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Citations to this article

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies
Laurie A. Silva, Terence S. Dermody
Laurie A. Silva, Terence S. Dermody
Published March 1, 2017
Citation Information: J Clin Invest. 2017;127(3):737-749. https://doi.org/10.1172/JCI84417.
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Review Article has an altmetric score of 34

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

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Abstract

Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and headache. CHIKV is transmitted by Aedes species of mosquitoes and is capable of an epidemic, urban transmission cycle with high rates of infection. Since 2004, CHIKV has spread to new areas, causing disease on a global scale, and the potential for CHIKV epidemics remains high. Although CHIKV has caused millions of cases of disease and significant economic burden in affected areas, no licensed vaccines or antiviral therapies are available. In this Review, we describe CHIKV epidemiology, replication cycle, pathogenesis and host immune responses, and prospects for effective vaccines and highlight important questions for future research.

Authors

Laurie A. Silva, Terence S. Dermody

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LoMascolo NJ, Cruz-Pulido YE, Mounce BC
Antimicrobial agents and chemotherapy 2022
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
Policastro LR, Dolci I, Godoy AS, Silva Júnior JV, Ruiz UE, Santos IA, Jardim AC, Samby K, Burrows JN, Wells TN, Gil LH, Oliva G, Fernandes RS
Viruses 2022
Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer
Ichihara R, Shiraki Y, Mizutani Y, Iida T, Miyai Y, Esaki N, Kato A, Mii S, Ando R, Hayashi M, Takami H, Fujii T, Takahashi M, Enomoto A
Pathology International 2022
The new invasive mosquito species Aedes koreicus as vector-borne diseases in the European area, a focus on Italian region: What we know from the scientific literature
Ganassi S, De Cristofaro A, Di Criscio D, Petrarca S, Leopardi C, Guarnieri A, Pietrangelo L, Venditti N, Di Marco R, Petronio Petronio G
Frontiers in microbiology 2022
Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography.
Chmielewski D, Schmid MF, Simmons G, Jin J, Chiu W
Nature Microbiology 2022
Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery.
Mangala Prasad V, Blijleven JS, Smit JM, Lee KK
Nature Communications 2022
Chikungunya Immunopathology as It Presents in Different Organ Systems
Traverse EM, Millsapps EM, Underwood EC, Hopkins HK, Young M, Barr KL
Viruses 2022
Updating the Insecticide Resistance Status of Aedes aegypti and Aedes albopictus in Asia: A Systematic Review and Meta-Analysis.
Zulfa R, Lo WC, Cheng PC, Martini M, Chuang TW
Tropical Medicine and Infectious Disease 2022
A Swin Transformer-based model for mosquito species identification.
Zhao DZ, Wang XK, Zhao T, Li H, Xing D, Gao HT, Song F, Chen GH, Li CX
Scientific Reports 2022
G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus.
Wang S, Merits A
Journal of virology 2022
Histopathological and immunological characteristics of placentas infected with chikungunya virus.
Salomão N, Rabelo K, Avvad-Portari E, Basílio-de-Oliveira C, Basílio-de-Oliveira R, Ferreira F, Ferreira L, de Souza TM, Nunes P, Lima M, Sales AP, Fernandes R, de Souza LJ, Dias L, Brasil P, Dos Santos F, Paes M
Frontiers in microbiology 2022
Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis
Silva NB, de Souza JH, Santiago MB, da Silva Aguiar JR, Martins DO, da Silva RA, de Andrade Santos I, Aldana-Mejía JA, Jardim AC, dos Santos Pedroso R, Ambrósio SR, Veneziani RC, Bastos JK, Pires RH, Martins CH
Scientific Reports 2022
UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis
Geng T, Yang D, Lin T, Cahoon JG, Wang P
mBio 2022
Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development
Hakim MS, Aman AT
Viruses 2022
The global burden of Chikungunya fever among children: A systematic literature review and meta-analysis
Nyamwaya DK, Thumbi SM, Bejon P, Warimwe GM, Mokaya J
2022
Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways
Ruiz UE, Santos IA, Grosche VR, Fernandes RS, de Godoy AS, Torres JD, Freire MC, Mesquita NC, Guevara-Vega M, Nicolau-Junior N, Sabino-Silva R, Mineo TW, Oliva G, Jardim AC
Virus Research 2022
The lncRNA ALPHA specifically targets chikungunya virus to control infection
Basavappa MG, Ferretti M, Dittmar M, Stoute J, Sullivan M, Whig K, Shen H, Liu KF, Schultz DC, Beiting D, Lynch K, Henao-Mejia J, Cherry S
Molecular Cell 2022
Complex Roles of Neutrophils during Arboviral Infections
A Muralidharan, SP Reid
Cells 2021
Prophylactic strategies to control chikungunya virus infection
FI Hucke, M Bestehorn-Willmann, JJ Bugert
Virus Genes 2021
Mosquito-bite infection of humanized mice with chikungunya virus produces systemic disease with long-term effects
BM Hibl, NJ Garnes, AR Kneubehl, MB Vogt, JL Clinton, RR Rico-Hesse, MR Holbrook
PLoS neglected tropical diseases 2021
Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya
Y Bedoui, A Septembre-Malaterre, C Giry, MC Jaffar-Bandjee, J Selambarom, P Guiraud, P Gasque, PV Aguilar
PLoS neglected tropical diseases 2021
Overview on Chikungunya Virus Infection: From Epidemiology to State-of-the-Art Experimental Models
LE Constant, BF Rajsfus, PH Carneiro, T Sisnande, R Mohana-Borges, D Allonso
Frontiers in microbiology 2021
Climatic and socio-economic factors supporting the co-circulation of dengue, Zika and chikungunya in three different ecosystems in Colombia
J Morgan, C Strode, JE Salcedo-Sora, RC Christofferson
PLoS neglected tropical diseases 2021
Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells
C Chiale, AM Marchese, Y Furuya, MD Robek
npj Vaccines 2021
Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus
IA Santos, JF Shimizu, DM de Oliveira, DO Martins, L Cardoso-Sousa, AC Cintra, VH Aquino, SV Sampaio, N Nicolau-Junior, R Sabino-Silva, A Merits, M Harris, AC Jardim
Scientific Reports 2021
BHK-21 Cell Clones Differ in Chikungunya Virus Infection and MXRA8 Receptor Expression
P Yin, M Kielian
Viruses 2021
Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil
IP Sousa, FB dos Santos, VS de Paula, TC Vieira, HG Dias, CA Barros, EE da Silva
Viruses 2021
Isolation and characterization of high affinity and highly stable anti-Chikungunya virus antibodies using ALTHEA Gold Libraries™
M Pedraza-Escalona, O Guzmán-Bringas, HI Arrieta-Oliva, K Gómez-Castellano, J Salinas-Trujano, J Torres-Flores, JC Muñoz-Herrera, R Camacho-Sandoval, P Contreras-Pineda, R Chacón-Salinas, SM Pérez-Tapia, JC Almagro
BMC Infectious Diseases 2021
Novel Analogues of the Chikungunya Virus Protease Inhibitor: Molecular Design, Synthesis, and Biological Evaluation
L Ivanova, K Rausalu, M Ošeka, DG Kananovich, E Žusinaite, J Tammiku-Taul, M Lopp, A Merits, M Karelson
ACS Omega 2021
Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody
JL Liu, EM Webb, D Zabetakis, CW Burke, CL Gardner, PJ Glass, PM Legler, J Weger-Lucarelli, GP Anderson, ER Goldman
Frontiers in Medicine 2021
Facile method for delivering chikungunya viral replicons into mosquitoes and mammalian cells
HC Lin, DJ Chiao, CC Lin, SC Kuo
Scientific Reports 2021
Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression
B Troost-Kind, MJ van Hemert, D van de Pol, H van der Ende-Metselaar, A Merits, M Borggrewe, IA Rodenhuis-Zybert, JM Smit, A Kohl
PLoS neglected tropical diseases 2021
Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
S Khongwichit, J Chansaenroj, C Chirathaworn, Y Poovorawan
Journal of Biomedical Science 2021
Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018
EA Luvai, AK Kyaw, NS Sabin, F Yu, SW Hmone, KZ Thant, S Inoue, K Morita, MM Tun, K Zinszer
PLoS neglected tropical diseases 2021
Chikungunya Virus Molecular Evolution in India Since its Re-emergence in 2005
S Chaudhary, J Jain, R Kumar, J Shrinet, SC Weaver, AJ Auguste, S Sunil
Virus Evolution 2021
Specific Recognition of a Stem-Loop RNA Structure by the Alphavirus Capsid Protein
RS Brown, L Kim, M Kielian
Viruses 2021
Mode-Dependent Antiviral Activity of Medicinal Plant Extracts against the Mosquito-Borne Chikungunya Virus
SM Chan, KS Khoo, SD Sekaran, NW Sit
Plants 2021
Molecular Epidemiology, Evolution and Reemergence of Chikungunya Virus in South Asia
N Sharif, MK Sarkar, RN Ferdous, SN Ahmed, B Billah, AA Talukder, M Zhang, SK Dey
Frontiers in microbiology 2021
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis
Z Li, J Wang, X Cheng, H Hu, C Guo, J Huang, Z Chen, J Lu, P Kittayapong
PLoS neglected tropical diseases 2021
Persistent Joint Pain Following Arthropod Virus Infections
K Suchowiecki, SP Reid, GL Simon, GS Firestein, A Chang
Current Rheumatology Reports 2021
Arbovirus Rash in the Febrile Returning Traveler as a Diagnostic Clue
E Wong, JA Suárez, L Naranjo, MM Castrejón-Alba
Current Tropical Medicine Reports 2021
An Overview of Current Uses and Future Opportunities for Computer-Assisted Design of Vaccines for Neglected Tropical Diseases
R Robleda-Castillo, A Ros-Lucas, N Martinez-Peinado, J Alonso-Padilla
Advances and applications in bioinformatics and chemistry : AABC 2021
Combination Regimens of Favipiravir Plus Interferon Alpha Inhibit Chikungunya Virus Replication in Clinically Relevant Human Cell Lines
EJ Franco, X Tao, KC Hanrahan, J Zhou, JB Bulitta, AN Brown
Microorganisms 2021
Prime-boost with Chikungunya virus E2 envelope protein combined with Poly (I:C) induces specific humoral and cellular immune responses
M Amaral, F Coirada, J de Souza Apostolico, N Tomita, E Fernandes, H Souza, R Chura-Chambi, L Morganti, S Boscardin, D Rosa
2021
Chikungunya: an emerging rheumatological pandemic?
Bilsborrow JB, Amaral JK, Schoen R
Current rheumatology research 2021
Chikungunya infection: De-linking replication from symptomatology reveals the central role of muscle
Anne Moscona
Journal of Clinical Investigation 2020
Antibody response patterns in chikungunya febrile phase predicts protection versus progression to chronic arthritis
Kaustuv Nayak, Vineet Jain, Manpreet Kaur, Naushad Khan, Kamalvishnu Gottimukkala, Charu Aggarwal, Rohit Sagar, Shipra Gupta, Ramesh Chandra Rai, Kritika Dixit, Mohammad Islamuddin, Wajihul Hasan Khan, Anil Verma, Deepti Maheshwari, Yadya M. Chawla, Elluri Seetharami Reddy, Harekrushna Panda, Pragati Sharma, Priya Bhatnagar, Prabhat Singh, Siva Raghavendhar, Ashok Kumar Patel, Vinod H. Ratageri, Anmol Chandele, Pratima Ray, Kaja Murali-Krishna
JCI Insight 2020
Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-α2 Expression
B Neupane, D Acharya, F Nazneen, G Gonzalez-Fernandez, AS Flynt, F Bai
Frontiers in immunology 2020
Current Efforts in the Development of Vaccines for the Prevention of Zika and Chikungunya Virus Infections
S Schrauf, R Tschismarov, E Tauber, K Ramsauer
Frontiers in immunology 2020
A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus
T Geng, T Lin, D Yang, AG Harrison, AT Vella, E Fikrig, P Wang
The Journal of Infectious Diseases 2020
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice
L Yang, T Geng, G Yang, J Ma, L Wang, H Ketkar, D Yang, T Lin, J Hwang, S Zhu, Y Wang, J Dai, F You, G Cheng, AT Vella, RA Flavell, E Fikrig, P Wang
2020
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
T Lin, T Geng, AG Harrison, D Yang, AT Vella, E Fikrig, P Wang
Viruses 2020
Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease
LE Fox, MC Locke, DJ Lenschow
Frontiers in immunology 2020
Current and Promising Antivirals Against Chikungunya Virus
FI Hucke, JJ Bugert
Frontiers in public health 2020
Interepidemic Detection of Chikungunya Virus Infection and Transmission in Northeastern Thailand
BC Le, T Ekalaksananan, K Thaewnongiew, S Phanthanawiboon, S Aromseree, T Phanitchat, J Chuerduangphui, AT Suwannatrai, N Alexander, HJ Overgaard, MJ Bangs, C Pientong
The American journal of tropical medicine and hygiene 2020
Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar
JY Shen, M Li, L Xie, JR Mao, HN Zhou, PG Wang, JY Jiang, J An
Virologica Sinica 2020
The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission
R Bellone, AB Failloux
Frontiers in microbiology 2020
Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis
P Kaur, LS Lello, A Utt, SK Dutta, A Merits, JJ Chu, AM Samy
PLoS neglected tropical diseases 2020
Viral and host heterogeneity and their effects on the viral life cycle
JE Jones, VL Sage, SS Lakdawala
Nature Reviews Microbiology 2020
Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections
K Maduray, R Parboosing
Biological Trace Element Research 2020
Dengue, Yellow Fever, Zika and Chikungunya epidemic arboviruses in Brazil: ultrastructural aspects
DF Barreto-Vieira, D Couto-Lima, FC Jácome, GC Caldas, OM Barth
Memórias do Instituto Oswaldo Cruz 2020
A Factor I-Like Activity Associated with Chikungunya Virus Contributes to Its Resistance to the Human Complement System
J Nag, RK Mukesh, SM Suma, U Kunnakkadan, NA Kumar, JB Johnson, MT Heise
Journal of virology 2020
Genomic surveillance of the Chikungunya Virus (CHIKV) in Northeast Brazil after the first outbreak in 2014
AM Rodrigues, RR Souza, LM dos Santos Fonseca, C de Araújo Rolo, RH Carvalho, SI Sardi, GS Campos
Revista da Sociedade Brasileira de Medicina Tropical 2020
Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors
N McAllister, Y Liu, LM Silva, AJ Lentscher, W Chai, N Wu, KA Griswold, K Raghunathan, L Vang, J Alexander, KL Warfield, MS Diamond, T Feizi, LA Silva, TS Dermody, T Gallagher
Journal of virology 2020
Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection
IC Albulescu, L White-Scholten, A Tas, TE Hoornweg, S Ferla, K Kovacikova, JM Smit, A Brancale, EJ Snijder, MJ van Hemert
Viruses 2020
Epidemiologic Characteristics of Imported and Domestic Chikungunya Cases in Taiwan: A 13-Year Retrospective Study
YC Chou, CJ Hsieh, CA Cheng, DC Wu, WC Wu, FH Lin, CP Yu
International journal of environmental research and public health 2020
Stimulation of dendritic cell functional maturation by capsid protein from chikungunya virus
Vu Xuan Nghia, Nguyen Van Giang, Nguyen Xuan Canh, Nguyen Hai Ha, Nguyen Thuy Duong, Nguyen Huy Hoang, Nguyen Thi Xuan
Iranian Journal of Basic Medical Sciences 2020
JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands
A Chowdhury, CM Modahl, ST Tan, BW Xiang, D Missé, T Vial, RM Kini, JF Pompon, G Dimopoulos
PLoS pathogens 2020
A molecular understanding of alphavirus entry
AC Holmes, K Basore, DH Fremont, MS Diamond, K Stapleford
PLoS pathogens 2020
Revisiting an old friend: new findings in alphavirus structure and assembly
JM Button, SA Qazi, JC Wang, S Mukhopadhyay
Current Opinion in Virology 2020
Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP
B Kim, S Arcos, K Rothamel, J Jian, KL Rose, WH McDonald, Y Bian, S Reasoner, NJ Barrows, S Bradrick, MA Garcia-Blanco, M Ascano
Molecular Cell 2020
Serotonergic Drugs Inhibit Chikungunya Virus Infection at Different Stages of the Cell Entry Pathway
EM Bouma, DP van de Pol, ID Sanders, IA Rodenhuis-Zybert, JM Smit, MT Heise
Journal of virology 2020
Tropism of the Chikungunya Virus
G Matusali, F Colavita, L Bordi, E Lalle, G Ippolito, M Capobianchi, C Castilletti
Viruses 2019
Systems analysis of subjects acutely infected with the Chikungunya virus
A Soares-Schanoski, NB Cruz, LA de Castro-Jorge, RV de Carvalho, CA dos Santos, N da Rós, Ú Oliveira, DD Costa, CL dos Santos, M dos Passos Cunha, ML Oliveira, JC Alves, RA de Lucena Couto Océa, DR Ribeiro, AN Gonçalves, P Gonzalez-Dias, A Suhrbier, PM de Andrade Zanotto, IJ de Azevedo, DS Zamboni, RP Almeida, PL Ho, J Kalil, MY Nishiyama, HI Nakaya, DH OConnor
PLoS pathogens 2019
Brief report: the disability of chronic chikungunya arthritis
JK Amaral, JB Bilsborrow, RT Schoen
Clinical Rheumatology 2019
Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012–2015
LI Alvarado, OD Lorenzi, BC Torres-Velásquez, TM Sharp, L Vargas, JL Muñoz-Jordán, EA Hunsperger, J Pérez-Padilla, A Rivera, GE González-Zeno, RL Galloway, MG Elrod, DL Mathis, MS Oberste, WA Nix, E Henderson, J McQuiston, J Singleton, C Kato, C García-Gubern, W Santiago-Rivera, R Muns-Sosa, JD Ortiz-Rivera, G Jiménez, V Rivera-Amill, DA Andújar-Pérez, K Horiuchi, KM Tomashek, ET Marques
PLoS neglected tropical diseases 2019
Chandipura Virus Utilizes the Prosurvival Function of RelA NF-κB for Its Propagation
SS Bais, Y Ratra, NA Khan, R Pandey, PK Kushawaha, S Tomar, G Medigeshi, A Singh, S Basak, BR Williams
Journal of virology 2019
Demographic and clinical characteristics of chikungunya patients from six Colombian cities, 2014–2015
JC Rueda, AM Santos, JI Angarita, RB Giraldo, EL Saldarriaga, JG Muñoz, E Forero, H Valencia, F Somoza, D Martin-Arsanios, EJ Quintero, V Reyes-Martinez, D Padilla, FM Cuervo, I Peláez-Ballestas, MH Cardiel, PX Pavía, J Londono
Emerging Microbes & Infections 2019
Molecular characteristics and replication mechanism of dengue, zika and chikungunya arboviruses, and their treatments with natural extracts from plants: An updated review
Anny Karely Rodriguez, Ana Luisa Muñoz, Nidya Alexandra Segura, Héctor Rafael Rangel, Felio Bello
EXCLI J 2019
Viromics Reveal a Number of Novel RNA Viruses in Swedish Mosquitoes
P Öhlund, J Hayer, H Lundén, JC Hesson, AL Blomström
Viruses 2019
Genetic and Phylogenetic Characterization of a Chikungunya Virus Imported into Shenzhen, China
Y Yang, Z Xu, H Zheng, J Song, Y Wu, Z Tong, J Yuan, G Wong, WJ Liu, Y Bi, Y Liu, GF Gao
Virologica Sinica 2019
Zika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal Lamina
Y Cui, DA Grant, J Lin, X Yu, AW Franz
Viruses 2019
Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N -(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 ( Ae Kir1) Channel
CD Aretz, MJ Morwitzer, AG Sanford, AM Hogan, MV Portillo, SV Kharade, M Kramer, JB McCarthey, RR Trigueros, PM Piermarini, JS Denton, CR Hopkins
ACS Infectious Diseases 2019
The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies
KZ Wong, JJ Chu
Viruses 2018
Cellular and Molecular Immune Response to Chikungunya Virus Infection
IS Tanabe, EL Tanabe, EC Santos, WV Martins, IM Araújo, MC Cavalcante, AR Lima, NO Câmara, L Anderson, D Yunusov, ÊJ Bassi
Frontiers in Cellular and Infection Microbiology 2018
How Do Virus–Mosquito Interactions Lead to Viral Emergence?
C Rückert, GD Ebel
Trends in Parasitology 2018
Zika, Chikungunya, and Other Emerging Vector-Borne Viral Diseases
SC Weaver, C Charlier, N Vasilakis, M Lecuit
Annual Review of Medicine 2018
The neurological complications of chikungunya virus: A systematic review
R Mehta, P Gerardin, CA de Brito, CN Soares, ML Ferreira, T Solomon
Reviews in Medical Virology 2018
Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis
D Contopoulos-Ioannidis, S Newman-Lindsay, C Chow, AD LaBeaud, MV Lacerda
PLoS neglected tropical diseases 2018
A Chikungunya Virus trans -Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells
K Bartholomeeusen, A Utt, S Coppens, K Rausalu, K Vereecken, KK Ariën, A Merits, MS Diamond
Journal of virology 2018
Neuromodulation treats Chikungunya arthralgia: a randomized controlled trial
E Silva-Filho, AH Okano, E Morya, J Albuquerque, E Cacho, G Unal, M Bikson, R Pegado
Scientific Reports 2018
The effectiveness of antiviral agents with broad-spectrum activity against chikungunya virus varies between host cell lines
EJ Franco, JL Rodriquez, JJ Pomeroy, KC Hanrahan, AN Brown
Antiviral Chemistry and Chemotherapy 2018
Silvestrol Inhibits Chikungunya Virus Replication
L Henss, T Scholz, A Grünweller, B Schnierle
Viruses 2018
Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate
E Abeyratne, J Freitas, A Zaid, S Mahalingam, A Taylor
Human vaccines 2018
Adult immunization – Need of the hour
A Jairaj, P Shirisha, MS Abdul, U Fatima, RV Tiwari, M Moothedath
Journal of International Society of Preventive and Community Dentistry 2018
Epidemiological Evidence for Lineage-Specific Differences in the Risk of Inapparent Chikungunya Virus Infection
FB Carrillo, D Collado, N Sanchez, S Ojeda, BL Mercado, R Burger-Calderon, L Gresh, A Gordon, A Balmaseda, G Kuan, E Harris, TS Dermody
Journal of virology 2018
A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control
JV Silva, LF Ludwig-Begall, EF de Oliveira-Filho, RA Oliveira, R Durães-Carvalho, TR Lopes, DE Silva, LH Gil
Acta Tropica 2018
The Alphavirus Exit Pathway: What We Know and What We Wish We Knew.
Brown RS, Wan JJ, Kielian M
Viruses 2018
Chikungunya Virus-Associated Disease
C Hua, B Combe
Current Rheumatology Reports 2017
Recent progress on chikungunya virus research
W An, N Ge, Y Cao, J Sun, X Jin
Virologica Sinica 2017
Lower temperatures reduce type I interferon activity and promote alphaviral arthritis
NA Prow, B Tang, J Gardner, TT Le, A Taylor, YS Poo, E Nakayama, TD Hirata, HI Nakaya, A Slonchak, P Mukhopadhyay, S Mahalingam, WA Schroder, W Klimstra, A Suhrbier, RJ Kuhn
PLoS pathogens 2017
18F-FDG PET/CT Findings in a Patient with Chikungunya Virus Infection
M Rose, A Kjaer, E Markova, J Graff
Diagnostics 2017

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