Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We conclude that NETs may be of more importance in autoimmunity and thrombosis than in innate immune defense.
Ole E. Sørensen, Niels Borregaard
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Role of Citrullinated Collagen in Autoimmune Arthritis
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Neutrophil extracellular traps contribute to myofibroblast differentiation and scar hyperplasia through the Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway.
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Frontiers in pharmacology | 2022 |
Mucocutaneous manifestations of Behçet’s disease: Pathogenesis and management from perspectives of vasculitis
Kim D, Nakamura K, Kaneko F, Alpsoy E, Bang D |
Frontiers in Medicine | 2022 |
Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review
Bui TA, Jickling GC, Winship IR |
Frontiers in aging neuroscience | 2022 |
Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination
Zhang XW, An MX, Huang ZK, Ma L, Zhao D, Yang Z, Shi JX, Liu DX, Li Q, Wu AH, Chen YH, Zhao WD |
Redox Biology | 2022 |
A novel biomarker for pleural effusion diagnosis: Interleukin‐36γ in pleural fluid
Guo L, Zhang Q, Lv C, Ma X, Song X, Huang J, Chen W, Li C, Ding Q |
Journal of Clinical Laboratory Analysis | 2022 |
Long non-coding RNA and non-coding nucleic acids: Signaling players in the networks of the tumor ecosystem
Lin X, Luo ML, Song E |
2022 | |
Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases
Christensen AO, Li G, Young CH, Snow B, Khan SA, DeVore SB, Edwards S, Bouma GJ, Navratil AM, Cherrington BD, Rothfuss HM |
Biology of reproduction | 2022 |
Sepsis: Immunopathology, Immunotherapies, and Future Perspectives
Tavaci T, Akgun N |
The Eurasian Journal of Medicine | 2022 |
坏疽性脓皮病发病机制与诊断的研究进展
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Zhonghua Shaoshang yu Chuangmian Xiufu Zazhi | 2022 |
NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFNα production in SLE patients
Spyros Georgakis, Katerina Gkirtzimanaki, Garyfalia Papadaki, Hariklia Gakiopoulou, Elias Drakos, Maija-Leena Eloranta, Manousos Makridakis, Georgia Kontostathi, Jerome Zoidakis, Eirini Baira, Lars Rönnblom, Dimitrios Boumpas, Prodromos Sidiropoulos, Panayotis Verginis, George Bertsias |
JCI Insight | 2021 |
Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis
C Yang, Z Wang, L Li, Z Zhang, X Jin, P Wu, S Sun, J Pan, K Su, F Jia, L Zhang, H Wang, X Yu, X Shao, K Wang, F Qiu, J Yan, J Huang |
Journal for ImmunoTherapy of Cancer | 2021 |
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
A Othman, M Sekheri, JG Filep |
The FEBS journal | 2021 |
The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic
R Bi, S Chen, S Chen, Q Peng, H Jin, B Hu |
Cellular and Molecular Life Sciences | 2021 |
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture
G Pan, M Liao, Y Dai, Y Li, X Yan, W Mai, J Liu, Y Liao, Z Qiu, Z Zhou |
Frontiers in Cardiovascular Medicine | 2021 |
Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis
D Tsukui, Y Kimura, H Kono |
2021 | |
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis
GR Kathamuthu, K Moideen, R Sridhar, D Baskaran, S Babu, F Quinn |
PloS one | 2021 |
Similarities between COVID-19 and systemic sclerosis early vasculopathy: A “viral” challenge for future research in scleroderma
M Matucci-Cerinic, M Hughes, G Taliani, B Kahaleh |
Autoimmunity Reviews | 2021 |
For Better or for Worse: A Look Into Neutrophils in Traumatic Spinal Cord Injury
S Zivkovic, M Ayazi, G Hammel, Y Ren |
Frontiers in cellular neuroscience | 2021 |
Neutrophil-Dependent Immunity During Pulmonary Infections and Inflammations
CY Effah, EK Drokow, C Agboyibor, L Ding, S He, S Liu, SY Akorli, E Nuamah, T Sun, X Zhou, H Liu, Z Xu, F Feng, Y Wu, X Zhang |
Frontiers in immunology | 2021 |
The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis
J Wan, Y Ren, X Yang, X Li, L Xia, N Lu |
Frontiers in Cell and Developmental Biology | 2021 |
Orchestration of Neutrophil Extracellular Traps (Nets), a Unique Innate Immune Function during Chronic Obstructive Pulmonary Disease (COPD) Development
A Trivedi, MA Khan, G Bade, A Talwar |
Biomedicines | 2021 |
Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture
M Korai, J Purcell, Y Kamio, K Mitsui, H Furukawa, K Yokosuka, T Miyamoto, H Sato, H Sato, S Eguchi, J Ai, MT Lawton, T Hashimoto |
Hypertension | 2021 |
miR‐3146 induces neutrophil extracellular traps to aggravate gout flare
L Shan, D Yang, F Feng, D Zhu, X Li |
Journal of Clinical Laboratory Analysis | 2021 |
The Role of Neutrophil Extracellular Traps in Periodontitis
J Wang, Y Zhou, B Ren, L Zou, B He, M Li |
Frontiers in Cellular and Infection Microbiology | 2021 |
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
M Osaka, M Deushi, J Aoyama, T Funakoshi, A Ishigami, M Yoshida |
JACC: Basic to Translational Science | 2021 |
Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3
Z Zheng, Y Li, S Jia, M Zhu, L Cao, M Tao, J Jiang, S Zhan, Y Chen, PJ Gao, W Hu, Y Wang, C Shao, Y Shi |
Nature Communications | 2021 |
DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis
BC Roy, I Ahmed, J Stubbs, J Zhang, T Attard, S Septer, D Welch, S Anant, V Sampath, S Umar |
Cell Death Discovery | 2021 |
The Role of Neutrophil Extracellular Traps in Cancer
BZ Shao, Y Yao, JP Li, NL Chai, EQ Linghu |
Frontiers in Oncology | 2021 |
Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches
A Hasan, E Al-Ozairi, Z Al-Baqsumi, R Ahmad, F Al-Mulla |
ImmunoTargets and Therapy | 2021 |
Proteinous Components of Neutrophil Extracellular Traps Are Arrested by the Cell Wall Proteins of Candida albicans during Fungal Infection, and Can Be Used in the Host Invasion
J Karkowska-Kuleta, M Smolarz, K Seweryn-Ozog, D Satala, M Zawrotniak, E Wronowska, O Bochenska, A Kozik, AH Nobbs, M Gogol, M Rapala-Kozik |
Cells | 2021 |
The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease
Z Elgamal, P Singh, P Geraghty |
Medicina | 2021 |
The FcγRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-κB and PKC-ROS Signaling Pathways
CH Lu, KJ Li, CH Wu, CY Shen, YM Kuo, SC Hsieh, CL Yu |
Biomedicines | 2021 |
Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer
RS Ahmad, TD Eubank, S Lukomski, BA Boone |
Biomolecules | 2021 |
Pathogenesis of Behçet's Syndrome: Genetic, Environmental and Immunological Factors
I Mattioli, A Bettiol, G Saruhan-Direskeneli, H Direskeneli, G Emmi |
Frontiers in Medicine | 2021 |
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
J Hazeldine, J M. |
Frontiers in immunology | 2021 |
Role of neutrophils in acute viral infection
Y Ma, Y Zhang, L Zhu |
Immunity, Inflammation and Disease | 2021 |
Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury
A Obermayer, LM Jakob, JD Haslbauer, MS Matter, A Tzankov, W Stoiber, R Pichler |
Disease Markers | 2021 |
NETosis in Wound Healing: When Enough Is Enough
M Sabbatini, V Magnelli, F Renò |
Cells | 2021 |
The pulmonary pathology of COVID-19
H Bösmüller, M Matter, F Fend, A Tzankov |
Virchows Archiv | 2021 |
Resistin, a Novel Host Defense Peptide of Innate Immunity
Y Li, Q Yang, D Cai, H Guo, J Fang, H Cui, L Gou, J Deng, Z Wang, Z Zuo |
Frontiers in immunology | 2021 |
The Antimicrobial Activity of Peripheral Blood Neutrophils Is Altered in Patients with Primary Ciliary Dyskinesia
M Cockx, M Blanter, M Gouwy, P Ruytinx, SA Salama, S Knoops, N Pörtner, L Vanbrabant, N Lorent, M Boon, S Struyf |
International journal of molecular sciences | 2021 |
Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients
KL Chan, X Feng, B Ip, S Huang, SH Ma, FS Fan, HL Ip, L Huang, VC Mok, YO Soo, TW Leung, X Leng |
Frontiers in aging neuroscience | 2021 |
Proteome Profiling of Recombinant DNase Therapy in Reducing NETs and Aiding Recovery in COVID-19 Patients
J Fisher, T Mohanty, CA Karlsson, SM Khademi, E Malmström, A Frigyesi, P Nordenfelt, J Malmstrom, A Linder |
Molecular & cellular proteomics : MCP | 2021 |
The predictive effect of the platelet-to-lymphocyte ratio (PLR) and the neutrophil-to-lymphocyte ratio (NLR) on the risk of death in patients with severe fever with thrombocytopenia syndrome (SFTS): a multi-center study in China
X Wang, L Lin, Z Zhao, W Zhou, Z Ge, Y Shen, L Wang, W Zhang, R Song, D Tian, J Wen, S Cui, X Yu, Y Feng, Y Liu, C Qiang, J Duan, Y Ma, X Li, T Fan, Y Zhao, Z Chen |
Annals of translational medicine | 2021 |
Neutrophil‐mediated mechanisms of damage and in‐vitro protective effect of colchicine in non‐vascular Behçet’s syndrome
A Bettiol, M Becatti, E Silvestri, FR Argento, E Fini, A Mannucci, S Galora, I Mattioli, ML Urban, D Malandrino, A Palermo, N Taddei, G Emmi, D Prisco, C Fiorillo |
Clinical & Experimental Immunology | 2021 |
Influence of iron- and zinc-chelating agents on neutrophil extracellular trap formation
W Kuźmicka, A Moskalik, A Manda-Handzlik, U Demkow, M Wachowska, O Ciepiela |
CENT EUR J IMMUNOL | 2021 |
Role of iBALT in Respiratory Immunity
Aaron Silva-Sanchez, Troy D Randall |
Current topics in microbiology and immunology | 2020 |
A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
V Mutua, LJ Gershwin |
Clinical Reviews in Allergy & Immunology | 2020 |
Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation
JG Filep, A Ariel |
American journal of physiology. Cell physiology | 2020 |
Role of Alarmins in the Pathogenesis of Systemic Sclerosis
A Giovannetti, E Straface, E Rosato, M Casciaro, G Pioggia, S Gangemi |
International journal of molecular sciences | 2020 |
Cell–Cell Interaction Mechanisms in Acute Lung Injury
H Zhou, EK Fan, J Fan |
Shock | 2020 |
Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice
S Watanabe, Y Iwata, H Fukushima, K Saito, Y Tanaka, Y Hasegawa, M Akiyama, K Sugiura |
Scientific Reports | 2020 |
Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease
VD Giacalone, C Margaroli, MA Mall, R Tirouvanziam |
International journal of molecular sciences | 2020 |
AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response
Y Xia, J He, H Zhang, H Wang, G Tetz, CA Maguire, Y Wang, A Onuma, D Genkin, V Tetz, A Stepanov, S Terekhov, V Ukrainskaya, H Huang, A Tsung |
Molecular Oncology | 2020 |
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
EA Middleton, XY He, F Denorme, RA Campbell, D Ng, SP Salvatore, M Mostyka, A Baxter-Stoltzfus, AC Borczuk, M Loda, MJ Cody, BK Manne, I Portier, ES Harris, AC Petrey, EJ Beswick, AF Caulin, A Iovino, LM Abegglen, AS Weyrich, MT Rondina, M Egeblad, JD Schiffman, CC Yost |
Blood | 2020 |
The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury
NJ Edwards, C Hwang, S Marini, CA Pagani, PJ Spreadborough, CJ Rowe, P Yu, A Mei, N Visser, S Li, GE Hespe, AK Huber, AL Strong, MA Shelef, JS Knight, TA Davis, B Levi |
The FASEB Journal | 2020 |
Histone H4 aggravates inflammatory injury through TLR4 in chlorine gas-induced acute respiratory distress syndrome
Y Zhang, J Zhao, L Guan, L Mao, S Li, J Zhao |
Journal of Occupational Medicine and Toxicology | 2020 |
Surgical Stress Promotes Tumor Progression: A Focus on the Impact of the Immune Response
AE Onuma, H Zhang, L Gil, H Huang, A Tsung |
Journal of Clinical Medicine | 2020 |
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis
MT Masucci, M Minopoli, SD Vecchio, MV Carriero |
Frontiers in immunology | 2020 |
Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update
A Bonaventura, A Vecchié, A Abbate, F Montecucco |
Cells | 2020 |
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis
Z Jin, J Sun, Z Song, K Chen, YS Nicolas, R KC, Q Ma, J Liu, M Zhang |
npj Regenerative Medicine | 2020 |
Role of Neutrophils in Systemic Vasculitides
D Michailidou, T Mustelin, C Lood |
Frontiers in immunology | 2020 |
Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions
S Shao, C Hao, B Zhan, Q Zhuang, L Zhao, Y Chen, J Huang, X Zhu |
Frontiers in immunology | 2020 |
Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease
KE Kluge, MS Langseth, TB Opstad, AÅ Pettersen, H Arnesen, T Tønnessen, I Seljeflot, R Helseth |
Mediators of Inflammation | 2020 |
Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes
SI Galkina, NV Fedorova, EA Golenkina, VI Stadnichuk, GF Sudina |
International journal of molecular sciences | 2020 |
Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia
Y Guo, R Liu, L Chen, W Wu, S Zhang |
BMC Cardiovascular Disorders | 2020 |
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
A Marki, K Buscher, C Lorenzini, M Meyer, R Saigusa, Z Fan, YT Yeh, N Hartmann, JM Dan, WB Kiosses, GJ Golden, R Ganesan, H Winkels, M Orecchioni, S McArdle, Z Mikulski, Y Altman, J Bui, M Kronenberg, S Chien, JD Esko, V Nizet, D Smalley, J Roth, K Ley |
Journal of Experimental Medicine | 2020 |
Abnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients
Q Lin, W Zhou, Y Wang, J Huang, X Hui, Z Zhou, Y Xiao |
Journal of Diabetes Research | 2020 |
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils
M Perego, VA Tyurin, YY Tyurina, J Yellets, T Nacarelli, C Lin, Y Nefedova, A Kossenkov, Q Liu, S Sreedhar, H Pass, J Roth, T Vogl, D Feldser, R Zhang, VE Kagan, DI Gabrilovich |
Science Translational Medicine | 2020 |
Antibodies clamp down on NET nucleosomes
M Radic |
Cellular and Molecular Immunology | 2020 |
Inflammation, Thrombosis, and Destruction: The Three-Headed Cerberus of Trauma- and SARS-CoV-2-Induced ARDS
L Lupu, A Palmer, M Huber-Lang |
Frontiers in immunology | 2020 |
The Emerging Role of Vitamin C as a Treatment for Sepsis
MG Kashiouris, M LHeureux, CA Cable, BJ Fisher, SW Leichtle, AA Fowler |
Nutrients | 2020 |
Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness
P Ruiz-Limon, ML Ladehesa-Pineda, M del Carmen Castro-Villegas, M del Carmen Abalos-Aguilera, C Lopez-Medina, C Lopez-Pedrera, N Barbarroja, D Espejo-Peralbo, JA Gonzalez-Reyes, JM Villalba, C Perez-Sanchez, A Escudero-Contreras, E Collantes-Estevez, P Font-Ugalde, Y Jimenez-Gomez |
Journal of Biomedical Science | 2020 |
The Enigma of Endothelium in COVID-19
S Kaur, DM Tripathi, A Yadav |
Frontiers in physiology | 2020 |
Neutrophil-mediated Thrombosis and NETosis in Behçet's Disease: a Hypothesis
ED Batu |
Journal of Korean Medical Science | 2020 |
Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases
MC Méchin, H Takahara, M Simon |
International journal of molecular sciences | 2020 |
Neutrophil Extracellular Trap–Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma
RF Rayes, P Vourtzoumis, MB Rjeily, R Seth, F Bourdeau, B Giannias, J Berube, YH Huang, S Rousseau, S Camilleri-Broet, RS Blumberg, N Beauchemin, S Najmeh, J Cools-Lartigue, JD Spicer, LE Ferri |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
The origin of extracellular DNA in bacterial biofilm infections in vivo
M Alhede, M Alhede, K Qvortrup, KN Kragh, PØ Jensen, PS Stewart, T Bjarnsholt |
Pathogens and Disease | 2020 |
Staphylococcus aureus drives expansion of low density neutrophils in diabetic mice
Taylor S Cohen, Virginia N. Takahashi, Jessica Bonnell, Andrey Tovchigrechko, Raghothama Chaerkady, Wen Yu, Omari Jones-Nelson, Young Lee, Rajiv Raja, Sonja Hess, Charles K Stover, John J. Worthington, Mark A Travis, Bret R. Sellman |
Journal of Clinical Investigation | 2019 |
Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis
CJ Lerche, LJ Christophersen, JP Goetze, PR Nielsen, K Thomsen, C Enevold, N Høiby, PØ Jensen, H Bundgaard, C Moser, PG de Frutos |
PloS one | 2019 |
The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity
R Golonka, BS Yeoh, M Vijay-Kumar |
Journal of Innate Immunity | 2019 |
Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk
S Shao, H Fang, E Dang, K Xue, J Zhang, B Li, H Qiao, T Cao, Y Zhuang, S Shen, T Zhang, P Qiao, C Li, JE Gudjonsson, G Wang |
Frontiers in immunology | 2019 |
The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses
C Egholm, LE Heeb, D Impellizzieri, O Boyman |
Frontiers in immunology | 2019 |
Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related With Hyper Inflammation and Severe Lung Tissue Damage
MG de Melo, ED Mesquita, MM Oliveira, C da Silva-Monteiro, AK Silveira, TS Malaquias, TC Dutra, RM Galliez, AL Kritski, EC Silva |
Frontiers in immunology | 2019 |
Endothelium structure and function in kidney health and disease
N Jourde-Chiche, F Fakhouri, L Dou, J Bellien, S Burtey, M Frimat, PA Jarrot, G Kaplanski, ML Quintrec, V Pernin, C Rigothier, M Sallée, V Fremeaux-Bacchi, D Guerrot, LT Roumenina |
Nature Reviews Nephrology | 2019 |
Neutrophil Activation and Early Features of NET Formation Are Associated With Dengue Virus Infection in Human
A Opasawatchai, P Amornsupawat, N Jiravejchakul, W Chan-in, NJ Spoerk, K Manopwisedjaroen, P Singhasivanon, T Yingtaweesak, S Suraamornkul, J Mongkolsapaya, A Sakuntabhai, P Matangkasombut, F Loison |
Frontiers in immunology | 2019 |
PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium
P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kumar |
Mucosal Immunology | 2019 |
Dendritic cells, T cells and their interaction in rheumatoid arthritis: Dendritic cells, T cells and their interaction
P Wehr, H Purvis, SC Law, R Thomas |
Clinical & Experimental Immunology | 2019 |
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis
LT Weckbach, U Grabmaier, A Uhl, S Gess, F Boehm, A Zehrer, R Pick, M Salvermoser, T Czermak, J Pircher, N Sorrelle, M Migliorini, DK Strickland, K Klingel, V Brinkmann, UA Abed, U Eriksson, S Massberg, S Brunner, B Walzog |
Journal of Experimental Medicine | 2019 |
Polysialic Acid Modulates the Binding of External Lactoferrin in Neutrophil Extracellular Traps
A Kühnle, T Lütteke, K Bornhöfft, S Galuska |
Biology : open access journal | 2019 |
Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion
A Meier, J Chien, L Hobohm, KA Patras, V Nizet, R Corriden |
Frontiers in pharmacology | 2019 |
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection
N Wang, X Yang, J Sun, Z Sun, Q Ma, Z Wang, Z Chen, Z Wang, F Hu, H Wang, L Zhou, M Zhang, J Xu |
Cell Death Discovery | 2019 |
Lactic Acid Accumulation During Exhaustive Exercise Impairs Release of Neutrophil Extracellular Traps in Mice
Y Shi, H Shi, DC Nieman, Q Hu, L Yang, T Liu, X Zhu, H Wei, D Wu, F Li, Y Cui, P Chen |
Frontiers in physiology | 2019 |
Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection
FC Kirsebom, F Kausar, R Nuriev, S Makris, C Johansson |
Mucosal Immunology | 2019 |
Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages
Z An, J Li, J Yu, X Wang, H Gao, W Zhang, Z Wei, J Zhang, Y Zhang, J Zhao, X Liang |
Cell cycle (Georgetown, Tex.) | 2019 |
Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
B Shrestha, T Ito, M Kakuuchi, T Totoki, T Nagasato, M Yamamoto, I Maruyama |
Frontiers in immunology | 2019 |
Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation
S Ueki, Y Miyabe, Y Yamamoto, M Fukuchi, M Hirokawa, LA Spencer, PF Weller |
Current Allergy and Asthma Reports | 2019 |
Periodontal therapy increases neutrophil extracellular trap degradation
CG Moonen, KG Buurma, MR Faruque, MG Balta, E Liefferink, S Bizzarro, EA Nicu, BG Loos |
Innate immunity | 2019 |
Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU)
L Fingerhut, B Ohnesorge, M von Borstel, A Schumski, K Strutzberg-Minder, M Mörgelin, CA Deeg, HP Haagsman, A Beineke, M von Köckritz-Blickwede, N de Buhr |
Cells | 2019 |
Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype
S Lambert, CA Hambro, A Johnston, PE Stuart, LC Tsoi, RP Nair, J T. |
Journal of Investigative Dermatology | 2019 |
Extracellular histones are clinically associated with primary graft dysfunction in human liver transplantation.
Li X, Gou C, Pang Y, Wang Y, Liu Y, Wen T |
RSC Advances | 2019 |
Vascular Nanomedicine: Current Status, Opportunities, and Challenges.
Sun M, Sen Gupta A |
Seminars in thrombosis and hemostasis | 2019 |
Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1b
Hsi-Min Hsiao, Ramiro Fernandez, Satona Tanaka, WenJun Li, Jessica Spahn, Stephen Chiu, Mahzad Akbarpour, Daniel Ruiz-Perez, Qiang Wu, Cem Turam, Davide Scozzi, Tsuyoshi Takahashi, Hannah Luehmann, Varun Puri, G.R. Scott Budinger, Alexander Krupnick, Alexander Misharin, Kory Lavine, Yongjian Liu, Andrew Gelman, Ankit Bharat, Daniel Kreisel |
Journal of Clinical Investigation | 2018 |
Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
L Chen, Y Zhao, D Lai, P Zhang, Y Yang, Y Li, K Fei, G Jiang, J Fan |
Cell Death and Disease | 2018 |
The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps
AA Manfredi, GA Ramirez, P Rovere-Querini, N Maugeri |
Frontiers in immunology | 2018 |
Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine
D Hartl, R Tirouvanziam, J Laval, CM Greene, D Habiel, L Sharma, AÖ Yildirim, CS Cruz, CM Hogaboam |
Journal of Innate Immunity | 2018 |
Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection
CS Curran, T Bolig, P Torabi-Parizi |
American journal of respiratory and critical care medicine | 2018 |
Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury
WM Raup-Konsavage, Y Wang, WW Wang, D Feliers, H Ruan, WB Reeves |
Kidney International | 2018 |
Amicus or Adversary Revisited: Platelets in Acute Lung Injury and Acute Respiratory Distress Syndrome
EA Middleton, MT Rondina, H Schwertz, GA Zimmerman |
American journal of respiratory cell and molecular biology | 2018 |
2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation
EN Palladino, LA Katunga, GR Kolar, DA Ford |
Journal of lipid research | 2018 |
Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma
M Garley, D Dziemiańczyk-Pakieła, K Grubczak, A Surażyński, D Dąbrowska, W Ratajczak-Wrona, J Sawicka-Powierza, J Borys, M Moniuszko, JA Pałka, E Jabłońska |
Journal of Cancer | 2018 |
Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C
B Ingelsson, D Söderberg, T Strid, A Söderberg, AC Bergh, V Loitto, K Lotfi, M Segelmark, G Spyrou, A Rosén |
Proceedings of the National Academy of Sciences | 2018 |
Two-in-one: UV radiation simultaneously induces apoptosis and NETosis
D Azzouz, MA Khan, N Sweezey, N Palaniyar |
Cell Death Discovery | 2018 |
Neutrophil Extracellular Traps Formation and Aggregation Orchestrate Induction and Resolution of Sterile Crystal-Mediated Inflammation
Y Li, X Cao, Y Liu, Y Zhao, M Herrmann |
Frontiers in immunology | 2018 |
Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and neutrophil extracellular traps
H Li, D Feng, Y Cai, Y Liu, M Xu, X Xiang, Z Zhou, Q Xia, MJ Kaplan, X Kong, B Gao |
Hepatology | 2018 |
NETQUANT: Automated Quantification of Neutrophil Extracellular Traps
T Mohanty, OE Sørensen, P Nordenfelt |
Frontiers in immunology | 2018 |
Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils
Y Zhou, LL An, R Chaerkady, N Mittereder, L Clarke, TS Cohen, B Chen, S Hess, GP Sims, T Mustelin |
Scientific Reports | 2018 |
A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses
T Stobernack, M du Teil Espina, LM Mulder, LM Medina, DR Piebenga, G Gabarrini, X Zhao, KM Janssen, J Hulzebos, E Brouwer, T Sura, D Becher, AJ van Winkelhoff, F Götz, A Otto, J Westra, JM van Dijl, R Rappuoli |
mBio | 2018 |
Going Fishing.
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Journal of Innate Immunity | 2018 |
Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis
AS Gukovskaya, I Gukovsky, H Algül, A Habtezion |
Gastroenterology | 2017 |
Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections
YH Shen, SA LeMaire |
Current Problems in Surgery | 2017 |
Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction
Z Zheng, S Chiu, M Akbarpour, H Sun, PA Reyfman, KR Anekalla, H Abdala-Valencia, D Edgren, W Li, D Kreisel, FV Korobova, R Fernandez, A McQuattie-Pimentel, ZJ Zhang, H Perlman, AV Misharin, GR Budinger, A Bharat |
Science Translational Medicine | 2017 |
Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil
SM Lawrence, R Corriden, V Nizet |
Frontiers in Pediatrics | 2017 |
The Role of Inflammation in Cardiovascular Outcome
F Montecucco, L Liberale, A Bonaventura, A Vecchiè, F Dallegri, F Carbone |
Current Atherosclerosis Reports | 2017 |
Re-Examining Neutrophil Participation in GN
DJ Caster, DW Powell, I Miralda, RA Ward, KR McLeish |
Journal of the American Society of Nephrology : JASN | 2017 |
Neutrophil Extracellular Traps and Endothelial Dysfunction in Atherosclerosis and Thrombosis
H Qi, S Yang, L Zhang |
Frontiers in immunology | 2017 |
Paucimannose-Rich N -glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions
I Loke, O Østergaard, NH Heegaard, NH Packer, M Thaysen-Andersen |
Molecular & cellular proteomics : MCP | 2017 |
Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
IB Regli, K Passelli, BP Hurrell, F Tacchini-Cottier |
Frontiers in immunology | 2017 |
Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS
H Li, X Zhou, H Tan, Y Hu, L Zhang, S Liu, M Dai, Y Li, Q Li, Z Mao, P Pan, X Su, C Hu |
Oncotarget | 2017 |
The immunopathology of sepsis and potential therapeutic targets
T van der Poll, FL van de Veerdonk, BP Scicluna, MG Netea |
Nature Reviews Immunology | 2017 |
Stem Cell Extracellular Vesicles: Extended Messages of Regeneration
M Riazifar, EJ Pone, J Lötvall, W Zhao |
Annual Review of Pharmacology and Toxicology | 2017 |
Consequences of extracellular trap formation in sepsis:
XM OBrien, BM Biron, JS Reichner |
Current Opinion in Hematology | 2017 |
Neutrophil extracellular traps in acute chorioamnionitis: A mechanism of host defense
N Gomez-Lopez, R Romero, Y Leng, V Garcia-Flores, Y Xu, D Miller, SS Hassan |
American Journal of Reproductive Immunology | 2017 |
Disentangling the role of neutrophil extracellular traps in rheumatic diseases:
YL Lightfoot, MJ Kaplan |
Current Opinion in Rheumatology | 2017 |
Neutrophil Extracellular Traps and Microcrystals
B Rada |
Journal of Immunology Research | 2017 |
Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies
R Panda, T Krieger, L Hopf, T Renné, F Haag, N Röber, K Conrad, E Csernok, TA Fuchs |
Frontiers in immunology | 2017 |
Multiple Phenotypic Changes Define Neutrophil Priming
I Miralda, SM Uriarte, KR McLeish |
Frontiers in Cellular and Infection Microbiology | 2017 |
Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation
A Lizcano, I Secundino, S Döhrmann, R Corriden, C Rohena, S Diaz, P Ghosh, L Deng, V Nizet, A Varki |
Blood | 2017 |
New Insights on Platelets and Platelet-Derived Microparticles in Systemic Lupus Erythematosus
M Scherlinger, V Sisirak, C Richez, E Lazaro, P Duffau, P Blanco |
Current Rheumatology Reports | 2017 |
Metabolic abnormalities and oxidative stress in lupus:
YL Lightfoot, LP Blanco, MJ Kaplan |
Current Opinion in Rheumatology | 2017 |
Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils
Y Zhou, B Chen, N Mittereder, R Chaerkady, M Strain, LL An, S Rahman, W Ma, CP Low, D Chan, F Neal, CO Bingham, K Sampson, E Darrah, RM Siegel, S Hasni, F Andrade, KA Vousden, T Mustelin, GP Sims |
Frontiers in immunology | 2017 |
Artificial Polysialic Acid Chains as Sialidase-Resistant Molecular-Anchors to Accumulate Particles on Neutrophil Extracellular Traps
CE Galuska, JA Dambon, A Kühnle, KF Bornhöfft, G Prem, K Zlatina, T Lütteke, SP Galuska |
Frontiers in immunology | 2017 |
Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB
MC Schechter, K Buac, T Adekambi, S Cagle, J Celli, SM Ray, CC Mehta, B Rada, J Rengarajan, N Palaniyar |
PloS one | 2017 |
d(−) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression
PA PA, CM CM, IC IC, MD MDC, TM TMC, LM LMRS, AT AT, CH CH, MA MAH, RA RAB |
Frontiers in immunology | 2017 |
Great Therapeutic Potential of Peptidylarginine Deiminase 4 (PAD4) Inhibitors: Treatment of Rheumatoid Arthritis, Epigenetic Tools, Regulation of Pluripotency in Stem Cells, and More
AF Abdel-Magid |
ACS Medicinal Chemistry Letters | 2017 |
Statins: antimicrobial resistance breakers or makers?
HH Ko, RR Lareu, BR Dix, JD Hughes |
PeerJ | 2017 |
Pathogenesis of Sepsis
van Engelen TS, Joost Wiersinga W, van der Poll T |
2017 | |
Neonatal NET-inhibitory factor (nNIF) and nNIF-related peptides inhibit neutrophil extracellular trap (NET) formation
Christian Yost, Hansjorg Schwertz, Mark Cody, Jared Wallace, Robert Campbell, Adriana Vieira-de-Abreu, Claudia Araujo, Sebastian Schubert, Estelle Harris, Jesse Rowley, Matthew Rondina, James Fulcher, Curry Koening, Andrew S. Weyrich, Guy Zimmerman |
Journal of Clinical Investigation | 2016 |
Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF
S Giaglis, M Stoikou, CS Chowdhury, G Schaefer, F Grimolizzi, SW Rossi, IM Hoesli, O Lapaire, P Hasler, S Hahn |
Frontiers in immunology | 2016 |
The immune system's role in sepsis progression, resolution, and long-term outcome
MJ Delano, PA Ward |
Immunological Reviews | 2016 |
New insights into the pathways initiating and driving pancreatitis:
AS Gukovskaya, SJ Pandol, I Gukovsky |
Current Opinion in Gastroenterology | 2016 |
Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy
S Nadkarni, J Smith, AN Sferruzzi-Perri, A Ledwozyw, M Kishore, R Haas, C Mauro, DJ Williams, SH Farsky, FM Marelli-Berg, M Perretti |
Proceedings of the National Academy of Sciences | 2016 |
Pondering neutrophil extracellular traps with healthy skepticism: Skepticism about neutrophil extracellular traps
WM Nauseef, P Kubes |
Cellular Microbiology | 2016 |
Neutrophil Extracellular Traps Go Viral
G Schönrich, MJ Raftery |
Frontiers in immunology | 2016 |
Cellular Innate Immunity: An Old Game with New Players
G Gasteiger, A D'Osualdo, DA Schubert, A Weber, EM Bruscia, D Hartl |
Journal of Innate Immunity | 2016 |
Neutrophil Extracellular Traps in the Amniotic Cavity of Women with Intra-Amniotic Infection: A New Mechanism of Host Defense
N Gomez-Lopez, R Romero, Y Xu, D Miller, R Unkel, M Shaman, SM Jacques, B Panaitescu, V Garcia-Flores, SS Hassan |
Reproductive sciences (Thousand Oaks, Calif.) | 2016 |
Immunodetection of NETs in Paraffin-Embedded Tissue
V Brinkmann, UA Abed, C Goosmann, A Zychlinsky |
Frontiers in immunology | 2016 |
Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor.
Boldenow E, Gendrin C, Ngo L, Bierle C, Vornhagen J, Coleman M, Merillat S, Armistead B, Whidbey C, Alishetti V, Santana-Ufret V, Ogle J, Gough M, Srinouanprachanh S, MacDonald JW, Bammler TK, Bansal A, Liggitt HD, Rajagopal L, Adams Waldorf KM |
Science Immunology | 2016 |