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Citations to this article

Alternatively activated macrophages determine repair of the infarcted adult murine heart
Manabu Shiraishi, … , Kenta Yashiro, Ken Suzuki
Manabu Shiraishi, … , Kenta Yashiro, Ken Suzuki
Published May 3, 2016
Citation Information: J Clin Invest. 2016;126(6):2151-2166. https://doi.org/10.1172/JCI85782.
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Alternatively activated macrophages determine repair of the infarcted adult murine heart

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Abstract

Alternatively activated (also known as M2) macrophages are involved in the repair of various types of organs. However, the contribution of M2 macrophages to cardiac repair after myocardial infarction (MI) remains to be fully characterized. Here, we identified CD206+F4/80+CD11b+ M2-like macrophages in the murine heart and demonstrated that this cell population predominantly increases in the infarct area and exhibits strengthened reparative abilities after MI. We evaluated mice lacking the kinase TRIB1 (Trib1–/–), which exhibit a selective depletion of M2 macrophages after MI. Compared with control animals, Trib1–/– mice had a catastrophic prognosis, with frequent cardiac rupture, as the result of markedly reduced collagen fibril formation in the infarct area due to impaired fibroblast activation. The decreased tissue repair observed in Trib1–/– mice was entirely rescued by an external supply of M2-like macrophages. Furthermore, IL-1α and osteopontin were suggested to be mediators of M2-like macrophage–induced fibroblast activation. In addition, IL-4 administration achieved a targeted increase in the number of M2-like macrophages and enhanced the post-MI prognosis of WT mice, corresponding with amplified fibroblast activation and formation of more supportive fibrous tissues in the infarcts. Together, these data demonstrate that M2-like macrophages critically determine the repair of infarcted adult murine heart by regulating fibroblast activation and suggest that IL-4 is a potential biological drug for treating MI.

Authors

Manabu Shiraishi, Yasunori Shintani, Yusuke Shintani, Hidekazu Ishida, Rie Saba, Atsushi Yamaguchi, Hideo Adachi, Kenta Yashiro, Ken Suzuki

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C Ravaud, N Ved, DG Jackson, JM Vieira, PR Riley
Cells 2021
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J Song, RA Frieler, TM Vigil, J Ma, F Brombacher, SN Goonewardena, DR Goldstein, RM Mortensen
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2021
iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases
G Germena, R Hinkel
Journal of Personalized Medicine 2021
Epicardial placement of human MSC-loaded fibrin sealant films for heart failure: Preclinical efficacy and mechanistic data
L Fields, T Ito, K Kobayashi, Y Ichihara, MN Podaru, M Hussain, K Yamashita, V Machado, F Lewis-McDougall, K Suzuki
Molecular Therapy 2021
The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemia
GH Chen, V Phan, X Luo, DJ Cao
Journal of Molecular and Cellular Cardiology 2021
Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)
N Li, J Chen, P Wang, H Fan, S Hou, Y Gong
Molecular medicine reports 2021
MACROPHAGE EFFEROCYTOSIS IN CARDIAC PATHOPHYSIOLOGY AND REPAIR
Yutian L, Qianqian L, Fan GC
Shock (Augusta, Ga.) 2021
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Ferrari I, Vagnozzi RJ
Journal of molecular and cellular cardiology 2021
Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection
Tengfang Li, Zhongqiang Zhang, Joseph Guido Bartolacci, Gaelen K. Dwyer, Quan Liu, Lisa Mathews, Murugesan Velayutham, Anna Roessing, Yoojin C. Lee, Helong Dai, Sruti Shiva, Martin H. Oberbarnscheidt, Jenna L. Dziki, Steven J. Mullett, Stacy G. Wendell, James D. Wilkinson, .Steven A Webber, Michelle A. Wood-Trageser, Simon C. Watkins, Anthony J. Demetris, George S. Hussey, Stephen F. Badylak, Heth R. Turnquist
Journal of Clinical Investigation 2020
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J Li, Y Song, JY Jin, GH Li, YZ Guo, HY Yi, JR Zhang, YJ Lu, JL Zhang, CY Li, C Gao, L Yang, F Fu, F Chen, SM Zhang, M Jia, GX Zheng, JM Pei, LH Chen
Theranostics 2020
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IS Toor, D Rückerl, I Mair, R Ainsworth, M Meloni, AM Spiroski, C Benezech, JM Felton, A Thomson, A Caporali, T Keeble, KH Tang, AG Rossi, DE Newby, JE Allen, GA Gray
JACC: Basic to Translational Science 2020
Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
T Weinberger, D Esfandyari, D Messerer, G Percin, C Schleifer, R Thaler, L Liu, C Stremmel, V Schneider, RJ Vagnozzi, J Schwanenkamp, M Fischer, K Busch, K Klapproth, H Ishikawa-Ankerhold, L Klösges, A Titova, JD Molkentin, Y Kobayashi, S Engelhardt, S Massberg, C Waskow, EG Perdiguero, C Schulz
Nature Communications 2020
A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction
LK Mullany, AD Rohira, JP Leach, JH Kim, TO Monroe, AR Ortiz, B Stork, MW Gaber, P Sarkar, AG Sikora, TK Rosengart, B York, Y Song, CC Dacso, DM Lonard, JF Martin, BW OMalley
Proceedings of the National Academy of Sciences 2020
Healing the Broken Heart; The Immunomodulatory Effects of Stem Cell Therapy
MJ Wagner, M Khan, S Mohsin
Frontiers in immunology 2020
Extracellular Matrix in Ischemic Heart Disease, Part 4/4
NG Frangogiannis, JC Kovacic
Journal of the American College of Cardiology 2020
Group 2 Innate Lymphoid Cells Must Partner with the Myeloid–Macrophage Lineage for Long-Term Postviral Lung Disease
K Wu, X Wang, SP Keeler, BJ Gerovac, EV Agapov, DE Byers, S Gilfillan, M Colonna, Y Zhang, MJ Holtzman
Journal of immunology (Baltimore, Md. : 1950) 2020
Dimeric Thymosin β4 Loaded Nanofibrous Interface Enhanced Regeneration of Muscular Artery in Aging Body through Modulating Perivascular Adipose Stem Cell–Macrophage Interaction
W Chen, S Jia, X Zhang, S Zhang, H Liu, X Yang, C Zhang, W Wu
Advanced Science 2020
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G Gula, S Rumiński, J Niderla-Bielińska, A Jasińska, E Kiernozek, E Jankowska-Steifer, A Flaht-Zabost, A Ratajska
Histochemistry and Cell Biology 2020
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NG Frangogiannis
Cardiovascular Research 2020
Cell Biology and Translational Medicine, Volume 11: Stem Cell Therapy - Potential and Challenges
K Turksen
2020
Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype
Y Liao, H Li, H Cao, Y Dong, L Gao, Z Liu, J Ge, H Zhu
Protein & Cell 2020
Macrophage Activities in Myocardial Infarction and Heart Failure
SE Duncan, S Gao, M Sarhene, JW Coffie, D Linhua, X Bao, Z Jing, S Li, R Guo, J Su, G Fan
Cardiology Research and Practice 2020
SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection
S Qin, J Li, C Zhou, B Privratsky, J Schettler, X Deng, Z Xia, Y Zeng, H Wu, M Wu
Frontiers in immunology 2020
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses
GM Coppock, LR Aronson, J Park, C Qiu, J Park, JH DeLong, E Radaelli, K Suszták, CA Hunter
Journal of immunology (Baltimore, Md. : 1950) 2020
Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology
M Sansonetti, FJ Waleczek, M Jung, T Thum, F Perbellini
Basic Research in Cardiology 2020
Trib1 Contributes to Recovery From Ischemia/Reperfusion-Induced Acute Kidney Injury by Regulating the Polarization of Renal Macrophages
X Xie, X Yang, J Wu, J Ma, W Wei, X Fei, M Wang
Frontiers in immunology 2020
YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction
MM Mia, DM Cibi, SA Ghani, W Song, N Tee, S Ghosh, J Mao, EN Olson, MK Singh, TC Freeman
PLoS Biology 2020
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy
N Lubos, S van der Gaag, M Gerçek, S Kant, RE Leube, CA Krusche
Basic Research in Cardiology 2020
Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction
MJ Daseke, MA Tenkorang-Impraim, Y Ma, U Chalise, SR Konfrst, MR Garrett, KY DeLeon-Pennell, ML Lindsey
Journal of Molecular and Cellular Cardiology 2020
Aminooxyacetic acid attenuates post‐infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice
P Zhao, W Zhou, Y Zhang, J Li, Y Zhao, L Pan, Z Shen, W Chen, J Hui
Journal of Cellular and Molecular Medicine 2020
Can Macrophages in Cirrhotic Ascites Fluid Predict Clinical Outcome in Spontaneous Bacterial Peritonitis?
AJ Kruger
Gastroenterology 2020
MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction
K Shirakawa, J Endo, M Kataoka, Y Katsumata, A Anzai, H Moriyama, H Kitakata, T Hiraide, S Ko, S Goto, G Ichihara, K Fukuda, T Minamino, M Sano
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2020
Cardiovascular Impairment in COVID-19: Learning From Current Options for Cardiovascular Anti-Inflammatory Therapy
L Wang, Y Zhang, S Zhang
Frontiers in Cardiovascular Medicine 2020
Biomaterials Loaded with Growth Factors/Cytokines and Stem Cells for Cardiac Tissue Regeneration
S Smagul, Y Kim, A Smagulova, K Raziyeva, A Nurkesh, A Saparov
International journal of molecular sciences 2020
Infarct Zone: a Novel Platform for Exosome Trade in Cardiac Tissue Regeneration
FG Thankam, DK Agrawal
Journal of Cardiovascular Translational Research 2020
TLR7 Expression Is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis
G Karadimou, O Plunde, SC Pawelzik, M Carracedo, P Eriksson, A Franco-Cereceda, G Paulsson-Berne, M Bäck
Cells 2020
Exosome-educated macrophages and exosomes differentially improve ligament healing
Connie S Chamberlain, John A Kink, Linzie A Wildenauer, Maxwell McCaughey, Katie Henry, Andrea M Spiker, Matthew A Halanski, Peiman Hematti, Ray Vanderby
Stem Cells 2020
Cadherin-11 blockade reduces inflammationdriven fibrotic remodeling and improves outcomes after myocardial infarction
Alison K Schroer, Matthew R Bersi, Cyndi Clark Clark, Qinkun Zhang, Lehanna Sanders, Antonis K. Hatzopoulos, Thomas Force, Susan M. Majka, Hind Lal, W. David Merryman
JCI Insight 2019
Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish
L Bevan, ZW Lim, B Venkatesh, PR Riley, P Martin, RJ Richardson
Cardiovascular Research 2019
IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction
L Wu, R Dalal, CD Cao, JL Postoak, G Yang, Q Zhang, Z Wang, H Lal, LV Kaer
Proceedings of the National Academy of Sciences 2019
Three in a Box: Understanding Cardiomyocyte, Fibroblast, and Innate Immune Cell Interactions to Orchestrate Cardiac Repair Processes
S Psarras, D Beis, S Nikouli, M Tsikitis, Y Capetanaki
Frontiers in Cardiovascular Medicine 2019
Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities
I Andreadou, HA Cabrera-Fuentes, Y Devaux, NG Frangogiannis, S Frantz, T Guzik, EA Liehn, CP Gomes, R Schulz, DJ Hausenloy
Cardiovascular Research 2019
Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling
T Suetomi, S Miyamoto, JH Brown
American journal of physiology. Heart and circulatory physiology 2019
Regulation of Type 2 Immunity in Myocardial Infarction
JY Xu, YY Xiong, XT Lu, YJ Yang
Frontiers in immunology 2019
Role of Macrophages in Cardioprotection
J Yap, HA Cabrera-Fuentes, J Irei, DJ Hausenloy, WA Boisvert
International journal of molecular sciences 2019
Macrophages in Heart Failure with Reduced versus Preserved Ejection Fraction
M DeBerge, SJ Shah, L Wilsbacher, EB Thorp
Trends in Molecular Medicine 2019
Cardiac monocytes and macrophages after myocardial infarction
C Peet, A Ivetic, DI Bromage, AM Shah
Cardiovascular Research 2019
Macrophage Plasticity and Function in the Eye and Heart
Z Wang, AL Koenig, KJ Lavine, RS Apte
Trends in Immunology 2019
Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6
HT Yang, J Wang, M Liu, Q Wu, Q Li, L Gao, Y Jiang, B Deng, W Huang, W Bi, Z Chen, YE Chin, C Paul, Y Wang
Antioxidants & Redox Signaling 2019
Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing
D Fraccarollo, S Thomas, CJ Scholz, D Hilfiker-Kleiner, P Galuppo, J Bauersachs
Hypertension 2019
Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine
LG Shamagian, R Madonna, D Taylor, AM Climent, F Prosper, L Bras-Rosario, A Bayes-Genis, P Ferdinandy, F Fernández-Avilés, JC Belmonte, V Fuster, R Bolli
Circulation research 2019
Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy
MN Podaru, L Fields, S Kainuma, Y Ichihara, M Hussain, T Ito, K Kobayashi, A Mathur, F DAcquisto, F Lewis-McDougall, K Suzuki
Basic Research in Cardiology 2019
The Role of the TGF-β Superfamily in Myocardial Infarction
A Hanna, NG Frangogiannis
Frontiers in Cardiovascular Medicine 2019
Lebetin 2, a Snake Venom-Derived B-Type Natriuretic Peptide, Provides Immediate and Prolonged Protection against Myocardial Ischemia-Reperfusion Injury via Modulation of Post-Ischemic Inflammatory Response
B Tourki, A Dumesnil, E Belaidi, S Ghrir, D Godin-Ribuot, N Marrakchi, V Richard, P Mulder, E Messadi
Toxins 2019
Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy
EB Brandt, SJ Bashar, AI Mahmoud
Bioelectronic medicine 2019
Enhanced monocyte recruitment and delayed alternative macrophage polarisation accompanies impaired repair following myocardial infarction in C57 BL /6 compared to BALB /c mice
IS Toor, D Rückerl, I Mair, A Thomson, AG Rossi, DE Newby, JE Allen, GA Gray
Clinical & Experimental Immunology 2019
A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction
J Sharkey, L Ressel, N Brillant, L Scarfe, B Wilm, BK Park, P Murray
Stem Cells International 2019
Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy
L Jin, Z Deng, J Zhang, C Yang, J Liu, W Han, P Ye, Y Si, G Chen
Journal of Translational Medicine 2019
Optimized protocols for isolation, fixation, and flow cytometric characterization of leukocytes in ischemic hearts
R Covarrubias, MA Ismahil, G Rokosh, T Hamid, F Accornero, H Singh, RJ Gumina, SD Prabhu, SS Bansal
American journal of physiology. Heart and circulatory physiology 2019
Macrophages assemble! But do they need IL-4R during schistosomiasis?
D Rückerl, PC Cook
European Journal of Immunology 2019
iRhom2-mediated pro-inflammatory signalling regulates heart repair following myocardial infarction
Damien Barnette, Thomas J. Cahill, Mala Rohling, Carolyn Carr, Matthew Freeman, Paul Riley
JCI Insight 2018
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
Fumiyuki Sasaki, Tomoaki Koga, Mai Ohba, Kazuko Saeki, Toshiaki Okuno, Keijiro Ishikawa, Takahito Nakama, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi, Hamid Ahmadieh, Mozhgan Rezaei Kanavi, Ali Hafezi-Moghadam, Josef Penninger, Koh-Hei Sonoda, Takehiko Yokomizo
JCI Insight 2018
Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction
Seung-Jun Lee, Choong-kun Lee, Seok Kang, Intae Park, Yoo Hyung Kim, Seo Ki Kim, Seon Pyo Hong, Hosung Bae, YULONG HE, Yoshiaki Kubota, Gou Young Koh
Journal of Clinical Investigation 2018
Cardiac macrophages promote diastolic dysfunction
M Hulsmans, HB Sager, JD Roh, M Valero-Muñoz, NE Houstis, Y Iwamoto, Y Sun, RM Wilson, G Wojtkiewicz, B Tricot, MT Osborne, J Hung, C Vinegoni, K Naxerova, DE Sosnovik, MR Zile, AD Bradshaw, R Liao, A Tawakol, R Weissleder, A Rosenzweig, FK Swirski, F Sam, M Nahrendorf
Journal of Experimental Medicine 2018
Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges: Targeting inflammation in myocardial infarction
S Huang, NG Frangogiannis
British Journal of Pharmacology 2018
Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction
M Jung, M Dodsworth, T Thum
Basic Research in Cardiology 2018
Morphological and functional analyses of skeletal muscles from an immunodeficient animal model of limb-girdle muscular dystrophy type 2E: Sgcb/Rag2/γc -Null Muscle Analysis
G Giovannelli, G Giacomazzi, H Grosemans, M Sampaolesi
Muscle & Nerve 2018
The Macrophage in Cardiac Homeostasis and Disease
KJ Lavine, AR Pinto, S Epelman, BJ Kopecky, X Clemente-Casares, J Godwin, N Rosenthal, JC Kovacic
Journal of the American College of Cardiology 2018
Cardiomyocytes and Macrophages Discourse on the Method to Govern Cardiac Repair
I Gomez, V Duval, JS Silvestre
Frontiers in Cardiovascular Medicine 2018
Immune responses in cardiac repair and regeneration: a comparative point of view
SL Lai, R Marín-Juez, DY Stainier
Cellular and Molecular Life Sciences 2018
Macrophage Transitions in Heart Valve Development and Myxomatous Valve DiseaseHighlights
A Hulin, LJ Anstine, AJ Kim, SJ Potter, T DeFalco, J Lincoln, KE Yutzey
Arteriosclerosis, thrombosis, and vascular biology 2018
Parallels between vertebrate cardiac and cutaneous wound healing and regeneration
RJ Richardson
npj Regenerative Medicine 2018
Myeloid cell contributions to cardiovascular health and disease
M Nahrendorf
Nature Medicine 2018
Role of cytokines and inflammation in heart function during health and disease
M Bartekova, J Radosinska, M Jelemensky, NS Dhalla
Heart Failure Reviews 2018
Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction
Y Ma, AJ Mouton, ML Lindsey
Translational research : the journal of laboratory and clinical medicine 2018
Adenosine Production by Biomaterial‐Supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury
EY Shin, L Wang, M Zemskova, J Deppen, K Xu, F Strobel, AJ García, R Tirouvanziam, RD Levit
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2018
Cell biological mechanisms in regulation of the post-infarction inflammatory response
NG Frangogiannis
Current Opinion in Physiology 2018
Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction
P Nakagawa, CA Romero, X Jiang, M DAmbrosio, G Bordcoch, EL Peterson, P Harding, XP Yang, OA Carretero, DE Casarini
PloS one 2018
HDAC inhibition helps post-MI healing by modulating macrophage polarization
D Kimbrough, SH Wang, LH Wright, SK Mani, H Kasiganesan, AC LaRue, Q Cheng, SN Nadig, C Atkinson, DR Menick
Journal of Molecular and Cellular Cardiology 2018
Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury
DJ Cao, GG Schiattarella, E Villalobos, N Jiang, HI May, T Li, ZJ Chen, TG Gillette, JA Hill
Circulation 2018
The puzzling mechanism of compensatory lung growth
SJ Mentzer
Stem Cell Investigation 2018
Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair
S Zhang, S Weinberg, M DeBerge, A Gainullina, M Schipma, JM Kinchen, I Ben-Sahra, DR Gius, LY Charvet, NS Chandel, PT Schumacker, EB Thorp
Cell Metabolism 2018
Ectonucleotidase (CD39)-driven control of post-infarction myocardial repair and rupture
Nadia Sutton, Takanori Hayasaki, Matthew Hyman, Anuli Anyanwu, Hui Liao, Danica Petrovic-Djergovic, Linda Badri, Amy Baek, Natalie Walker, Keigo Fukase, Yogendra Kanthi, Scott Visovatti, Ellen Horste, Jessica Ray, Sascha Goonewardena, David J. Pinsky
JCI Insight 2017
Periodontal induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast mediated cardiac wound healing
Kristine DeLeon-Pennell, Rugmani Iyer, Osasere Ero, Courtney Cates, Elizabeth Flynn, Presley Cannon, Mira Jung, DeAries Shannon, Michael Garrett, William Buchanan, Michael Hall, Yonggang Ma, Merry Lindsey
JCI Insight 2017
Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice
D Palevski, LP LevinKotler, D Kain, N NaftaliShani, N Landa, T BenMordechai, T Konfino, R Holbova, N Molotski, R RosinArbesfeld, RA Lang, J Leor
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2017
Macrophages and skeletal health
MN Michalski, LK McCauley
Pharmacology & Therapeutics 2017
Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy
AJ Lechner, IH Driver, J Lee, CM Conroy, A Nagle, RM Locksley, JR Rock
Cell Stem Cell 2017
Harnessing the early post-injury inflammatory responses for cardiac regeneration
B Cheng, HC Chen, IW Chou, TW Tang, PC Hsieh
Journal of Biomedical Science 2017
Efferocytosis and Outside-In Signaling by Cardiac Phagocytes. Links to Repair, Cellular Programming, and Intercellular Crosstalk in Heart
M DeBerge, S Zhang, K Glinton, L Grigoryeva, I Hussein, E Vorovich, K Ho, X Luo, EB Thorp
Frontiers in immunology 2017
Diabetic Cardiomyopathy: An Immunometabolic Perspective
PK Mishra, W Ying, SS Nandi, GK Bandyopadhyay, KK Patel, SK Mahata
Frontiers in Endocrinology 2017
Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice
S Ishikawa, T Noma, HY Fu, T Matsuzaki, M Ishizawa, K Ishikawa, K Murakami, N Nishimoto, A Nishiyama, T Minamino, M Bader
PloS one 2017
Macrophage-based therapeutic strategies in regenerative medicine
KL Spiller, TJ Koh
Advanced Drug Delivery Reviews 2017
Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1-dependent mechanisms of cardiac repair
S Dehn, EB Thorp
The FASEB Journal 2017
Macrophage activation and polarization in post-infarction cardiac remodeling
A Gombozhapova, Y Rogovskaya, V Shurupov, M Rebenkova, J Kzhyshkowska, SV Popov, RS Karpov, V Ryabov
Journal of Biomedical Science 2017
Temporal cascade of inflammatory cytokines and cell-type populations in monocyte chemotactic protein-1 (MCP-1)-mediated aneurysm healing
BL Hoh, HZ Fazal, S Hourani, M Li, L Lin, K Hosaka
Journal of NeuroInterventional Surgery 2017
Mechanisms of Fibroblast Activation in the Remodeling Myocardium
AV Shinde, NG Frangogiannis
Current Pathobiology Reports 2017
The Common Cytokine Receptor γ Chain Family of Cytokines
JX Lin, WJ Leonard
Cold Spring Harbor perspectives in biology 2017
Prolyl-hydroxylase inhibition induces SDF-1 associated with increased CXCR4+/CD11b+ subpopulations and cardiac repair
SK Ghadge, M Messner, TV Pham, M Doppelhammer, A Petry, A Görlach, B Husse, WM Franz, MM Zaruba
Journal of Molecular Medicine 2017
IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice
Y Shintani, T Ito, L Fields, M Shiraishi, Y Ichihara, N Sato, M Podaru, S Kainuma, H Tanaka, K Suzuki
Scientific Reports 2017
Long‐Term Administration of Eicosapentaenoic Acid Improves Post–Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization
M Takamura, K Kurokawa, H Ootsuji, O Inoue, H Okada, A Nomura, S Kaneko, S Usui
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2017
Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium
GA Gray, CI White, RF Castellan, SJ McSweeney, KE Chapman
Journal of Molecular Endocrinology 2016
Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment
AS Hasan, L Luo, C Yan, TX Zhang, Y Urata, S Goto, SA Mangoura, MH Abdel-Raheem, S Zhang, TS Li, Y Tang
PloS one 2016
Role of Macrophages in the Repair Process during the Tissue Migrating and Resident Helminth Infections
B Faz-López, J Morales-Montor, LI Terrazas
BioMed Research International 2016
Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from a Rat Model
NG Campbell, M Kaneko, Y Shintani, T Narita, V Sawhney, SR Coppen, K Yashiro, A Mathur, K Suzuki, Z Ivanovic
PloS one 2016

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