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Abstract
Immune-suppressive cell populations, including Tregs and suppressor monocytes, have been implicated in long-term survival of allografts in both human transplant recipients and animal models. The factors that drive differentiation and function of these cell populations are not completely understood. In this issue, Bézie and colleagues identify IL-34 as an important mediator of allograft tolerance in a rat model of heart transplantation. Their data support a model in which IL-34 production by Tregs promotes a population of suppressive macrophages that in turn promote Treg differentiation. The results of this study support further exploration of the immunosuppressive properties of IL-34.
Authors
James I. Kim, Laurence A. Turka
Citation information
Citations to this article (5)
| Title and authors | Publication | Year |
|---|---|---|
|
Role of IL-34 in Tumors and Its Application to Regulate Inflammation.
Igarashi Y, Seino KI |
Cancer science | 2025 |
|
Targeted Therapy of Interleukin-34 as a Promising Approach to Overcome Cancer Therapy Resistance
Monteleone G, Franzè E, Maresca C, Colella M, Pacifico T, Stolfi C |
Cancers | 2023 |
|
Mudskipper interleukin-34 modulates the functions of monocytes/macrophages via the colony-stimulating factor-1 receptor 1
S Hai-Yu, Z Yan, Z Qian-Jin, L Ming-Yun, C Jiong |
Zoological Research | 2020 |
|
Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/− Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice
S Bézie, D Meistermann, L Boucault, S Kilens, J Zoppi, E Autrusseau, A Donnart, V Nerrière-Daguin, F Bellier-Waast, E Charpentier, F Duteille, L David, I Anegon, C Guillonneau |
Frontiers in immunology | 2018 |
|
Immunoregulatory properties of the cytokine IL-34
C Guillonneau, S Bézie, I Anegon |
Cellular and Molecular Life Sciences | 2017 |
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ISSN: 0021-9738 (print), 1558-8238 (online)