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Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

Rohit N. Kulkarni, … , Douglas Hanahan, C. Ronald Kahn

Rohit N. Kulkarni, … , Douglas Hanahan, C. Ronald Kahn

Published December 15, 1999
Citation Information: J Clin Invest. 1999;104(12):R69-R75. https://doi.org/10.1172/JCI8339.

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Title and authors	Publication	Year
Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats Toyoshima Y, Nakamura K, Taguchi Y, Tokita R, Takeuchi S, Osawa H, Teramoto N, Sugihara H, Yoshizawa F, Yamanouchi K, Minami S	Scientific Reports	2025
Rethinking Diabetes from the Perspective of Diverse Insulin Actions in Various Organs Ueki K	JMA Journal	2024
Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones K Girdhar, M Soto, Q Huang, L Orliaguet, C Cederquist, B Sundaresh, J Hu, M Figura, A Raisingani, E Canfora, E Dirice, S Fujisaka, G Goossens, E Blaak, R Kulkarni, C Kahn, E Altindis	Diabetes	2022
Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets G Pradhan, J Lee, C Wu, H Wang, L Lin, T Donti, B Graham, A Rajan, A Balasubramanyam, S Samson, S Guo, Y Sun	Biomolecules	2022
Insulin Regulates Arginine-Stimulated Insulin Secretion in Humans Halperin F, Mezza T, Li P, Shirakawa J, Kulkarni RN, Goldfine AB	Metabolism: clinical and experimental	2022
Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice T Takatani, J Shirakawa, K Shibue, MK Gupta, H Kim, S Lu, J Hu, MF White, RT Kennedy, RN Kulkarni	The Journal of biological chemistry	2021
Relationship Between Insulin-Receptor Substrate 1 and Langerhans’ Islet in a Rat Model of Type 2 Diabetes Mellitus WL Atmodjo, YO Larasati, J Jo, R Nufika, S Naomi, I Winoto	In vivo (Athens, Greece)	2021
Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus N Rachdaoui	International journal of molecular sciences	2020
Pyrosequencing analysis of IRS1 methylation levels in schizophrenia with tardive dyskinesia Y Li, K Wang, P Zhang, J Huang, Y Liu, Z Wang, Y Lu, S Tan, F Yang, Y Tan	Molecular medicine reports	2020
Targeted pharmacological therapy restores β-cell function for diabetes remission S Sachs, A Bastidas-Ponce, S Tritschler, M Bakhti, A Böttcher, MA Sánchez-Garrido, M Tarquis-Medina, M Kleinert, K Fischer, S Jall, A Harger, E Bader, S Roscioni, S Ussar, A Feuchtinger, B Yesildag, A Neelakandhan, CB Jensen, M Cornu, B Yang, B Finan, RD DiMarchi, MH Tschöp, FJ Theis, SM Hofmann, TD Müller, H Lickert	Nature metabolism	2020
Targeted pharmacological therapy restores β-cell function for diabetes remission S Sachs, A Bastidas-Ponce, S Tritschler, M Bakhti, A Böttcher, MA Sánchez-Garrido, M Tarquis-Medina, M Kleinert, K Fischer, S Jall, A Harger, E Bader, S Roscioni, S Ussar, A Feuchtinger, B Yesildag, A Neelakandhan, CB Jensen, M Cornu, B Yang, B Finan, RD DiMarchi, MH Tschöp, FJ Theis, SM Hofmann, TD Müller, H Lickert		2020
Human duct cells contribute to β-cell compensation in insulin resistance Ercument Dirice, Dario F. De Jesus, Sevim Kahraman, Giorgio Basile, Raymond W.S. Ng, Abdelfattah El Ouaamari, Adrian Teo, Shweta Bhatt, Jiang Hu, Rohit Kulkarni	JCI Insight	2019
Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes R Ye, T Onodera, PE Scherer	Journal of the Endocrine Society	2019
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes E Dirice, S Kahraman, DF Jesus, AE Ouaamari, G Basile, RL Baker, B Yigit, PD Piehowski, MJ Kim, AJ Dwyer, RW Ng, C Schuster, H Vethe, T Martinov, Y Ishikawa, AK Teo, RD Smith, J Hu, K Haskins, T Serwold, WJ Qian, BT Fife, S Kissler, RN Kulkarni		2019
Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β -Cell Apoptosis N Rachdaoui, L Polo-Parada, F Ismail-Beigi	Journal of the Endocrine Society	2018
Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27 Kip1 levels and poor prognosis: HuD suppresses pancreatic NETs through enhancing p27 Kip1 translation C Kim, DE Jeong, S Heo, E Ji, JG Rho, M Jung, S Ahn, YJ Kim, YS Kim, SW Nam, RN Kulkarni, KB Lee, EK Lee, W Kim	The Journal of Pathology	2018
Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats AO Morakinyo, TA Samuel, DA Adekunbi	Endocrine Regulations	2018
Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation J Shirakawa, M Fernandez, T Takatani, AE Ouaamari, P Jungtrakoon, ER Okawa, W Zhang, P Yi, A Doria, RN Kulkarni	Cell Metabolism	2017
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells N Caporarello, C Parrino, V Trischitta, L Frittitta, C Miele	PloS one	2017
Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth J Rodríguez-Comas, A Moreno-Asso, J Moreno-Vedia, M Martín, C Castaño, A Marzà-Florensa, XB Ros, J Mir-Coll, J Montané, C Fillat, R Gasa, A Novials, JM Servitja	Diabetes	2017
Involvement of exogenous 3-deoxyglucosone in β-cell dysfunction induces impaired glucose regulation L Zhang, L Zhou, X Song, G Liang, Z Xu, F Wang, F Huang, G Jiang	Molecular medicine reports	2017
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation T Takatani, J Shirakawa, MW Roe, CA Leech, BF Maier, RG Mirmira, RN Kulkarni	Scientific Reports	2016
PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets J Kolic, JE Fox, OG Chepurny, AF Spigelman, M Ferdaoussi, F Schwede, GG Holz, PE MacDonald	Molecular Metabolism	2016
Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors T Mezza, J Shirakawa, R Martinez, J Hu, A Giaccari, RN Kulkarni	The Journal of biological chemistry	2016
DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid J Shirakawa, T Okuyama, M Kyohara, E Yoshida, Y Togashi, K Tajima, S Yamazaki, M Kaji, M Koganei, H Sasaki, Y Terauchi	Diabetology & metabolic syndrome	2016
Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas G Singhal, M Fisher, MJ Chee, TG Tan, AE Ouaamari, AC Adams, R Najarian, RN Kulkarni, C Benoist, JS Flier, E Maratos-Flier, J Sastre	PloS one	2016
Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival P Malakar, L Chartarifsky, A Hija, G Leibowitz, B Glaser, Y Dor, R Karni	Scientific Reports	2016
Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β -Cells Treated with Palmitate and Oleate LR Cataldo, ML Mizgier, D Busso, P Olmos, JE Galgani, R Valenzuela, D Mezzano, E Aranda, VA Cortés, JL Santos	Journal of Diabetes Research	2016
Ryanodine receptor/calcium release channel regulates insulin release and glucose homeostasis Gaetano santulli, Gennaro Pagano, Celestino Sardu, Wenjun xie, Steve Reiken, Salvatore D'Ascia, Michele Cannone, Nicola Marziliano, Bruno Trimarco, Theresa Guise, Alain Lacampagne, Andrew R. Marks	Journal of Clinical Investigation	2015
Insulin receptor isoform a confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-i signalling O Escribano, A Gómez-Hernández, S Díaz-Castroverde, C Nevado, G García, YF Otero, L Perdomo, N Beneit, M Benito	Molecular and Cellular Endocrinology	2015
Deficiency of FcϵR1 increases body weight gain but improves glucose tolerance in diet-induced obese mice YJ Lee, C Liu, M Liao, GK Sukhova, J Shirakawa, M Abdennour, K Iamarene, S Andre, K Inouye, K Clement, RN Kulkarni, AS Banks, P Libby, GP Shi	Endocrinology	2015
The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins F Hakuno, T Fukushima, Y Yoneyama, H Kamei, A Ozoe, H Yoshihara, D Yamanaka, T Shibano, M Sone-Yonezawa, BC Yu, K Chida, SI Takahashi	Frontiers in Endocrinology	2015
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics AE Ouaamari, JY Zhou, CW Liew, J Shirakawa, E Dirice, N Gedeon, S Kahraman, DF de Jesus, S Bhatt, JS Kim, TR Clauss, DG Camp, RD Smith, WJ Qian, RN Kulkarni	Journal of Proteome Research	2015
Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats CS Salvatierra, SR Reis, AF Pessoa, LM de Souza, LF Stoppiglia, RV Veloso, MA Reis, EM Carneiro, AC Boschero, EM Colodel, VC Arantes, MQ Latorraca	Anais da Academia Brasileira de Ciências	2015
Disruption of Protein-Tyrosine Phosphatase 1B Expression in the Pancreas Affects β-Cell Function S Liu, Y Xi, A Bettaieb, K Matsuo, I Matsuo, RN Kulkarni, FG Haj	Endocrinology	2014
Tissue-specific insulin signaling in the regulation of metabolism and aging: Insulin Signaling in Metabolism and Aging J Zhang, F Liu	IUBMB Life	2014
Hepatocyte Growth Factor Ameliorates Hyperglycemia and Corrects β-Cell Mass in IRS2-Deficient Mice JC Alvarez-Perez, TC Rosa, GP Casinelli, SR Valle, J Lakshmipathi, C Rosselot, F Rausell-Palamos, RC Vasavada, A García-Ocaña	Molecular Endocrinology	2014
Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals Y Wei, CR Yang, YP Wei, ZA Zhao, Y Hou, H Schatten, QY Sun	Proceedings of the National Academy of Sciences	2014
Islets of Langerhans, 2. ed MS Islam	Islets of Langerhans, 2. ed.	2014
Islets of Langerhans S Islam		2014
Soluble Factors Secreted by T Cells Promote β-Cell Proliferation E Dirice, S Kahraman, W Jiang, AE Ouaamari, DF de Jesus, AK Teo, J Hu, D Kawamori, JL Gaglia, D Mathis, RN Kulkarni	Diabetes	2013
PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16(ink4a.) N Zeng, KT Yang, JA Bayan, L He, R Aggarwal, JW Stiles, X Hou, V Medina, D Abad, BM Palian, I Al-Abdullah, F Kandeel, DL Johnson, BL Stiles	Aging Cell	2013
Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells J Kolic, AF Spigelman, G Plummer, E Leung, C Hajmrle, T Kin, AM Shapiro, JE Fox, PE MacDonald	Diabetologia	2013
The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes S Ezzat, L Zheng, JC Florez, N Stefan, T Mayr, MM Hliang, K Jablonski, M Harden, A Stančáková, M Laakso, HU Haring, A Ullrich, SL Asa	Cell Metabolism	2013
Joint Effect of Insulin Signaling Genes on Insulin Secretion and Glucose Homeostasis S Prudente, E Morini, L Marselli, R Baratta, M Copetti, C Mendonca, F Andreozzi, M Chandalia, F Pellegrini, D Bailetti, F Alberico, H Shah, N Abate, G Sesti, L Frittitta, P Marchetti, A Doria, V Trischitta	The Journal of clinical endocrinology and metabolism	2013
Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States A El Ouaamari, D Kawamori, E Dirice, CW Liew, JL Shadrach, J Hu, H Katsuta, J Hollister-Lock, WJ Qian, AJ Wagers, RN Kulkarni	Cell Reports	2013
Functional differences between aggregated and dispersed insulin-producing cells A Chowdhury, O Dyachok, A Tengholm, S Sandler, P Bergsten	Diabetologia	2013
Timing of maternal exposure to a high fat diet and development of obesity and hyperinsulinemia in male rat offspring: same metabolic phenotype, different developmental pathways? GJ Howie, DM Sloboda, CM Reynolds, MH Vickers	Journal of nutrition and metabolism	2013
Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study Xiang Feng, Katherine L Tucker, Laurence D Parnell, Jian Shen, Yu-Chi Lee, José M Ordovás, Wen-Hua Ling, Chao-Qiang Lai	Asia Pacific Journal of Clinical Nutrition	2013
Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance HJ Kim, M Kobayashi, T Sasaki, O Kikuchi, K Amano, T Kitazumi, YS Lee, H Yokota-Hashimoto, VY Susanti, YI Kitamura, J Nakae, T Kitamura	Endocrinology	2012
Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line JY Cheng, J Whitelock, L Poole-Warren	Histochemistry and Cell Biology	2012
Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans F Halperin, X Lopez, R Manning, CR Kahn, RN Kulkarni, AB Goldfine	Diabetes	2012
Post-transcriptional regulation in metabolic diseases W Kim, EK Lee	RNA biology	2012
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation W Kim, Q Lao, YK Shin, OD Carlson, EK Lee, M Gorospe, RN Kulkarni, JM Egan	Science signaling	2012
PI3K p110α/Akt Signaling Negatively Regulates Secretion of the Intestinal Peptide Neurotensin Through Interference of Granule Transport J Li, J Song, MG Cassidy, P Rychahou, ME Starr, J Liu, X Li, G Epperly, HL Weiss, CM Townsend, T Gao, BM Evers	Molecular Endocrinology	2012
The Zinc Finger Protein ZBTB20 Regulates Transcription of Fructose-1,6-Bisphosphatase 1 and ? Cell Function in Mice Y Zhang, Z Xie, L Zhou, L Li, H Zhang, G Zhou, X Ma, PL Herrera, Z Liu, MJ Grusby, WJ Zhang	Gastroenterology	2012
Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets V Bravo-Egana, S Rosero, D Klein, Z Jiang, N Vargas, N Tsinoremas, M Doni, M Podetta, C Ricordi, RD Molano, A Pileggi, RL Pastori	Journal of Transplantation	2012
Analysis of Codon 972 (Gly → Arg) Polymorphism in IRS-1 Gene in Type 2 Diabetic Population R Kumar, N Sharan	Journal of Medical Biochemistry	2012
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Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue LM Berends, DS Fernandez-Twinn, MS Martin-Gronert, RL Cripps, SE Ozanne	International Journal of Obesity	2012
Rosuvastatin may Modulate Insulin Signaling and Inhibit Atherogenesis Beyond its Plasma Cholesterol-Lowering Effect in Insulin-Resistant Mice H Guo, H Lv, W Tang, J Chi, L Liu, F Xu, Z Ji, X Zhai, F Peng	Cardiovascular Drugs and Therapy	2012
Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets AC Marçal, JP Camporez, TM Lima-Salgado, DE Cintra, EH Akamine, LM Ribeiro, FN Almeida, RP Zanuto, R Curi, SC Boldrini, EA Liberti, J Fiamoncini, SM Hirabara, FC Deschamps, AR Carpinelli, CR Carvalho	British Journal of Nutrition	2012
The linkage between inflammation and Type 2 diabetes mellitus NG Cruz, LP Sousa, MO Sousa, NT Pietrani, AP Fernandes, KB Gomes	Diabetes Research and Clinical Practice	2012
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells F Zhao, F Huang, M Tang, X Li, N Zhang, A Amfilochiadis, Y Li, R Hu, T Jin, C Peng, Q Wang	American journal of physiology. Endocrinology and metabolism	2012
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells F Zhao, F Huang, M Tang, X Li, N Zhang, A Amfilochiadis, Y Li, R Hu, T Jin, C Peng, Q Wang	American journal of physiology. Endocrinology and metabolism	2012
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus F Folli, T Okada, C Perego, J Gunton, CW Liew, M Akiyama, A D'Amico, SL Rosa, C Placidi, R Lupi, P Marchetti, G Sesti, M Hellerstein, L Perego, RN Kulkarni	PloS one	2011
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic -Cells W Kim, ME Doyle, Z Liu, Q Lao, YK Shin, OD Carlson, HS Kim, S Thomas, JK Napora, EK Lee, R Moaddel, Y Wang, S Maudsley, B Martin, RN Kulkarni, JM Egan	Diabetes	2011
Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E F Fiory, A Lombardi, C Miele, J Giudicelli, F Beguinot, EV Obberghen	Diabetologia	2011
Exploring the evolutionary relationship of insulin receptor substrate family using computational biology C Chakraborty, G Agoramoorthy, MJ Hsu	PloS one	2011
Efficacy of chitooligosaccharides for the management of diabetes in alloxan induced mice: A correlative study with antihyperlipidemic and antioxidative activity D Katiyar, B Singh, AM Lall, C Haldar	European Journal of Pharmaceutical Sciences	2011
Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids X Lopez, A Cypess, R Manning, S O'Shea, RN Kulkarni, AB Goldfine	The Journal of clinical endocrinology and metabolism	2011
Insulin Infusion During Normoglycemia Modulates Insulin Secretion According to Whole-Body Insulin Sensitivity C Anderwald, A Tura, A Grassi, M Krebs, J Szendroedi, M Roden, MG Bischof, A Luger, G Pacini	Diabetes care	2011
Exploring the Evolutionary Relationship of Insulin Receptor Substrate Family Using Computational Biology C Chakraborty, G Agoramoorthy, MJ Hsu, V Uversky	PloS one	2011
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus F Folli, T Okada, C Perego, J Gunton, CW Liew, M Akiyama, A D'Amico, SL Rosa, C Placidi, R Lupi, P Marchetti, G Sesti, M Hellerstein, L Perego, RN Kulkarni, A Vella	PloS one	2011
Insulin enhances glucose-stimulated insulin secretion in healthy humans C Bouche, X Lopez, A Fleischman, AM Cypess, S O'Shea, D Stefanovski, RN Bergman, E Rogatsky, DT Stein, CR Kahn, RN Kulkarni, AB Goldfine	Proceedings of the National Academy of Sciences	2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
The Islets of Langerhans S Islam		2010
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents S Georgia, C Hinault, D Kawamori, J Hu, J Meyer, M Kanji, A Bhushan, RN Kulkarni	Diabetes	2010
Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic β Cells* S Xuan, M Szabolcs, F Cinti, S Perincheri, D Accili, A Efstratiadis	The Journal of biological chemistry	2010
Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic β Cells S Xuan, M Szabolcs, F Cinti, S Perincheri, D Accili, A Efstratiadis	The Journal of biological chemistry	2010
Apoptotic, regenerative, and immune-related signaling in human islets from type 2 diabetes individuals HK Nyblom, M Bugliani, E Fung, U Boggi, R Zubarev, P Marchetti, P Bergsten	Journal of Proteome Research	2009
Slow and steady is the key to β-cell replication K Brennand, D Melton	Journal of Cellular and Molecular Medicine	2009
Growth factor control of pancreatic islet regeneration and function A Assmann, C Hinault, RN Kulkarni	Pediatric Diabetes	2009
Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2 A Assmann, K Ueki, JN Winnay, T Kadowaki, RN Kulkarni	Molecular and cellular biology	2009
Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach R Li, A Pourpak, SW Morris	Journal of Medicinal Chemistry	2009
Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo D Kawamori, AJ Kurpad, J Hu, CW Liew, JL Shih, EL Ford, PL Herrera, KS Polonsky, OP McGuinness, RN Kulkarni	Cell Metabolism	2009
Insulin signaling regulates mitochondrial function in pancreatic beta-cells S Liu, T Okada, A Assmann, J Soto, CW Liew, H Bugger, OS Shirihai, ED Abel, RN Kulkarni	PloS one	2009
Regulation of glucose-dependent insulin secretion by insulin: Possible role of AMP-activated protein kinase SH Park, SY Kim, WK Baek, B Lim, JH Park, HY Sung, YK Kim, KC Bae, JH Bae, DK Song	Life Sciences	2009
Insulin Granule Recruitment and Exocytosis Is Dependent on p110 in Insulinoma and Human -Cells GM Pigeau, J Kolic, BJ Ball, MB Hoppa, YW Wang, T Ruckle, M Woo, JE Fox, PE MacDonald	Diabetes	2009
Reduced pancreatic β-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats A Rafacho, VA Giozzet, AC Boschero, JL Abrantes, TM Cestari, EM Carneiro, JR Bosqueiro	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.]	2009
Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance I Takamoto, Y Terauchi, N Kubota, M Ohsugi, K Ueki, T Kadowaki	Diabetes, Obesity and Metabolism	2008
Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic -Cell Growth S Torii, N Saito, A Kawano, N Hou, K Ueki, RN Kulkarni, T Takeuchi	Diabetes	2008
IGF-1 protects against dexamethasone-induced cell death in insulin secreting INS-1 cells independent of AKT/PKB phosphorylation D Avram, F Ranta, AM Hennige, S Berchtold, S Hopp, HU Häring, F Lang, S Ullrich	Cellular Physiology and Biochemistry	2008
Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion ML Hribal, F Tornei, A Pujol, R Menghini, D Barcaroli, D Lauro, R Amoruso, R Lauro, F Bosch, G Sesti, M Federici	Journal of Cellular and Molecular Medicine	2008
Insulin Signaling in the Pancreatic β-Cell IB Leibiger, B Leibiger, PO Berggren	Annual Review of Nutrition	2008
Mathematical models of energy homeostasis R Pattaranit, HA van Berg	Journal of the Royal Society, Interface / the Royal Society	2008
Are the available experimental models of type 2 diabetes appropriate for a gender perspective? F Franconi, G Seghieri, S Canu, E Straface, I Campesi, W Malorni	Pharmacological Research	2008
Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic -Cells E Hisanaga, M Nagasawa, K Ueki, RN Kulkarni, M Mori, I Kojima	Diabetes	2008
The Development of Insulin Resistance in Type 2 Diabetes: Insights from Knockout Studies R Pattaranit, HA Berg, D Spanswick	Science Progress	2008
The development of insulin resistance in Type 2 diabetes: insights from knockout studies. Pattaranit R, van den Berg HA, Spanswick D	Science Progress	2008
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice through skeletal muscle – pancreatic beta cell cross-talk Christoph Handschin, Cheol Soo Choi, Sherry Chin, Sheene Kim, Dan Kawamori, Amarnath J. Kurpad, Nicole Neubauer, Jiang Hu, Fenfen Liu, Eleftheria Maratos-Flier, Vamsi K. Mootha, Young-Bum Kim, Rohit N. Kulkarni, Gerald I. Shulman, and Bruce M. Spiegelman	Journal of Clinical Investigation	2007
From the Cover: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance T Okada, CW Liew, J Hu, C Hinault, MD Michael, J Krtzfeldt, C Yin, M Holzenberger, M Stoffel, RN Kulkarni	Proceedings of the National Academy of Sciences	2007
Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth P Pissios, U Ozcan, E Kokkotou, T Okada, CW Liew, S Liu, JN Peters, G Dahlgren, J Karamchandani, YC Kudva, AJ Kurpad, RT Kennedy, E Maratos-Flier, RN Kulkarni	Diabetes	2007
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice J Cantley, AI Choudhury, H Asare-Anane, C Selman, S Lingard, H Heffron, P Herrera, SJ Persaud, DJ Withers	Diabetologia	2007
Aquaporin 7 Is a β-Cell Protein and Regulator of Intraislet Glycerol Content and Glycerol Kinase Activity, β-Cell Mass, and Insulin Production and Secretion K Matsumura, BH Chang, M Fujimiya, W Chen, RN Kulkarni, Y Eguchi, H Kimura, H Kojima, L Chan	Molecular and cellular biology	2007
Does IGF-I stimulate pancreatic islet cell growth? JL Liu	Cell Biochemistry and Biophysics	2007
Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats B Liu, WS Liu, BQ Han, YY Sun	World journal of gastroenterology : WJG	2007
Mechanisms of Insulin Action AR Saltiel, JE Pessin		2007
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance Haruka Okamoto, Marta Letizia Hribal, Hua V. Lin, William R. Bennett, Andrew Ward and Domenico Accili	Journal of Clinical Investigation	2006
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes K Ueki, T Okada, J Hu, CW Liew, A Assmann, GM Dahlgren, JL Peters, JG Shackman, M Zhang, I Artner, LS Satin, R Stein, M Holzenberger, RT Kennedy, CR Kahn, RN Kulkarni	Nature Genetics	2006
Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus NG Smart, AA Apelqvist, X Gu, EB Harmon, JN Topper, RJ MacDonald, SK Kim	PLoS Biology	2006
The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 β-cells KD Hettiarachchi, PZ Zimmet, MA Myers	Cell Biology and Toxicology	2006
Molecular Approaches to Study Control of Glucose Homeostasis N Neubauer, RN Kulkarni	ILAR journal / National Research Council, Institute of Laboratory Animal Resources	2006
Identification of Insulin Signaling Elements in Human -Cells: Autocrine Regulation of Insulin Gene Expression D Muller, GC Huang, S Amiel, PM Jones, SJ Persaud	Diabetes	2006
On the role of IRS2 in the regulation of functional β-cell mass M Niessen	Archives Of Physiology And Biochemistry	2006
The role of insulin receptor substrate (Irs) 2 in hypothalamic and beta cell function Agharul I. Choudhury, Helen Heffron, Mark A. Smith, Hind Al-Qassab, Allison W. Xu, Colin Selman, Marcus Simmgen, Melanie Clements, Marc Claret, Gavin MacColl, , Kazunari Hisadome, Ivan Diakonov, Vazira Moosajee, Jimmy D Bell, John R. Speakman, Rachel L. Batterham, Gregory S. Barsh, Michael L. J. Ashford, Dominic J. Withers	Journal of Clinical Investigation	2005
Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance C Dai, CG Huh, SS Thorgeirsson, Y Liu	The American Journal of Pathology	2005
Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes Z Asghar, D Yau, F Chan, D LeRoith, CB Chan, MB Wheeler	Diabetologia	2005
New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass RN Kulkarni	Reviews in Endocrine and Metabolic Disorders	2005
Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ Hawthorne, YH Tseng, RS Roberson, C Ricordi, PJ O’Connell, FJ Gonzalez, CR Kahn	Cell	2005
Genes and Type 2 Diabetes Mellitus MT Luna	Archives of Medical Research	2005
The Forkhead Transcription Factor Foxo1 Bridges the JNK Pathway and the Transcription Factor PDX-1 through Its Intracellular Translocation D Kawamori, H Kaneto, Y Nakatani, T Matsuoka, M Matsuhisa, M Hori, Y Yamasaki	The Journal of biological chemistry	2005
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient β-cells AM Hennige, U Ozcan, T Okada, US Jhala, M Schubert, MF White, RN Kulkarni	American journal of physiology. Endocrinology and metabolism	2005
Atherosclerosis: Diet and Drugs A von Eckardstein		2005
Insulin receptor substrate-2 plays a crucial role in b cells and the hypothalamus Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, Wataru Yano, Ryo Suzuki, Kohjiro Ueki, Iseki Takamoto, Hidemi Satoh, Toshiyuki Maki, Tetsuya Kubota, Masao Moroi, Miki Okada-Iwabu, Osamu Ezaki, Ryozo Nagai, Yoichi Ueta, Takashi Kadowaki, and Tetsuo Noda	Journal of Clinical Investigation	2004
Transgenic rescue of insulin receptor-deficient mice Haruka Okamoto, Jun Nakae, Tadahiro Kitamura, Byung-Chul Park, Ioannis Dragatsis, Domenico Accili	Journal of Clinical Investigation	2004
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia in response to insulin resistance Rohit N. Kulkarni, Ulupi S. Jhala, Jonathon N. Winnay, Marc R. Montminy & C. Ronald Kahn	Journal of Clinical Investigation	2004
Mouse Models of Insulin Resistance A NANDI	Physiological reviews	2004
New Insights into the Integrated Physiology of Insulin Action Y Kitamura, D Accili	Reviews in Endocrine and Metabolic Disorders	2004
Glucose Homeostasis and Tissue Transcript Content of Insulin Signaling Intermediates in Four Inbred Strains of Mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1 HJ Goren, RN Kulkarni, CR Kahn	Endocrinology	2004
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load T Sir-Petermann, B Angel, M Maliqueo, JL Santos, MV Riesco, H Toloza, F Pérez-Bravo	Nutrition	2004
Expression of glucose transporter 4 in the human pancreatic islet of Langerhans H Kobayashi, T Mitsui, S Nomura, Y Ohno, K Kadomatsu, T Muramatsu, T Nagasaka, S Mizutani	Biochemical and Biophysical Research Communications	2004
Unraveling Lipid Metabolism With Microarrays: The implication of palmitate in lipotoxicity J Xiao, A Reziwanggu, T òrntoft, K Hermansen, M Kruhffer, PB Jeppesen	Unraveling Lipid Metabolism With Microarrays: The implication of palmitate in lipotoxicity	2004
Autocrine regulation of glucose metabolism in pancreatic islets MI Borelli, F Francini, JJ Gagliardino	American journal of physiology. Endocrinology and metabolism	2004
Growth Factors and their Receptors in Cancer Metastasis CR Snyder, WG Jiang, K Matsumoto, T Nakamura		2004
Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans ML Hribal, L Perego, S Lovari, F Andreozzi, R Menghini, C Perego, G Finzi, L Usellini, C Placidi, C Capella, V Guzzi, D Lauro, F Bertuzzi, A Davalli, G Pozza, A Pontiroli, M Federici, R Lauro, A Brunetti, F Folli, G Sesti	The FASEB Journal	2003
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis ED Rosen, RN Kulkarni, P Sarraf, U Ozcan, T Okada, CH Hsu, D Eisenman, MA Magnuson, FJ Gonzalez, CR Kahn, BM Spiegelman	Molecular and cellular biology	2003
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice K Otani, RN Kulkarni, AC Baldwin, J Krutzfeldt, K Ueki, M Stoffel, CR Kahn, KS Polonsky	American journal of physiology. Endocrinology and metabolism	2003
Lessons for human diabetes from experimental mouse models RN Kulkarni, A Zisman	Current Diabetes Reports	2003
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice CR Kahn	Transactions of the American Clinical and Climatological Association	2003
I NSULIN R ECEPTOR K NOCKOUT M ICE T Kitamura, CR Kahn, D Accili	Annual Review of Physiology	2003
Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets EP Haber, SM Hirabara, AD Gomes, R Curi, AR Carpinelli, CR Carvalho	FEBS Letters	2003
Type 2 diabetes: simple, dual or multiple pathogenetic defects? SD Prato, A Coppelli, P Marchetti	International Congress Series	2003
The protein tyrosine phosphatase α modifies insulin secretion in INS-1E cells K Kapp, E Metzinger, M Kellerer, HU Häring, R Lammers	Biochemical and Biophysical Research Communications	2003
IRS-3 inhibits IRS-2-mediated signaling in pancreatic β-cells MK Lingohr, LM Dickson, CE Wrede, JF McCuaig, MG Myers, CJ Rhodes	Molecular and Cellular Endocrinology	2003
In Vivo Mutagenesis of the Insulin Receptor H Okamoto, D Accili	The Journal of biological chemistry	2003
Insulin Receptor Substrate 1 Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 3 in Insulin-secreting β-Cells PD Borge, BA Wolf	The Journal of biological chemistry	2003
Handbook of Proteomic Methods PM Conn		2003
cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2 US Jhala, G Canettieri, RA Screaton, RN Kulkarni, S Krajewski, J Reed, J Walker, X Lin, M White, M Montminy	Genes & development	2003
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor Shouhong Xuan, Tadahiro Kitamura, Jun Nakae, Katerina Politi, Yoshiaki Kido, Peter E. Fisher, Manrico Morroni, Saverio Cinti, Morris F. White, Pedro L. Herrera, Domenico Accili and Argiris Efstratiadis	Journal of Clinical Investigation	2002
Tissue-Specific Targeting of the Insulin Receptor Gene RN Kulkarni, T Okada	Endocrine	2002
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 J Nakae, WH Biggs, T Kitamura, WK Cavenee, CV Wright, KC Arden, D Accili	Nature Genetics	2002
Glucose promotes pancreatic islet β-cell survival through a PI 3-kinase/Akt-signaling pathway S Srinivasan, E Bernal-Mizrachi, M Ohsugi, MA Permutt	American journal of physiology. Endocrinology and metabolism	2002
Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes AS Greenberg, ML McDaniel	European Journal of Clinical Investigation	2002
Pleiotropic effects of fatty acids on pancreatic ?-cells EP Haber, HM Ximenes, J Proc�pio, CR Carvalho, R Curi, AR Carpinelli	Journal of Cellular Physiology	2002
Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche L Ibáñez, MV Marcos, N Potau, C White, CE Aston, SF Witchel	Fertility and Sterility	2002
Molecular insights into insulin action and secretion CJ Rhodes, MF White	European Journal of Clinical Investigation	2002
Insights into Molecular Pathogenesis of Type 2 Diabetes from Knockout Mouse Models Y Terauchi, T Kadowaki	Endocrine Journal	2002
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance F Mauvais-Jarvis, RN Kulkarni, CR Kahn	Clinical Endocrinology	2002
Genetically defined pancreatic beta cell failure JW Smit, M Diamant	Pharmacogenomics	2002
Hexosamines as mediators of nutrient sensing and regulation in diabetes DA McClain	Journal of Diabetes and its Complications	2002
Insulin feedback action on pancreatic β-cell function IB Leibiger, B Leibiger, PO Berggren	FEBS Letters	2002
Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion EP Araujo, ME Amaral, CT Souza, S Bordin, F Ferreira, MJ Saad, AC Boschero, EC Magalhães, LA Velloso	FEBS Letters	2002
Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice T Nakagawa, M Ono-Kishino, E Sugaru, M Yamanaka, M Taiji, H Noguchi	Diabetes/Metabolism Research and Reviews	2002
Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly972->Arg IRS-1 Polymorphism P Marchetti, R Lupi, M Federici, L Marselli, M Masini, U Boggi, SD Guerra, G Patane, S Piro, M Anello, E Bergamini, F Purrello, R Lauro, F Mosca, G Sesti, SD Prato	Diabetes	2002
Effect of the Insulin Mimetic L-783,281 on Intracellular [Ca2+] and Insulin Secretion From Pancreatic -Cells MG Roper, W Qian, BB Zhang, RN Kulkarni, CR Kahn, RT Kennedy	Diabetes	2002
Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? G Sesti	Annals of Medicine	2002
β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass RN Kulkarni, M Holzenberger, DQ Shih, U Ozcan, M Stoffel, MA Magnuson, CR Kahn	Nature Genetics	2002
β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass RN Kulkarni, M Holzenberger, DQ Shih, U Ozcan, M Stoffel, MA Magnuson, CR Kahn	Nature Genetics	2002
Mouse models of insulin resistance ML Hribal, F Oriente, D Accili	American journal of physiology. Endocrinology and metabolism	2002
Phosphorylated inositol compounds in β-cell stimulus-response coupling CJ Barker, IB Leibiger, B Leibiger, PO Berggren	American journal of physiology. Endocrinology and metabolism	2002
Lipoatrophic diabetes in Irs1 −/− /Irs3 −/− double knockout mice PG Laustsen, MD Michael, BE Crute, SE Cohen, K Ueki, RN Kulkarni, SR Keller, GE Lienhard, CR Kahn	Genes & development	2002
Obesity and insulin resistance in a transgenic model of melanin concentrating hormone overexpression David S. Ludwig, Nicholas A. Tritos, Jason W. Mastaitis, Rohit Kulkarni, Efi Kokkotou, Joel Elmquist, Bradford Lowell, Jeffrey S. Flier, Eleftheria Maratos-Flier	Journal of Clinical Investigation	2001
A kinase in the life of the B-cell Domenico Accili	Journal of Clinical Investigation	2001
Evidence for a circulating islet cell growth factor in insulin-resistant states SN Flier, RN Kulkarni, CR Kahn	Proceedings of the National Academy of Sciences	2001
Insulin signalling and the regulation of glucose and lipid metabolism AR Saltiel, CR Kahn	Nature	2001
The pathophysiology of type 2 diabetes mellitus: an overview CG Ostenson	Acta Physiologica Scandinavica	2001
Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells B Leibiger, IB Leibiger, T Moede, S Kemper, RN Kulkarni, CR Kahn, LM de Vargas, PO Berggren	Molecular Cell	2001
Glucose homeostasis: lessons from knockout mice J Nakae, Y Kido, T Kitamura, D Accili	Current Opinion in Endocrinology & Diabetes	2001
Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice J Nakae, Y Kido, D Accili	Annals of Medicine	2001
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice M Pende, SC Kozma, M Jaquet, V Oorschot, R Burcelin, YL Marchand-Brustel, J Klumperman, B Thorens, G Thomas	Nature	2001
NEW INSIGHTS INTO INSULIN RESISTANCE PATHOPHYSIOLOGY: HOW IT AFFECTS GLUCOSE AND LIPID METABOLISM V Col	ACTA CLINICA BELGICA	2001
Secreção da insulina: efeito autócrino da insulina e modulação por ácidos graxos EP Haber, R Curi, CR Carvalho, AR Carpinelli	Arquivos brasileiros de endocrinologia e metabologia	2001
Defects of the insulin receptor substrate (IRS) system in human metabolic disorders G Sesti, M Federici, ML Hribal, DA Lauro, P Sbraccia, R Lauro	The FASEB Journal	2001
Genetics of Diabetes Mellitus WL Lowe		2001
Regulation of Insulin Gene Transcription by a Ca2+-Responsive Pathway Involving Calcineurin and Nuclear Factor of Activated T Cells MC Lawrence, HS Bhatt, JM Watterson, RA Easom	Molecular Endocrinology	2001
Molecular Basis of Pancreas Development and Function JF Habener, MA Hussain		2001
Preserved Pancreatic β-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor T Kitamura, Y Kido, S Nef, J Merenmies, LF Parada, D Accili	Molecular and cellular biology	2001
The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets M Federici, ML Hribal, M Ranalli, L Marselli, O Porzio, D Lauro, P Borboni, R Lauro, P Marchetti, G Melino, G Sesti	The FASEB Journal	2000
Interactions between insulin resistance and insulin secretion in the development of glucose intolerance Melissa K. Cavaghan, David A. Ehrmann, Kenneth S. Polonsky, Kenneth S. Polonsky	Journal of Clinical Investigation	2000
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, MA Magnuson, CR Kahn	Molecular Cell	2000
Insulin receptor variant forms and Type 2 diabetes mellitus G Sesti	Pharmacogenomics	2000
Insulin receptor substrate polymorphisms and Type 2 diabetes mellitus G Sesti	Pharmacogenomics	2000
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential B Giovannone, ML Scaldaferri, M Federici, O Porzio, D Lauro, A Fusco, P Sbraccia, P Borboni, R Lauro, G Sesti	Diabetes/Metabolism Research and Reviews	2000
Dysregulation of IRS-proteins causes insulin resistance and diabetes: V Aguirre, MF White	Current Opinion in Endocrinology & Diabetes	2000
Perspective: The Insulin Signaling System—A Common Link in the Pathogenesis of Type 2 Diabetes DJ Withers, M White	Endocrinology	2000
Insulin Regulation of β-Cell Function Involves a Feedback Loop on SERCA Gene Expression, Ca 2+ Homeostasis, and Insulin Expression and Secretion GG Xu, Z Gao, PD Borge, PA Jegier, RA Young, BA Wolf	Biochemistry	2000
Pharmacochemistry Library D Andisik, P Bernstein, F Brown, C Bryant, C Ceccarelli, J Damewood, P Edwards, S Feeney, B Gomes, R Green, B Kosmider, A Shaw, G Steelman, R Thomas, P Tuthill, E Vacek, C Veale, P Warner, J Williams, D Wolanin, S Woolson	Pharmacochemistry Library	1997

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