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Prevention of preeclampsia
Chad A. Grotegut
Chad A. Grotegut
Published November 14, 2016
Citation Information: J Clin Invest. 2016;126(12):4396-4398. https://doi.org/10.1172/JCI91300.
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Prevention of preeclampsia

Abstract

Preeclampsia is a common complication of pregnancy that is associated with an increased risk of maternal and neonatal morbidity and mortality. Currently, delivery is the only cure for preeclampsia; therefore, effective prevention and treatment options for this condition are sorely needed. In the current issue of the JCI, Mirzakhani et al. report the findings of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), a well-conducted large, randomized, double-blind, placebo-controlled trial of vitamin D supplementation for the prevention of preeclampsia. Though vitamin D supplementation had no effect on the risk of preeclampsia, reduced maternal serum vitamin D levels did correlate with preeclampsia risk. Mirzakhani and colleagues identified a number of gene pathways that are differentially regulated among women with low serum vitamin D levels who develop preeclampsia. These results indicate that further research on the role of vitamin D in preeclampsia is warranted.

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Chad A. Grotegut

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Citations to this article (11)

Title and authors Publication Year
Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface
Fei H, Lu X, Shi Z, Liu X, Yang C, Zhu X, Lin Y, Jiang Z, Wang J, Huang D, Liu L, Zhang S, Jiang L 		eLife 2025
Vitamin D supplementation for women during pregnancy
Palacios C, Kostiuk LL, Cuthbert A, Weeks J 		The Cochrane Database of Systematic Reviews 2024
FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway
Xu X, Ye X, Zhu M, Zhang Q, Li X, Yan J 		BMC pregnancy and childbirth 2023
NLRP3 inflammasome in peripheral blood monocytes as a risk factor for early -onset preeclampsia
Yang H, Ai M, Guo Y, Li B, Liu C, Qu D 		BMC pregnancy and childbirth 2023
MiR-133a-3p Relieves the Oxidative Stress Induced Trophoblast Cell Apoptosis Through the BACH1/Nrf2/HO-1 Signaling Pathway
H Guo, Y Wang, W Jia, L Liu 		Physiological research / Academia Scientiarum Bohemoslovaca 2021
Adherence to a Dietary Approaches to Stop Hypertension (DASH)-style Diet in Relation to Preeclampsia: A Case-Control Study
Y Cao, Y Liu, X Zhao, D Duan, W Dou, W Fu, H Chen, Y Bo, Y Qiu, G Chen, Q Lyu 		Scientific Reports 2020
A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway
L Xue, K Xie, L Wu, X Yu, W Long, C Li, R Jia, H Ding 		International journal of molecular medicine 2020
Vitamin D supplementation for women during pregnancy
C Palacios, LK Kostiuk, JP Peña-Rosas 		Cochrane Database of Systematic Reviews 2019
GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway
WS Lai, YL Ding 		International journal of molecular medicine 2019
Regimens of vitamin D supplementation for women during pregnancy
C Palacios, MA Trak-Fellermeier, RX Martinez, L Lopez-Perez, P Lips, JA Salisi, JC John, JP Peña-Rosas 		Cochrane Database of Systematic Reviews 2019
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd 		Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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