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Satoru Osuka, Erwin G. Van Meir
Published February 1, 2017
Citation Information: J Clin Invest. 2017;127(2):415-426. https://doi.org/10.1172/JCI89587.
Citation Information: J Clin Invest. 2017;127(2):415-426. https://doi.org/10.1172/JCI89587.
Abstract
Glioblastoma is the most common and lethal primary malignant brain tumor in adults. Patients die from recurrent tumors that have become resistant to therapy. New strategies are needed to design future therapies that target resistant cells. Recent genomic studies have unveiled the complexity of tumor heterogeneity in glioblastoma and provide new insights into the genomic landscape of tumor cells that survive and initiate tumor recurrence. Resistant cells also co-opt developmental pathways and display stem-like properties; hence we propose to name them recurrence-initiating stem-like cancer (RISC) cells. Genetic alterations and genomic reprogramming underlie the innate and adaptive resistance of RISC cells, and both need to be targeted to prevent glioblastoma recurrence.
Authors
Satoru Osuka, Erwin G. Van Meir
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Citations to this article (275)
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K Khattar, J Safi, A Rodriguez, M Vignais |
Cancers | 2022 |
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Blockade of Nuclear Factor-Κb (NF-Κb) Pathway Using Bay 11-7082 Enhances Arsenic Trioxide-Induced Antiproliferative Activity in U87 Glioblastoma Cells
A Nasrollahzadeh, M Momeny, D Bashash, H Yousefi, S Mousavi, S Ghaffari |
Reports of Biochemistry & Molecular Biology | 2022 |
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Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance
V Dolce, S Dusi, M Giannattasio, C Joseph, M Fumasoni, D Branzei |
Genes & development | 2022 |
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MD2 Is a Potential Biomarker Associated with Immune Cell Infiltration in Gliomas
M Zhao, X Li, Y Chen, S Wang |
Frontiers in Oncology | 2022 |
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CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression
W Peng, S Shi, J Zhong, H Liang, J Hou, X Hu, F Wang, J Zhang, S Geng, X Sun, D Zhong, H Cui |
Oncogene | 2022 |
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Integrative analysis of therapy resistance and transcriptomic profiling data in glioblastoma cells identifies sensitization vulnerabilities for combined modality radiochemotherapy
L Schnöller, V Albrecht, N Brix, A Nieto, D Fleischmann, M Niyazi, J Hess, C Belka, K Unger, K Lauber, M Orth |
Radiation Oncology | 2022 |
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HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme
E Arunachalam, W Rogers, G Simpson, C Möller-Levet, G Bolton, M Ismael, C Smith, K Keegen, I Bagwan, T Brend, S Short, B Hong, Y Otani, B Kaur, N Annels, R Morgan, H Pandha |
BMC Cancer | 2022 |
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Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy
J Xu, P Wu, T Lai, P Sharma, A Canella, A Welker, C Beattie, J Brad, M Easley, R Lonser, N Jacob, M Pietrzak, C Timmers, F Lang, D Sampath, V Puduvalli |
Clinical cancer research | 2022 |
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Pyroptosis-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Glioma
Y Zhang, C Zhang, Y Yang, G Wang, Z Wang, J Liu, L Zhang, Y Yu |
Frontiers in Cell and Developmental Biology | 2022 |
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Effects of Long-Term Temozolomide Treatment on Glioblastoma and Astrocytoma WHO Grade 4 Stem-like Cells
J Feldheim, A Kessler, J Feldheim, E Schulz, D Wend, L Lazaridis, C Kleinschnitz, M Glas, R Ernestus, S Brandner, C Monoranu, M Löhr, C Hagemann |
International journal of molecular sciences | 2022 |
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RNF216 Alleviates Radiation-Induced Apoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation of p53 in Glioblastoma
S Xie, Z Hong, Y Li, J Wang, J Wang, S Li, Y Liu |
Molecular Neurobiology | 2022 |
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Sedoheptulose Kinase SHPK Expression in Glioblastoma: Emerging Role of the Nonoxidative Pentose Phosphate Pathway in Tumor Proliferation
Franceschi S, Lessi F, Morelli M, Menicagli M, Pasqualetti F, Aretini P, Mazzanti CM |
International journal of molecular sciences | 2022 |
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Integrin-αvβ3 as a Therapeutic Target in Glioblastoma: Back to the Future?
Echavidre W, Picco V, Faraggi M, Montemagno C |
Pharmaceutics | 2022 |
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Targeting adaptive radioresistance in glioblastoma
Osuka S |
Neuro-Oncology | 2022 |
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Real‐time longitudinal analysis of human gliomas reveals in vivo genome evolution and therapeutic impact under standardized treatment
Xu S, Sheng Z, Yu J, Deng K, Wu S, Bu Y, Guo G, Zhang Z, Liu G, Gao Y, Yan Z, Bu C, He Y, Liu G, Zemmar A, Hernesniemi J, Kong L, Wang M, Li T, Bu X |
Clinical and Translational Medicine | 2022 |
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Chronically Radiation-Exposed Survivor Glioblastoma Cells Display Poor Response to Chk1 Inhibition under Hypoxia
Pinarbasi-Degirmenci N, Sur-Erdem I, Akcay V, Bolukbasi Y, Selek U, Solaroglu I, Bagci-Onder T |
International journal of molecular sciences | 2022 |
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Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy
Zhou Y, Guo Y, Chen L, Zhang X, Wu W, Yang Z, Li X, Wang Y, Hu Z, Wang Z |
Theranostics | 2022 |
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Drug Repurposing, a Fast-Track Approach to Develop Effective Treatments for Glioblastoma
Ntafoulis I, Koolen SL, Leenstra S, Lamfers ML |
Cancers | 2022 |
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Nanotechnology-Based Combinatorial Anti-Glioblastoma Therapies: Moving from Terminal to Treatable
Barzegar Behrooz A, Talaie Z, Syahir A |
Pharmaceutics | 2022 |
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Advanced Cell Therapies for Glioblastoma.
Wang G, Wang W |
Frontiers in immunology | 2022 |
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Disulfiram in glioma: Literature review of drug repurposing
Zhong S, Shengyu Liu, Xin Shi, Zhang X, Li K, Liu G, Li L, Tao S, Zheng B, Sheng W, Ye Z, Xing Q, Zhai Q, Ren L, Wu Y, Bao Y |
Frontiers in pharmacology | 2022 |
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A novel hypoxia-driven gene signature that can predict the prognosis and drug resistance of gliomas.
Ren P, Wang JY, Zeng ZR, Li NX, Chen HL, Peng XG, Bhawal UK, Guo WZ |
Frontiers in Genetics | 2022 |
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Emerging roles of purinergic signaling in anti-cancer therapy resistance
Zanoni M, Pegoraro A, Adinolfi E, De Marchi E |
Frontiers in Cell and Developmental Biology | 2022 |
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Global research trends and hotspots on glioma stem cells
Song S, Wu H, Wang F, Jiao J, Xu L, Wang H, Tong X, Yan H |
Frontiers in Oncology | 2022 |
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Potassium Ion Channels in Malignant Central Nervous System Cancers
Boyle Y, Johns TG, Fletcher EV |
Cancers | 2022 |
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P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells
Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI |
Nature Communications | 2022 |
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Detecting monocyte trafficking in an animal model of glioblastoma using R2* and quantitative susceptibility mapping.
Yang R, Hamilton AM, Sun H, Rawji KS, Sarkar S, Mirzaei R, Pike GB, Yong VW, Dunn JF |
Cancer Immunology, Immunotherapy | 2022 |
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Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma.
Joshkon A, Tabouret E, Traboulsi W, Bachelier R, Simoncini S, Roffino S, Jiguet-Jiglaire C, Badran B, Guillet B, Foucault-Bertaud A, Leroyer AS, Dignat-George F, Chinot O, Fayyad-Kazan H, Bardin N, Blot-Chabaud M |
Acta Neuropathologica Communications | 2022 |
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DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts.
Spina R, Mills I, Ahmad F, Chen C, Ames HM, Winkles JA, Woodworth GF, Bar EE |
Oncogene | 2022 |
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Assessing Spatial Distribution of Multicellular Self-Assembly Enables the Prediction of Phenotypic Heterogeneity in Glioblastoma
Cha J, Sim W, Yong I, Park J, Shim JK, Chang JH, Kang SG, Kim P |
Cancers | 2022 |
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Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling
Xu J, Sun S, Zhang W, Dong J, Huang C, Wang X, Jia M, Yang H, Wang Y, Jiang Y, Cao L, Huang Z |
Frontiers in pharmacology | 2022 |
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Endovascular Chemotherapy: Selective Targeting for Brain Cancer
Patel A, Foreman M, Tabarestani A, Sheth S, Mumtaz M, Reddy A, Sharaf R, Lucke-Wold B |
2022 | |
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Anti‐cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression
Miao Y, Deng Y, Liu J, Wang J, Hu B, Hao S, Wang H, Zhang Z, Jin Z, Zhang Y, Li C, Zhang P, Wan H, Zhang S, Feng J, Ji N |
CNS Neuroscience & Therapeutics | 2022 |
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N-cadherin upregulation mediates adaptive radioresistance in glioblastoma
Satoru Osuka, DAN ZHU, Zhaobin Zhang, Chaoxi Li, Christian T Stackhouse, Oltea Sampetrean, Jeffrey J. Olson, G. Yancey Gillespie, Hideyuki Saya, Christopher D Willey, Erwin G Van Meir |
Journal of Clinical Investigation | 2021 |
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asymmetric division promotes therapeutic resistance in glioblastoma stem cells
Masahiro Hitomi, Anastasia P. Chumakova, Daniel J. Silver, Arnon M. Knudsen, W. Dean Pontius, Stephanie Murphy, Neha S. Anand, Bjarne Winther Kristensen, Justin Lathia |
JCI Insight | 2021 |
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Comprehensive Analysis of the Clinical and Biological Significances of Endoplasmic Reticulum Stress in Diffuse Gliomas
R Huang, G Li, K Wang, Z Wang, F Zeng, H Hu, T Jiang |
Frontiers in Cell and Developmental Biology | 2021 |
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Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers
Y Cheng, W Li, R Gui, C Wang, J Song, Z Wang, X Wang, Y Shen, Z Wang, L Hao |
Frontiers in Cell and Developmental Biology | 2021 |
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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response
J Li, MM Kaneda, J Ma, M Li, RM Shepard, K Patel, T Koga, A Sarver, F Furnari, B Xu, S Dhawan, J Ning, H Zhu, A Wu, G You, T Jiang, AS Venteicher, JN Rich, CK Glass, JA Varner, CC Chen |
Proceedings of the National Academy of Sciences | 2021 |
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Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling
Y Hou, B Sun, W Liu, B Yu, Q Shi, F Luo, Y Bai, H Feng |
Theranostics | 2021 |
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A New Perspective on Cancer Therapy: Changing the Treaded Path?
JN Baidoo, S Mukherjee, K Kashfi, P Banerjee |
International journal of molecular sciences | 2021 |
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Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment
R Huang, R Dong, N Wang, Y He, P Zhu, C Wang, B Lan, Y Gao, L Sun |
Cellular and Molecular Neurobiology | 2021 |
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Repurposing FDA approved drugs inhibiting mitochondrial function for targeting glioma-stem like cells
S Datta, T Sears, G Cortopassi, K Woolard, JM Angelastro |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2021 |
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β-Elemene Triggers ROS-dependent Apoptosis in Glioblastoma Cells Through Suppressing STAT3 Signaling Pathway
S Cai, Q Xiong, L Zhao, Y Ji, Z Luo, Z Ma |
Pathology oncology research : POR | 2021 |
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Efficacy of Whole-Ventricular Radiotherapy in Patients Undergoing Maximal Tumor Resection for Glioblastomas Involving the Ventricle
KH Kim, J Yoo, N Kim, JH Moon, HK Byun, SG Kang, JH Chang, HI Yoon, CO Suh |
Frontiers in Oncology | 2021 |
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Disulfiram Sensitizes a Therapeutic-Resistant Glioblastoma to the TGF-β Receptor Inhibitor
CC Liu, CL Wu, MX Lin, CI Sze, PW Gean |
International journal of molecular sciences | 2021 |
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Stem cells for the treatment of glioblastoma: a 20-year perspective
AA Calinescu, MK Kauss, Z Sultan, WN Al-Holou, SK OShea |
CNS Oncology | 2021 |
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Pathogenetic Features and Current Management of Glioblastoma
HM Nguyen, K Guz-Montgomery, DB Lowe, D Saha |
Cancers | 2021 |
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Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma
MB Khan, R Ruggieri, E Jamil, NL Tran, C Gonzalez, N Mugridge, S Gao, J MacDiarmid, H Brahmbhatt, JN Sarkaria, J Boockvar, M Symons |
Molecular Medicine | 2021 |
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Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma
L He, K Bhat, A Ioannidis, L Zhang, NT Nguyen, JE Allen, PL Nghiemphu, TF Cloughesy, LM Liau, HI Kornblum, F Pajonk |
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | 2021 |
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Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond
M Orth, V Albrecht, K Seidl, L Kinzel, K Unger, J Hess, L Kreutzer, N Sun, B Stegen, A Nieto, J Maas, N Winssinger, AA Friedl, AK Walch, C Belka, H Zitzelsberger, M Niyazi, K Lauber |
Frontiers in Oncology | 2021 |
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Lessons learned from contemporary glioblastoma randomized clinical trials through systematic review and network meta-analysis: part 2 recurrent glioblastoma
S Taslimi, VC Ye, PY Wen, G Zadeh |
2021 | |
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Refinement of response assessment in neuro-oncology (RANO) using non-enhancing lesion type and contrast enhancement evolution pattern in IDH wild-type glioblastomas
HH Moon, HS Kim, JE Park, YH Kim, JH Kim |
BMC Cancer | 2021 |
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Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma
E Tirrò, M Massimino, C Romano, F Martorana, MS Pennisi, S Stella, G Pavone, SD Gregorio, A Puma, C Tomarchio, SR Vitale, L Manzella, P Vigneri |
Frontiers in Oncology | 2021 |
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Glioma: molecular signature and crossroads with tumor microenvironment
L Barthel, M Hadamitzky, P Dammann, M Schedlowski, U Sure, BK Thakur, S Hetze |
Cancer and Metastasis Reviews | 2021 |
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Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development
B Majc, M Novak, N Kopitar-Jerala, A Jewett, B Breznik |
Cells | 2021 |
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FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells
WS Choi, X Xu, S Goruk, Y Wang, S Patel, M Chow, CJ Field, R Godbout |
Nutrients | 2021 |
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Neobavaisoflavone May Modulate the Activity of Topoisomerase Inhibitors towards U-87 MG Cells: An In Vitro Study
M Maszczyk, Z Rzepka, J Rok, A Beberok, D Wrześniok |
Molecules (Basel, Switzerland) | 2021 |
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Novel Insights into the Role of the Mineralocorticoid Receptor in Human Glioblastoma
P Aldaz, A Fernández-Celis, N López-Andrés, I Arozarena |
International journal of molecular sciences | 2021 |
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Efficacy and safety of nivolumab in Japanese patients with first recurrence of glioblastoma: an open-label, non-comparative study
T Aoki, N Kagawa, K Sugiyama, T Wakabayashi, Y Arakawa, S Yamaguchi, S Tanaka, E Ishikawa, Y Muragaki, M Nagane, M Nakada, S Suehiro, N Hata, J Kuroda, Y Narita, Y Sonoda, Y Iwadate, M Natsumeda, Y Nakazato, H Minami, Y Hirata, S Hagihara, R Nishikawa |
International Journal of Clinical Oncology | 2021 |
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Immune-related genes with APA in microenvironment indicate risk stratification and clinical prognosis in grade II/III gliomas
S Xu, L Tang, G Dai, C Luo, Z Liu |
Molecular Therapy — Nucleic Acids | 2021 |
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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution
Z Bao, Y Wang, Q Wang, S Fang, X Shan, J Wang, T Jiang |
Frontiers of Medicine | 2021 |
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Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications
A Comba, SM Faisal, ML Varela, T Hollon, WN Al-Holou, Y Umemura, FJ Nunez, S Motsch, MG Castro, PR Lowenstein |
Frontiers in Oncology | 2021 |
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Mechanisms of Long Non-Coding RNAs in Biological Characteristics and Aerobic Glycolysis of Glioma
N Zhao, J Zhang, Q Zhao, C Chen, H Wang |
International journal of molecular sciences | 2021 |
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Adjusting the Molecular Clock: The Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy
PM Wagner, CG Prucca, BL Caputto, ME Guido |
International journal of molecular sciences | 2021 |
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Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme
SH Lee, HJ Kwon, S Park, CI Kim, H Ryu, SS Kim, JB Park, JT Kwon, JA Bauer |
PloS one | 2021 |
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Glial and myeloid heterogeneity in the brain tumour microenvironment
BM Andersen, CF Akl, MA Wheeler, EA Chiocca, DA Reardon, FJ Quintana |
Nature Reviews Cancer | 2021 |
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A Composite Nanosystem as a Potential Tool for the Local Treatment of Glioblastoma: Chitosan-Coated Solid Lipid Nanoparticles Embedded in Electrospun Nanofibers
B Vigani, C Valentino, G Sandri, R Listro, F Fagiani, S Collina, C Lanni, MC Bonferoni, CM Caramella, S Rossi, F Ferrari |
Polymers | 2021 |
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An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5
TL Turnšek, X Jiao, M Novak, S Jammula, G Cicero, AW Ashton, D Joyce, RG Pestell |
International journal of molecular sciences | 2021 |
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Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma
IN Lee, JT Yang, C Huang, HC Huang, YP Wu, JC Chen |
Oncology Letters | 2021 |
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Cytosolic Ca 2+ transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells
RB Rosenblatt, JA Frank, SR Burks |
Theranostics | 2021 |
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PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway
R Mirzaei, A Gordon, FJ Zemp, M Kumar, S Sarkar, HA Luchman, AC Bellail, C Hao, DJ Mahoney, JF Dunn, P Bose, VW Yong |
Science Advances | 2021 |
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Low expression of CDHR1 is an independent unfavorable prognostic factor in glioma
H Wang, X Wang, L Xu, Y Lin, J Zhang, H Cao |
Journal of Cancer | 2021 |
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Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism
Z Zhou, X Zheng, X Mei, W Li, S Qi, Y Deng, B Lei |
Annals of translational medicine | 2021 |
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Recurrent glioblastoma: Nuances and insights
M Alimohamadi, A Larijani |
Asian Journal of Neurosurgery | 2021 |
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Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized 13 C‐MRI
T Kawai, JR Brender, JA Lee, T Kramp, S Kishimoto, MC Krishna, P Tofilon, KA Camphausen |
NMR in Biomedicine | 2021 |
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Characterizing the Genomic Profile in High-Grade Gliomas: From Tumor Core to Peritumoral Brain Zone, Passing through Glioma-Derived Tumorspheres
M Giambra, E Messuti, AD Cristofori, C Cavandoli, R Bruno, R Buonanno, M Marzorati, M Zambuto, V Rodriguez-Menendez, S Redaelli, C Giussani, A Bentivegna |
Biology : open access journal | 2021 |
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A Ferroptosis-Related Prognostic Risk Score Model to Predict Clinical Significance and Immunogenic Characteristics in Glioblastoma Multiforme
D Xiao, Y Zhou, X Wang, H Zhao, C Nie, X Jiang, X Li |
Oxidative Medicine & Cellular Longevity | 2021 |
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A Hypoxia-Associated Prognostic Gene Signature Risk Model and Prognosis Predictors in Gliomas
F Gao, Z Wang, J Gu, X Zhang, H Wang |
Frontiers in Oncology | 2021 |
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MT1-MMP Cooperates with TGF-β Receptor-Mediated Signaling to Trigger SNAIL and Induce Epithelial-to-Mesenchymal-like Transition in U87 Glioblastoma Cells
S Djediai, NG Suarez, LE Cheikh-Hussein, SR Torres, L Gresseau, S Dhayne, Z Joly-Lopez, B Annabi |
International journal of molecular sciences | 2021 |
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RUNX1 (RUNX family transcription factor 1), a target of microRNA miR-128-3p, promotes temozolomide resistance in glioblastoma multiform by upregulating multidrug resistance-associated protein 1 (MRP1)
J Xu, J Song, M Xiao, C Wang, Q Zhang, X Yuan, S Tian |
Bioengineered | 2021 |
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A novel risk signature with 6 RNA binding proteins for prognosis prediction in patients with glioblastoma
Huang QR, Li JW, Pan XB |
Medicine | 2021 |
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Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
Knudsen AM, Halle B, Cédile O, Burton M, Baun C, Thisgaard H, Anand A, Hubert C, Thomassen M, Michaelsen SR, Olsen BB, Dahlrot RH, Bjerkvig R, Lathia JD, Kristensen BW |
Neuro-Oncology | 2021 |
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Gene Therapy for the Treatment of Malignant Glioma
DY Zhang, L Singer, AM Sonabend, RV Lukas |
2021 | |
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Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.
Fletcher-Sananikone E, Kanji S, Tomimatsu N, Di Cristofaro LFM, Kollipara RK, Saha D, Floyd JR, Sung P, Hromas R, Burns TC, Kittler R, Habib AA, Mukherjee B, Burma S |
Cancer research | 2021 |
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Chimeric Antigen Receptor T-Cell Therapy in Glioblastoma: Current and Future
L Li, X Zhu, Y Qian, X Yuan, Y Ding, D Hu, X He, Y Wu |
Frontiers in immunology | 2020 |
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ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang |
Theranostics | 2020 |
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Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study
C Helaine, AE Ferré, MM Leblond, EA Pérès, M Bernaudin, S Valable, E Petit |
Cancers | 2020 |
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mTOR Modulates Intercellular Signals for Enlargement and Infiltration in Glioblastoma Multiforme
L Ryskalin, F Biagioni, P Lenzi, A Frati, F Fornai |
Cancers | 2020 |
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Publication Landscape Analysis on Gliomas: How Much Has Been Done in the Past 25 Years?
C Feng, Y Wu, L Gao, X Guo, Z Wang, B Xing |
Frontiers in Oncology | 2020 |
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Contrast-enhanced, conebeam CT-based, fractionated radiotherapy and follow-up monitoring of orthotopic mouse glioblastoma: a proof-of-concept study
B Stegen, A Nieto, V Albrecht, J Maas, M Orth, K Neumaier, S Reinhardt, M Weick-Kleemann, W Goetz, M Reinhart, K Parodi, C Belka, M Niyazi, K Lauber |
Radiation Oncology | 2020 |
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Intracranial glioma xenograft model rapidly reestablishes blood–brain barrier integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography and contrast agents
LM Habimana-Griffin, D Ye, J Carpenter, J Prior, G Sudlow, L Marsala, M Mixdorf, JB Rubin, H Chen, S Achilefu |
Journal of Biomedical Optics | 2020 |
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Identification of an ATP metabolism‐related signature associated with prognosis and immune microenvironment in gliomas
R Huang, G Li, Z Wang, H Hu, F Zeng, K Zhang, K Wang, F Wu |
Cancer Science | 2020 |
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Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
S Oh, J Yeom, HJ Cho, JH Kim, SJ Yoon, H Kim, JK Sa, S Ju, H Lee, MJ Oh, W Lee, Y Kwon, H Li, S Choi, JH Han, JH Chang, E Choi, J Kim, NG Her, SH Kim, SG Kang, E Paek, DH Nam, C Lee, HS Kim |
Nature Communications | 2020 |
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Injectable Biomaterials for Treatment of Glioblastoma
AR Anderson, T Segura |
Advanced Materials Interfaces | 2020 |
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Bioinformatics analysis of high-throughput data to validate potential novel biomarkers and small molecule drugs for glioblastoma multiforme
F Qi, Q Li, X Lu, Z Chen |
J INT MED RES | 2020 |
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Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
H Liu, H Hu, G Li, Y Zhang, F Wu, X Liu, K Wang, C Zhang, T Jiang |
Frontiers in Cell and Developmental Biology | 2020 |
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Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting
H Liu, W Weng, R Guo, J Zhou, J Xue, S Zhong, J Cheng, MX Zhu, SJ Pan, Y Li |
Cell Death and Differentiation | 2020 |
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Tumor cell network integration in glioma represents a stemness feature
R Xie, T Kessler, J Grosch, L Hai, V Venkataramani, L Huang, DC Hoffmann, G Solecki, M Ratliff, M Schlesner, W Wick, F Winkler |
Neuro-Oncology | 2020 |
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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
PY Wen, M Weller, EQ Lee, BM Alexander, JS Barnholtz-Sloan, FP Barthel, TT Batchelor, RS Bindra, SM Chang, EA Chiocca, TF Cloughesy, JF DeGroot, E Galanis, MR Gilbert, ME Hegi, C Horbinski, RY Huang, AB Lassman, EL Rhun, M Lim, MP Mehta, IK Mellinghoff, G Minniti, D Nathanson, M Platten, M Preusser, P Roth, M Sanson, D Schiff, SC Short, MJ Taphoorn, JC Tonn, J Tsang, RG Verhaak, A von Deimling, W Wick, G Zadeh, DA Reardon, KD Aldape, MJ van den Bent |
Neuro-Oncology | 2020 |
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Enterovirus A71 Oncolysis of Malignant Gliomas
X Zhang, H Wang, Y Sun, M Qi, W Li, Z Zhang, XE Zhang, Z Cui |
Molecular Therapy | 2020 |
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PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III
JY Kim, HJ Kim, CW Jung, BI Choi, DH Lee, MJ Park |
Oncogene | 2020 |
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MicroRNA-1298-3p inhibits proliferation and invasion of glioma cells by downregulating Nidogen-1
X Xu, Y Ban, Z Zhao, Q Pan, J Zou |
Aging | 2020 |
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Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells
J Zheng, B Wang, R Zheng, J Zhang, C Huang, R Zheng, Z Huang, W Qiu, M Liu, K Yang, Z Mao, A Ji, Y Yuan |
Cell Death and Disease | 2020 |
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Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies
K Connor, DW Murray, MA Jarzabek, NL Tran, K White, P Dicker, KJ Sweeney, PJ OHalloran, B MacCarthy, LP Shiels, F Lodi, D Lambrechts, JN Sarkaria, RM Schiffelers, M Symons, AT Byrne |
Cancers | 2020 |
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Current Progress of Phytomedicine in Glioblastoma Therapy
FH Shah, S Salman, J Idrees, F Idrees, ST Shah, AA Khan, B Ahmad |
2020 | |
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IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells
C Dong, J Zhang, S Fang, F Liu |
Cell division | 2020 |
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Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma
W Wu, Y Wu, K Mayer, C von Rosenstiel, J Schecker, S Baur, S Würstle, F Liesche-Starnecker, J Gempt, J Schlegel |
Translational oncology | 2020 |
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Extracellular Vesicles Loaded miRNAs as Potential Modulators Shared Between Glioblastoma, and Parkinson’s and Alzheimer’s Diseases
L Thomas, T Florio, C Perez-Castro |
Frontiers in cellular neuroscience | 2020 |
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CCR5-Mediated Signaling is Involved in Invasion of Glioblastoma Cells in Its Microenvironment
M Novak, MK Krajnc, B Hrastar, B Breznik, B Majc, M Mlinar, A Rotter, A Porčnik, J Mlakar, K Stare, RG Pestell, TL Turnšek |
International journal of molecular sciences | 2020 |
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Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas
V Ramakrishnan, B Xu, J Akers, T Nguyen, J Ma, S Dhawan, J Ning, Y Mao, W Hua, E Kokkoli, F Furnari, BS Carter, CC Chen |
EBioMedicine | 2020 |
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Ribosomal Protein S27/Metallopanstimulin-1 (RPS27) in Glioma—A New Disease Biomarker?
J Feldheim, AF Kessler, D Schmitt, E Salvador, CM Monoranu, JJ Feldheim, RI Ernestus, M Löhr, C Hagemann |
Cancers | 2020 |
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Measuring Cancer Hallmark Mediation of the TET1 Glioma Survival Effect with Linked Neural-Network Based Mediation Experiments
T Luechtefeld, N Lin, C Paller, K Kuhns, JJ Laterra, JP Bressler |
Scientific Reports | 2020 |
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Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
A Choromanska, J Kulbacka, J Saczko, P Surowiak |
Biomedical Reports | 2020 |
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Potential roads for reaching the summit: an overview on target therapies for high-grade gliomas
Alice Giotta Lucifero, Sabino Luzzi, Ilaria Brambilla, Lucia Schena, Mario Mosconi, Thomas Foiadelli, Salvatore Savasta |
Acta bio-medica : Atenei Parmensis | 2020 |
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Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology
J Yang, Z Shi, R Liu, Y Wu, X Zhang |
Theranostics | 2020 |
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Nanocarrier-based drug combination therapy for glioblastoma
M Zhao, D van Straten, ML Broekman, V Préat, RM Schiffelers |
Theranostics | 2020 |
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The role of extracellular vesicles in acquisition of resistance to therapy in glioblastomas
A Yekula, A Taylor, A Beecroft, K Kang, J Small, K Muralidharan, Z Rosh, B Carter, L Balaj |
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Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
J Jiang, L Zhang, H Chen, Y Lei, T Zhang, Y Wang, P Jin, J Lan, L Zhou, Z Huang, B Li, Y Liu, W Gao, K Xie, L Zhou, EC Nice, Y Peng, Y Cao, Y Wei, K Wang, C Huang |
Autophagy | 2019 |
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TGF‐β‐activated lncRNA LINC00115 is a critical regulator of glioma stem‐like cell tumorigenicity
J Tang, B Yu, Y Li, W Zhang, AA Alvarez, B Hu, SY Cheng, H Feng |
EMBO reports | 2019 |
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MIR93 ( microRNA -93 ) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy
T Huang, X Wan, AA Alvarez, CD James, X Song, Y Yang, N Sastry, I Nakano, EP Sulman, B Hu, SY Cheng |
Autophagy | 2019 |
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Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux
Z Wen, W Zeng, Y Chen, H Li, J Wang, Q Cheng, J Yu, H Zhou, Z Liu, J Xiao, X Chen |
Journal of Experimental & Clinical Cancer Research | 2019 |
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Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy
Q Zhu, X Ling, Y Yang, J Zhang, Q Li, X Niu, G Hu, B Chen, H Li, Y Wang, Z Deng |
Advanced Science | 2019 |
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Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells
P Vora, M Seyfrid, C Venugopal, MA Qazi, S Salim, R Isserlin, M Subapanditha, E OFarrell, S Mahendram, M Singh, D Bakhshinyan, C Chokshi, N McFarlane, A Dvorkin-Gheva, KR Brown, N Murty, J Moffat, GD Bader, SK Singh |
Journal of Neuro-Oncology | 2019 |
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Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers
D Hui, K Tam, I Jiao, C Ong |
International journal of molecular sciences | 2019 |
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Radiation-Induced Changes in Tumor Vessels and Microenvironment Contribute to Therapeutic Resistance in Glioblastoma
YS Seo, IO Ko, H Park, YJ Jeong, JA Park, KS Kim, MJ Park, HJ Lee |
Frontiers in Oncology | 2019 |
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Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2–mediated signaling
Y Sang, Y Hou, R Cheng, L Zheng, AA Alvarez, B Hu, SY Cheng, W Zhang, Y Li, H Feng |
Neuro-Oncology | 2019 |
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Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma
T Hasan, SP Caragher, JM Shireman, CH Park, F Atashi, S Baisiwala, G Lee, D Guo, JY Wang, M Dey, M Wu, MS Lesniak, CM Horbinski, CD James, AU Ahmed |
Cell Death and Disease | 2019 |
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CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
Y Sang, Y Li, Y Zhang, AA Alvarez, B Yu, W Zhang, B Hu, SY Cheng, H Feng |
Nature Communications | 2019 |
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Oligonucleotide Therapeutics as a New Class of Drugs for Malignant Brain Tumors: Targeting mRNAs, Regulatory RNAs, Mutations, Combinations, and Beyond
AM Krichevsky, EJ Uhlmann |
Neurotherapeutics | 2019 |
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Splicing Dysregulation as Oncogenic Driver and Passenger Factor in Brain Tumors
P Bielli, V Pagliarini, M Pieraccioli, C Caggiano, C Sette |
Cells | 2019 |
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Combined elevation of TRIB2 and MAP3K1 indicates poor prognosis and chemoresistance to temozolomide in glioblastoma
J Wang, J Zuo, A Wahafu, M Wang, R Li, W Xie |
CNS Neuroscience & Therapeutics | 2019 |
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Phage Display Libraries: From Binders to Targeted Drug Delivery and Human Therapeutics
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Molecular Biotechnology | 2019 |
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Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma
G Yu, Z Wang, S Zeng, S Liu, C Zhu, R Xu, R Liu |
BioMed Research International | 2019 |
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Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage
G Frosina, D Marubbi, D Marcello, A Daga |
Radiation Oncology | 2019 |
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Deregulated MicroRNA Signature Following Glioblastoma Irradiation
EA Toraih, A El-Wazir, HY Abdallah, MA Tantawy, MS Fawzy |
Cancer control : journal of the Moffitt Cancer Center | 2019 |
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Overlapping migratory mechanisms between neural progenitor cells and brain tumor stem cells
N Zarco, E Norton, A Quiñones-Hinojosa, H Guerrero-Cázares |
Cellular and Molecular Life Sciences | 2019 |
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Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma
A Hara, T Kanayama, K Noguchi, A Niwa, M Miyai, M Kawaguchi, K Ishida, Y Hatano, M Niwa, H Tomita |
Journal of Oncology | 2019 |
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Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas
PK Todorova, E Fletcher-Sananikone, B Mukherjee, R Kollipara, V Vemireddy, XJ Xie, PM Guida, MD Story, K Hatanpaa, AA Habib, R Kittler, R Bachoo, R Hromas, JR Floyd, S Burma |
Cancer research | 2019 |
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Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens
S Pedron, GL Wolter, JW Chen, SE Laken, JN Sarkaria, BA Harley |
Biomaterials | 2019 |
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Asunercept as an innovative therapeutic approach for recurrent glioblastoma and other malignancies A Krendyukov, C Gieffers |
Cancer management and research | 2019 |
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Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets
OG Taylor, JS Brzozowski, KA Skelding |
Frontiers in Oncology | 2019 |
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SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
X Song, X Wan, T Huang, C Zeng, N Sastry, B Wu, CD James, C Horbinski, I Nakano, W Zhang, B Hu, SY Cheng |
Cancer research | 2019 |
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Theranostic nanoparticles enhance the response of glioblastomas to radiation
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Nanotheranostics | 2019 |
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PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas
A Passariello, ME Errico, V Donofrio, M Maestrini, A Zerbato, L Cerchia, M Capasso, M Capasso, M Fedele |
Cancers | 2019 |
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A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis
Wen, Wu, Bamodu, Wei, Lin, Yen, Chao, Mukhopadhyay, Hsiao, Huang |
Cancers | 2019 |
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Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration
M Portela, V Venkataramani, N Fahey-Lozano, E Seco, M Losada-Perez, F Winkler, S Casas-Tintó, JN Rich |
PLoS Biology | 2019 |
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Changes of O6-Methylguanine DNA Methyltransferase (MGMT) Promoter Methylation in Glioblastoma Relapse—A Meta-Analysis Type Literature Review
J Feldheim, AF Kessler, CM Monoranu, RI Ernestus, M Löhr, C Hagemann |
Cancers | 2019 |
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Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches
HP Ellis, CE McInerney, D Schrimpf, F Sahm, A Stupnikov, M Wadsley, C Wragg, P White, KM Prise, DG McArt, KM Kurian |
Journal of Oncology | 2019 |
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To be Wild or Mutant: Role of Isocitrate Dehydrogenase 1 (IDH1) and 2-Hydroxy Glutarate (2-HG) in Gliomagenesis and Treatment Outcome in Glioma
B Bhavya, CR Anand, UK Madhusoodanan, P Rajalakshmi, K Krishnakumar, HV Easwer, AN Deepti, S Gopala |
Cellular and Molecular Neurobiology | 2019 |
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Clinical and metabolomics analysis of hepatocellular carcinoma patients with diabetes mellitus
H Xia, J Chen, K Sekar, M Shi, T Xie, KM Hui |
Metabolomics | 2019 |
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18F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling
F Henderson, S Brem, DM ORourke, ML Nasrallah, VP Buch, AJ Young, RK Doot, A Pantel, A Desai, SJ Bagley, SA Nabavizadeh |
Neuro-Oncology Practice | 2019 |
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Long Noncoding RNA HOTAIRM1 Maintains Tumorigenicity of Glioblastoma Stem-Like Cells Through Regulation of HOX Gene Expression
H Xia, Y Liu, Z Wang, W Zhang, M Qi, B Qi, X Jiang |
Neurotherapeutics | 2019 |
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A new model isolates glioblastoma clonal interactions and reveals unexpected modes for regulating motility, proliferation, and drug resistance
JB Davis, SS Krishna, RA Jomaa, CT Duong, V Espina, LA Liotta, C Mueller |
Scientific Reports | 2019 |
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Novel N -arylamide derivatives of ( S )-perillic acid (( S )-PA): in vitro and in vivo cytotoxicity and antitumor evaluation
Y Mukhtar, K Wang, R Li, W Deng, M Adu-Frimpong, H Zhang, K Zhang, C Gu, X Xu, J Yu |
RSC Advances | 2019 |
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Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression
TA Melhuish, I Kowalczyk, A Manukyan, Y Zhang, A Shah, R Abounader, D Wotton |
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2018 |
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Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma
KC Pituch, J Miska, G Krenciute, WK Panek, G Li, T Rodriguez-Cruz, M Wu, Y Han, MS Lesniak, S Gottschalk, IV Balyasnikova |
Molecular Therapy | 2018 |
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TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3
Y Sang, Y Li, L Song, AA Alvarez, W Zhang, D Lv, J Tang, F Liu, Z Chang, S Hatakeyama, B Hu, SY Cheng, H Feng |
Cancer research | 2018 |
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Identification of an energy metabolism-related signature associated with clinical prognosis in diffuse glioma
Z Zhou, R Huang, R Chai, X Zhou, Z Hu, W Wang, B Chen, L Deng, Y Liu, F Wu |
Aging | 2018 |
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Targeting of BMI-1 with PTC-209 inhibits glioblastoma development
Y Kong, C Ai, F Dong, X Xia, X Zhao, C Yang, C Kang, Y Zhou, Q Zhao, X Sun, X Wu |
Cell cycle (Georgetown, Tex.) | 2018 |
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
RP Pangeni, Z Zhang, AA Alvarez, X Wan, N Sastry, S Lu, T Shi, T Huang, CX Lei, CD James, JA Kessler, CW Brennan, I Nakano, X Lu, B Hu, W Zhang, SY Cheng |
Epigenetics : official journal of the DNA Methylation Society | 2018 |
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Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival
RT Varghese, S Young, L Pham, Y Liang, KJ Pridham, S Guo, S Murphy, DF Kelly, Z Sheng |
Scientific Reports | 2018 |
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Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium
K Aldape, SB Amin, DM Ashley, JS Barnholtz-Sloan, AJ Bates, R Beroukhim, C Bock, DJ Brat, EB Claus, JF Costello, JF de Groot, G Finocchiaro, PJ French, HK Gan, B Griffith, CC Herold-Mende, C Horbinski, A Iavarone, SN Kalkanis, K Karabatsou, H Kim, MC Kouwenhoven, KL McDonald, H Miletic, DH Nam, HK Ng, SP Niclou, H Noushmehr, DR Ormond, LM Poisson, G Reifenberger, F Roncaroli, JK Sa, PA Smitt, M Smits, CF Souza, G Tabatabai, EG Meir, RG Verhaak, C Watts, P Wesseling, A Woehrer, WK Yung, C Jungk, AC Hau, E van Dyck, BA Westerman, J Yin, O Abiola, N Zeps, S Grimmond, M Buckland, M Khasraw, EP Sulman, AM Muscat, L Stead |
Neuro-Oncology | 2018 |
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The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance
DS Hersh, BG Harder, A Roos, S Peng, JE Heath, T Legesse, AJ Kim, GF Woodworth, NL Tran, JA Winkles |
Neuro-Oncology | 2018 |
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CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells
S Mukherjee, C Tucker-Burden, E Kaissi, A Newsam, H Duggireddy, M Chau, C Zhang, B Diwedi, M Rupji, S Seby, J Kowalski, J Kong, R Read, DJ Brat |
Cell Reports | 2018 |
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Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma
S Miki, S Imamichi, H Fujimori, A Tomiyama, K Fujimoto, K Satomi, Y Matsushita, S Matsuzaki, M Takahashi, E Ishikawa, T Yamamoto, A Matsumura, A Mukasa, R Nishikawa, K Masutomi, Y Narita, M Masutani, K Ichimura |
Cancer Science | 2018 |
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A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells
EM Ahmed, G Bandopadhyay, B Coyle, A Grabowska |
Cellular Oncology | 2018 |
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An orthotopic glioblastoma animal model suitable for high-throughput screenings
L Pudelko, S Edwards, M Balan, D Nyqvist, J Al-Saadi, J Dittmer, I Almlöf, T Helleday, L Bräutigam |
Neuro-Oncology | 2018 |
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ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration
G Fròsina, A Profumo, D Marubbi, D Marcello, JL Ravetti, A Daga |
Radiation Oncology | 2018 |
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Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance
H Nguyen, S Shabani, A Awad, M Kaushal, N Doan |
International journal of molecular sciences | 2018 |
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Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection
A González-Morales, A Zabaleta, E Guruceaga, MM Alonso, M García-Moure, J Fernández-Irigoyen, E Santamaría |
Oncotarget | 2018 |
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Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiforme
L Huang, W Boling, JH Zhang |
Medical Gas Research | 2018 |
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Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation
Z Wang, G Yu, Z Liu, J Zhu, C Chen, R Liu, R Xu |
Cancer management and research | 2018 |
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Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy [ARRIVE 1]
G Frosina, JL Ravetti, R Corvò, M Fella, ML Garrè, F Levrero, D Marcello, D Marubbi, G Morana, M Mussap, CE Neumaier, A Profumo, A Raso, F Rosa, S Vagge, D Vecchio, A Verrico, G Zona, A Daga |
Scientific Reports | 2018 |
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PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β–catenin axis
Q Deng, J Hou, L Feng, A Lv, X Ke, H Liang, F Wang, K Zhang, K Chen, H Cui |
Cell Death and Disease | 2018 |
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Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles
LB Hoang-Minh, M Dutra-Clarke, JJ Breunig, MR Sarkisian |
Cilia | 2018 |
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Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma
N Shao, J Mao, L Xue, R Wang, F Zhi, Q Lan |
Journal of Neuro-Oncology | 2018 |
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Association between autocrine motility factor receptor gene polymorphism (rs2440472, rs373191257) and glioblastoma multiform in a representative Iranian population
AE Oskouei, L Rafiee, P Mahzouni, M Gharipour, SH Javanmard |
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences | 2018 |
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MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
T Huang, CK Kim, AA Alvarez, RP Pangeni, X Wan, X Song, T Shi, Y Yang, N Sastry, CM Horbinski, S Lu, R Stupp, JA Kessler, R Nishikawa, I Nakano, EP Sulman, X Lu, CD James, XM Yin, B Hu, SY Cheng |
Cancer Cell | 2017 |
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Evaluation of chemical chaperones based on the monitoring of Bip promoter activity and visualization of extracellular vesicles by real-time bioluminescence imaging
T Horibe, N Okushima, A Torisawa, R Akiyoshi, Y Hatta-Ohashi, H Suzuki, K Kawakami |
Luminescence | 2017 |
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Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs
MN Park, HS Song, M Kim, MJ Lee, W Cho, HJ Lee, CH Hwang, S Kim, Y Hwang, B Kang, B Kim |
BioMed Research International | 2017 |
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Cancer therapy: Neutrophils traffic in cancer nanodrugs
S Osuka, EG van Meir |
Nature Nanotechnology | 2017 |
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Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action
AM da Silva, LC Silva-Gonçalves, FA Oliveira, M Arcisio-Miranda |
Molecular Neurobiology | 2017 |
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Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo
F Vaglini, C Pardini, TD Desidero, P Orlandi, F Pasqualetti, A Ottani, S Pacini, D Giuliani, S Guarini, G Bocci |
Molecular Neurobiology | 2017 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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