Review 10.1172/JCI84417

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

Laurie A. Silva and Terence S. Dermody

Department of Pediatrics, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Address correspondence to: Terence S. Dermody, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of UPMC, Administrative Office Building, Suite 5300, CHP, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA. Phone: 412.692.8071; E-mail: terence.dermody@chp.edu.

Find articles by Silva, L. in: JCI | PubMed | Google Scholar

Department of Pediatrics, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Address correspondence to: Terence S. Dermody, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of UPMC, Administrative Office Building, Suite 5300, CHP, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA. Phone: 412.692.8071; E-mail: terence.dermody@chp.edu.

Find articles by Dermody, T. in: JCI | PubMed | Google Scholar

First published March 1, 2017 - More info

Published in Volume 127, Issue 3 (March 1, 2017)
J Clin Invest. 2017;127(3):737–749. doi:10.1172/JCI84417.
Copyright © 2017, American Society for Clinical Investigation

Published March 1, 2017

Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and headache. CHIKV is transmitted by Aedes species of mosquitoes and is capable of an epidemic, urban transmission cycle with high rates of infection. Since 2004, CHIKV has spread to new areas, causing disease on a global scale, and the potential for CHIKV epidemics remains high. Although CHIKV has caused millions of cases of disease and significant economic burden in affected areas, no licensed vaccines or antiviral therapies are available. In this Review, we describe CHIKV epidemiology, replication cycle, pathogenesis and host immune responses, and prospects for effective vaccines and highlight important questions for future research.

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