Go to
JCI Insight
Citations to this article
Abstract
Authors
Joshua W. Knowles, Weijia Xie, Zhongyang Zhang, Indumathi Chennamsetty, Themistocles L. Assimes, Jussi Paananen, Ola Hansson, James Pankow, Mark O. Goodarzi, Ivan Carcamo-Orive, Andrew P. Morris, Yii-Der I. Chen, Ville-Petteri Mäkinen, Andrea Ganna, Anubha Mahajan, Xiuqing Guo, Fahim Abbasi, Danielle M. Greenawalt, Pek Lum, Cliona Molony, Lars Lind, Cecilia Lindgren, Leslie J. Raffel, Philip S. Tsao, The RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium, The EUGENE (European Network on Functional Genomics of Type Diabetes) Study, The GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium, The SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study, Eric E. Schadt, Jerome I. Rotter, Alan Sinaiko, Gerald Reaven, Xia Yang, Chao A. Hsiung, Leif Groop, Heather J. Cordell, Markku Laakso, Ke Hao, Erik Ingelsson, Timothy M. Frayling, Michael N. Weedon, Mark Walker, Thomas Quertermous
Total citations by year
Citation information
Citations to this article (60)
| Title and authors | Publication | Year |
|---|---|---|
|
Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases
Zhu Y, Verkhratsky A, Chen H, Yi C |
Acta Physiologica (Oxford, England) | 2025 |
|
Predictability of genetic risk score for insulin resistance is influenced by both BMI and race
Yurchishin ML, Fowler LA, Goss AM, Garvey WT, Gower BA |
Obesity (Silver Spring, Md.) | 2025 |
|
Evaluating the Bidirectional Causal Effects of Alzheimer’s Disease Across Multiple Conditions: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies
Zhu H, Ni H, Yang Q, Ni J, Ji J, Yang S, Peng F |
International Journal of Molecular Sciences | 2025 |
|
Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.
Oliveri A, Rebernick RJ, Kuppa A, Pant A, Chen Y, Du X, Cushing KC, Bell HN, Raut C, Prabhu P, Chen VL, Halligan BD, Speliotes EK |
Nature Genetics | 2024 |
|
Function and expression of N-acetyltransferases 1 and 2 are altered in lymphocytes in type 2 diabetes and obesity
Paz-Rodríguez VA, Herrera-Vargas DJ, Turiján-Espinoza E, Martínez-Leija ME, Rivera-López E, Hernández-González O, Zavala-Reyes D, García-Hernández MH, Vargas-Morales JM, Milán-Segovia RD, Portales-Pérez DP |
Biochemistry and Biophysics Reports | 2024 |
|
Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes
Hong KU, Aureliano AP, Walls KM, Hein DW |
Frontiers in Pharmacology | 2024 |
|
Cross-sectional, interventional, and causal investigation of insulin sensitivity using plasma proteomics in diverse populations
Kho PF, Wary N, Zanetti D, Abbasi F, Knowles JW, Panyard DJ, Watson KT, Stell L, Lazzeroni LC, Gustafsson S, Lind L, Petrie JR, Assimes TL |
medRxiv | 2024 |
|
Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders
Hong KU, Walls KM, Hein DW |
Frontiers in pharmacology | 2023 |
|
High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes
Duan YY, Chen XF, Zhu RJ, Jia YY, Huang XT, Zhang M, Yang N, Dong SS, Zeng M, Feng Z, Zhu DL, Wu H, Jiang F, Shi W, Hu WX, Ke X, Chen H, Liu Y, Jing RH, Guo Y, Li M, Yang TL |
The American Journal of Human Genetics | 2023 |
|
Clinical Significance of NAT2 Genetic Variations in Type II Diabetes Mellitus and Lipid Regulation.
Jarrar Y, Abudahab S, Abdul-Wahab G, Zaiter D, Madani A, Abaalkhail SJ, Abulebdah D, Alhawari H, Musleh R, Lee SJ |
Pharmacogenomics and Personalized Medicine | 2023 |
|
Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response—Toward an Actionable Strategy for Anti-Aging
Kasai S, Kokubu D, Mizukami H, Itoh K |
Biomolecules | 2023 |
|
NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.
Gutiérrez-Virgen JE, Piña-Pozas M, Hernández-Tobías EA, Taja-Chayeb L, López-González ML, Meraz-Ríos MA, Gómez R |
PloS one | 2023 |
|
Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans
D Bailetti, F Sentinelli, S Prudente, F Cimini, I Barchetta, M Totaro, A Costanzo, A Barbonetti, F Leonetti, M Cavallo, M Baroni |
International journal of molecular sciences | 2022 |
|
Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes
M Gloudemans, B Balliu, D Nachun, T Schnurr, M Durrant, E Ingelsson, M Wabitsch, T Quertermous, S Montgomery, J Knowles, I Carcamo-Orive |
Genome Medicine | 2022 |
|
Deletion of arylamine N ‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis
M Doll, A Ray, R SalazarGonzález, P Shah, A Vega, S Sears, A Krueger, K Hong, L Beverly, D Hein |
Molecular Carcinogenesis | 2022 |
|
Biological mechanisms of aging predict age‐related disease co‐occurrence in patients
H Fraser, V Kuan, R Johnen, M Zwierzyna, A Hingorani, A Beyer, L Partridge |
Aging Cell | 2022 |
|
Effects of glycemic traits on left ventricular structure and function: a mendelian randomization study
S Ai, X Wang, S Wang, Y Zhao, S Guo, G Li, Z Chen, F Lin, S Guo, Y Li, J Zhang, G Zhao |
Cardiovascular Diabetology | 2022 |
|
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li M, Chi X, Wang Y, Setrerrahmane S, Xie W, Xu H |
Signal Transduction and Targeted Therapy | 2022 |
|
LncRNA-Associated Genetic Etiologies Are Shared between Type 2 Diabetes and Cancers in the UAE Population
Giordo R, Gulsha R, Kalla S, Calin GA, Lipovich L |
Cancers | 2022 |
|
N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances.
Salazar-González RA, Doll MA, Hein DW |
Archives of Toxicology | 2022 |
|
An update of the consensus statement on insulin resistance in children 2010
Tagi VM, Samvelyan S, Chiarelli F |
Frontiers in Endocrinology | 2022 |
|
Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines
Hong KU, Salazar-González RA, Walls KM, Hein DW |
Toxicological Sciences | 2022 |
|
Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes
Vollenbrock CE, Roshandel D, van der Klauw MM, Wolffenbuttel BH, Paterson AD |
BMC Genomics | 2022 |
|
Diabetes: discovery of insulin, genetic, epigenetic and viral infection mediated regulation
S Ghosh, S Mahalanobish, PC Sil |
The Nucleus | 2021 |
|
Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography
R Skals, ML Krogager, EV Appel, TM Schnurr, CT Have, G Gislason, HE Poulsen, L Køber, T Engstrøm, S Stender, T Hansen, N Grarup, CJ Lee, C Andersson, C Torp-Pedersen, PE Weeke, GI Colombo |
PloS one | 2021 |
|
FAM13A affects body fat distribution and adipocyte function
M Fathzadeh, J Li, A Rao, N Cook, I Chennamsetty, M Seldin, X Zhou, P Sangwung, MJ Gloudemans, M Keller, A Attie, J Yang, M Wabitsch, I Carcamo-Orive, Y Tada, AJ Lusis, MK Shin, CM Molony, T McLaughlin, G Reaven, SB Montgomery, D Reilly, T Quertermous, E Ingelsson, JW Knowles |
Nature Communications | 2020 |
|
Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications
P Sangwung, KF Petersen, GI Shulman, JW Knowles |
Endocrinology | 2020 |
|
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
L Wang, N Sinnott-Armstrong, A Wagschal, AR Wark, JP Camporez, RJ Perry, F Ji, Y Sohn, J Oh, S Wu, J Chery, BN Moud, A Saadat, SN Dankel, G Mellgren, DS Tallapragada, SM Strobel, MJ Lee, R Tewhey, PC Sabeti, A Schaefer, A Petri, S Kauppinen, RT Chung, A Soukas, J Avruch, SK Fried, H Hauner, RI Sadreyev, GI Shulman, M Claussnitzer, AM Näär |
Cell | 2020 |
|
Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness
I Carcamo-Orive, MY Henrion, K Zhu, ND Beckmann, P Cundiff, S Moein, Z Zhang, M Alamprese, SL DSouza, M Wabitsch, EE Schadt, T Quertermous, JW Knowles, R Chang, S Chandrasekaran |
PLoS computational biology | 2020 |
|
Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference
JD Song, TC Alves, DE Befroy, RJ Perry, GF Mason, XM Zhang, A Munk, Y Zhang, D Zhang, GW Cline, DL Rothman, KF Petersen, GI Shulman |
Cell Metabolism | 2020 |
|
Pharmacogenetics of Type 2 Diabetes—Progress and Prospects
YA Nasykhova, ZN Tonyan, AA Mikhailova, MM Danilova, AS Glotov |
International journal of molecular sciences | 2020 |
|
Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2
KU Hong, MA Doll, A Lykoudi, RA Salazar-González, MR Habil, KM Walls, AF Bakr, SS Ghare, SS Barve, GE Arteel, DW Hein |
Toxicology Reports | 2020 |
|
Causal associations of insulin resistance with coronary artery disease and ischemic stroke: a Mendelian randomization analysis
W Chen, S Wang, W Lv, Y Pan |
BMJ Open Diabetes Research & Care | 2020 |
|
Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging
R Correa-de-Araujo, O Addison, I Miljkovic, BH Goodpaster, BC Bergman, RV Clark, JW Elena, KA Esser, L Ferrucci, MO Harris-Love, SB Kritchevsky, A Lorbergs, JA Shepherd, GI Shulman, CJ Rosen |
Frontiers in physiology | 2020 |
|
Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans
NK Sharma, CC Key, M Civelek, M Wabitsch, ME Comeau, CD Langefeld, JS Parks, SK Das |
Diabetes | 2019 |
|
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
M Zhou, J Shao, CY Wu, L Shu, W Dong, Y Liu, M Chen, RM Wynn, J Wang, J Wang, WJ Gui, X Qi, AJ Lusis, Z Li, W Wang, G Ning, X Yang, DT Chuang, Y Wang, H Sun |
Diabetes | 2019 |
|
Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes
C Vangenot, P Gagneux, NG de Groot, A Baumeyer, M Mouterde, B Crouau-Roy, P Darlu, A Sanchez-Mazas, A Sabbagh, ES Poloni |
G3: Genes|Genomes|Genetics | 2019 |
|
Reduced Skeletal Muscle Phosphocreatine Concentration in Type 2 Diabetic Patients: A Quantitative Image-Based Phosphorus-31 MR Spectroscopy Study
EM Ripley, GD Clarke, V Hamidi, RA Martinez, FD Settles, C Solis, S Deng, M Abdul-Ghani, D Tripathy, RA DeFronzo |
American journal of physiology. Endocrinology and metabolism | 2018 |
|
Mechanisms of Insulin Action and Insulin Resistance
MC Petersen, GI Shulman |
Physiological reviews | 2018 |
|
Implications of publicly available genomic data resources in searching for therapeutic targets of obesity and type 2 diabetes
S Jung |
Experimental & molecular medicine | 2018 |
|
An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese
AS Graae, M Hollensted, JT Kloppenborg, Y Mahendran, TM Schnurr, EV Appel, J Rask, TR Nielsen, MØ Johansen, A Linneberg, ME Jørgensen, N Grarup, HN Kadarmideen, B Holst, O Pedersen, JC Holm, T Hansen |
Diabetologia | 2018 |
|
Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1
RA Salazar-González, E Turiján-Espinoza, DW Hein, RC Milán-Segovia, EE Uresti-Rivera, DP Portales-Pérez |
Biochemical Pharmacology | 2018 |
|
Mechanism by which arylamine N -acetyltransferase 1 ablation causes insulin resistance in mice
JP Camporez, Y Wang, K Faarkrog, N Chukijrungroat, KF Petersen, GI Shulman |
Proceedings of the National Academy of Sciences | 2017 |
|
Adropin deficiency worsens HFD-induced metabolic defects
S Chen, K Zeng, Q Liu, Z Guo, S Zhang, X Chen, J Lin, J Wen, C Zhao, X Lin, F Gao |
Cell Death and Disease | 2017 |
|
Genetic aetiology of glycaemic traits: approaches and insights
E Wheeler, G Marenne, I Barroso |
Human Molecular Genetics | 2017 |
|
The association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study
L Philips, J Visser, D Nel, R Blaauw |
BMC Infectious Diseases | 2017 |
|
Induced Pluripotent Stem Cell–Derived Endothelial Cells in Insulin Resistance and Metabolic Syndrome
I Carcamo-Orive, NF Huang, T Quertermous, JW Knowles |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
|
Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
VD de Mello, A Matte, A Perfilyev, V Männistö, T Rönn, E Nilsson, P Käkelä, C Ling, J Pihlajamäki |
Epigenetics : official journal of the DNA Methylation Society | 2017 |
|
Cohort Profile: The Healthy Aging Longitudinal Study in Taiwan (HALST)
CC Hsu, HY Chang, IC Wu, CC Chen, HJ Tsai, YF Chiu, SC Chuang, WC Hsiung, TL Tsai, WJ Liaw, IC Lin, SC Shen, CC Juan, LM Lien, M Lee, YD Chen, K Liu, CA Hsiung |
International Journal of Epidemiology | 2017 |
|
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
TF Meehan, N Conte, DB West, JO Jacobsen, J Mason, J Warren, CK Chen, I Tudose, M Relac, P Matthews, N Karp, L Santos, T Fiegel, N Ring, H Westerberg, S Greenaway, D Sneddon, H Morgan, GF Codner, ME Stewart, J Brown, N Horner, M Haendel, N Washington, CJ Mungall, CL Reynolds, J Gallegos, V Gailus-Durner, T Sorg, G Pavlovic, LR Bower, M Moore, I Morse, X Gao, GP Tocchini-Valentini, Y Obata, SY Cho, JK Seong, J Seavitt, AL Beaudet, ME Dickinson, Y Herault, W Wurst, MH de Angelis, KC Lloyd, AM Flenniken, LM Nutter, S Newbigging, C McKerlie, MJ Justice, SA Murray, KL Svenson, RE Braun, JK White, A Bradley, P Flicek, S Wells, WC Skarnes, DJ Adams, H Parkinson, AM Mallon, SD Brown, D Smedley |
Nature Genetics | 2017 |
|
Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus
MS Ahmad, T Kimhofer, S Ahmad, MN AlAma, HH Mosli, SI Hindawi, DO Mook-Kanamori, K Šebeková, ZA Damanhouri, E Holmes, M Zmijewski |
PloS one | 2017 |
|
Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation
Q Wang, MV Holmes, GD Smith, M Ala-Korpela |
Diabetes care | 2017 |
|
Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice
I Chennamsetty, M Coronado, K Contrepois, MP Keller, I Carcamo-Orive, J Sandin, G Fajardo, AJ Whittle, M Fathzadeh, M Snyder, G Reaven, AD Attie, D Bernstein, T Quertermous, JW Knowles |
Cell Reports | 2016 |
|
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
LA Lotta, P Gulati, FR Day, F Payne, H Ongen, M de Bunt, KJ Gaulton, JD Eicher, SJ Sharp, J Luan, ED Rolfe, ID Stewart, E Wheeler, SM Willems, C Adams, H Yaghootkar, C Langenberg, RA Scott, SJ Sharp, NG Forouhi, ND Kerrison, M Sims, DM Lucarelli, I Barroso, P Deloukas, MI McCarthy, L Arriola, B Balkau, A Barricarte, H Boeing, PW Franks, C Gonzalez, S Grioni, R Kaaks, TJ Key, C Navarro, PM Nilsson, K Overvad, D Palli, S Panico, JR Quirós, O Rolandsson, C Sacerdote, E Salamanca-Fernández, N Slimani, A Tjonneland, R Tumino, AM Spijkerman, DL van der A, YT van der Schouw, E Riboli, NJ Wareham, RK Semple, C Adams, A Stears, S George, M Walker, E Gurnell, D Maguire, R Mukhtar, S Nag, A Adler, M Soeters, K Laji, A Watt, S Aylwin, A Johnson, G Rayman, F Hanna, S Ellard, R Ross, K Blaslov, LS Duvnjak, S O'Rahilly, DB Savage, NG Forouhi, KT Khaw, AD Johnson, RK Semple, T Frayling, JR Perry, E Dermitzakis, MI McCarthy, I Barroso, NJ Wareham, DB Savage, C Langenberg, S O'Rahilly, RA Scott |
Nature Genetics | 2016 |
|
Genetics of Insulin Resistance and the Metabolic Syndrome
AE Brown, M Walker |
Current Cardiology Reports | 2016 |
|
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
GA Walford, S Gustafsson, D Rybin, A Stančáková, H Chen, CT Liu, J Hong, RA Jensen, K Rice, AP Morris, R Mägi, A Tönjes, I Prokopenko, ME Kleber, G Delgado, G Silbernagel, AU Jackson, EV Appel, N Grarup, JP Lewis, ME Montasser, C Landenvall, H Staiger, J Luan, TM Frayling, MN Weedon, W Xie, S Morcillo, MT Martínez-Larrad, ML Biggs, YD Chen, A Corbaton-Anchuelo, K Færch, JM Gómez-Zumaquero, MO Goodarzi, JR Kizer, HA Koistinen, A Leong, L Lind, C Lindgren, F Machicao, AK Manning, GM Martín-Núñez, G Rojo-Martínez, JI Rotter, DS Siscovick, JM Zmuda, Z Zhang, M Serrano-Rios, U Smith, F Soriguer, T Hansen, TJ Jørgensen, A Linnenberg, O Pedersen, M Walker, C Langenberg, RA Scott, NJ Wareham, A Fritsche, HU Häring, N Stefan, L Groop, JR OConnell, M Boehnke, RN Bergman, FS Collins, KL Mohlke, J Tuomilehto, W März, P Kovacs, M Stumvoll, BM Psaty, J Kuusisto, M Laakso, JB Meigs, J Dupuis, E Ingelsson, JC Florez |
Diabetes | 2016 |
|
New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins
D Roshandel, R Klein, BE Klein, BH Wolffenbuttel, MM van der Klauw, JV van Vliet-Ostaptchouk, G Atzmon, D Ben-Avraham, JP Crandall, N Barzilai, SB Bull, AJ Canty, SM Hosseini, LT Hiraki, J Maynard, DR Sell, VM Monnier, PA Cleary, BH Braffett, AD Paterson |
Diabetes | 2016 |
|
Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals:
K Xu, L Jiang, M Zhang, X Zheng, Y Gu, Z Wang, Y Cai, H Dai, Y Shi, S Zheng, Y Chen, L Ji, X Xu, H Chen, M Sun, T Yang |
Medicine | 2016 |
|
Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease
A Sharma, A Vella |
Physiology (Bethesda, Md.) | 2016 |
|
Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa
E Podgorná, I Diallo, C Vangenot, A Sanchez-Mazas, A Sabbagh, V Černý, ES Poloni |
BMC Evolutionary Biology | 2015 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)