Microglia are the main resident macrophage population of the CNS and perform numerous functions required for CNS development, homeostasis, immunity, and repair. Many lines of evidence also indicate that dysregulation of microglia contributes to the pathogenesis of neurodegenerative and behavioral diseases. These observations provide a compelling argument to more clearly define the mechanisms that control microglia identity and function in health and disease. In this Review, we present a conceptual framework for how different classes of transcription factors interact to select and activate regulatory elements that control microglia development and their responses to internal and external signals. We then describe functions of specific transcription factors in normal and pathological contexts and conclude with a consideration of open questions to be addressed in the future.
Inge R. Holtman, Dylan Skola, Christopher K. Glass
Title and authors | Publication | Year |
---|---|---|
Enhancer Dynamics and Spatial Organization Drive Anatomically Restricted Cellular States in the Human Spinal Cord
Kandror EK, Wang A, Carriere M, Peterson A, Liao W, Tjärnberg A, Fung JH, Mahbubani KT, Loper J, Pangburn W, Xu Y, Saeb-Parsy K, Rabadan R, Maniatis T, Rizvi AH |
bioRxiv | 2025 |
Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration
Ramaswami G, Yuva-Aydemir Y, Akerberg B, Matthews B, Williams J, Golczer G, Huang J, Al Abdullatif A, Huh D, Burkly LC, Engle SJ, Sehgal A, Sigova AA, Fremeau RT Jr, Liu Y, Bumcrot D |
Scientific Reports | 2024 |
Established and emerging techniques for the study of microglia: visualization, depletion, and fate mapping.
Bobotis BC, Halvorson T, Carrier M, Tremblay MÈ |
Frontiers in cellular neuroscience | 2024 |
Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution
Donovan LJ, Bridges CM, Nippert AR, Wang M, Wu S, Forman TE, Haight ES, Huck NA, Bond SF, Jordan CE, Gardner AM, Nair RV, Tawfik VL |
Cell Reports | 2024 |
A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease.
Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Finkbeiner S, Head E, Liu Y, Jiang P |
bioRxiv : the preprint server for biology | 2024 |
HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology
Thompson LJ, Genovese J, Hong Z, Singh MV, Singh VB |
International journal of molecular sciences | 2024 |
Evolution of glial cells: a non-bilaterian perspective
Sheloukhova L, Watanabe H |
Neural development | 2024 |
The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
Tharp ME, Han CZ, Balak CD, Fitzpatrick C, O\u2019Connor C, Preissl S, Buchanan J, Nott A, Escoubet L, Mavrommatis K, Gupta M, Schwartz MS, Sang UH, Jones PS, Levy ML, Gonda DD, Ben-Haim S, Ciacci J, Barba D, Khalessi A, Coufal NG, Chen CC, Glass CK, Page DC |
2024 | |
Co-Transplantation-Based Human-Mouse Chimeric Brain Models to Study Human Glial-Glial and Glial-Neuronal Interactions
Jin M, Ma Z, Zhang H, Papetti AV, Dang R, Stillitano AC, Goldman SA, Jiang P |
2024 | |
CD11c-expressing microglia are transient, driven by interactions with apoptotic cells
Ghena N, Anderson SR, Roberts JM, Irvin E, Schwakopf J, Bosco A, Vetter ML |
2024 | |
Purinergic exposure induces epigenomic and transcriptomic-mediated preconditioning resembling epilepsy-associated microglial states
Martins-Ferreira R, Calafell-Segura J, Chaves J, Ciudad L, Martins da Silva A, Pinho e Costa P, Leal B, Ballestar E |
iScience | 2024 |
Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types.
Holtman IR, Glass CK, Nott A |
Advances in neurobiology | 2024 |
Microglia in physiological conditions and the importance of understanding their homeostatic functions in the arcuate nucleus
Guzmán-Ruíz MA, Guerrero Vargas NN, Ramírez-Carreto RJ, González-Orozco JC, Torres-Hernández BA, Valle-Rodríguez M, Guevara-Guzmán R, Chavarría A |
Frontiers in Immunology | 2024 |
Simple and highly specific targeting of resident microglia with adeno-associated virus.
Serrano C, Cananzi S, Shen T, Wang LL, Zhang CL |
iScience | 2024 |
Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation
Barbalace MC, Freschi M, Rinaldi I, Zallocco L, Malaguti M, Manera C, Ortore G, Zuccarini M, Ronci M, Cuffaro D, Macchia M, Hrelia S, Giusti L, Digiacomo M, Angeloni C |
Antioxidants | 2024 |
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Chen J, Crouch EE, Zawadzki ME, Jacobs KA, Mayo LN, Choi JJ, Lin PY, Shaikh S, Tsui J, Gonzalez-Granero S, Waller S, Kelekar A, Kang G, Valenzuela EJ, Birrueta JO, Diafos LN, Wedderburn-Pugh K, Di Marco B, Xia W, Han CZ, Coufal NG, Glass CK, Fancy SPJ, Alfonso J, Kriegstein AR, Oldham MC, Garcia-Verdugo JM, Kutys ML, Lehtinen MK, Combes AJ, Huang EJ |
Nature neuroscience | 2024 |
Batf3-cDC1 control Th1 and fungicidal responses during cryptococcal meningitis: is this enough to control meningitis?
Coelho C |
mBio | 2024 |
Epigenetic and 3D genome reprogramming during the aging of human hippocampus
Zemke NR, Lee S, Mamde S, Yang B, Berchtold N, Maximiliano Garduño B, Indralingam HS, Bartosik WM, Lau PK, Dong K, Yang A, Tani Y, Chen C, Zeng Q, Ajith V, Tong L, Seng C, Li D, Wang T, Xu X, Ren B |
bioRxiv | 2024 |
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1(+) microglial phenotype via a PPARγ-dependent mechanism.
Yuan NJ, Zhu WJ, Ma QY, Huang MY, Huo RR, She KJ, Pan JP, Wang JG, Chen JX |
Acta pharmacologica Sinica | 2024 |
The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.
Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y |
Cell death and differentiation | 2024 |
Human Microglia-Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation.
Llaves-López A, Micoli E, Belmonte-Mateos C, Aguilar G, Alba C, Marsal A, Pulido-Salgado M, Rabaneda-Lombarte N, Solà C, Serratosa J, Vidal-Taboada JM, Saura J |
Molecular neurobiology | 2024 |
Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived Microglia.
Garg A, Vo S, Brase L, Aladyeva E, Albanus RD, Nallapu A, Fu H, Harari O |
Research square | 2024 |
Spliceosomal GTPase Eftud2 regulates microglial activation and polarization.
Yang GC, Shi Y, Fan CN, Li Y, Yuan MQ, Pei J, Wu Y, Wu HT |
Neural Regeneration Research | 2023 |
Deep learning predicts the impact of regulatory variants on cell-type-specific enhancers in the brain
Zheng A, Shen Z, Glass CK, Gymrek M |
2023 | |
Transcriptomic analysis reveals the immune response of human microglia to a soy protein and collagen hybrid bioscaffold
Yao L, Blasi J, Shippy T, Brice R |
Heliyon | 2023 |
Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements
Anderson AG, Rogers BB, Loupe JM, Rodriguez-Nunez I, Roberts SC, White LM, Brazell JN, Bunney WE, Bunney BG, Watson SJ, Cochran JN, Myers RM, Rizzardi LF |
2023 | |
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, Tomita T |
iScience | 2023 |
Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
Garcia-Bonilla L, Shahanoor Z, Sciortino R, Nazarzoda O, Racchumi G, Iadecola C, Anrather J |
2023 | |
Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids.
Mossine VV, Waters JK, Sun GY, Gu Z, Mawhinney TP |
Molecular Neurobiology | 2023 |
Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease.
Sobue A, Komine O, Yamanaka K |
Ensho Saisei | 2023 |
Human microglia show unique transcriptional changes in Alzheimer's disease.
Prater KE, Green KJ, Mamde S, Sun W, Cochoit A, Smith CL, Chiou KL, Heath L, Rose SE, Wiley J, Keene CD, Kwon RY, Snyder-Mackler N, Blue EE, Logsdon B, Young JE, Shojaie A, Garden GA, Jayadev S |
2023 | |
Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing
Yaqubi M, Groh AM, Dorion MF, Afanasiev E, Luo JX, Hashemi H, Sinha S, Kieran NW, Blain M, Cui QL, Biernaskie J, Srour M, Dudley R, Hall JA, Sonnen JA, Arbour N, Prat A, Stratton JA, Antel J, Healy LM |
Journal of Neuroinflammation | 2023 |
Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension
Wagner VA, Deng G, Claflin KE, Ritter ML, Cui H, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL, Kwitek AE |
Frontiers in cellular neuroscience | 2023 |
Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
Hong SY, Lu YT, Chen SY, Hsu CF, Lu YC, Wang CY, Huang KL |
Cell Death and Disease | 2023 |
Microglial Responses to Stress-Induced Depression: Causes and Consequences
Afridi R, Suk K |
Cells | 2023 |
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.
Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK |
Nature Immunology | 2023 |
Microglia in the context of multiple sclerosis
Zhang X, Chen F, Sun M, Wu N, Liu B, Yi X, Ge R, Fan X |
Frontiers in neurology | 2023 |
Omega-3 Polyunsaturated Fatty Acids Protect Neurological Function After Traumatic Brain Injury by Suppressing Microglial Transformation to the Proinflammatory Phenotype and Activating Exosomal NGF/TrkA Signaling.
Lin L, Zheng S, Lai J, Ye D, Huang Q, Wu Z, Chen X, Wang S |
Molecular Neurobiology | 2023 |
Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes.
Gainullina A, Mogilenko DA, Huang LH, Todorov H, Narang V, Kim KW, Yng LS, Kent A, Jia B, Seddu K, Krchma K, Wu J, Crozat K, Tomasello E, Dress R, See P, Scott C, Gibbings S, Bajpai G, Desai JV, Maier B, This S, Wang P, Aguilar SV, Poupel L, Dussaud S, Zhou TA, Angeli V, Blander JM, Choi K, Dalod M, Dzhagalov I, Gautier EL, Jakubzick C, Lavine K, Lionakis MS, Paidassi H, Sieweke MH, Ginhoux F, Guilliams M, Benoist C, Merad M, Randolph GJ, Sergushichev A, Artyomov MN |
Cell Reports | 2023 |
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
Pesämaa I, Müller SA, Robinson S, Darcher A, Paquet D, Zetterberg H, Lichtenthaler SF, Haass C |
Molecular Neurodegeneration | 2023 |
Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation
Schmassmann P, Roux J, Dettling S, Hogan S, Shekarian T, Martins TA, Ritz MF, Herter S, Bacac M, Hutter G |
eLife | 2023 |
Simple and Highly Specific Targeting of Resident Microglia with Adeno-Associated Virus.
Serrano C, Cananzi S, Shen T, Wang LL, Zhang CL |
bioRxiv : the preprint server for biology | 2023 |
Eriocalyxin B alleviated ischemic cerebral injury by limiting microglia-mediated excessive neuroinflammation in mice
Chen Y, Zhang C, Zhao L, Chen R, Zhang P, Li J, Zhang X, Zhang X |
Experimental Animals | 2023 |
Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma
R do Nascimento, B dos Santos, J Amparo, J Soares, K da Silva, M Santana, Á Almeida, V da Silva, M de Fátima Dias Costa, H Ulrich, V Moura-Neto, G de Faria Lopes, S Costa |
Pharmaceutics | 2022 |
Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain
S Tansley, S Uttam, A Guzmán, M Yaqubi, A Pacis, M Parisien, H Deamond, C Wong, O Rabau, N Brown, L Haglund, J Ouellet, C Santaguida, A Ribeiro-da-Silva, S Tahmasebi, M Prager-Khoutorsky, J Ragoussis, J Zhang, M Salter, L Diatchenko, L Healy, J Mogil, A Khoutorsky |
Nature Communications | 2022 |
Natural Products as Novel Neuroprotective Agents; Computational Predictions of the Molecular Targets, ADME Properties, and Safety Profile
S Alghamdi, R Suliman, N Aljammaz, K Kahtani, D Aljatli, G Albadrani |
Plants | 2022 |
Epigenetic regulation of innate immune memory in microglia
X Zhang, L Kracht, A Lerario, M Dubbelaar, N Brouwer, E Wesseling, E Boddeke, B Eggen, S Kooistra |
Journal of Neuroinflammation | 2022 |
Polarization of Microglia and Its Therapeutic Potential in Sepsis
L Castro, C Gonçalves-de-Albuquerque, A Silva |
International journal of molecular sciences | 2022 |
Neuroinflammation and galectins: a key relationship in neurodegenerative diseases
E Hernández, B Olvera, D González, O Marín, D Mercado, L Gil, L Hernández-Zimbrón, J Salgado, I Limón, E Zenteno |
Glycoconjugate Journal | 2022 |
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level
Wang F, Ding P, Liang X, Ding X, Brandt CB, Sjöstedt E, Zhu J, Bolund S, Zhang L, de Rooij LP, Luo L, Wei Y, Zhao W, Lv Z, Haskó J, Li R, Qin Q, Jia Y, Wu W, Yuan Y, Pu M, Wang H, Wu A, Xie L, Liu P, Chen F, Herold J, Kalucka J, Karlsson M, Zhang X, Helmig RB, Fagerberg L, Lindskog C, Pontén F, Uhlen M, Bolund L, Jessen N, Jiang H, Xu X, Yang H, Carmeliet P, Mulder J, Chen D, Lin L, Luo Y |
Nature Communications | 2022 |
Microglia-derived CCL2 has a prime role in neocortex neuroinflammation
Errede M, Annese T, Petrosino V, Longo G, Girolamo F, de Trizio I, d\u2019Amati A, Uccelli A, Kerlero de Rosbo N, Virgintino D |
Fluids and barriers of the CNS | 2022 |
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder
Sreeram S, Ye F, Garcia-Mesa Y, Nguyen K, El Sayed A, Leskov K, Karn J |
Trends in Immunology | 2022 |
Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P |
Cell Stem Cell | 2022 |
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP.
Cui J, Meshesha M, Churgulia N, Merlo C, Fuchs E, Breakey J, Jones J, Stivers JT |
Retrovirology | 2022 |
Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders
Mills J, Ladner L, Soliman E, Leonard J, Morton PD, Theus MH |
Cells | 2022 |
The Role of Interferon Regulatory Factor 1 in Regulating Microglial Activation and Retinal Inflammation
Yang X, Diaz V, Huang H |
International journal of molecular sciences | 2022 |
More than meets the eye: The role of microglia in healthy and diseased retina
Murenu E, Gerhardt MJ, Biel M, Michalakis S |
Frontiers in immunology | 2022 |
Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.
Han RT, Vainchtein ID, Schlachetzki JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV |
Journal of Experimental Medicine | 2022 |
TREM2 dependent and independent functions of microglia in Alzheimer's disease.
Hou J, Chen Y, Grajales-Reyes G, Colonna M |
Molecular Neurodegeneration | 2022 |
The role of DNA methylation in progression of neurological disorders and neurodegenerative diseases as well as the prospect of using DNA methylation inhibitors as therapeutic agents for such disorders
Rasmi Y, Shokati A, Hassan A, Aziz SG, Bastani S, Jalali L, Moradi F, Alipour S |
2022 | |
Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products
Angeloni C, Malaguti M, Prata C, Freschi M, Barbalace MC, Hrelia S |
Antioxidants | 2022 |
Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis
Nechanitzky R, Nechanitzky D, Ramachandran P, Duncan GS, Zheng C, Göbl C, Gill KT, Haight J, Wakeham AC, Snow BE, Bradaschia-Correa V, Ganguly M, Lu Z, Saunders ME, Flavell RA, Mak TW |
Cell Death and Differentiation | 2022 |
Physiological and Pathological Inflammation Induced by Antibodies and Pentraxins
CE Geyer, L Mes, M Newling, J den Dunnen, W Hoepel |
Cells | 2021 |
Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement
R Morini, M Bizzotto, F Perrucci, F Filipello, M Matteoli |
Frontiers in immunology | 2021 |
Role of microglia and P2X4 receptors in chronic pain
K Kohno, M Tsuda |
PAIN Reports | 2021 |
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response
AA Pimenova, M Herbinet, I Gupta, SI Machlovi, KR Bowles, E Marcora, AM Goate |
Neurobiology of Disease | 2021 |
Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
L Friess, M Cheray, L Keane, K Grabert, B Joseph |
Molecular brain | 2021 |
Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
L Wang, CC Yu, XY Liu, XN Deng, Q Tian, YJ Du, LJ Wu |
Neural plasticity | 2021 |
p38 MAP Kinase Signaling in Microglia Plays a Sex-Specific Protective Role in CNS Autoimmunity and Regulates Microglial Transcriptional States
MM McGill, AR Richman, JR Boyd, B Sabikunnahar, KG Lahue, TL Montgomery, S Caldwell, S Varnum, S Frietze, DN Krementsov |
Frontiers in immunology | 2021 |
Alterations in Chromatin Structure and Function in the Microglia
Y Fujita, T Yamashita |
Frontiers in Cell and Developmental Biology | 2021 |
Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia
BP Gaire |
Cellular and Molecular Neurobiology | 2021 |
Epigenetics and Communication Mechanisms in Microglia Activation with a View on Technological Approaches
S Petralla, FD Chirico, A Miti, O Tartagni, F Massenzio, E Poeta, M Virgili, G Zuccheri, B Monti |
Biomolecules | 2021 |
Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder
ML Seney, SM Kim, JR Glausier, MA Hildebrand, X Xue, W Zong, J Wang, MA Shelton, BD Phan, C Srinivasan, AR Pfenning, GC Tseng, DA Lewis, Z Freyberg, RW Logan |
Biological Psychiatry | 2021 |
Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia
L Lian, Y Zhang, L Liu, L Yang, Y Cai, J Zhang, S Xu |
Frontiers in molecular neuroscience | 2021 |
Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
S Bido, S Muggeo, L Massimino, MJ Marzi, SG Giannelli, E Melacini, M Nannoni, D Gambarè, E Bellini, G Ordazzo, G Rossi, C Maffezzini, A Iannelli, M Luoni, M Bagicaluppi, S Gregori, F Nicassio, V Broccoli |
Nature Communications | 2021 |
Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia
F Yan, X Cheng, M Zhao, S Gong, Y Han, L Ding, D Wu, Y Luo, W Zuo, L Zhu, M Fan, X Ji |
BMJ (Clinical research ed.) | 2021 |
The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia
A Bhattacherjee, J Jung, S Zia, M Ho, G Eskandari-Sedighi, CD Laurent, KA McCord, A Bains, G Sidhu, S Sarkar, JR Plemel, MS Macauley |
Molecular Neurodegeneration | 2021 |
scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks
T Jin, P Rehani, M Ying, J Huang, S Liu, P Roussos, D Wang |
Genome Medicine | 2021 |
Ferulic acid attenuates microglia-mediated neuroinflammation in retinal degeneration
X Sun, P Sun, L Liu, P Jiang, Y Li |
BMC ophthalmology | 2021 |
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
A Sobue, O Komine, Y Hara, F Endo, H Mizoguchi, S Watanabe, S Murayama, T Saito, TC Saido, N Sahara, M Higuchi, T Ogi, K Yamanaka |
Acta Neuropathologica Communications | 2021 |
Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology
H Katsuki |
Pharmacology Research & Perspectives | 2021 |
Microglial Metamorphosis in Three Dimensions in Virus Limbic Encephalitis: An Unbiased Pictorial Representation Based on a Stereological Sampling Approach of Surveillant and Reactive Microglia
LS da Silva Creão, JB Neto, CM de Lima, RR dos Reis, AA de Sousa, ZA dos Santos, JA Diniz, DG Diniz, CW Diniz |
Brain Sciences | 2021 |
Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model
L Joshi, I Plastira, E Bernhart, H Reicher, A Triebl, HC Köfeler, W Sattler |
International journal of molecular sciences | 2021 |
Activated microglia do not increase 18 kDa translocator protein ( TSPO ) expression in the multiple sclerosis brain
E Nutma, E Gebro, MC Marzin, P Valk, PM Matthews, DR Owen, S Amor |
Glia | 2021 |
A ferret brain slice model of oxygen–glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes
T Wood, K Hildahl, H Helmbrecht, K Corry, D Moralejo, S Kolnik, K Prater, S Juul, E Nance |
Bioengineering & Translational Medicine | 2021 |
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
E Pasciuto, OT Burton, CP Roca, V Lagou, WD Rajan, T Theys, R Mancuso, RY Tito, L Kouser, Z Callaerts-Vegh, AG de la Fuente, T Prezzemolo, LG Mascali, A Brajic, CE Whyte, L Yshii, A Martinez-Muriana, M Naughton, A Young, A Moudra, P Lemaitre, S Poovathingal, J Raes, BD Strooper, DC Fitzgerald, J Dooley, A Liston |
Cell | 2020 |
Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era
K Borst, M Prinz |
Brain Pathology | 2020 |
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
JS Seidman, TD Troutman, M Sakai, A Gola, NJ Spann, H Bennett, CM Bruni, Z Ouyang, RZ Li, X Sun, BC Vu, MP Pasillas, KM Ego, D Gosselin, VM Link, LW Chong, RM Evans, BM Thompson, JG McDonald, M Hosseini, JL Witztum, RN Germain, CK Glass |
Immunity | 2020 |
Promising molecular targets for pharmacological therapy of neurodegenerative pathologies
ME Neganova, YR Aleksandrova, VO Nebogatikov, S Klochkov, AA Ustyugov |
Acta Naturae | 2020 |
The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target
T Okada, H Suzuki, ZD Travis, JH Zhang |
Current neuropharmacology | 2020 |
Candesartan modulates microglia activation and polarization via NF-κB signaling pathway
S Qie, Y Ran, X Lu, W Su, W Li, , W Gong, Z Liu |
International journal of immunopathology and pharmacology | 2020 |
Transcription cofactor GRIP1 differentially affects myeloid cell–driven neuroinflammation and response to IFN-β therapy
S Mimouna, DA Rollins, G Shibu, B Tharmalingam, DK Deochand, , D Oliver, Y Chinenov, I Rogatsky |
Journal of Experimental Medicine | 2020 |
RANK/RANKL/OPG Signaling in the Brain: A Systematic Review of the Literature
A Glasnović, N O'Mara, N Kovačić, D Grčević, S Gajović |
Frontiers in neurology | 2020 |
A human cell atlas of fetal gene expression
J Cao, DR ODay, HA Pliner, PD Kingsley, M Deng, RM Daza, MA Zager, KA Aldinger, R Blecher-Gonen, F Zhang, M Spielmann, J Palis, D Doherty, FJ Steemers, IA Glass, C Trapnell, J Shendure |
Science | 2020 |
Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy
C Rawlinson, S Jenkins, L Thei, ML Dallas, R Chen |
Brain Sciences | 2020 |
An association between mitochondria and microglia effector function: what do we think we know?
GJ Harry, G Childers, S Giridharan, IL Hernandes |
Neuroimmunology and Neuroinflammation | 2020 |
Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth
J Wang, JW Leavenworth, AB Hjelmeland, R Smith, N Patel, B Borg, Y Si, PH King |
Glia | 2019 |
The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies
S Thorsdottir, B Henriques-Normark, F Iovino |
Frontiers in microbiology | 2019 |
A modular analysis of microglia gene expression, insights into the aged phenotype
CE Cho, SS Damle, EV Wancewicz, S Mukhopadhyay, CE Hart, C Mazur, EE Swayze, F Kamme |
BMC Genomics | 2019 |
The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System
T Veremeyko, AW Yung, M Dukhinova, T Strekalova, ED Ponomarev |
Frontiers in cellular neuroscience | 2019 |
Cx3cr1- deficient microglia exhibit a premature aging transcriptome
S Gyoneva, R Hosur, D Gosselin, B Zhang, Z Ouyang, AC Cotleur, M Peterson, N Allaire, R Challa, P Cullen, C Roberts, K Miao, TL Reynolds, CK Glass, L Burkly, RM Ransohoff |
Life science alliance | 2019 |
Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
AL Hemonnot, J Hua, L Ulmann, H Hirbec |
Frontiers in aging neuroscience | 2019 |
Progress in Brain Cannabinoid CB2 Receptor Research: From Genes to Behavior
CJ Jordan, |
Neuroscience and biobehavioral reviews | 2019 |
A general computational approach to predicting synergistic transcriptional cores that determine cell subpopulation identities
S Okawa, A del Sol |
Nucleic Acids Research | 2019 |
Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia
SR Anderson, JM Roberts, J Zhang, MR Steele, CO Romero, A Bosco, ML Vetter |
Cell Reports | 2019 |
Long Noncoding RNA Expression Profile in BV2 Microglial Cells Exposed to Lipopolysaccharide
Y Li, Q Li, C Wang, S Li, L Yu |
BioMed Research International | 2019 |
Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery
W Eldahshan, SC Fagan, A Ergul |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2019 |
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease
Woojin Jeong, Hyein Lee, Sukhee Cho, Jinsoo Seo |
Molecules and Cells | 2019 |
Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway
C Qin, Q Liu, ZW Hu, LQ Zhou, K Shang, DB Bosco, LJ Wu, DS Tian, W Wang |
Theranostics | 2018 |
The role of innate immunity in mucopolysaccharide diseases
H Parker, BW Bigger |
Journal of Neurochemistry | 2018 |
Developmental roles of microglia: A window into mechanisms of disease
SR Anderson, ML Vetter |
Developmental Dynamics | 2018 |
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
K Inoue, M Tsuda |
Nature Reviews Neuroscience | 2018 |
Epigenetics Control Microglia Plasticity
M Cheray, B Joseph |
Frontiers in cellular neuroscience | 2018 |
An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa -null mice
CJ Finno, MH Bordbari, G Gianino, B Ming-Whitfield, E Burns, J Merkel, M Britton, B Durbin-Johnson, EA Sloma, M McMackin, G Cortopassi, V Rivas, M Barro, CK Tran, I Gennity, H Habib, L Xu, B Puschner, AD Miller |
Free radical biology & medicine | 2018 |
Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish
JR Morrice, CY Gregory-Evans, CA Shaw |
Scientific Reports | 2018 |