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Citations to this article

Intestinal fungi contribute to development of alcoholic liver disease
An-Ming Yang, … , Derrick E. Fouts, Bernd Schnabl
An-Ming Yang, … , Derrick E. Fouts, Bernd Schnabl
Published May 22, 2017
Citation Information: J Clin Invest. 2017;127(7):2829-2841. https://doi.org/10.1172/JCI90562.
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Research Article Hepatology Article has an altmetric score of 190

Intestinal fungi contribute to development of alcoholic liver disease

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Abstract

Chronic liver disease with cirrhosis is the 12th leading cause of death in the United States, and alcoholic liver disease accounts for approximately half of all cirrhosis deaths. Chronic alcohol consumption is associated with intestinal bacterial dysbiosis, yet we understand little about the contribution of intestinal fungi, or mycobiota, to alcoholic liver disease. Here we have demonstrated that chronic alcohol administration increases mycobiota populations and translocation of fungal β-glucan into systemic circulation in mice. Treating mice with antifungal agents reduced intestinal fungal overgrowth, decreased β-glucan translocation, and ameliorated ethanol-induced liver disease. Using bone marrow chimeric mice, we found that β-glucan induces liver inflammation via the C-type lectin–like receptor CLEC7A on Kupffer cells and possibly other bone marrow–derived cells. Subsequent increases in IL-1β expression and secretion contributed to hepatocyte damage and promoted development of ethanol-induced liver disease. We observed that alcohol-dependent patients displayed reduced intestinal fungal diversity and Candida overgrowth. Compared with healthy individuals and patients with non–alcohol-related cirrhosis, alcoholic cirrhosis patients had increased systemic exposure and immune response to mycobiota. Moreover, the levels of extraintestinal exposure and immune response correlated with mortality. Thus, chronic alcohol consumption is associated with an altered mycobiota and translocation of fungal products. Manipulating the intestinal mycobiome might be an effective strategy for attenuating alcohol-related liver disease.

Authors

An-Ming Yang, Tatsuo Inamine, Katrin Hochrath, Peng Chen, Lirui Wang, Cristina Llorente, Sena Bluemel, Phillipp Hartmann, Jun Xu, Yukinori Koyama, Tatiana Kisseleva, Manolito G. Torralba, Kelvin Moncera, Karen Beeri, Chien-Sheng Chen, Kim Freese, Claus Hellerbrand, Serene M.L. Lee, Hal M. Hoffman, Wajahat Z. Mehal, Guadalupe Garcia-Tsao, Ece A. Mutlu, Ali Keshavarzian, Gordon D. Brown, Samuel B. Ho, Ramon Bataller, Peter Stärkel, Derrick E. Fouts, Bernd Schnabl

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Crosstalk between liver macrophages and gut microbiota: An important component of inflammation-associated liver diseases
Zhou Z, Pan X, Li L
Frontiers in Cell and Developmental Biology 2022
The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis
Chen Y, Tang L
Frontiers in immunology 2022
Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different
Malnick SD, Alin P, Somin M, Neuman MG
International journal of molecular sciences 2022
Candida Administration in 5/6 Nephrectomized Mice Enhanced Fibrosis in Internal Organs: An Impact of Lipopolysaccharide and (1→3)-β-D-Glucan from Leaky Gut.
Tungsanga S, Udompornpitak K, Worasilchai J, Ratana-Aneckchai T, Wannigama DL, Katavetin P, Leelahavanichkul A
International journal of molecular sciences 2022
The Ethanolic Extract of Lindera aggregata Modulates Gut Microbiota Dysbiosis and Alleviates Ethanol-Induced Acute Liver Inflammation and Oxidative Stress SIRT1/Nrf2/NF-κB Pathway
Zhao X, Tan M, He Y, Pan Y, Fan X, Ye L, Liu L, Fu L
Oxidative medicine and cellular longevity 2022
Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota
Hou X, Rong C, Zhang Q, Song S, Cong Y, Zhang HT
The International Journal of Neuropsychopharmacology 2022
Fungal infections and the fungal microbiome in hepatobiliary disorders.
Hartmann P, Schnabl B
Journal of Hepatology 2022
Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease
Wu X, Fan X, Miyata T, Kim A, Cajigas-Du Ross CK, Ray S, Huang E, Taiwo M, Arya R, Wu J, Nagy LE
Annual review of pathology 2022
IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis
Szabo G, Mitchell M, McClain CJ, Dasarathy S, Barton B, McCullough AJ, Nagy LE, Kroll-Desrosiers A, Tornai D, Min HA, Radaeva S, Holbein ME, Casey L, Cuthbert J
Hepatology 2022
Alterations of the gut mycobiome in patients with MS
S Shah, A Locca, Y Dorsett, C Cantoni, L Ghezzi, Q Lin, S Bokoliya, H Panier, C Suther, M Gormley, Y Liu, E Evans, R Mikesell, K Obert, A Salter, AH Cross, PI Tarr, A Lovett-Racke, L Piccio, Y Zhou
EBioMedicine 2021
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice
H Chu, L Jiang, B Gao, N Gautam, JA Alamoudi, S Lang, Y Wang, Y Duan, Y Alnouti, EE Cable, B Schnabl
Translational research : the journal of laboratory and clinical medicine 2021
Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases
SP Sharma, KT Suk, DJ Kim
World journal of gastroenterology : WJG 2021
A perspective of intestinal immune-microbiome interactions in alcohol-associated Liver Disease
R Bruellman
International journal of biological sciences 2021
The Gut–Liver Axis in Chronic Liver Disease: A Macrophage Perspective
KD Muynck, B Vanderborght, HV Vlierberghe, L Devisscher
Cells 2021
The gut commensal fungus, Candida parapsilosis, promotes high fat-diet induced obesity in mice
S Sun, L Sun, K Wang, S Qiao, X Zhao, X Hu, W Chen, S Zhang, H Li, H Dai, H Liu
2021
Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies
I Doron, I Leonardi, XV Li, WD Fiers, A Semon, M Bialt-DeCelie, M Migaud, IH Gao, WY Lin, T Kusakabe, A Puel, ID Iliev
Cell 2021
The Mammalian Metaorganism: A Holistic View on How Microbes of All Kingdoms and Niches Shape Local and Systemic Immunity
S Runge, SP Rosshart
Frontiers in immunology 2021
Gut non-bacterial microbiota contributing to alcohol-associated liver disease
W Gao, Y Zhu, J Ye, H Chu
Gut microbes 2021
Host–Microbiota Interactions in Liver Inflammation and Cancer
J Giraud, M Saleh
Cancers 2021
Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities
X Wu, Y Xia, F He, C Zhu, W Ren
Microbiome 2021
In vitro infection models to study fungal–host interactions
A Last, M Maurer, AS Mosig, MS Gresnigt, B Hube
FEMS Microbiology Reviews 2021
Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases
A Bruneau, J Hundertmark, A Guillot, F Tacke
Frontiers in Medicine 2021
Cirrhosis-associated immune dysfunction
A Albillos, R Martin-Mateos, SV der Merwe, R Wiest, R Jalan, M Álvarez-Mon
Nature Reviews Gastroenterology & Hepatology 2021
Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction
T Sauerbruch, M Hennenberg, J Trebicka, U Beuers
Frontiers in physiology 2021
Current and Emerging Approaches for Hepatic Fibrosis Treatment
J Li, B Tuo, S Gitto
Gastroenterology Research and Practice 2021
Prevalence, Predictors, and Outcomes of Esophageal Candidiasis in Cirrhosis: An Observational Study With Systematic Review and Meta-Analysis (CANDID-VIEW)
N Verma, S Mishra, S Singh, A De, M Premkumar, S Taneja, A Duseja, V Singh
Journal of Clinical and Experimental Hepatology 2021
Appendectomy Is Associated With Alteration of Human Gut Bacterial and Fungal Communities
S Cai, Y Fan, B Zhang, J Lin, X Yang, Y Liu, J Liu, J Ren, H Xu
Frontiers in microbiology 2021
Candida Administration Worsens Uremia-Induced Gut Leakage in Bilateral Nephrectomy Mice, an Impact of Gut Fungi and Organismal Molecules in Uremia
W Panpetch, C Kullapanich, CP Dang, P Visitchanakun, W Saisorn, J Wongphoom, DL Wannigama, A Thim-uam, K Patarakul, N Somboonna, S Tumwasorn, A Leelahavanichkul, R Alegado
mSystems 2021
The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?
BL Daré, PJ Ferron, T Gicquel
International journal of molecular sciences 2021
Integrated Analyses of the Gut Microbiota, Intestinal Permeability, and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
F Yang, J Wei, M Shen, Y Ding, Y Lu, HM Ishaq, D Li, D Yan, Q Wang, R Zhang, SJ Liu
Applied and environmental microbiology 2021
Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder
P Hartmann, S Lang, S Zeng, Y Duan, X Zhang, Y Wang, M Bondareva, A Kruglov, DE Fouts, P Stärkel, B Schnabl
Frontiers in physiology 2021
An Introduction to Next Generation Sequencing Bioinformatic Analysis in Gut Microbiome Studies
B Gao, L Chi, Y Zhu, X Shi, P Tu, B Li, J Yin, N Gao, W Shen, B Schnabl
Biomolecules 2021
Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival
A Ren, Z Li, X Zhang, R Deng, Y Ma
Journal of inflammation research 2021
Human Gut Microbiome and Liver Diseases: From Correlation to Causation
R Li, Z Mao, X Ye, T Zuo
Microorganisms 2021
Fecal Fungal Dysbiosis in Chinese Patients With Alzheimer’s Disease
Z Ling, M Zhu, X Liu, L Shao, Y Cheng, X Yan, R Jiang, S Wu
Frontiers in Cell and Developmental Biology 2021
Gut dysbiosis as a driver in alcohol-induced liver injury
B Fairfield, B Schnabl
2021
Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features
L Lv, S Gu, H Jiang, R Yan, Y Chen, Y Chen, R Luo, C Huang, H Lu, B Zheng, H Zhang, J Xia, L Tang, G Sheng, L Li
2021
Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases
ID Iliev, K Cadwell
Gastroenterology 2021
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury
X Pan, L Wang, H You, M Cheng, Y Yang, C Huang, J Li
Laboratory Investigation 2021
Fungi–Bacteria Correlation in Alcoholic Hepatitis Patients
B Gao, X Zhang, B Schnabl
Toxins 2021
Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice
Y Zhang, Q Jia, C Hu, M Han, Q Guo, S Li, C Bo, Y Zhang, X Qi, L Sai, C Peng
Toxicology Research 2021
Gut Microbiota and NAFLD: Pathogenetic Mechanisms, Microbiota Signatures, and Therapeutic Interventions
T Hrncir, L Hrncirova, M Kverka, R Hromadka, V Machova, E Trckova, K Kostovcikova, P Kralickova, J Krejsek, H Tlaskalova-Hogenova
Microorganisms 2021
Circulating β- d -Glucan as a Marker of Subclinical Coronary Plaque in Antiretroviral Therapy-Treated People With Human Immunodeficiency Virus
S Isnard, B Fombuena, M Sadouni, J Lin, C Richard, B Routy, J Ouyang, R Ramendra, X Peng, Y Zhang, M Finkelman, D Tremblay-Sher, C Tremblay, C Chartrand-Lefebvre, M Durand, JP Routy
Open Forum Infectious Diseases 2021
Candida Administration in Bilateral Nephrectomy Mice Elevates Serum (1→3)-β-D-glucan That Enhances Systemic Inflammation Through Energy Augmentation in Macrophages
J Issara-Amphorn, CP Dang, W Saisorn, K Limbutara, A Leelahavanichkul
International journal of molecular sciences 2021
Gut‐liver axis‐mediated mechanism of liver cancer: A special focus on the role of gut microbiota
N Ohtani, E Hara
Cancer Science 2021
New Developments in Microbiome in Alcohol-Associated and Nonalcoholic Fatty Liver Disease
P Hartmann, B Schnabl
Seminars in liver disease 2021
Gut microbiome changes in Nonalcoholic fatty liver disease & alcoholic liver disease
EK Kwong, P Puri
Translational Gastroenterology and Hepatology 2021
Integrative Analysis of Metabolome and Microbiome in Patients with Progressive Alcohol-Associated Liver Disease
B Gao, Y Zhu, N Gao, W Shen, P Stärkel, B Schnabl
Metabolites 2021
Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s disease
I Doron, M Mesko, XV Li, T Kusakabe, I Leonardi, DG Shaw, WD Fiers, WY Lin, M Bialt-DeCelie, E Román, RS Longman, J Pla, PC Wilson, ID Iliev
Nature Microbiology 2021
An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
A Marfil-Sánchez, L Zhang, P Alonso-Pernas, M Mirhakkak, M Mueller, B Seelbinder, Y Ni, R Santhanam, A Busch, C Beemelmanns, M Ermolaeva, M Bauer, G Panagiotou
Gut microbes 2021
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
S Ibragimova, R Ramachandran, FR Ali, L Lipovich, SB Ho
Frontiers in Cell and Developmental Biology 2021
Food Habit Associated Mycobiota Composition and Their Impact on Human Health
J Shankar
Frontiers in Nutrition 2021
Host Factors in Dysregulation of the Gut Barrier Function during Alcohol-Associated Liver Disease
L Maccioni, IA Leclercq, B Schnabl, P Stärkel
International journal of molecular sciences 2021
Alcohol Use and Abuse Conspires With HIV Infection to Aggravate Intestinal Dysbiosis and Increase Microbial Translocation in People Living With HIV: A Review
J Yan, J Ouyang, S Isnard, X Zhou, V Harypursat, JP Routy, Y Chen
Frontiers in immunology 2021
Chronic Liver Diseases and the Microbiome—Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease
C Acharya, J Bajaj
Gastroenterology 2021
Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches
Jenks JD, Nam HH, Hoenigl M
Mycoses 2021
Systemic Immunoregulatory Consequences of Gut Commensal Translocation
McPherson AC, Pandey SP, Bender MJ, Meisel M
Trends in Immunology 2021
Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis
A Kim, A Bellar, MR McMullen, X Li, LE Nagy
Hepatology Communications 2020
Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes
Z Wang, Y Wang, N Bradbury, CG Bravo, B Schnabl, AD Nardo
Scientific Reports 2020
Fecal Microbiota Transplantation for Chronic Liver Diseases: Current Understanding and Future Direction
S Lechner, M Yee, BN Limketkai, EA Pham
Digestive Diseases and Sciences 2020
Immunological mechanisms and therapeutic targets of fatty liver diseases
H Wang, W Mehal, LE Nagy, Y Rotman
Cellular and Molecular Immunology 2020
Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease
YR Shim, WI Jeong
Experimental & molecular medicine 2020
Combined alcoholic and non-alcoholic steatohepatitis
LC Wandji, V Gnemmi, P Mathurin, A Louvet
2020
Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol‐Related Liver Disease
I Marrero, I Maricic, TR Morgan, AA Stolz, B Schnabl, ZX Liu, H Tsukamoto, V Kumar
Alcoholism, clinical and experimental research 2020

Pathogen-Associated Molecules from Gut Translocation Enhance Severity of Cecal Ligation and Puncture Sepsis in Iron-Overload β-Thalassemia Mice


K Sae-khow, A Charoensappakit, P Visitchanakun, W Saisorn, S Svasti, S Fucharoen, A Leelahavanichkul
Journal of inflammation research 2020
Transcriptomic Profiling Identifies Novel Hepatic and Intestinal Genes Following Chronic Plus Binge Ethanol Feeding in Mice
L Jiang, H Chu, B Gao, S Lang, Y Wang, Y Duan, B Schnabl
Digestive Diseases and Sciences 2020
The mycobiota of the human body: a spark can start a prairie fire
D Zhang, Y Wang, S Shen, Y Hou, Y Chen, T Wang
Gut microbes 2020
Gut microbiome, liver immunology, and liver diseases
R Wang, R Tang, B Li, X Ma, B Schnabl, H Tilg
Cellular and Molecular Immunology 2020
Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice
S Bluemel, Y Wang, S Lee, B Schnabl
World journal of gastroenterology : WJG 2020
Alcoholic-Hepatitis, Links to Brain and Microbiome: Mechanisms, Clinical and Experimental Research
MG Neuman, HK Seitz, SW French, S Malnick, H Tsukamoto, LB Cohen, P Hoffman, B Tabakoff, M Fasullo, LE Nagy, PL Tuma, B Schnabl, S Mueller, JL Groebner, FA Barbara, J Yue, A Nikko, M Alejandro, T Brittany, V Edward, K Harrall, L Saba, O Mihai
Biomedicines 2020
Gut microbiota in non‐alcoholic fatty liver disease and alcohol‐related liver disease: Current concepts and perspectives
JP Arab, M Arrese, VH Shah
Hepatology Research 2020
Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery
ME Cornide-Petronio, AI Álvarez-Mercado, MB Jiménez-Castro, C Peralta
Nutrients 2020
Microbial Products and Metabolites Contributing to Alcohol‐Related Liver Disease
B Gao, A Emami, S Nath, B Schnabl
Molecular Nutrition & Food Research 2020
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
J Trebicka, P Bork, A Krag, M Arumugam
Nature Reviews Gastroenterology & Hepatology 2020
Beta-glucans in advanced CKD: role in endotoxaemia and inflammation
J Wong, Y Zhang, O Swift, M Finkelman, A Patidar, S Ramanarayanan, E Vilar, K Farrington
BMC Nephrology 2020
Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans
L Maccioni, B Gao, S Leclercq, B Pirlot, Y Horsmans, PD Timary, I Leclercq, D Fouts, B Schnabl, P Stärkel
Gut microbes 2020
Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract
B Zhou, Y Yuan, S Zhang, C Guo, X Li, G Li, W Xiong, Z Zeng
Frontiers in immunology 2020
Glucan rich nutrition does not increase gut translocation of beta‐glucan
M Hoenigl, J Lin, M Finkelman, Y Zhang, MY Karris, SL Letendre, RJ Ellis, L Burke, B Richard, T Gaufin, S Isnard, JP Routy, S Gianella
Mycoses 2020
Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement
JD Jenks, JP Gangneux, IS Schwartz, A Alastruey-Izquierdo, K Lagrou, GR Thompson, C Lass-Flörl, M Hoenigl, EC of Medical Mycology ECMM Council Investigators
Journal of Fungi 2020
Candida albicans and candidalysin in inflammatory disorders and cancer
J Ho, G Camilli, JS Griffiths, JP Richardson, N Kichik, JR Naglik
Immunology 2020
From Birth and Throughout Life: Fungal Microbiota in Nutrition and Metabolic Health
WD Fiers, I Leonardi, ID Iliev
Annual Review of Nutrition 2020
Gut Microbiota and Liver Fibrosis: One Potential Biomarker for Predicting Liver Fibrosis
Z Li, M Ni, H Yu, L Wang, X Zhou, T Chen, G Liu, Y Gao
BioMed Research International 2020
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks, M Hoenigl, HJ Salzer, M Ilkit, C Lass-Flörl, DS Perlin
Antibiotics 2020
Overview of the Potential Role of Malassezia in Gut Health and Disease
M Spatz, ML Richard
Frontiers in Cellular and Infection Microbiology 2020
The gut mycobiome: a novel player in chronic liver diseases
L Jiang, P Stärkel, JG Fan, DE Fouts, P Bacher, B Schnabl
Journal of Gastroenterology 2020
Modulating the gut–liver axis and the pivotal role of the faecal microbiome in cirrhosis
C Woodhouse, A Singanayagam, VC Patel
Clinical Medicine 2020
Mycobiome in the Gut: A Multiperspective Review
VK Chin, VC Yong, PP Chong, SA Nordin, R Basir, M Abdullah
Mediators of Inflammation 2020
Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future
S Lang, B Schnabl
Cell Host & Microbe 2020
Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE 2 to alcoholic hepatic steatosis
S Sun, K Wang, L Sun, B Cheng, S Qiao, H Dai, W Shi, J Ma, H Liu
Gut microbes 2020
Blood Aspergillus PCR: The Good, the Bad, and the Ugly
M Egger, JD Jenks, M Hoenigl, J Prattes
Journal of Fungi 2020
Candida Administration Worsens Cecal Ligation and Puncture-Induced Sepsis in Obese Mice Through Gut Dysbiosis Enhanced Systemic Inflammation, Impact of Pathogen-Associated Molecules From Gut Translocation and Saturated Fatty Acid
W Panpetch, V Sawaswong, P Chanchaem, T Ondee, CP Dang, S Payungporn, S Tumwasorn, A Leelahavanichkul
Frontiers in immunology 2020
Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
X Chi, CQ Pan, S Liu, D Cheng, Z Cao, H Xing, A Granito
Canadian journal of gastroenterology & hepatology 2020
The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease
H Chu, Y Duan, S Lang, L Jiang, Y Wang, C Llorente, J Liu, S Mogavero, F Bosques-Padilla, JG Abraldes, V Vargas, XM Tu, L Yang, X Hou, B Hube, P Stärkel, B Schnabl
Journal of Hepatology 2020
COVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions?
A Arastehfar, A Carvalho, MH Nguyen, MT Hedayati, MG Netea, DS Perlin, M Hoenigl
Journal of Fungi 2020
Specificity Influences in (1→3)-β-d-Glucan-Supported Diagnosis of Invasive Fungal Disease
MA Finkelman
Journal of Fungi 2020
The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases
N You, L Zhuo, J Zhou, Y Song, J Shi
Gut and Liver 2020
Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic
E Scarpellini, S Fagoonee, E Rinninella, C Rasetti, I Aquila, T Larussa, P Ricci, F Luzza, L Abenavoli
Journal of Clinical Medicine 2020
Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights
K Ikejima, K Kon, S Yamashina
Clinical and Molecular Hepatology 2020
Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
DM Chopyk, A Grakoui
Gastroenterology 2020
Gut mycobiomes are altered in people with type 2 Diabetes Mellitus and Diabetic Retinopathy
R Jayasudha, T Das, SK Chakravarthy, GS Prashanthi, A Bhargava, M Tyagi, PK Rani, RR Pappuru, S Shivaji, S Yenugu
PloS one 2020
Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl 4 -induced acute liver injury
C Xiang, M Cao, A Miao, F Gao, X Li, G Pan, W Zhang, Y Zhang, P Yu, Y Teng
RSC Advances 2020
Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis
P Amornphimoltham, PS Yuen, RA Star, A Leelahavanichkul
Digestive Diseases and Sciences 2019
The Role of Gut-Derived Microbial Antigens on Liver Fibrosis Initiation and Progression
D Chen, TH Le, H Shahidipour, SA Read, G Ahlenstiel
Cells 2019
Profound mycobiome differences between segregated mouse colonies do not influence Th17 responses to a newly introduced gut fungal commensal
I Doron, I Leonardi, ID Iliev
Fungal genetics and biology : FG & B 2019
Gut Mycobiota in Immunity and Inflammatory Disease
XV Li, I Leonardi, ID Iliev
Immunity 2019
Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science
G Brar, H Tsukamoto
Journal of Gastroenterology 2019
Inflammatory pathways in alcoholic steatohepatitis
B Gao, MF Ahmad, LE Nagy, H Tsukamoto
Journal of Hepatology 2019
Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
MA Avila, JF Dufour, AL Gerbes, F Zoulim, R Bataller, P Burra, H Cortez-Pinto, B Gao, I Gilmore, P Mathurin, C Moreno, V Poznyak, B Schnabl, G Szabo, M Thiele, MR Thursz
Gut 2019
Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis
S Lang, Y Duan, J Liu, MG Torralba, C Kuelbs, M VenturaCots, JG Abraldes, F BosquesPadilla, EC Verna, RS Brown, V Vargas, J Altamirano, J Caballería, D Shawcross, MR Lucey, A Louvet, P Mathurin, G GarciaTsao, SB Ho, XM Tu, R Bataller, P Stärkel, DE Fouts, B Schnabl
Hepatology 2019
Functional Microbiomics in Liver Transplantation: Identifying Novel Targets for Improving Allograft Outcomes
M Kriss, EC Verna, HR Rosen, CA Lozupone
Transplantation 2019
Oral Candida administration in a Clostridium difficile mouse model worsens disease severity but is attenuated by Bifidobacterium
W Panpetch, N Somboonna, M Palasuk, P Hiengrach, M Finkelman, S Tumwasorn, A Leelahavanichkul, S Diezmann
PloS one 2019
Intestinal iNKT cells migrate to liver and contribute to hepatocyte apoptosis during alcoholic liver disease
KC Lee, P Chen, I Maricic, T Inamine, J Hu, S Gong, JC Sun, S Dasgupta, HC Lin, YT Lin, R Loomba, P Stärkel, V Kumar, B Schnabl
AJP Gastrointestinal and Liver Physiology 2019
miRNAs Involved in M1/M2 Hyperpolarization Are Clustered and Coordinately Expressed in Alcoholic Hepatitis
A Kim, P Saikia, LE Nagy
Frontiers in immunology 2019
Targeting Microbiota: What Do We Know about It at Present?
A Derovs, S Laivacuma, A Krumina
MED LITH 2019
Alcohol or Gut Microbiota: Who Is the Guilty?
M Meroni, M Longo, P Dongiovanni
International journal of molecular sciences 2019
C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
K Tone, MH Stappers, JA Willment, GD Brown
European Journal of Immunology 2019
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
H Fukui
Diseases 2019
Microbiome dysbiosis and alcoholic liver disease
F Li, CJ McClain, W Feng
Liver Research 2019
Long‐lasting microbial dysbiosis and altered enteric neurotransmitters in adult rats following adolescent binge ethanol exposure
RP Vetreno, V Massey, FT Crews
Addiction Biology 2019
The role of gut microbiota in liver disease development and treatment
L Wang, YJ Wan
Liver Research 2019
The gut–liver axis and the intersection with the microbiome
A Tripathi, J Debelius, DA Brenner, M Karin, R Loomba, B Schnabl, R Knight
Nature Reviews Gastroenterology & Hepatology 2018
Publisher Correction: The gut–liver axis and the intersection with the microbiome
A Tripathi, J Debelius, DA Brenner, M Karin, R Loomba, B Schnabl, R Knight
Nature Reviews Gastroenterology & Hepatology 2018
Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice
R Mukherjee, ME Moreno-Fernandez, DA Giles, M Cappelletti, TE Stankiewicz, CC Chan, S Divanovic
Hepatology Communications 2018
Alcoholic liver disease: A current molecular and clinical perspective
K Ohashi, M Pimienta, E Seki
Liver Research 2018
Antifungal Innate Immunity: A Perspective from the Last 10 Years
F Salazar, GD Brown
Journal of Innate Immunity 2018
Transplantation of human microbiota into conventional mice durably reshapes the gut microbiota
L Wrzosek, D Ciocan, P Borentain, M Spatz, V Puchois, C Hugot, G Ferrere, C Mayeur, G Perlemuter, AM Cassard
Scientific Reports 2018
CX3CR1 + mononuclear phagocytes control immunity to intestinal fungi
I Leonardi, X Li, A Semon, D Li, I Doron, G Putzel, A Bar, D Prieto, M Rescigno, DP McGovern, J Pla, ID Iliev
Science 2018
Managing portal hypertension in patients with liver cirrhosis
T Sauerbruch, R Schierwagen, J Trebicka
F1000Research 2018
The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis
P Puri, S Liangpunsakul, JE Christensen, VH Shah, PS Kamath, GJ Gores, S Walker, M Comerford, B Katz, A Borst, Q Yu, DP Kumar, F Mirshahi, S Radaeva, NP Chalasani, DW Crabb, AJ Sanyal
Hepatology 2018
Molecular quantification and differentiation of Candida species in biological specimens of patients with liver cirrhosis
S Krohn, K Zeller, S Böhm, A Chatzinotas, H Harms, J Hartmann, A Heidtmann, A Herber, T Kaiser, M Treuheit, A Hoffmeister, T Berg, C Engelmann, P Strnad
PloS one 2018
The Role of Intestinal C-type Regenerating Islet Derived-3 Lectins for Nonalcoholic Steatohepatitis
S Bluemel, L Wang, C Martino, S Lee, Y Wang, B Williams, A Horvath, V Stadlbauer, K Zengler, B Schnabl
Hepatology Communications 2018
Grand Rounds: Alcoholic Hepatitis
AK Singal, A Louvet, VH Shah, PS Kamath
Journal of Hepatology 2018
Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure
J Trebicka, T Reiberger, W Laleman
Viszeralmedizin 2018
Local Acetaldehyde—An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis
M Nieminen, M Salaspuro
Cancers 2018
The Microbiome in Cirrhosis and Its Complications
C Acharya, JS Bajaj
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018
Microbiota, a key player in alcoholic liver disease
AM Cassard, D Ciocan
Clinical and Molecular Hepatology 2018
The mammalian mycobiome: A complex system in a dynamic relationship with the host
GC Lai, TG Tan, N Pavelka
Wiley interdisciplinary reviews. Systems biology and medicine 2018
Antimicrobial proteins: intestinal guards to protect against liver disease
T Hendrikx, B Schnabl
Journal of Gastroenterology 2018
Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis
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Toxicological Sciences 2018
Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice
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Therapeutic Opportunities for Alcoholic Steatohepatitis and Non-Alcoholic Steatohepatitis: Exploiting Similarities and Differences in Pathogenesis
Thomas Greuter, Harmeet Malhi, Gregory J Gores, Vijay H. Shah
JCI Insight 2017
Targeting inflammation for the treatment of alcoholic liver disease
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Pharmacology & Therapeutics 2017
Targeting the gut barrier for the treatment of alcoholic liver disease
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Liver Research 2017
Commensal Fungi in Health and Disease
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Cell Host & Microbe 2017
Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame
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Cancers 2017
Host–microbe interactions: commensal fungi in the gut
MJ Paterson, S Oh, DM Underhill
Current Opinion in Microbiology 2017
Immunoglobulin A and liver diseases
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Journal of Gastroenterology 2017
Intestinal fungi fuel the inflammatory fire in alcoholic liver disease
H Thomas
Nature Reviews Gastroenterology & Hepatology 2017
Fungus-derived hydroxyl radicals kill hepatic cells by enhancing nuclear transglutaminase
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Scientific Reports 2017
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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