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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

Jan Wijnholds, … , Douwe D. Breimer, Piet Borst

Jan Wijnholds, … , Douwe D. Breimer, Piet Borst

Published February 1, 2000
Citation Information: J Clin Invest. 2000;105(3):279-285. https://doi.org/10.1172/JCI8267.

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Title and authors	Publication	Year
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The impact of ATP-binding cassette transporters in the diseased brain: Context matters Baltira C, Aronica E, Elmquist WF, Langer O, Löscher W, Sarkaria JN, Wesseling P, de Gooijer MC, van Tellingen O	Cell reports. Medicine	2024
Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat. Zhang W, Liu QY, Haqqani AS, Liu Z, Sodja C, Leclerc S, Baumann E, Delaney CE, Brunette E, Stanimirovic DB	Pharmaceutics	2023
Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs. Torres-Vergara P, Rivera R, Escudero C, Penny J	Advances in experimental medicine and biology	2023
Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. Sun A, Hagenbuch B, Kelly EJ, Wang J	Molecular pharmacology	2023
Progress in characterizing ABC multidrug transporters in zebrafish Thomas JR, Frye WJ, Robey RW, Gottesman MM	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2023
Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier Sun A, Wang J	Pharmaceutical research	2023
Evaluation of Blood-CSF Barrier Transport by Quantitative Real Time Fluorescence Microscopy. Sun A, Wang J	Pharmaceutical Research	2022
Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy. Jang A, Petrova B, Cheong TC, Zawadzki ME, Jones JK, Culhane AJ, Shipley FB, Chiarle R, Wong ET, Kanarek N, Lehtinen MK	Neuron	2022
Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier. Hu T, Zha W, Sun A, Wang J	Molecular pharmacology	2022
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway K Liu, J Song, Y Yan, K Zou, Y Che, B Wang, Z Li, W Yu, W Guo, L Zou, W Deng, X Sun	Translational oncology	2021
Choroid Plexus and Drug Removal Mechanisms A Sun, J Wang	The AAPS Journal	2021
The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer’s Disease T Behl, I Kaur, A Sehgal, A Kumar, S Uddin, S Bungau	Molecular Neurobiology	2020
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Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters M Grube, P Hagen, G Jedlitschky	Frontiers in pharmacology	2018
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SLC and ABC Transporters: Expression, Localization, and Species Differences at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers ME Morris, V Rodriguez-Cruz, MA Felmlee	The AAPS Journal	2017
Targeting Glioma Stem Cell-Derived Pericytes Disrupts the Blood-Tumor Barrier and Improves Chemotherapeutic Efficacy W Zhou, C Chen, Y Shi, Q Wu, RC Gimple, X Fang, Z Huang, K Zhai, SQ Ke, YF Ping, H Feng, JN Rich, JS Yu, S Bao, XW Bian	Cell Stem Cell	2017
Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations Y Yamamoto, M Danhof, EC de Lange	The AAPS Journal	2017
Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies RP Dash, RJ Babu, NR Srinivas	European Journal of Drug Metabolism and Pharmacokinetics	2017
The Impact of Melatonin on Colon Cancer Cells’ Resistance to Doxorubicin in an in Vitro Study M Fic, A Gomulkiewicz, J Grzegrzolka, M Podhorska-Okolow, M Zabel, P Dziegiel, K Jablonska	International journal of molecular sciences	2017
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Expression of tight junction proteins and transporters for xenobiotic metabolism at the blood–CSF barrier during development in the nonhuman primate (P. hamadryas) CJ Ek, B D’Angelo, C Lehner, P Nathanielsz, C Li, C Mallard	Reproductive Toxicology	2015
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Mass Spectrometry in Drug Metabolism and Disposition G Luo, C Lu, X Ding, D Zhang	Mass Spectrometry in Drug Metabolism and Disposition	2011
Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat S Gazzin, AL Berengeno, N Strazielle, F Fazzari, A Raseni, JD Ostrow, R Wennberg, JF Ghersi-Egea, C Tiribelli	PloS one	2011
The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy CP Wu, CH Hsieh, YS Wu	Molecular Pharmaceutics	2011
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Expression of multidrug resistance proteins is localized principally to the Malpighian tubules in larvae of the cabbage looper moth, Trichoplusia ni R Labbé, S Caveney, C Donly	The Journal of experimental biology	2011
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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo. Mairinger S, Erker T, Muller M, Langer O	Current drug metabolism	2011
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ABC Transporters and Drug Efflux at the Blood-Brain Barrier S Shen, W Zhang	Reviews in the Neurosciences	2010
Phenotype Prediction of Non-Synonymous Single-Nucleotide Polymorphisms in Human ATP-Binding Cassette Transporter Genes LL Wang, YH Liu, LL Meng, CG Li, SF Zhou	Basic & Clinical Pharmacology & Toxicology	2010
Multidrug resistance-associated proteins and implications in drug development YH Liu, YM Di, ZW Zhou, SL Mo, SF Zhou	Clinical and Experimental Pharmacology and Physiology	2010
Vitamins & Hormones KJ Hare, FK Knop	Vitamins & Hormones	2010
ABC Transporters: Unvalidated Therapeutic Targets in Cancer and the CNS RW Robey, PR Massey, L Amiri-Kordestani, SE Bates	Anti-cancer agents in medicinal chemistry	2010
MDR1 gene polymorphisms and response to acute risperidone treatment M Kastelic, J Koprivšek, BK Plesničar, A Serretti, L Mandelli, I Locatelli, I Grabnar, V Dolžan	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2010
Regulation of Multidrug Resistance Protein 1 by Tumor Necrosis Factor α in Cultured Glial Cells: Involvement of Nuclear Factor-κB and c-Jun N-Terminal Kinase Signaling Pathways PT Ronaldson, T Ashraf, R Bendayan	Molecular pharmacology	2010
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Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression? J Pahnke, LC Walker, K Scheffler, M Krohn	Neuroscience and biobehavioral reviews	2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Multi-Drug Resistance in Cancer J Zhou		2009
Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier M Niehof, J Borlak	BMC Molecular Biology	2009
Drug interactions at the blood-brain barrier: fact or fantasy? S Eyal, P Hsiao, JD Unadkat	Pharmacology & Therapeutics	2009
Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin R Beedholm-Ebsen, K de Wetering, T Hardlei, E Nexo, P Borst, SK Moestrup	Blood	2009
Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii I Bottova, AB Hehl, S Stefanić, G Fabriàs, J Casas, E Schraner, J Pieters, S Sonda	The Journal of biological chemistry	2009
Pharmacogenetics of Membrane Transporters: An Update on Current Approaches TM Sissung, CE Baum, CT Kirkland, R Gao, ER Gardner, WD Figg	Molecular Biotechnology	2009
Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2 J Cattelotte, N Tournier, N Rizzo-Padoin, AH Schinkel, JM Scherrmann, S Cisternino	Journal of Neurochemistry	2009
Pharmacology PJ McNamara, M Leggas	Pharmacology	2009
Blood–brain interfaces and cerebral drug bioavailability JF Ghersi-Egea, KS Mönkkönen, C Schmitt, J Honnorat, M Fèvre-Montange, N Strazielle	Revue Neurologique	2009
Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior LA Stanley, BC Horsburgh, J Ross, N Scheer, CR Wolf	Drug Metabolism Reviews	2009
Host Cell P-glycoprotein Is Essential for Cholesterol Uptake and Replication of Toxoplasma gondii I Bottova, AB Hehl, S Štefanić, G Fabriàs, J Casas, E Schraner, J Pieters, S Sonda	The Journal of biological chemistry	2009
Transporters as Drug Carriers: Structure, Function, Substrates G Ecker, P Chiba	Transporters as Drug Carriers: Structure, Function, Substrates	2009
Functions of sphingolipid metabolism in mammals — Lessons from genetic defects F Sabourdy, B Kedjouar, SC Sorli, S Colié, D Milhas, Y Salma, T Levade	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
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Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Pharmacogenomics in Drug Discovery and Development Q Yan		2008
Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges S Shukla, CP Wu, SV Ambudkar	Expert Opinion on Drug Metabolism & Toxicology	2008
Use of Z310 cells as an in vitro blood-cerebrospinal fluid barrier model: tight junction proteins and transport properties LZ Shi, GJ Li, S Wang, W Zheng	Toxicology in vitro : an international journal published in association with BIBRA	2008
Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease J Pahnke, O Wolkenhauer, M Krohn, LC Walker	Current Alzheimer research	2008
Xenobiotic Transporters: Ascribing Function from Gene Knockout and Mutation Studies CD Klaassen, H Lu	Toxicological Sciences	2008
ABC multidrug transporters: structure, function and role in chemoresistance FJ Sharom	Pharmacogenomics	2008
Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation LM Roberts, DS Black, C Raman, K Woodford, M Zhou, JE Haggerty, AT Yan, SE Cwirla, KK Grindstaff	Neuroscience	2008
Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces S Gazzin, N Strazielle, C Schmitt, M Fevre-Montange, JD Ostrow, C Tiribelli, JF Ghersi-Egea	The Journal of Comparative Neurology	2008
Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) ML Holland, JD Allen, JC Arnold	European Journal of Pharmacology	2008
Mutational analysis of ABC proteins TW Loo, DM Clarke	Archives of Biochemistry and Biophysics	2008
Neuroscience in Medicine PM Conn	Neuroscience in Medicine	2008
Progress in Brain Penetration Evaluation in Drug Discovery and Development X Liu, C Chen, BJ Smith	The Journal of pharmacology and experimental therapeutics	2008
Mechanistic Differences between GSH Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) and GSH Modulation of MRP1-Mediated Transport A Rothnie, G Conseil, AY Lau, RG Deeley, SP Cole	Molecular pharmacology	2008
Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice M der Deen, W Timens, H Timmer-Bosscha, BW van der Strate, RJ Scheper, DS Postma, EG de Vries, HA Kerstjens	Respiratory Research	2007
Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis D Halter, S Neumann, SM van Dijk, J Wolthoorn, AM de Mazière, OV Vieira, P Mattjus, J Klumperman, G Meer, H Sprong	The Journal of Cell Biology	2007
A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1 X Chang	Cancer and Metastasis Reviews	2007
Meeting Practical Challenges of a Trial Involving a Multitude of Treatment Regimens: An Example of a Multi-Center Randomized Controlled Clinical Trial in NeuroAIDS S May, S Letendre, R Haubrich, JA McCutchan, R Heaton, E Capparelli, R Ellis	Journal of Neuroimmune Pharmacology	2007
Central nervous system distribution kinetics of indinavir in rats M Hamidi	Journal of Pharmacy and Pharmacology	2007
Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice GD Kruh, MG Belinsky, JM Gallo, K Lee	Cancer and Metastasis Reviews	2007
The role of membrane transporters in drug delivery to brain tumors AT Nies	Cancer Letters	2007
Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin AS Falcão, C Bellarosa, A Fernandes, MA Brito, RF Silva, C Tiribelli, D Brites	Neuroscience	2007
Lopinavir with Ritonavir Reduces the HIV RNA Level in Cerebrospinal Fluid SL Letendre, GB van den, A Hermes, SW Paul, J Durelle, JM Beck, JA McCutchan, C Okamoto, RJ Ellis	Clinical Infectious Diseases	2007
Comprehensive Medicinal Chemistry II E Littler, XX Zhou	Comprehensive Medicinal Chemistry II	2007
Handbook of Neurochemistry and Molecular Neurobiology VH Routh, JJ McArdle, NM Sanders, Z Song, R Wang	Handbook of Neurochemistry and Molecular Neurobiology	2007
Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1) É Bakos, L Homolya	Pflügers Archiv - European Journal of Physiology	2006
Human pharmacogenomic variations and their implications for antifungal efficacy J Meletiadis, S Chanock, TJ Walsh	Clinical microbiology reviews	2006
Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents L Cerveny, P Pavek, J Malakova, F Staud, Z Fendrich	Epilepsia	2006
Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis N Melaine, AP Satie, J Lassurguere, S Desmots, B Jegou, M Samson	International Journal of Andrology	2006
The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes T Minich, J Riemer, JB Schulz, P Wielinga, J Wijnholds, R Dringen	Journal of Neurochemistry	2006
P-glycoprotein in the placenta: Expression, localization, regulation and function M Ceckova-Novotna, P Pavek, F Staud	Reproductive Toxicology	2006
Blood–brain barrier and chemotherapeutic treatment of brain tumors NA de Vries, JH Beijnen, W Boogerd, O Tellingen	Expert Review of Neurotherapeutics	2006
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs P Breedveld, JH Beijnen, JH Schellens	Trends in Pharmacological Sciences	2006
Transport of glutathione and glutathione conjugates by MRP1 SP Cole, RG Deeley	Trends in Pharmacological Sciences	2006
Role of SLC xenobiotic transporters and their regulatory mechanisms PDZ proteins in drug delivery and disposition T Sugiura, Y Kato, A Tsuji	Journal of Controlled Release	2006
Flavonoid–drug interactions: Effects of flavonoids on ABC transporters ME Morris, S Zhang	Life Sciences	2006
Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3) A Lespine, J Dupuy, S Orlowski, T Nagy, H Glavinas, P Krajcsi, M Alvinerie	Chemico-Biological Interactions	2006
Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood–brain barrier A Soontornmalai, ML Vlaming, JM Fritschy	Neuroscience	2006
Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity S Calligaris, D Cekic, L Roca-Burgos, F Gerin, G Mazzone, JD Ostrow, C Tiribelli	FEBS Letters	2006
Brain protection at the blood-cerebrospinal fluid interface involves a glutathione-dependent metabolic barrier mechanism JF Ghersi-Egea, N Strazielle, A Murat, A Jouvet, A Buénerd, MF Belin	Journal of Cerebral Blood Flow & Metabolism	2006
G2677T and C3435T Genotype and Haplotype Are Associated With Hepatic ABCB1 ( MDR1 ) Expression P Song, JK Lamba, L Zhang, E Schuetz, N Shukla, B Meibohm, CR Yates	The Journal of Clinical Pharmacology	2006
Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters S Choudhuri, CD Klaassen	International Journal of Toxicology	2006
Role of GSH in Estrone Sulfate Binding and Translocation by the Multidrug Resistance Protein 1 (MRP1/ABCC1) A Rothnie, R Callaghan, RG Deeley, SP Cole	The Journal of biological chemistry	2006
Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins RG Deeley, C Westlake, SP Cole	Physiological reviews	2006
The Cell Cycle in the Central Nervous System D Janigro		2006
Optimizing the “Drug-Like” Properties of Leads in Drug Discovery RT Borchardt, EH Kerns, MJ Hageman, DR Thakker, JL Stevens		2006
Choroid plexus epithelial monolayers – a cell culture model from porcine brain C Baehr, V Reichel, G Fricker	Cerebrospinal fluid research	2006
Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System S Dallas, DS Miller, R Bendayan	Pharmacological reviews	2006
ABC drug transporter at the blood–brain barrier: Effects on drug metabolism and drug response M Ebinger, M Uhr	European Archives of Psychiatry and Clinical Neuroscience	2006
Mitochondria are sensors for HIV drugs F Petit, B Fromenty, A Owen, J Estaquier	Trends in Pharmacological Sciences	2005
Apical/Basolateral Surface Expression of Drug Transporters and its Role in Vectorial Drug Transport K Ito, H Suzuki, T Horie, Y Sugiyama	Pharmaceutical Research	2005
Function of prokaryotic and eukaryotic ABC proteins in lipid transport A Pohl, PF Devaux, A Herrmann	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2005
ATP-binding cassette (ABC) transporters in normal and pathological lung M der Deen, EG de Vries, W Timens, RJ Scheper, H Timmer-Bosscha, DS Postma	Respiratory Research	2005
Use ofin vitrotransporter assays to understand hepatic and renal disposition of new drug candidates J Sahi	Expert Opinion on Drug Metabolism & Toxicology	2005
Immuno-histochemical detection of MRPs in human lung cells in culture AR Torky, E Stehfest, K Viehweger, C Taege, H Foth	Toxicology	2005
Blood-brain barrier active efflux transporters: ATP-binding cassette gene family W Löscher, H Potschka	NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics	2005
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense EM Leslie, RG Deeley, SP Cole	Toxicology and Applied Pharmacology	2005
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases W Löscher, H Potschka	Progress in Neurobiology	2005
Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2 ER Lepper, K Nooter, J Verweij, MR Acharya, WD Figg, A Sparreboom	Pharmacogenomics	2005
Efflux transport systems at the blood–brain barrier and blood CSF barrier H Kusuhara, Y Sugiyama	International Congress Series	2005
The Blood-Brain Barrier and Its Microenvironment: Basic Physiology to Neurological Disease H Wolburg, A Warth	The Blood-Brain Barrier and Its Microenvironment: Basic Physiology to Neurological Disease	2005
Modulation of Oral Drug Bioavailability: From Preclinical Mechanism to Therapeutic Application IE Kuppens, P Breedveld, JH Beijnen, JH Schellens	Cancer Investigation	2005
The Blood-Cerebrospinal Fluid Barrier G Silverberg, J Szmydynger-Chodobska, A Chodobski	The Blood-Cerebrospinal Fluid Barrier	2005
Modulation of p-Glycoprotein Transport Function at the Blood-Brain Barrier B Bauer, AM Hartz, G Fricker, DS Miller	Experimental biology and medicine (Maywood, N.J.)	2005
LC/MS/MS in drug development: targeting the brain P Song, B Meibohm, CR Yates	BioTechniques	2005
Multiple Components of 2,4-Dichlorophenoxyacetic Acid Uptake by Rat Choroid Plexus S Lowes, D Sykes, CM Breen, LJ Ragone, DS Miller	The Journal of pharmacology and experimental therapeutics	2005
N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx RJ Veldman, S Zerp, WJ van Blitterswijk, M Verheij	British Journal of Cancer	2004
The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy P Borst, J Balzarini, N Ono, G Reid, H Vries, P Wielinga, J Wijnholds, N Zelcer	Antiviral Research	2004
The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin I Rigato, L Pascolo, C Fernetti, JD Ostrow, C Tiribelli	Biochemical Journal	2004
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy M Leggas, M Adachi, GL Scheffer, D Sun, P Wielinga, G Du, KE Mercer, Y Zhuang, JC Panetta, B Johnston, RJ Scheper, CF Stewart, JD Schuetz	Molecular and cellular biology	2004
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1) F Gennuso, C Fernetti, C Tirolo, N Testa, F L'Episcopo, S Caniglia, MC Morale, JD Ostrow, L Pascolo, C Tiribelli, B Marchetti	Proceedings of the National Academy of Sciences	2004
Molecular basis of bilirubin-induced neurotoxicity JD Ostrow, L Pascolo, D Brites, C Tiribelli	Trends in Molecular Medicine	2004
Rapid Production of Chicken Egg Yolk Antibodies Against Multidrug Resistance-Associated Protein 1 (MRP-1) T Özben, I Akan	Critical Reviews in Analytical Chemistry	2004
Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes C Mercier, C Masseguin, F Roux, J Gabrion, JM Scherrmann	Brain Research	2004
Progress in defining multidrug resistance in leukemia J Kappelmayer, Á Simon, F Kiss, Z Hevessy	Expert Review of Molecular Diagnostics	2004
Blood-Spinal Cord and Brain Barriers in Health and Disease E Anderson, L Ryan, H Xiong, S Swindells, J Zheng, HE Gendelman	Blood-Spinal Cord and Brain Barriers in Health and Disease	2004
The involvement of the blood–brain and the blood–cerebrospinal fluid barriers in the distribution of leptin into and out of the rat brain D Kurrimbux, Z Gaffen, CL Farrell, D Martin, SA Thomas	Neuroscience	2004
Handbook of Analytical Separations G Hempel	Handbook of Analytical Separations	2004
Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain AT Nies, G Jedlitschky, J König, C Herold-Mende, HH Steiner, HP Schmitt, D Keppler	Neuroscience	2004
Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells A Somogyvari-Vigh, AJ Kastin, J Liao, JE Zadina, W Pan	Experimental Brain Research	2004
A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence M Sawicka, M Kalinowska, J Skierski, W Lewandowski	Journal of Pharmacy and Pharmacology	2004
Identification of Proline Residues in the Core Cytoplasmic and Transmembrane Regions of Multidrug Resistance Protein 1 (MRP1/ABCC1) Important for Transport Function, Substrate Specificity, and Nucleotide Interactions K Koike, G Conseil, EM Leslie, RG Deeley, SP Cole	The Journal of biological chemistry	2004
Natural Phosphatidylcholine Is Actively Translocated across the Plasma Membrane to the Surface of Mammalian Cells N Kälin, J Fernandes, S Hrafnsdóttir, G Meer	The Journal of biological chemistry	2004
P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline MT Grauer, M Uhr	Journal of Psychopharmacology (Oxford, England)	2004
N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx RJ Veldman, S Zerp, WJ van Blitterswijk, M Verheij	British Journal of Cancer	2004
Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 ( Slc22a8 )-null mice D Sykes, DH Sweet, S Lowes, SK Nigam, JB Pritchard, DS Miller	American journal of physiology. Renal physiology	2004
Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy CM Breen, DB Sykes, C Baehr, G Fricker, DS Miller	American journal of physiology. Renal physiology	2004
Transport of HIV Protease Inhibitors Through the Blood-Brain Barrier and Interactions With the Efflux Proteins, P-Glycoprotein and Multidrug Resistance Proteins: F Gimenez, C Fernandez, A Mabondzo	Journal of acquired immune deficiency syndromes (1999)	2004
Molekularmedizinische Grundlagen von altersspezifischen Erkrankungen D Ganten, K Ruckpaul, A Ruiz-Torres		2004
Handbook of Anticancer Pharmacokinetics and Pharmacodynamics WD Figg, HL McLeod		2004
Cellular Drug Delivery DR Lu, S Øie		2004
Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice H Sasabe, Y Kato, T Suzuki, M Itose, G Miyamoto, Y Sugiyama	The Journal of pharmacology and experimental therapeutics	2004
New concepts in bilirubin encephalopathy JD Ostrow, L Pascolo, SM Shapiro, C Tiribelli	European Journal of Clinical Investigation	2003
In vitro and in vivo models for assessing drug efflux transporter activity Y Zhang, C Bachmeier, DW Miller	Advanced Drug Delivery Reviews	2003
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview AH Schinkel, JW Jonker	Advanced Drug Delivery Reviews	2003
P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo O Tellingen, T Buckle, JW Jonker, MA van der Valk, JH Beijnen	British Journal of Cancer	2003
Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria TM Davis, TQ Binh, KF Ilett, KT Batty, HL Phuöng, GM Chiswell, VD Phuong, C Agus	Antimicrobial agents and chemotherapy	2003
Bilirubin, a curse and a boon JD Ostrow, C Tiribelli	Gut	2003
Drug efflux transporters in the CNS H Sun, H Dai, N Shaik, WF Elmquist	Advanced Drug Delivery Reviews	2003
Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17?-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier? YJ Lee, H Kusuhara, Y Sugiyama	Journal of Pharmaceutical Sciences	2003
Pharmacogenomics of ABC transporters and its role in cancer chemotherapy A Sparreboom, R Danesi, Y Ando, J Chan, WD Figg	Drug Resistance Updates	2003
Basal Membrane Localization of MRP1 in Human Placental Trophoblast M Nagashige, F Ushigome, N Koyabu, K Hirata, M Kawabuchi, T Hirakawa, S Satoh, K Tsukimori, H Nakano, T Uchiumi, M Kuwano, H Ohtani, Y Sawada	Placenta	2003
Blood-brain barrier efflux transport PL Golden, GM Pollack	Journal of Pharmaceutical Sciences	2003
The role of multidrug transporters in drug availability, metabolism and toxicity A Bodó, É Bakos, F Szeri, A Váradi, B Sarkadi	Toxicology Letters	2003
abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice M Uhr, MT Grauer	Journal of Psychiatric Research	2003
P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes C Mercier, X Declèves, C Masseguin, P Fragner, M Tardy, F Roux, J Gabrion, JM Scherrmann	Journal of Neurochemistry	2003
ABC Proteins PA Rea, R Sánchez-Fernández, S Chen, M Peng, M Klein, M Geisler, E Martinoia	ABC Proteins	2003
Drugs and the Pharmaceutical Sciences D Thompson	Drugs and the Pharmaceutical Sciences	2003
Role of Multiple Drug Resistance Protein 1 in Neutral but Not Acidic Glycosphingolipid Biosynthesis MF de Rosa, D Sillence, C Ackerley, C Lingwood	The Journal of biological chemistry	2003
The MRP family of drug efflux pumps GD Kruh, MG Belinsky	Oncogene	2003
Peptide Transport and Delivery into the Central Nervous System L Prokai, K Prokai-Tatrai		2003
Impact of Drug Transporter Studies on Drug Discovery and Development N Mizuno, T Niwa, Y Yotsumoto, Y Sugiyama	Pharmacological reviews	2003
Functional Expression of the Multidrug Resistance Protein 1 in Microglia S Dallas, X Zhu, S Baruchel, L Schlichter, R Bendayan	The Journal of pharmacology and experimental therapeutics	2003
CONSTITUTIVE EXPRESSION OF VARIOUS XENOBIOTIC AND ENDOBIOTIC TRANSPORTER mRNAs IN THE CHOROID PLEXUS OF RATS S Choudhuri, NJ Cherrington, N Li, CD Klaassen	Drug Metabolism and Disposition	2003
Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier Daisuke Sugiyama, Hiroyuki Kusuhara, Yong-Joo Lee, Yuichi Sugiyama	Pharmaceutical Research	2003
Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells Salvatore Cisternino, Christophe Rousselle, Aurelio Lorico, Germana Rappa, Jean-Michel Scherrmann	Pharmaceutical Research	2003
MAMMALIANABC TRANSPORTERS INHEALTH ANDDISEASE P Borst, RO Elferink	Annual Review of Biochemistry	2002
The Role of Drug Efflux Pumps in Acute Myeloid Leukemia DM van der Kolk, EG de Vries, M Müller, E Vellenga	Leukemia & Lymphoma	2002
An oncological view on the blood–testis barrier J Bart, HJ Groen, WT van der Graaf, H Hollema, NH Hendrikse, W Vaalburg, DT Sleijfer, EG de Vries	The Lancet Oncology	2002
A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance S Conrad, HM Kauffmann, K Ito, EM Leslie, RG Deeley, D Schrenk, SP Cole	Pharmacogenetics	2002
Encyclopedia of Cancer G Sgouros	Encyclopedia of Cancer	2002
The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1) DP Olson, DT Scadden, RT D'Aquila, MP de Pasquale	AIDS	2002
Drug Transporters: Their Role and Importance in the Selection and Development of New Drugs N MIZUNO, Y SUGIYAMA	Drug Metabolism and Pharmacokinetics	2002
Role of the Multidrug Resistance Protein 1 in Protection from Heavy Metal Oxyanions: Investigations in Vitro and in MRP1-Deficient Mice A Lorico, A Bertola, C Baum, O Fodstad, G Rappa	Biochemical and Biophysical Research Communications	2002
Does P-glycoprotein play a role in pharmacoresistance to antiepileptic drugs? MA Rogawski	Epilepsy & Behavior	2002
Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney H Kusuhara, Y Sugiyama	Journal of Controlled Release	2002
Role of the multidrug resistance protein 1 gene in the carcinogenicity of aflatoxin B1: investigations using mrp1-null mice A Lorico, J Nesland, E Emilsen, O Fodstad, G Rappa	Toxicology	2002
M AMMALIAN ABC T RANSPORTERS IN H EALTH AND D ISEASE P Borst, RO Elferink	Annual Review of Biochemistry	2002
Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1 T Hegedűs, L Őrfi, A Seprődi, A Váradi, B Sarkadi, G Kéri	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2002
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs Maarten T Huisman, Johan W Smit, Kristel M L Crommentuyn, Noam Zelcer, Hugh R Wiltshire, Jos H Beijnen, Alfred H Schinkel	AIDS	2002
Multiple Membrane-associated Tryptophan Residues Contribute to the Transport Activity and Substrate Specificity of the Human Multidrug Resistance Protein, MRP1 K Koike, CJ Oleschuk, A Haimeur, SL Olsen, RG Deeley, SP Cole	The Journal of biological chemistry	2002
Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy SM Sisodiya, WR Lin, BN Harding, MV Squier, M Thom	Brain	2002
Confocal imaging of organic anion transport in intact rat choroid plexus CM Breen, DB Sykes, G Fricker, DS Miller	American journal of physiology. Renal physiology	2002
Localisation of breast cancer resistance protein in microvessel endothelium of human brain: HC Cooray, CG Blackmore, L Maskell, MA Barrand	NeuroReport	2002
Considerations in the Use of Cerebrospinal Fluid Pharmacokinetics to Predict Brain Target Concentrations in the Clinical Setting: Implications of the Barriers Between Blood and Brain EC de Lange, M Danhof	Clinical Pharmacokinetics	2002
Improvement of Oral Drug Treatment by Temporary Inhibition of Drug Transporters and/or Cytochrome P450 in the Gastrointestinal Tract and Liver: An Overview CM Kruijtzer, JH Beijnen, JH Schellens	The oncologist	2002
Neotrofin Is Transported Out of Brain by a Saturable Mechanism: Possible Involvement of Multidrug Resistance and Monocarboxylic Acid Transporters R Yan, EM Taylor	Drug Metabolism and Disposition	2002
Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs W Löscher, H Potschka	The Journal of pharmacology and experimental therapeutics	2002
Inhibition of the Multidrug Resistance Protein 1 (MRP1) by Peptidomimetic Glutathione-Conjugate Analogs D Burg, P Wielinga, N Zelcer, T Saeki, GJ Mulder, P Borst	Molecular pharmacology	2002
Expression and Functional Characterization of Rat Organic Anion Transporter 3 (rOat3) in the Choroid Plexus Y Nagata, H Kusuhara, H Endou, Y Sugiyama	Molecular pharmacology	2002
Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis Tessa ten Hove, Paul Drillenburg, Jan Wijnholds, Anje A Te Velde, Sander J H van Deventer	Digestive Diseases and Sciences	2002
The Impact of Efflux Transporters in the Brain on the Development of Drugs for CNS Disorders: EM Taylor	Clinical Pharmacokinetics	2002
Anticancer drug resistance in primary human brain tumors M Bredel	Brain Research Reviews	2001
The use of transgenic mice in pharmacokinetic and pharmacodynamic studies WF Elmquist, DW Miller	Journal of Pharmaceutical Sciences	2001
Intestinal drug efflux: formulation and food effects D Wagner, H Spahn-Langguth, A Hanafy, A Koggel, P Langguth	Advanced Drug Delivery Reviews	2001
Conditionally Immortalized Cell Lines as a New In Vitro Model for the Study of Barrier Functions T TERASAKI, K HOSOYA	Biological & Pharmaceutical Bulletin	2001
Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 2) H Kusuhara, Y Sugiyama	Drug Discovery Today	2001
Erythrocyte Membrane ATP Binding Cassette (ABC) Proteins: MRP1 and CFTR as Well as CD39 (Ecto-apyrase) Involved in RBC ATP Transport and Elevated Blood Plasma ATP of Cystic Fibrosis EH Abraham, KM Sterling, RJ Kim, AY Salikhova, HB Huffman, MA Crockett, N Johnston, HW Parker, WE Boyle, A Hartov, E Demidenko, J Efird, J Kahn, SA Grubman, DM Jefferson, SC Robson, JH Thakar, A Lorico, G Rappa, AC Sartorelli, P Okunieff	Blood Cells, Molecules, and Diseases	2001
Transport of Fluorescein in MDCKII-MRP1 Transfected Cells and mrp1-Knockout Mice H Sun, DR Johnson, RA Finch, AC Sartorelli, DW Miller, WF Elmquist	Biochemical and Biophysical Research Communications	2001
Cyclosporin A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicin T Saito, ZJ Zhang, M Tokuriki, T Ohtsubo, Y Shibamori, T Yamamoto, H Saito	Brain Research	2001
Expression of multidrug resistance protein 1 (MRP1) in the rat cochlea with special reference to the blood–inner ear barrier T Saito, ZJ Zhang, M Tokuriki, T Ohtsubo, I Noda, Y Shibamori, T Yamamoto, H Saito	Brain Research	2001
Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 1) H Kusuhara, Y Sugiyama	Drug Discovery Today	2001
Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig T Saito	Neuroscience Letters	2001
New concepts in bilirubin neurotoxicity and the need for studies at clinically relevant bilirubin concentrations JD Ostrow, C Tiribelli	Journal of Hepatology	2001
Influence of Multidrug Resistance (MDR) Proteins at the Blood–Brain Barrier on the Transport and Brain Distribution of Enaminone Anticonvulsants DS Cox, KR Scott, H Gao, S Raje, ND Eddington	Journal of Pharmaceutical Sciences	2001
Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3) N Zelcer, T Saeki, G Reid, JH Beijnen, P Borst	The Journal of biological chemistry	2001
Transport of the β- O -Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1): REQUIREMENT FOR GLUTATHIONE OR A NON-SULFUR-CONTAINING ANALOG EM Leslie, K Ito, P Upadhyaya, SS Hecht, RG Deeley, SP Cole	The Journal of biological chemistry	2001
Blood—Brain Barrier D Kobiler, S Lustig, S Shapira		2001
Biological Reactive Intermediates VI PM Dansette, R Snyder, M Delaforge, GG Gibson, H Greim, DJ Jollow, TJ Monks, IG Sipes		2001
Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models H Sun, D W Miller, W F Elmquist	Pharmaceutical Research	2001
The blood-brain barrier and oncology: new insights into function and modulation J Bart, HJ Groen, NH Hendrikse, WT der Graaf, W Vaalburg, EG Vries	Cancer Treatment Reviews	2000
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs J Wijnholds, CA Mol, L Deemter, M Haas, GL Scheffer, F Baas, JH Beijnen, RJ Scheper, S Hatse, ED Clercq, J Balzarini, P Borst	Proceedings of the National Academy of Sciences	2000
Drug efflux transporters and antiviral drug therapy RB Kim	Expert Opinion on Therapeutic Targets	2000
Multidrug resistance transporters and modulation B Tan, D Piwnica-Worms, L Ratner	Current Opinion in Oncology	2000
Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus JF Ghersi-Egea, N Strazielle	Microscopy Research and Technique	2000
A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins P Borst, R Evers, M Kool, J Wijnholds	JNCI Journal of the National Cancer Institute	2000
The (patho)physiological functions of the MRP family J Renes, EG de Vries, PL Jansen, M Müller	Drug Resistance Updates	2000
Drug Delivery to the Brain WM Pardridge	Journal of Cerebral Blood Flow & Metabolism	1997

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