endocrinology 2019
The circulating metabolome of human starvation
Matthew Steinhauser, Benjamin Olenchock, John O'Keefe, Mingyue Lun, Kerry Pierce, Hang Lee, Lorena Pantano, Anne Klibanski, Gerald I. Shulman, Clary Clish, Pouneh Fazeli 		JCI Insight 2018
Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor
DM Cohen, DJ Steger 		Trends in Endocrinology & Metabolism 2017

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