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Suzanne Hood, Shimon Amir
Published February 1, 2017
Citation Information: J Clin Invest. 2017;127(2):437-446. https://doi.org/10.1172/JCI90328.
Citation Information: J Clin Invest. 2017;127(2):437-446. https://doi.org/10.1172/JCI90328.
Abstract
Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in the vast majority of species on Earth. The biological clockwork that regulates these rhythms is dynamic over the lifespan: rhythmic activities such as sleep/wake patterns change markedly as we age, and in many cases they become increasingly fragmented. Given that prolonged disruptions of normal rhythms are highly detrimental to health, deeper knowledge of how our biological clocks change with age may create valuable opportunities to improve health and longevity for an aging global population. In this Review, we synthesize key findings from the study of circadian rhythms in later life, identify patterns of change documented to date, and review potential physiological mechanisms that may underlie these changes.
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Suzanne Hood, Shimon Amir
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Citations to this article (231)
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Science Advances | 2022 |
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An Overview of the Circadian Clock in the Frame of Chronotherapy: From Bench to Bedside
Vandenberghe A, Lefranc M, Furlan A |
Pharmaceutics | 2022 |
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Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Lu JY, Simon M, Zhao Y, Ablaeva J, Corson N, Choi Y, Yamada KY, Schork NJ, Hood WR, Hill GE, Miller RA, Seluanov A, Gorbunova V |
Cell Metabolism | 2022 |
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High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults
Duffy JF, Wang W, Ronda JM, Czeisler CA |
Journal of Pineal Research | 2022 |
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Rest-activity rhythms and tract specific white matter lesions in older adults at risk for cognitive decline.
Palmer JR, Wang C, Kong D, Cespedes M, Pye J, Hickie IB, Barnett M, Naismith SL |
Molecular Psychiatry | 2022 |
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Human circadian rhythm studies: Practical guidelines for inclusion/exclusion criteria and protocol
Yousefzadehfard Y, Wechsler B, DeLorenzo C |
Neurobiology of Sleep and Circadian Rhythms | 2022 |
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Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms
Zou H, Zhou H, Yan R, Yao Z, Lu Q |
Frontiers in neuroscience | 2022 |
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Time to target the circadian clock for drug discovery.
Rasmussen ES, Takahashi JS, Green CB |
Trends in Biochemical Sciences | 2022 |
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Circadian disruption of hippocampus in an early senescence male mouse model
Davis JA, Paul JR, Mokashi MV, Yates SA, Mount DJ, Munir HA, Goode LK, Young ME, Allison DB, Gamble KL |
Pharmacology, biochemistry, and behavior | 2022 |
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The neurovascular unit and systemic biology in stroke - implications for translation and treatment.
Tiedt S, Buchan AM, Dichgans M, Lizasoain I, Moro MA, Lo EH |
Nature reviews. Neurology | 2022 |
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Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging.
Noh SG, Jung HJ, Kim S, Arulkumar R, Kim DH, Park D, Chung HY |
International journal of molecular sciences | 2022 |
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The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging
Wiersema JM, Kamphuis AE, Rohling JH, Kervezee L, Akintola AA, Jansen SW, Slagboom PE, van Heemst D, van der Spoel E |
Aging | 2022 |
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Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging.
Carpenter BJ, Dierickx P |
American journal of physiology. Cell physiology | 2022 |
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Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development.
Lee J, Sul HJ, Choi H, Oh DH, Shong M |
Cell Death and Disease | 2022 |
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The circadian transcription factor ARNTL2 is regulated by weight-loss interventions in human white adipose tissue and inhibits adipogenesis.
Mandl M, Viertler HP, Zopoglou M, Mitterberger-Vogt MC, Gasser J, Hatzmann FM, Rauchenwald T, Zwierzina ME, Mattesich M, Weiss AKH, Mottes L, Brucker C, Waldegger P, Pierer G, Zwerschke W |
Cell Death Discovery | 2022 |
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Is there a diurnal variation of COVID-19 patients warranting presentation to the health centre? A chronobiological observational cross-sectional study.
Romdhani M, Vedasalam S, Souissi A, Fessi MS, Varma A, Taheri M, Ghram A, Al Naama A, Mkaouer B, Ben Saad H, Dergaa I |
Annals of Medicine | 2022 |
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Day time-restricted feeding shows differential synchronizing effects on age-related changes of serotonin metabolism in SCN and the pineal gland in male Wistar rats.
Reddy VDK, Dalai M, Khan MS, Jagota A |
Biogerontology | 2022 |
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Time-of-day dependent effects of midazolam administration on myocardial injury in non-cardiac surgery
Prin M, Pattee J, Douin DJ, Scott BK, Ginde AA, Eckle T |
Frontiers in Cardiovascular Medicine | 2022 |
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Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster
Johnstone PS, Ogueta M, Akay O, Top I, Syed S, Stanewsky R, Top D |
eLife | 2022 |
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Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease.
Li L, Zhang M, Zhao C, Cheng Y, Liu C, Shi M |
BMC Pulmonary Medicine | 2022 |
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Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock.
Colombini B, Dinu M, Murgo E, Lotti S, Tarquini R, Sofi F, Mazzoccoli G |
2022 | |
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Time-restricted feeding and cognitive function in sedentary and physically active elderly individuals: Ramadan diurnal intermittent fasting as a model
Boujelbane MA, Trabelsi K, Jahrami HA, Masmoudi L, Ammar A, Khacharem A, Boukhris O, Puce L, Garbarino S, Scoditti E, Khanfir S, Msaad A, Msaad A, Akrout S, Hakim A, Bragazzi NL, Bryk K, Glenn JM, Chtourou H |
Frontiers in Nutrition | 2022 |
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Changes in Circadian Variations in Blood Pressure, Pain Pressure Threshold and the Elasticity of Tissue after a Whole-Body Photobiomodulation Treatment in Patients with Fibromyalgia: A Tripled-Blinded Randomized Clinical Trial.
Navarro-Ledesma S, Carroll J, González-Muñoz A, Pruimboom L, Burton P |
Biomedicines | 2022 |
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Anorexia of Aging: Metabolic Changes and Biomarker Discovery
Picca A, Calvani R, Coelho-Júnior HJ, Landi F, Marzetti E |
Clinical Interventions in Aging | 2022 |
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Sleep disturbances in Lewy body dementia: A systematic review
Elder GJ, Lazar AS, Alfonso\u2010Miller P, Taylor J |
International Journal of Geriatric Psychiatry | 2022 |
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Blunted Rest–Activity Circadian Rhythm Is Associated With Increased Rate of Biological Aging: An Analysis of NHANES 2011–2014
Xu Y, Wang X, Belsky DW, McCall WV, Liu Y, Su S |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2022 |
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A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation
Wu T, Li M, Tian L, Cong P, Huang X, Wu H, Zhang Q, Zhang H, Xiong L |
Experimental Animals | 2022 |
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Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Body Mass Index in Older Men: A Novel Analysis Using Harmonic Hidden Markov Models.
Heckler B, Lee M, Stone K, Bauer C, Xiao Q |
Journal of Biological Rhythms | 2022 |
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Two novel mouse models of slow-wave-sleep enhancement in aging and Alzheimer’s disease
Ogbeide-Latario OE, Ferrari LL, Gompf HS, Anaclet C |
2022 | |
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Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment.
Keihani A, Mayeli A, Ferrarelli F |
2022 | |
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The Role of Race, Sex, and Age in Circadian Disruption and Metabolic Disorders
Zhang C, Tait C, Minacapelli CD, Bhurwal A, Gupta K, Amin R, Rustgi VK |
2022 | |
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Circadian effect of time of anaesthesia on postoperative outcomes in major elective and urgent intervention: a secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE)
Hoogma DF, Al Tmimi L, Fieuws S, Tournoy J, Kowark A, Rossaint R, Coburn M, Rex S |
European Journal of Anaesthesiology and Intensive Care | 2022 |
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Nuclear Receptors and Clock Components in Cardiovascular Diseases
B Pourcet, H Duez |
International journal of molecular sciences | 2021 |
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Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis
AW Man, H Li, N Xia |
International journal of molecular sciences | 2021 |
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Sleep in Normal Aging, Homeostatic and Circadian Regulation and Vulnerability to Sleep Deprivation
J Taillard, C Gronfier, S Bioulac, P Philip, P Sagaspe |
Brain Sciences | 2021 |
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Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice
M Schilperoort, J Kroon, S Kooijman, AE Smit, M Gentenaar, K Mletzko, FN Schmidt, L Ruijven, B Busse, AM Pereira, NM AppelmanDijkstra, N Bravenboer, PC Rensen, OC Meijer, EM Winter |
Aging Cell | 2021 |
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Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
XL Wang, L Li |
Frontiers in Cellular and Infection Microbiology | 2021 |
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Changes in Circadian Rhythms Dysregulate Inflammation in Ageing: Focus on Leukocyte Trafficking
P Nathan, JE Gibbs, GE Rainger, M Chimen |
Frontiers in immunology | 2021 |
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Circadian rhythm as a therapeutic target
W Ruan, X Yuan, HK Eltzschig |
Nature Reviews Drug Discovery | 2021 |
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Circadian Rhythms of the Hypothalamus: From Function to Physiology
RV Drunen, K Eckel-Mahan |
2021 | |
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A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes
M Yalçin, D Malhan, A Basti, AR Peralta, JJ Ferreira, A Relógio |
Cancers | 2021 |
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Importance of circadian timing for aging and longevity
VA Acosta-Rodríguez, F Rijo-Ferreira, CB Green, JS Takahashi |
Nature Communications | 2021 |
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NAD+ metabolism, stemness, the immune response, and cancer
LE Navas, A Carnero |
Signal Transduction and Targeted Therapy | 2021 |
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Demographic characteristics associated with circadian rest-activity rhythm patterns: a cross-sectional study
J Li, VK Somers, F Lopez-Jimenez, J Di, N Covassin |
The international journal of behavioral nutrition and physical activity | 2021 |
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Chronobiology and Chronotherapy of Osteoporosis
EM Winter, S Kooijman, NM AppelmanDijkstra, OC Meijer, PC Rensen, M Schilperoort |
JBMR Plus | 2021 |
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Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction
S Aoyama, Y Nakahata, K Shinohara |
Frontiers in neuroscience | 2021 |
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Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex
JH Harkness, AE Gonzalez, PN Bushana, ET Jorgensen, DM Hegarty, AA Nardo, A Prochiantz, JP Wisor, SA Aicher, TE Brown, BA Sorg |
Brain structure & function | 2021 |
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Managing Travel Fatigue and Jet Lag in Athletes: A Review and Consensus Statement
DC van Rensburg, AJ van Rensburg, PM Fowler, AM Bender, D Stevens, KO Sullivan, HH Fullagar, JM Alonso, M Biggins, A Claassen-Smithers, R Collins, M Dohi, MW Driller, IC Dunican, L Gupta, SL Halson, M Lastella, KH Miles, M Nedelec, T Page, G Roach, C Sargent, M Singh, GE Vincent, JA Vitale, T Botha |
Sports Medicine | 2021 |
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Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
NM Held, MR Buijink, HL Elfrink, S Kooijman, GE Janssens, AC Luyf, ML Pras-Raves, FM Vaz, S Michel, RH Houtkooper, M van Weeghel |
Scientific Reports | 2021 |
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Circadian Effects of Drug Responses
Y Nahmias, IP Androulakis |
Annual Review of Biomedical Engineering | 2021 |
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Bright daytime light enhances circadian amplitude in a diurnal mammal
B Bano-Otalora, F Martial, C Harding, DA Bechtold, AE Allen, TM Brown, MD Belle, RJ Lucas |
Proceedings of the National Academy of Sciences | 2021 |
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Inflammaging and Cannabinoids
B Baban, H Khodadadi, ÉL Salles, V Costigliola, JC Morgan, DC Hess, K Vaibhav, KM Dhandapani, JC Yu |
Ageing Research Reviews | 2021 |
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Cancer and Aging: Two Tightly Interconnected Biological Processes
L Berben, G Floris, H Wildiers, S Hatse |
Cancers | 2021 |
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Sociodemographic, Health and Lifestyle, Sampling, and Mental Health Determinants of 24-Hour Motor Activity Patterns: Observational Study
S Difrancesco, H Riese, KR Merikangas, H Shou, V Zipunnikov, N Antypa, AM van Hemert, RA Schoevers, BW Penninx, F Lamers |
Journal of Medical Internet Research | 2021 |
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Better later: evening practice is advantageous for motor skill consolidation in the elderly
M Korman, C Gal, E Gabitov, A Karni |
Learning & memory (Cold Spring Harbor, N.Y.) | 2021 |
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Anti-aging effects of Korean Red Ginseng (KRG) in differentiated embryo chondrocyte (DEC) knockout mice
YH Nam, SY Jeong, YH Kim, I Rodriguez, W Nuankaew, UK Bhawal, BN Hong, TH Kang |
Journal of Ginseng Research | 2021 |
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Association between conventional or blue-light-filtering intraocular lenses and survival in bilateral cataract surgery patients
JE Griepentrog, X Zhang, OC Marroquin, MB Garver, AE Rosengart, JC Chang, H Esfandiari, NA Loewen, MR Rosengart |
iScience | 2021 |
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Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea
LS Gaspar, J Hesse, M Yalçin, B Santos, C Carvalhas-Almeida, M Ferreira, J Moita, A Relógio, C Cavadas, AR Álvaro |
EBioMedicine | 2021 |
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Gaining Insights Into the Estimation of the Circadian Rhythms of Social Activity in Older Adults From Their Telephone Call Activity With Statistical Learning: Observational Study
T Aubourg, J Demongeot, N Vuillerme |
Journal of Medical Internet Research | 2021 |
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The circadian clock and diseases of the skin
J Duan, EN Greenberg, SS Karri, B Andersen |
FEBS Letters | 2021 |
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L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR Pathway
S Yang, Y Wan, N Wu, L Song, Z Liu, J Zhao, Y Liu, Z Liu, J Gan |
Frontiers in aging neuroscience | 2021 |
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Body Temperature Is Associated With Cognitive Performance in Older Adults With and Without Mild Cognitive Impairment: A Cross-sectional Analysis
P Eggenberger, M Bürgisser, RM Rossi, S Annaheim |
Frontiers in aging neuroscience | 2021 |
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Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin
AK Verma, S Singh, SI Rizvi |
Biogerontology | 2021 |
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COVID-19 Lockdowns: A Worldwide Survey of Circadian Rhythms and Sleep Quality in 3911 Athletes from 49 Countries, with Data-Driven Recommendations
M Romdhani, DE Rae, M Nédélec, A Ammar, H Chtourou, RA Horani, HB Saad, N Bragazzi, G Dönmez, T Driss, HH Fullagar, A Farooq, S Garbarino, O Hammouda, B Hassanmirzaei, K Khalladi, S Khemila, LJ Mataruna-Dos-Santos, I Moussa-Chamari, I Mujika, HM Helú, AN Fashkhami, LL Paineiras-Domingos, MR Khaneghah, Y Saita, K Trabelsi, JA Vitale, JA Washif, J Weber, N Souissi, L Taylor, K Chamari |
Sports Medicine | 2021 |
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More Than Morningness: The Effect of Circadian Rhythm Amplitude and Stability on Resilience, Coping, and Sleep Duration
LD Milia, S Folkard |
Frontiers in psychology | 2021 |
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Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
S Turkiewicz, M Ditmer, M Sochal, P Białasiewicz, D Strzelecki, A Gabryelska |
International journal of molecular sciences | 2021 |
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Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
BS de Alencar Silva, JS Uzeloto, FS Lira, T Pereira, MJ Coelho-E-Silva, A Caseiro |
International journal of environmental research and public health | 2021 |
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Reuniting the Body “Neck Up and Neck Down” to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience
A Hernandez, J Hoffman, C Hernandez, C Cortes, P Jumbo-Lucioni, M Baxter, K Esser, A Liu, L McMahon, J Bizon, S Burke, T Buford, C Carter, R Anderson |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2021 |
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Circadian rhythms and the HPA axis: A systems view
I Androulakis |
2021 | |
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A stress-induced miR-31-CLOCK-ERK pathway is a key driver and therapeutic target for skin aging.
Yu Y, Zhang X, Liu F, Zhu P, Zhang L, Peng Y, Yan X, Li Y, Hua P, Liu C, Li Q, Zhang L |
2021 | |
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Paraventricular hypothalamus mediates diurnal rhythm of metabolism
ER Kim, Y Xu, RM Cassidy, Y Lu, Y Yang, J Tian, DP Li, RV Drunen, A Ribas-Latre, ZL Cai, M Xue, BR Arenkiel, K Eckel-Mahan, Y Xu, Q Tong |
Nature Communications | 2020 |
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Circadian Regulation of Blood Pressure: of Mice and Men
MK Rhoads, V Balagee, SJ Thomas |
Current Hypertension Reports | 2020 |
|
Arthritis and the role of endogenous glucocorticoids
E Macfarlane, MJ Seibel, H Zhou |
Bone Research | 2020 |
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Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases
M Manevski, T Muthumalage, D Devadoss, IK Sundar, Q Wang, KP Singh, HJ Unwalla, HS Chand, I Rahman |
Redox Biology | 2020 |
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The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration
BV Lananna, ES Musiek |
Neurobiology of Disease | 2020 |
|
Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease
Y Leng, T Blackwell, PM Cawthon, S Ancoli-Israel, KL Stone, K Yaffe |
JAMA NEUROL | 2020 |
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Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?
B Poljsak, V Kovač, I Milisav, JN Myers |
Oxidative Medicine & Cellular Longevity | 2020 |
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Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging
R Correa-de-Araujo, O Addison, I Miljkovic, BH Goodpaster, BC Bergman, RV Clark, JW Elena, KA Esser, L Ferrucci, MO Harris-Love, SB Kritchevsky, A Lorbergs, JA Shepherd, GI Shulman, CJ Rosen |
Frontiers in physiology | 2020 |
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Circadian Rhythms, Sleep, Immunity, and Fragility in the Elderly: The Model of the Susceptibility to Infections
S Garbarino, P Lanteri, WG Sannita, NL Bragazzi, E Scoditti |
Frontiers in neurology | 2020 |
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Innovations in Geroscience to enhance mobility in older adults
SD Anton, Y Cruz-Almeida, A Singh, J Alpert, B Bensadon, M Cabrera, DJ Clark, NC Ebner, KA Esser, RB Fillingim, SM Goicolea, SM Han, H Kallas, A Johnson, C Leeuwenburgh, AC Liu, TM Manini, M Marsiske, F Moore, P Qiu, RT Mankowski, M Mardini, C McLaren, S Ranka, P Rashidi, S Saini, KT Sibille, S Someya, S Wohlgemuth, C Tucker, R Xiao, M Pahor |
Experimental Gerontology | 2020 |
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Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster
JB Thompson, OO Su, N Yang, JH Bauer |
Biology Open | 2020 |
|
COVID-19-mandated social restrictions unveil the impact of social time pressure on sleep and body clock
M Korman, V Tkachev, C Reis, Y Komada, S Kitamura, D Gubin, V Kumar, T Roenneberg |
Scientific Reports | 2020 |
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Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men
Q Xiao, J Qian, DS Evans, S Redline, NE Lane, S Ancoli-Israel, FA Scheer, K Stone |
Diabetes care | 2020 |
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Ageing hallmarks exhibit organ-specific temporal signatures
N Schaum, B Lehallier, O Hahn, R Pálovics, S Hosseinzadeh, SE Lee, R Sit, DP Lee, PM Losada, ME Zardeneta, T Fehlmann, JT Webber, A McGeever, K Calcuttawala, H Zhang, D Berdnik, V Mathur, W Tan, A Zee, M Tan, N Almanzar, J Antony, AS Baghel, I Bakerman, I Bansal, BA Barres, PA Beachy, D Berdnik, B Bilen, D Brownfield, C Cain, CK Chan, MB Chen, MF Clarke, SD Conley, S Darmanis, A Demers, K Demir, A de Morree, T Divita, H du Bois, H Ebadi, FH Espinoza, M Fish, Q Gan, BM George, A Gillich, R Gòmez-Sjöberg, F Green, G Genetiano, X Gu, GS Gulati, O Hahn, MS Haney, Y Hang, L Harris, M He, S Hosseinzadeh, A Huang, KC Huang, T Iram, T Isobe, F Ives, R Jones, KS Kao, J Karkanias, G Karnam, A Keller, AM Kershner, N Khoury, SK Kim, BM Kiss, W Kong, MA Krasnow, ME Kumar, CS Kuo, JY Lam, DP Lee, SE Lee, B Lehallier, O Leventhal, G Li, Q Li, L Liu, A Lo, WJ Lu, MF Lugo-Fagundo, A Manjunath, AP May, A Maynard, A McGeever, M McKay, MW McNerney, B Merrill, RJ Metzger, M Mignardi, D Min, AN Nabhan, NF Neff, KM Ng, PK Nguyen, J Noh, R Nusse, R Pálovics, R Patkar, WC Peng, L Penland, AO Pisco, K Pollard, R Puccinelli, Z Qi, SR Quake, TA Rando, EJ Rulifson, N Schaum, JM Segal, SS Sikandar, R Sinha, RV Sit, J Sonnenburg, D Staehli, K Szade, M Tan, W Tan, C Tato, K Tellez, LB Dulgeroff, KJ Travaglini, C Tropini, M Tsui, L Waldburger, BM Wang, LJ van Weele, K Weinberg, IL Weissman, MN Wosczyna, SM Wu, T Wyss-Coray, J Xiang, S Xue, KA Yamauchi, AC Yang, LP Yerra, J Youngyunpipatkul, B Yu, F Zanini, ME Zardeneta, A Zee, C Zhao, F Zhang, H Zhang, MJ Zhang, L Zhou, J Zou, AO Pisco, J Karkanias, NF Neff, A Keller, S Darmanis, SR Quake, T Wyss-Coray |
Nature | 2020 |
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Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker
AA de Souza Teixeira, FS Lira, JC Rosa-Neto |
Life Sciences | 2020 |
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Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators
C Camello-Almaraz, FE Martin-Cano, FJ Santos, MT Espin, JA Madrid, MJ Pozo, PJ Camello |
International journal of molecular sciences | 2020 |
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Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus
M Hudec, P Dankova, R Solc, N Bettazova, M Cerna |
International journal of molecular sciences | 2020 |
|
Circadian rhythms of mineral metabolism in chronic kidney disease–mineral bone disorder
S Egstrand, K Olgaard, E Lewin |
Current Opinion in Nephrology and Hypertension | 2020 |
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Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6
B Chhunchha, E Kubo, DP Singh |
Cells | 2020 |
|
Angelman syndrome and melatonin: What can they teach us about sleep regulation
D Buonfiglio, DL Hummer, A Armstrong, JC Ehlen, JP DeBruyne |
Journal of Pineal Research | 2020 |
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Aging Disrupts Normal Time-of-Day Variation in Cardiac Electrophysiology
Z Wang, S Tapa, SD Stuart, L Wang, J Bossuyt, BP Delisle, CM Ripplinger |
Circulation. Arrhythmia and electrophysiology | 2020 |
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Aging Disrupts the Circadian Patterns of Protein Expression in the Murine Hippocampus
P Adler, CK Chiang, J Mayne, Z Ning, X Zhang, B Xu, HY Cheng, D Figeys |
Frontiers in aging neuroscience | 2020 |
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Insights About Circadian Clock and Molecular Pathogenesis in Gliomas
K Arafa, M Emara |
Frontiers in Oncology | 2020 |
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Diurnal, metabolic and thermogenic alterations in a murine model of accelerated aging
DB Allison, G Ren, RA Peliciari-Garcia, S Mia, GR McGinnis, J Davis, KL Gamble, JA Kim, ME Young |
Chronobiology International | 2020 |
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Moderate-to-vigorous physical activity duration is more important than timing for physical function in older adults
TF Lai, Y Liao, CY Lin, WC Huang, MC Hsueh, DC Chan |
Scientific Reports | 2020 |
|
Relationship Between Chronic Stress and Heart Rate Over Time Modulated by Gender in a Cohort of Office Workers: Cross-Sectional Study Using Wearable Technologies
AW van Kraaij, G Schiavone, E Lutin, S Claes, CV Hoof |
Journal of Medical Internet Research | 2020 |
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Multidimensional sleep health domains in older men and women: an actigraphy factor analysis
ML Wallace, L Yu, DJ Buysse, KL Stone, S Redline, SF Smagula, ML Stefanick, D Kritz-Silverstein, MH Hall |
Sleep | 2020 |
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Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia
T Ihara, Y Nakamura, T Mitsui, S Tsuchiya, M Kanda, S Kira, H Nakagomi, N Sawada, M Kamiyama, E Shigetomi, Y Shinozaki, M Yoshiyama, A Nakao, S Koizumi, M Takeda |
Scientific Reports | 2019 |
|
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
O BarcaMayo, AJ Boender, A Armirotti, DD Tonelli |
Glia | 2019 |
|
Working against the biological clock: a review for the Occupational Physician
A COPERTARO, M BRACCI |
Industrial Health | 2019 |
|
Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging
L Ryan, M Hay, MJ Huentelman, A Duarte, T Rundek, B Levin, A Soldan, C Pettigrew, MR Mehl, CA Barnes |
Frontiers in aging neuroscience | 2019 |
|
Association between circadian rhythms and neurodegenerative diseases
Y Leng, ES Musiek, K Hu, FP Cappuccio, K Yaffe |
Lancet neurology | 2019 |
|
Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations
LC Hunt, J Jiao, YD Wang, D Finkelstein, D Rao, M Curley, M Robles-Murguia, A Shirinifard, VR Pagala, J Peng, Y Fan, F Demontis |
Genome research | 2019 |
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Circadian Variation in Vasoconstriction and Vasodilation Mediators and Baroreflex Sensitivity in Hypertensive Rats
T Kezeli, N Gongadze, G Sukoyan, M Shikhashvili, Z Chapichadze, M Okujava, N Dolidze |
Journal of circadian rhythms | 2019 |
|
Pharmacological basis and new insights of resveratrol action in the cardiovascular system
CK Cheng, JY Luo, CW Lau, ZY Chen, XY Tian, Y Huang |
British Journal of Pharmacology | 2019 |
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Autophagy in aging and longevity
SQ Wong, AV Kumar, J Mills, LR Lapierre |
Human Genetics | 2019 |
|
Meal Timing, Aging, and Metabolic Health
K Kessler, O Pivovarova-Ramich |
International journal of molecular sciences | 2019 |
|
Associations between sleep conditions and body composition states: results of the EPISONO study
RD Piovezan, C Hirotsu, R Moizinho, HS Souza, V D'Almeida, S Tufik, D Poyares |
Journal of Cachexia, Sarcopenia and Muscle | 2019 |
|
Age-related changes in B cell metabolism
RK Kurupati, LH Haut, KE Schmader, HC Ertl |
Aging | 2019 |
|
Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms
P Lax, I Ortuño-Lizarán, V Maneu, M Vidal-Sanz, N Cuenca |
International journal of molecular sciences | 2019 |
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Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia
F Pifferi, J Epelbaum, F Aujard |
Frontiers in pharmacology | 2019 |
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A Delayed Advantage: Multi-Session Training at Evening Hours Leads to Better Long-Term Retention of Motor Skill in the Elderly
C Gal, E Gabitov, R Maaravi-Hesseg, A Karni, M Korman |
Frontiers in aging neuroscience | 2019 |
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The Development and Decay of the Circadian Clock in Drosophila melanogaster
J Zhao, G Warman, J Cheeseman |
2019 | |
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Structural insights into melatonin receptors
B Stauch, LC Johansson, V Cherezov |
The FEBS journal | 2019 |
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The Impact of a Cycled Lighting Intervention on Nursing Home Residents: A Pilot Study
OM Giggins, J Doyle, K Hogan, M George |
Gerontology and Geriatric Medicine | 2019 |
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Astrocytes and Aging
AL Palmer, SS Ousman |
Frontiers in aging neuroscience | 2018 |
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Aging and the clock: Perspective from flies to humans
AK Nobrega, LC Lyons |
The European journal of neuroscience | 2018 |
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Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization
SC Tao, SC Guo |
International journal of biological sciences | 2018 |
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Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver
H Whitton, LN Singh, MA Patrick, AJ Price, FG Osorio, C López-Otín, IM Bochkis |
Aging Cell | 2018 |
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Of Microbes and Minds: A Narrative Review on the Second Brain Aging
R Calvani, A Picca, MR Monaco, F Landi, R Bernabei, E Marzetti |
Frontiers in Medicine | 2018 |
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Circadian monitoring as an aging predictor
A Martinez-Nicolas, JA Madrid, FJ García, M Campos, MT Moreno-Casbas, PF Almaida-Pagán, A Lucas-Sánchez, MA Rol |
Scientific Reports | 2018 |
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Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways
F Georg, J Ludger, AC Alan, L Walter, G Manfred, S Andreas, S Nadine, C Francesca, B Alessandra, A Peter, K Rüdiger, W Brecht, M Steffen |
Aging and disease | 2018 |
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Circadian disruption: What do we actually mean?
C Vetter |
The European journal of neuroscience | 2018 |
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SNCA overexpression disturbs hippocampal gene expression trajectories in midlife
T Hentrich, Z Wassouf, O Riess, JM Schulze-Hentrich |
Aging | 2018 |
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Neurodegeneration and the Circadian Clock
S Hood, SA Amir |
Frontiers in aging neuroscience | 2017 |
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Sleep, Health and Wellness at Work: A Scoping Review
N Magnavita, S Garbarino |
International journal of environmental research and public health | 2017 |
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CirGRDB: a database for the genome-wide deciphering circadian genes and regulators
X Li, L Shi, K Zhang, W Wei, Q Liu, F Mao, J Li, W Cai, H Chen, H Teng, J Li, Z Sun |
Nucleic Acids Research | 2017 |
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