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Inge R. Holtman, … , Dylan Skola, Christopher K. Glass
Published July 31, 2017
Citation Information: J Clin Invest. 2017;127(9):3220-3229. https://doi.org/10.1172/JCI90604.
Citation Information: J Clin Invest. 2017;127(9):3220-3229. https://doi.org/10.1172/JCI90604.
Abstract
Microglia are the main resident macrophage population of the CNS and perform numerous functions required for CNS development, homeostasis, immunity, and repair. Many lines of evidence also indicate that dysregulation of microglia contributes to the pathogenesis of neurodegenerative and behavioral diseases. These observations provide a compelling argument to more clearly define the mechanisms that control microglia identity and function in health and disease. In this Review, we present a conceptual framework for how different classes of transcription factors interact to select and activate regulatory elements that control microglia development and their responses to internal and external signals. We then describe functions of specific transcription factors in normal and pathological contexts and conclude with a consideration of open questions to be addressed in the future.
Authors
Inge R. Holtman, Dylan Skola, Christopher K. Glass
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Citations to this article (115)
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An association between mitochondria and microglia effector function: what do we think we know?
GJ Harry, G Childers, S Giridharan, IL Hernandes |
Neuroimmunology and Neuroinflammation | 2020 |
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Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth
J Wang, JW Leavenworth, AB Hjelmeland, R Smith, N Patel, B Borg, Y Si, PH King |
Glia | 2019 |
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The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies
S Thorsdottir, B Henriques-Normark, F Iovino |
Frontiers in microbiology | 2019 |
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A modular analysis of microglia gene expression, insights into the aged phenotype
CE Cho, SS Damle, EV Wancewicz, S Mukhopadhyay, CE Hart, C Mazur, EE Swayze, F Kamme |
BMC Genomics | 2019 |
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The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System
T Veremeyko, AW Yung, M Dukhinova, T Strekalova, ED Ponomarev |
Frontiers in cellular neuroscience | 2019 |
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Cx3cr1- deficient microglia exhibit a premature aging transcriptome
S Gyoneva, R Hosur, D Gosselin, B Zhang, Z Ouyang, AC Cotleur, M Peterson, N Allaire, R Challa, P Cullen, C Roberts, K Miao, TL Reynolds, CK Glass, L Burkly, RM Ransohoff |
Life science alliance | 2019 |
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Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
AL Hemonnot, J Hua, L Ulmann, H Hirbec |
Frontiers in aging neuroscience | 2019 |
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Progress in Brain Cannabinoid CB2 Receptor Research: From Genes to Behavior
CJ Jordan, |
Neuroscience and biobehavioral reviews | 2019 |
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A general computational approach to predicting synergistic transcriptional cores that determine cell subpopulation identities
S Okawa, A del Sol |
Nucleic Acids Research | 2019 |
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Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia
SR Anderson, JM Roberts, J Zhang, MR Steele, CO Romero, A Bosco, ML Vetter |
Cell Reports | 2019 |
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Long Noncoding RNA Expression Profile in BV2 Microglial Cells Exposed to Lipopolysaccharide
Y Li, Q Li, C Wang, S Li, L Yu |
BioMed Research International | 2019 |
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Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery
W Eldahshan, SC Fagan, A Ergul |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2019 |
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ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease
Woojin Jeong, Hyein Lee, Sukhee Cho, Jinsoo Seo |
Molecules and Cells | 2019 |
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Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway
C Qin, Q Liu, ZW Hu, LQ Zhou, K Shang, DB Bosco, LJ Wu, DS Tian, W Wang |
Theranostics | 2018 |
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The role of innate immunity in mucopolysaccharide diseases
H Parker, BW Bigger |
Journal of Neurochemistry | 2018 |
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Developmental roles of microglia: A window into mechanisms of disease
SR Anderson, ML Vetter |
Developmental Dynamics | 2018 |
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Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
K Inoue, M Tsuda |
Nature Reviews Neuroscience | 2018 |
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Epigenetics Control Microglia Plasticity
M Cheray, B Joseph |
Frontiers in cellular neuroscience | 2018 |
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An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa -null mice
CJ Finno, MH Bordbari, G Gianino, B Ming-Whitfield, E Burns, J Merkel, M Britton, B Durbin-Johnson, EA Sloma, M McMackin, G Cortopassi, V Rivas, M Barro, CK Tran, I Gennity, H Habib, L Xu, B Puschner, AD Miller |
Free radical biology & medicine | 2018 |
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Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish
JR Morrice, CY Gregory-Evans, CA Shaw |
Scientific Reports | 2018 |
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