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Citations to this article

Neutrophil extracellular traps — the dark side of neutrophils
Ole E. Sørensen, Niels Borregaard
Ole E. Sørensen, Niels Borregaard
Published May 2, 2016
Citation Information: J Clin Invest. 2016;126(5):1612-1620. https://doi.org/10.1172/JCI84538.
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Neutrophil extracellular traps — the dark side of neutrophils

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Abstract

Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We conclude that NETs may be of more importance in autoimmunity and thrombosis than in innate immune defense.

Authors

Ole E. Sørensen, Niels Borregaard

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 Total
Citations: 18 27 29 45 37 32 24 17 28 11 268
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Nutrients 2022
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin
Masso-Silva JA, Sakoulas G, Olay J, Groysberg V, Geriak M, Nizet V, Crotty Alexander LE, Meier A
Frontiers in immunology 2022
Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022
Wan Y, Shen J, Ouyang J, Dong P, Hong Y, Liang L, Liu J
Frontiers in immunology 2022
Changes in HDL cholesterol, particles, and function associate with pediatric COVID-19 severity.
Mietus-Snyder M, Suslovic W, Delaney M, Playford MP, Ballout RA, Barber JR, Otvos JD, DeBiasi RL, Mehta NN, Remaley AT
Frontiers in Cardiovascular Medicine 2022
Correlation between Neutrophil Extracellular Traps (NETs) Expression and Primary Graft Dysfunction Following Human Lung Transplantation
Bonneau S, Landry C, Bégin S, Adam D, Villeneuve L, Clavet-Lanthier MÉ, Dasilva A, Charles E, Dumont BL, Neagoe PE, Brochiero E, Menaouar A, Nasir B, Stevens LM, Ferraro P, Noiseux N, Sirois MG
Cells 2022
Blood neutrophil extracellular traps: a novel target for the assessment of mammary health in transition dairy cows
Jiang L, Sun H, Gu F, He J, Zhao F, Liu J
Journal of Animal Science and Biotechnology 2022
Neutrophil extracellular traps contribute to myofibroblast differentiation and scar hyperplasia through the Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway.
Shao Y, Guo Z, Yang Y, Liu L, Huang J, Chen Y, Li L, Sun B
Burns & Trauma 2022
PAD4 and Its Inhibitors in Cancer Progression and Prognosis.
Zhu D, Lu Y, Wang Y, Wang Y
Pharmaceutics 2022
Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy.
Rizo-Téllez SA, Sekheri M, Filep JG
2022
Specific signature biomarkers highlight the potential mechanisms of circulating neutrophils in aneurysmal subarachnoid hemorrhage
Weng W, Cheng F, Zhang J
Frontiers in pharmacology 2022
Mucocutaneous manifestations of Behçet’s disease: Pathogenesis and management from perspectives of vasculitis
Kim D, Nakamura K, Kaneko F, Alpsoy E, Bang D
Frontiers in Medicine 2022
Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review
Bui TA, Jickling GC, Winship IR
Frontiers in aging neuroscience 2022
Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination
Zhang XW, An MX, Huang ZK, Ma L, Zhao D, Yang Z, Shi JX, Liu DX, Li Q, Wu AH, Chen YH, Zhao WD
Redox Biology 2022
A novel biomarker for pleural effusion diagnosis: Interleukin‐36γ in pleural fluid
Guo L, Zhang Q, Lv C, Ma X, Song X, Huang J, Chen W, Li C, Ding Q
Journal of Clinical Laboratory Analysis 2022
Long non-coding RNA and non-coding nucleic acids: Signaling players in the networks of the tumor ecosystem
Lin X, Luo ML, Song E
2022
Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases
Christensen AO, Li G, Young CH, Snow B, Khan SA, DeVore SB, Edwards S, Bouma GJ, Navratil AM, Cherrington BD, Rothfuss HM
Biology of reproduction 2022
Sepsis: Immunopathology, Immunotherapies, and Future Perspectives
Tavaci T, Akgun N
The Eurasian Journal of Medicine 2022
坏疽性脓皮病发病机制与诊断的研究进展
Zhonghua Shaoshang yu Chuangmian Xiufu Zazhi 2022
NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFNα production in SLE patients
Spyros Georgakis, Katerina Gkirtzimanaki, Garyfalia Papadaki, Hariklia Gakiopoulou, Elias Drakos, Maija-Leena Eloranta, Manousos Makridakis, Georgia Kontostathi, Jerome Zoidakis, Eirini Baira, Lars Rönnblom, Dimitrios Boumpas, Prodromos Sidiropoulos, Panayotis Verginis, George Bertsias
JCI Insight 2021
Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis
C Yang, Z Wang, L Li, Z Zhang, X Jin, P Wu, S Sun, J Pan, K Su, F Jia, L Zhang, H Wang, X Yu, X Shao, K Wang, F Qiu, J Yan, J Huang
Journal for ImmunoTherapy of Cancer 2021
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
A Othman, M Sekheri, JG Filep
The FEBS journal 2021
The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic
R Bi, S Chen, S Chen, Q Peng, H Jin, B Hu
Cellular and Molecular Life Sciences 2021
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture
G Pan, M Liao, Y Dai, Y Li, X Yan, W Mai, J Liu, Y Liao, Z Qiu, Z Zhou
Frontiers in Cardiovascular Medicine 2021
Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis
D Tsukui, Y Kimura, H Kono
2021
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis
GR Kathamuthu, K Moideen, R Sridhar, D Baskaran, S Babu, F Quinn
PloS one 2021
Similarities between COVID-19 and systemic sclerosis early vasculopathy: A “viral” challenge for future research in scleroderma
M Matucci-Cerinic, M Hughes, G Taliani, B Kahaleh
Autoimmunity Reviews 2021
For Better or for Worse: A Look Into Neutrophils in Traumatic Spinal Cord Injury
S Zivkovic, M Ayazi, G Hammel, Y Ren
Frontiers in cellular neuroscience 2021
Neutrophil-Dependent Immunity During Pulmonary Infections and Inflammations
CY Effah, EK Drokow, C Agboyibor, L Ding, S He, S Liu, SY Akorli, E Nuamah, T Sun, X Zhou, H Liu, Z Xu, F Feng, Y Wu, X Zhang
Frontiers in immunology 2021
The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis
J Wan, Y Ren, X Yang, X Li, L Xia, N Lu
Frontiers in Cell and Developmental Biology 2021
Orchestration of Neutrophil Extracellular Traps (Nets), a Unique Innate Immune Function during Chronic Obstructive Pulmonary Disease (COPD) Development
A Trivedi, MA Khan, G Bade, A Talwar
Biomedicines 2021
Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture
M Korai, J Purcell, Y Kamio, K Mitsui, H Furukawa, K Yokosuka, T Miyamoto, H Sato, H Sato, S Eguchi, J Ai, MT Lawton, T Hashimoto
Hypertension 2021
miR‐3146 induces neutrophil extracellular traps to aggravate gout flare
L Shan, D Yang, F Feng, D Zhu, X Li
Journal of Clinical Laboratory Analysis 2021
The Role of Neutrophil Extracellular Traps in Periodontitis
J Wang, Y Zhou, B Ren, L Zou, B He, M Li
Frontiers in Cellular and Infection Microbiology 2021
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
M Osaka, M Deushi, J Aoyama, T Funakoshi, A Ishigami, M Yoshida
JACC: Basic to Translational Science 2021
Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3
Z Zheng, Y Li, S Jia, M Zhu, L Cao, M Tao, J Jiang, S Zhan, Y Chen, PJ Gao, W Hu, Y Wang, C Shao, Y Shi
Nature Communications 2021
DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis
BC Roy, I Ahmed, J Stubbs, J Zhang, T Attard, S Septer, D Welch, S Anant, V Sampath, S Umar
Cell Death Discovery 2021
The Role of Neutrophil Extracellular Traps in Cancer
BZ Shao, Y Yao, JP Li, NL Chai, EQ Linghu
Frontiers in Oncology 2021
Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches
A Hasan, E Al-Ozairi, Z Al-Baqsumi, R Ahmad, F Al-Mulla
ImmunoTargets and Therapy 2021
Proteinous Components of Neutrophil Extracellular Traps Are Arrested by the Cell Wall Proteins of Candida albicans during Fungal Infection, and Can Be Used in the Host Invasion
J Karkowska-Kuleta, M Smolarz, K Seweryn-Ozog, D Satala, M Zawrotniak, E Wronowska, O Bochenska, A Kozik, AH Nobbs, M Gogol, M Rapala-Kozik
Cells 2021
The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease
Z Elgamal, P Singh, P Geraghty
Medicina 2021
The FcγRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-κB and PKC-ROS Signaling Pathways
CH Lu, KJ Li, CH Wu, CY Shen, YM Kuo, SC Hsieh, CL Yu
Biomedicines 2021
Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer
RS Ahmad, TD Eubank, S Lukomski, BA Boone
Biomolecules 2021
Pathogenesis of Behçet's Syndrome: Genetic, Environmental and Immunological Factors
I Mattioli, A Bettiol, G Saruhan-Direskeneli, H Direskeneli, G Emmi
Frontiers in Medicine 2021
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
J Hazeldine, J M.
Frontiers in immunology 2021
Role of neutrophils in acute viral infection
Y Ma, Y Zhang, L Zhu
Immunity, Inflammation and Disease 2021
Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury
A Obermayer, LM Jakob, JD Haslbauer, MS Matter, A Tzankov, W Stoiber, R Pichler
Disease Markers 2021
NETosis in Wound Healing: When Enough Is Enough
M Sabbatini, V Magnelli, F Renò
Cells 2021
The pulmonary pathology of COVID-19
H Bösmüller, M Matter, F Fend, A Tzankov
Virchows Archiv 2021
Resistin, a Novel Host Defense Peptide of Innate Immunity
Y Li, Q Yang, D Cai, H Guo, J Fang, H Cui, L Gou, J Deng, Z Wang, Z Zuo
Frontiers in immunology 2021
The Antimicrobial Activity of Peripheral Blood Neutrophils Is Altered in Patients with Primary Ciliary Dyskinesia
M Cockx, M Blanter, M Gouwy, P Ruytinx, SA Salama, S Knoops, N Pörtner, L Vanbrabant, N Lorent, M Boon, S Struyf
International journal of molecular sciences 2021
Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients
KL Chan, X Feng, B Ip, S Huang, SH Ma, FS Fan, HL Ip, L Huang, VC Mok, YO Soo, TW Leung, X Leng
Frontiers in aging neuroscience 2021
Proteome Profiling of Recombinant DNase Therapy in Reducing NETs and Aiding Recovery in COVID-19 Patients
J Fisher, T Mohanty, CA Karlsson, SM Khademi, E Malmström, A Frigyesi, P Nordenfelt, J Malmstrom, A Linder
Molecular & cellular proteomics : MCP 2021
The predictive effect of the platelet-to-lymphocyte ratio (PLR) and the neutrophil-to-lymphocyte ratio (NLR) on the risk of death in patients with severe fever with thrombocytopenia syndrome (SFTS): a multi-center study in China
X Wang, L Lin, Z Zhao, W Zhou, Z Ge, Y Shen, L Wang, W Zhang, R Song, D Tian, J Wen, S Cui, X Yu, Y Feng, Y Liu, C Qiang, J Duan, Y Ma, X Li, T Fan, Y Zhao, Z Chen
Annals of translational medicine 2021
Neutrophil‐mediated mechanisms of damage and in‐vitro protective effect of colchicine in non‐vascular Behçet’s syndrome
A Bettiol, M Becatti, E Silvestri, FR Argento, E Fini, A Mannucci, S Galora, I Mattioli, ML Urban, D Malandrino, A Palermo, N Taddei, G Emmi, D Prisco, C Fiorillo
Clinical & Experimental Immunology 2021
Influence of iron- and zinc-chelating agents on neutrophil extracellular trap formation
W Kuźmicka, A Moskalik, A Manda-Handzlik, U Demkow, M Wachowska, O Ciepiela
CENT EUR J IMMUNOL 2021
Role of iBALT in Respiratory Immunity
Aaron Silva-Sanchez, Troy D Randall
Current topics in microbiology and immunology 2020
A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
V Mutua, LJ Gershwin
Clinical Reviews in Allergy & Immunology 2020
Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation
JG Filep, A Ariel
American journal of physiology. Cell physiology 2020
Role of Alarmins in the Pathogenesis of Systemic Sclerosis
A Giovannetti, E Straface, E Rosato, M Casciaro, G Pioggia, S Gangemi
International journal of molecular sciences 2020
Cell–Cell Interaction Mechanisms in Acute Lung Injury
H Zhou, EK Fan, J Fan
Shock 2020
Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice
S Watanabe, Y Iwata, H Fukushima, K Saito, Y Tanaka, Y Hasegawa, M Akiyama, K Sugiura
Scientific Reports 2020
Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease
VD Giacalone, C Margaroli, MA Mall, R Tirouvanziam
International journal of molecular sciences 2020
AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response
Y Xia, J He, H Zhang, H Wang, G Tetz, CA Maguire, Y Wang, A Onuma, D Genkin, V Tetz, A Stepanov, S Terekhov, V Ukrainskaya, H Huang, A Tsung
Molecular Oncology 2020
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
EA Middleton, XY He, F Denorme, RA Campbell, D Ng, SP Salvatore, M Mostyka, A Baxter-Stoltzfus, AC Borczuk, M Loda, MJ Cody, BK Manne, I Portier, ES Harris, AC Petrey, EJ Beswick, AF Caulin, A Iovino, LM Abegglen, AS Weyrich, MT Rondina, M Egeblad, JD Schiffman, CC Yost
Blood 2020
The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury
NJ Edwards, C Hwang, S Marini, CA Pagani, PJ Spreadborough, CJ Rowe, P Yu, A Mei, N Visser, S Li, GE Hespe, AK Huber, AL Strong, MA Shelef, JS Knight, TA Davis, B Levi
The FASEB Journal 2020
Histone H4 aggravates inflammatory injury through TLR4 in chlorine gas-induced acute respiratory distress syndrome
Y Zhang, J Zhao, L Guan, L Mao, S Li, J Zhao
Journal of Occupational Medicine and Toxicology 2020
Surgical Stress Promotes Tumor Progression: A Focus on the Impact of the Immune Response
AE Onuma, H Zhang, L Gil, H Huang, A Tsung
Journal of Clinical Medicine 2020
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis
MT Masucci, M Minopoli, SD Vecchio, MV Carriero
Frontiers in immunology 2020
Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update
A Bonaventura, A Vecchié, A Abbate, F Montecucco
Cells 2020
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis
Z Jin, J Sun, Z Song, K Chen, YS Nicolas, R KC, Q Ma, J Liu, M Zhang
npj Regenerative Medicine 2020
Role of Neutrophils in Systemic Vasculitides
D Michailidou, T Mustelin, C Lood
Frontiers in immunology 2020
Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions
S Shao, C Hao, B Zhan, Q Zhuang, L Zhao, Y Chen, J Huang, X Zhu
Frontiers in immunology 2020
Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease
KE Kluge, MS Langseth, TB Opstad, AÅ Pettersen, H Arnesen, T Tønnessen, I Seljeflot, R Helseth
Mediators of Inflammation 2020
Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes
SI Galkina, NV Fedorova, EA Golenkina, VI Stadnichuk, GF Sudina
International journal of molecular sciences 2020
Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia
Y Guo, R Liu, L Chen, W Wu, S Zhang
BMC Cardiovascular Disorders 2020
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
A Marki, K Buscher, C Lorenzini, M Meyer, R Saigusa, Z Fan, YT Yeh, N Hartmann, JM Dan, WB Kiosses, GJ Golden, R Ganesan, H Winkels, M Orecchioni, S McArdle, Z Mikulski, Y Altman, J Bui, M Kronenberg, S Chien, JD Esko, V Nizet, D Smalley, J Roth, K Ley
Journal of Experimental Medicine 2020
Abnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients
Q Lin, W Zhou, Y Wang, J Huang, X Hui, Z Zhou, Y Xiao
Journal of Diabetes Research 2020
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils
M Perego, VA Tyurin, YY Tyurina, J Yellets, T Nacarelli, C Lin, Y Nefedova, A Kossenkov, Q Liu, S Sreedhar, H Pass, J Roth, T Vogl, D Feldser, R Zhang, VE Kagan, DI Gabrilovich
Science Translational Medicine 2020
Antibodies clamp down on NET nucleosomes
M Radic
Cellular and Molecular Immunology 2020
Inflammation, Thrombosis, and Destruction: The Three-Headed Cerberus of Trauma- and SARS-CoV-2-Induced ARDS
L Lupu, A Palmer, M Huber-Lang
Frontiers in immunology 2020
The Emerging Role of Vitamin C as a Treatment for Sepsis
MG Kashiouris, M LHeureux, CA Cable, BJ Fisher, SW Leichtle, AA Fowler
Nutrients 2020
Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness
P Ruiz-Limon, ML Ladehesa-Pineda, M del Carmen Castro-Villegas, M del Carmen Abalos-Aguilera, C Lopez-Medina, C Lopez-Pedrera, N Barbarroja, D Espejo-Peralbo, JA Gonzalez-Reyes, JM Villalba, C Perez-Sanchez, A Escudero-Contreras, E Collantes-Estevez, P Font-Ugalde, Y Jimenez-Gomez
Journal of Biomedical Science 2020
The Enigma of Endothelium in COVID-19
S Kaur, DM Tripathi, A Yadav
Frontiers in physiology 2020
Neutrophil-mediated Thrombosis and NETosis in Behçet's Disease: a Hypothesis
ED Batu
Journal of Korean Medical Science 2020
Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases
MC Méchin, H Takahara, M Simon
International journal of molecular sciences 2020
Neutrophil Extracellular Trap–Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma
RF Rayes, P Vourtzoumis, MB Rjeily, R Seth, F Bourdeau, B Giannias, J Berube, YH Huang, S Rousseau, S Camilleri-Broet, RS Blumberg, N Beauchemin, S Najmeh, J Cools-Lartigue, JD Spicer, LE Ferri
Journal of immunology (Baltimore, Md. : 1950) 2020
The origin of extracellular DNA in bacterial biofilm infections in vivo
M Alhede, M Alhede, K Qvortrup, KN Kragh, PØ Jensen, PS Stewart, T Bjarnsholt
Pathogens and Disease 2020
Staphylococcus aureus drives expansion of low density neutrophils in diabetic mice
Taylor S Cohen, Virginia N. Takahashi, Jessica Bonnell, Andrey Tovchigrechko, Raghothama Chaerkady, Wen Yu, Omari Jones-Nelson, Young Lee, Rajiv Raja, Sonja Hess, Charles K Stover, John J. Worthington, Mark A Travis, Bret R. Sellman
Journal of Clinical Investigation 2019
Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis
CJ Lerche, LJ Christophersen, JP Goetze, PR Nielsen, K Thomsen, C Enevold, N Høiby, PØ Jensen, H Bundgaard, C Moser, PG de Frutos
PloS one 2019
The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity
R Golonka, BS Yeoh, M Vijay-Kumar
Journal of Innate Immunity 2019
Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk
S Shao, H Fang, E Dang, K Xue, J Zhang, B Li, H Qiao, T Cao, Y Zhuang, S Shen, T Zhang, P Qiao, C Li, JE Gudjonsson, G Wang
Frontiers in immunology 2019
The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses
C Egholm, LE Heeb, D Impellizzieri, O Boyman
Frontiers in immunology 2019
Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related With Hyper Inflammation and Severe Lung Tissue Damage
MG de Melo, ED Mesquita, MM Oliveira, C da Silva-Monteiro, AK Silveira, TS Malaquias, TC Dutra, RM Galliez, AL Kritski, EC Silva
Frontiers in immunology 2019
Endothelium structure and function in kidney health and disease
N Jourde-Chiche, F Fakhouri, L Dou, J Bellien, S Burtey, M Frimat, PA Jarrot, G Kaplanski, ML Quintrec, V Pernin, C Rigothier, M Sallée, V Fremeaux-Bacchi, D Guerrot, LT Roumenina
Nature Reviews Nephrology 2019
Neutrophil Activation and Early Features of NET Formation Are Associated With Dengue Virus Infection in Human
A Opasawatchai, P Amornsupawat, N Jiravejchakul, W Chan-in, NJ Spoerk, K Manopwisedjaroen, P Singhasivanon, T Yingtaweesak, S Suraamornkul, J Mongkolsapaya, A Sakuntabhai, P Matangkasombut, F Loison
Frontiers in immunology 2019
PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium
P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kumar
Mucosal Immunology 2019
Dendritic cells, T cells and their interaction in rheumatoid arthritis: Dendritic cells, T cells and their interaction
P Wehr, H Purvis, SC Law, R Thomas
Clinical & Experimental Immunology 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis
LT Weckbach, U Grabmaier, A Uhl, S Gess, F Boehm, A Zehrer, R Pick, M Salvermoser, T Czermak, J Pircher, N Sorrelle, M Migliorini, DK Strickland, K Klingel, V Brinkmann, UA Abed, U Eriksson, S Massberg, S Brunner, B Walzog
Journal of Experimental Medicine 2019
Polysialic Acid Modulates the Binding of External Lactoferrin in Neutrophil Extracellular Traps
A Kühnle, T Lütteke, K Bornhöfft, S Galuska
Biology : open access journal 2019
Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion
A Meier, J Chien, L Hobohm, KA Patras, V Nizet, R Corriden
Frontiers in pharmacology 2019
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection
N Wang, X Yang, J Sun, Z Sun, Q Ma, Z Wang, Z Chen, Z Wang, F Hu, H Wang, L Zhou, M Zhang, J Xu
Cell Death Discovery 2019
Lactic Acid Accumulation During Exhaustive Exercise Impairs Release of Neutrophil Extracellular Traps in Mice
Y Shi, H Shi, DC Nieman, Q Hu, L Yang, T Liu, X Zhu, H Wei, D Wu, F Li, Y Cui, P Chen
Frontiers in physiology 2019
Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection
FC Kirsebom, F Kausar, R Nuriev, S Makris, C Johansson
Mucosal Immunology 2019
Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages
Z An, J Li, J Yu, X Wang, H Gao, W Zhang, Z Wei, J Zhang, Y Zhang, J Zhao, X Liang
Cell cycle (Georgetown, Tex.) 2019
Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
B Shrestha, T Ito, M Kakuuchi, T Totoki, T Nagasato, M Yamamoto, I Maruyama
Frontiers in immunology 2019
Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation
S Ueki, Y Miyabe, Y Yamamoto, M Fukuchi, M Hirokawa, LA Spencer, PF Weller
Current Allergy and Asthma Reports 2019
Periodontal therapy increases neutrophil extracellular trap degradation
CG Moonen, KG Buurma, MR Faruque, MG Balta, E Liefferink, S Bizzarro, EA Nicu, BG Loos
Innate immunity 2019
Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU)
L Fingerhut, B Ohnesorge, M von Borstel, A Schumski, K Strutzberg-Minder, M Mörgelin, CA Deeg, HP Haagsman, A Beineke, M von Köckritz-Blickwede, N de Buhr
Cells 2019
Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype
S Lambert, CA Hambro, A Johnston, PE Stuart, LC Tsoi, RP Nair, J T.
Journal of Investigative Dermatology 2019
Extracellular histones are clinically associated with primary graft dysfunction in human liver transplantation.
Li X, Gou C, Pang Y, Wang Y, Liu Y, Wen T
RSC Advances 2019
Vascular Nanomedicine: Current Status, Opportunities, and Challenges.
Sun M, Sen Gupta A
Seminars in thrombosis and hemostasis 2019
Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1b
Hsi-Min Hsiao, Ramiro Fernandez, Satona Tanaka, WenJun Li, Jessica Spahn, Stephen Chiu, Mahzad Akbarpour, Daniel Ruiz-Perez, Qiang Wu, Cem Turam, Davide Scozzi, Tsuyoshi Takahashi, Hannah Luehmann, Varun Puri, G.R. Scott Budinger, Alexander Krupnick, Alexander Misharin, Kory Lavine, Yongjian Liu, Andrew Gelman, Ankit Bharat, Daniel Kreisel
Journal of Clinical Investigation 2018
Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
L Chen, Y Zhao, D Lai, P Zhang, Y Yang, Y Li, K Fei, G Jiang, J Fan
Cell Death and Disease 2018
The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps
AA Manfredi, GA Ramirez, P Rovere-Querini, N Maugeri
Frontiers in immunology 2018
Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine
D Hartl, R Tirouvanziam, J Laval, CM Greene, D Habiel, L Sharma, AÖ Yildirim, CS Cruz, CM Hogaboam
Journal of Innate Immunity 2018
Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection
CS Curran, T Bolig, P Torabi-Parizi
American journal of respiratory and critical care medicine 2018
Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury
WM Raup-Konsavage, Y Wang, WW Wang, D Feliers, H Ruan, WB Reeves
Kidney International 2018
Amicus or Adversary Revisited: Platelets in Acute Lung Injury and Acute Respiratory Distress Syndrome
EA Middleton, MT Rondina, H Schwertz, GA Zimmerman
American journal of respiratory cell and molecular biology 2018
2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation
EN Palladino, LA Katunga, GR Kolar, DA Ford
Journal of lipid research 2018
Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma
M Garley, D Dziemiańczyk-Pakieła, K Grubczak, A Surażyński, D Dąbrowska, W Ratajczak-Wrona, J Sawicka-Powierza, J Borys, M Moniuszko, JA Pałka, E Jabłońska
Journal of Cancer 2018
Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C
B Ingelsson, D Söderberg, T Strid, A Söderberg, AC Bergh, V Loitto, K Lotfi, M Segelmark, G Spyrou, A Rosén
Proceedings of the National Academy of Sciences 2018
Two-in-one: UV radiation simultaneously induces apoptosis and NETosis
D Azzouz, MA Khan, N Sweezey, N Palaniyar
Cell Death Discovery 2018
Neutrophil Extracellular Traps Formation and Aggregation Orchestrate Induction and Resolution of Sterile Crystal-Mediated Inflammation
Y Li, X Cao, Y Liu, Y Zhao, M Herrmann
Frontiers in immunology 2018
Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and neutrophil extracellular traps
H Li, D Feng, Y Cai, Y Liu, M Xu, X Xiang, Z Zhou, Q Xia, MJ Kaplan, X Kong, B Gao
Hepatology 2018
NETQUANT: Automated Quantification of Neutrophil Extracellular Traps
T Mohanty, OE Sørensen, P Nordenfelt
Frontiers in immunology 2018
Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils
Y Zhou, LL An, R Chaerkady, N Mittereder, L Clarke, TS Cohen, B Chen, S Hess, GP Sims, T Mustelin
Scientific Reports 2018
A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses
T Stobernack, M du Teil Espina, LM Mulder, LM Medina, DR Piebenga, G Gabarrini, X Zhao, KM Janssen, J Hulzebos, E Brouwer, T Sura, D Becher, AJ van Winkelhoff, F Götz, A Otto, J Westra, JM van Dijl, R Rappuoli
mBio 2018
Going Fishing.
Journal of Innate Immunity 2018
Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis
AS Gukovskaya, I Gukovsky, H Algül, A Habtezion
Gastroenterology 2017
Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections
YH Shen, SA LeMaire
Current Problems in Surgery 2017
Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction
Z Zheng, S Chiu, M Akbarpour, H Sun, PA Reyfman, KR Anekalla, H Abdala-Valencia, D Edgren, W Li, D Kreisel, FV Korobova, R Fernandez, A McQuattie-Pimentel, ZJ Zhang, H Perlman, AV Misharin, GR Budinger, A Bharat
Science Translational Medicine 2017
Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil
SM Lawrence, R Corriden, V Nizet
Frontiers in Pediatrics 2017
The Role of Inflammation in Cardiovascular Outcome
F Montecucco, L Liberale, A Bonaventura, A Vecchiè, F Dallegri, F Carbone
Current Atherosclerosis Reports 2017
Re-Examining Neutrophil Participation in GN
DJ Caster, DW Powell, I Miralda, RA Ward, KR McLeish
Journal of the American Society of Nephrology : JASN 2017
Neutrophil Extracellular Traps and Endothelial Dysfunction in Atherosclerosis and Thrombosis
H Qi, S Yang, L Zhang
Frontiers in immunology 2017
Paucimannose-Rich N -glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions
I Loke, O Østergaard, NH Heegaard, NH Packer, M Thaysen-Andersen
Molecular & cellular proteomics : MCP 2017
Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
IB Regli, K Passelli, BP Hurrell, F Tacchini-Cottier
Frontiers in immunology 2017
Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS
H Li, X Zhou, H Tan, Y Hu, L Zhang, S Liu, M Dai, Y Li, Q Li, Z Mao, P Pan, X Su, C Hu
Oncotarget 2017
The immunopathology of sepsis and potential therapeutic targets
T van der Poll, FL van de Veerdonk, BP Scicluna, MG Netea
Nature Reviews Immunology 2017
Stem Cell Extracellular Vesicles: Extended Messages of Regeneration
M Riazifar, EJ Pone, J Lötvall, W Zhao
Annual Review of Pharmacology and Toxicology 2017
Consequences of extracellular trap formation in sepsis:
XM OBrien, BM Biron, JS Reichner
Current Opinion in Hematology 2017
Neutrophil extracellular traps in acute chorioamnionitis: A mechanism of host defense
N Gomez-Lopez, R Romero, Y Leng, V Garcia-Flores, Y Xu, D Miller, SS Hassan
American Journal of Reproductive Immunology 2017
Disentangling the role of neutrophil extracellular traps in rheumatic diseases:
YL Lightfoot, MJ Kaplan
Current Opinion in Rheumatology 2017
Neutrophil Extracellular Traps and Microcrystals
B Rada
Journal of Immunology Research 2017
Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies
R Panda, T Krieger, L Hopf, T Renné, F Haag, N Röber, K Conrad, E Csernok, TA Fuchs
Frontiers in immunology 2017
Multiple Phenotypic Changes Define Neutrophil Priming
I Miralda, SM Uriarte, KR McLeish
Frontiers in Cellular and Infection Microbiology 2017
Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation
A Lizcano, I Secundino, S Döhrmann, R Corriden, C Rohena, S Diaz, P Ghosh, L Deng, V Nizet, A Varki
Blood 2017
New Insights on Platelets and Platelet-Derived Microparticles in Systemic Lupus Erythematosus
M Scherlinger, V Sisirak, C Richez, E Lazaro, P Duffau, P Blanco
Current Rheumatology Reports 2017
Metabolic abnormalities and oxidative stress in lupus:
YL Lightfoot, LP Blanco, MJ Kaplan
Current Opinion in Rheumatology 2017
Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils
Y Zhou, B Chen, N Mittereder, R Chaerkady, M Strain, LL An, S Rahman, W Ma, CP Low, D Chan, F Neal, CO Bingham, K Sampson, E Darrah, RM Siegel, S Hasni, F Andrade, KA Vousden, T Mustelin, GP Sims
Frontiers in immunology 2017
Artificial Polysialic Acid Chains as Sialidase-Resistant Molecular-Anchors to Accumulate Particles on Neutrophil Extracellular Traps
CE Galuska, JA Dambon, A Kühnle, KF Bornhöfft, G Prem, K Zlatina, T Lütteke, SP Galuska
Frontiers in immunology 2017
Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
MC Schechter, K Buac, T Adekambi, S Cagle, J Celli, SM Ray, CC Mehta, B Rada, J Rengarajan, N Palaniyar
PloS one 2017
d(−) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression
PA PA, CM CM, IC IC, MD MDC, TM TMC, LM LMRS, AT AT, CH CH, MA MAH, RA RAB
Frontiers in immunology 2017
Great Therapeutic Potential of Peptidylarginine Deiminase 4 (PAD4) Inhibitors: Treatment of Rheumatoid Arthritis, Epigenetic Tools, Regulation of Pluripotency in Stem Cells, and More
AF Abdel-Magid
ACS Medicinal Chemistry Letters 2017
Statins: antimicrobial resistance breakers or makers?
HH Ko, RR Lareu, BR Dix, JD Hughes
PeerJ 2017
Pathogenesis of Sepsis
van Engelen TS, Joost Wiersinga W, van der Poll T
2017
Neonatal NET-inhibitory factor (nNIF) and nNIF-related peptides inhibit neutrophil extracellular trap (NET) formation
Christian Yost, Hansjorg Schwertz, Mark Cody, Jared Wallace, Robert Campbell, Adriana Vieira-de-Abreu, Claudia Araujo, Sebastian Schubert, Estelle Harris, Jesse Rowley, Matthew Rondina, James Fulcher, Curry Koening, Andrew S. Weyrich, Guy Zimmerman
Journal of Clinical Investigation 2016
Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF
S Giaglis, M Stoikou, CS Chowdhury, G Schaefer, F Grimolizzi, SW Rossi, IM Hoesli, O Lapaire, P Hasler, S Hahn
Frontiers in immunology 2016
The immune system's role in sepsis progression, resolution, and long-term outcome
MJ Delano, PA Ward
Immunological Reviews 2016
New insights into the pathways initiating and driving pancreatitis:
AS Gukovskaya, SJ Pandol, I Gukovsky
Current Opinion in Gastroenterology 2016
Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy
S Nadkarni, J Smith, AN Sferruzzi-Perri, A Ledwozyw, M Kishore, R Haas, C Mauro, DJ Williams, SH Farsky, FM Marelli-Berg, M Perretti
Proceedings of the National Academy of Sciences 2016
Pondering neutrophil extracellular traps with healthy skepticism: Skepticism about neutrophil extracellular traps
WM Nauseef, P Kubes
Cellular Microbiology 2016
Neutrophil Extracellular Traps Go Viral
G Schönrich, MJ Raftery
Frontiers in immunology 2016
Cellular Innate Immunity: An Old Game with New Players
G Gasteiger, A D'Osualdo, DA Schubert, A Weber, EM Bruscia, D Hartl
Journal of Innate Immunity 2016
Neutrophil Extracellular Traps in the Amniotic Cavity of Women with Intra-Amniotic Infection: A New Mechanism of Host Defense
N Gomez-Lopez, R Romero, Y Xu, D Miller, R Unkel, M Shaman, SM Jacques, B Panaitescu, V Garcia-Flores, SS Hassan
Reproductive sciences (Thousand Oaks, Calif.) 2016
Immunodetection of NETs in Paraffin-Embedded Tissue
V Brinkmann, UA Abed, C Goosmann, A Zychlinsky
Frontiers in immunology 2016
Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor.
Boldenow E, Gendrin C, Ngo L, Bierle C, Vornhagen J, Coleman M, Merillat S, Armistead B, Whidbey C, Alishetti V, Santana-Ufret V, Ogle J, Gough M, Srinouanprachanh S, MacDonald JW, Bammler TK, Bansal A, Liggitt HD, Rajagopal L, Adams Waldorf KM
Science Immunology 2016

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